Activating ERBB4 mutations in non-small cell lung cancer

ERBB4 Mutations that Disrupt the Neuregulin-ErbB4 Pathway Cause Amyotrophic Lateral Sclerosis Type 19

(2013) Yuji Takahashi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Oncogenic ERBB3 Mutations in Human Cancers

(2013) Bijay S. Jaiswal et al.   CANCER CELL

Management of non-small-cell lung cancer: recent developments

(2013) Martin Reck et al.   LANCET

Mechanism for activation of mutated epidermal growth factor receptors in lung cancer

(2013) M. Red Brewer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blocking NRG1 and Other Ligand-Mediated Her4 Signaling Enhances the Magnitude and Duration of the Chemotherapeutic Response of Non-Small Cell Lung Cancer

(2013) G. V. Hegde et al.   Science Translational Medicine

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

(2012) Marcin Imielinski et al.   CELL

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

A single ligand is sufficient to activate EGFR dimers

(2012) P. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2

(2012) H. Greulich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

(2011) Kathleen Aertgeerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

(2010) Diego Alvarado et al.   CELL

Cell Death or Survival Promoted by Alternative Isoforms of ErbB4

(2010) Maria Sundvall et al.   MOLECULAR BIOLOGY OF THE CELL

A Therapeutic Opportunity in Melanoma: ErbB4 Makes a Mark on Skin

(2009) Jeff Settleman   CANCER CELL

Her4 and Her2/neu Tyrosine Kinase Domains Dimerize and Activate in a Reconstitutedin VitroSystem

(2009) John Monsey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Vascular Endothelial Growth Factor D Variants with Increased Biological Activity

(2009) Pyry I. Toivanen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4

(2009) Todd D Prickett et al.   NATURE GENETICS

MutatedERBB4: a novel drug target in metastatic melanoma?

(2009) Kari Kurppa et al.   Pigment Cell & Melanoma Research

Somatic Mutations of ErbB4

(2008) Denis Tvorogov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

Lung Cancer

(2008) Roy S. Herbst et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase

(2008) Chen Qiu et al.   STRUCTURE