USP7 is essential for maintaining Rad18 stability and DNA damage tolerance

DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis

(2014) Michelle K. Zeman et al.   JOURNAL OF CELL BIOLOGY

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

(2014) Robert Huether et al.   Nature Communications

Deubiquitylating Enzymes and DNA Damage Response Pathways

(2013) Xavier Jacq et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

DUB-Resistant Ubiquitin to Survey Ubiquitination Switches in Mammalian Cells

(2013) Miklós Békés et al.   Cell Reports

Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme

(2012) Céline Reverdy et al.   CHEMISTRY & BIOLOGY

The Vital Role of Polymerase ζ and REV1 in Mutagenic, but Not Correct, DNA Synthesis across Benzo[a]pyrene-dG and Recruitment of Polymerase ζ by REV1 to Replication-stalled Site

(2012) Keiji Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Rev1 by the Fanconi anemia core complex

(2012) Hyungjin Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Requirement of Rad18 protein for replication through DNA lesions in mouse and human cells

(2012) J.-H. Yoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Multifaceted Roles of USP7: New Therapeutic Opportunities

(2011) Benjamin Nicholson et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition

(2011) Komaraiah Palle et al.   CELL CYCLE

DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation

(2011) Yong-Sam Jung et al.   DNA REPAIR

USP7 regulates the stability and function of HLTF through deubiquitination

(2011) Peng Qing et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The hMsh2-hMsh6 Complex Acts in Concert with Monoubiquitinated PCNA and Pol η in Response to Oxidative DNA Damage in Human Cells

(2011) Anastasia Zlatanou et al.   MOLECULAR CELL

SHPRH and HLTF Act in a Damage-Specific Manner to Coordinate Different Forms of Postreplication Repair and Prevent Mutagenesis

(2011) Jia-Ren Lin et al.   MOLECULAR CELL

Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A–RAD18 ternary complex

(2011) Yuji Masuda et al.   NUCLEIC ACIDS RESEARCH

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

(2011) Max Felle et al.   NUCLEIC ACIDS RESEARCH

Phosphorylated Rad18 directs DNA Polymerase η to sites of stalled replication

(2010) Tovah A. Day et al.   JOURNAL OF CELL BIOLOGY

Unconventional Ubiquitin Recognition by the Ubiquitin-Binding Motif within the Y Family DNA Polymerases ι and Rev1

(2010) Martha G. Bomar et al.   MOLECULAR CELL

Regulation of Translesion Synthesis DNA Polymerase η by Monoubiquitination

(2010) Marzena Bienko et al.   MOLECULAR CELL

Separate Domains of Rev1 Mediate Two Modes of DNA Damage Bypass in Mammalian Cells

(2009) J. G. Jansen et al.   MOLECULAR AND CELLULAR BIOLOGY

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

(2009) F. Colland et al.   MOLECULAR CANCER THERAPEUTICS

Cisplatin-Induced DNA Damage Activates Replication Checkpoint Signaling Components that Differentially Affect Tumor Cell Survival

(2009) J. M. Wagner et al.   MOLECULAR PHARMACOLOGY

Principles of ubiquitin and SUMO modifications in DNA repair

(2009) Steven Bergink et al.   NATURE

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

(2009) Jun Huang et al.   NATURE CELL BIOLOGY

hRev7, putative subunit of hPolζ, plays a critical role in survival, induction of mutations, and progression through S-phase, of UV(254nm)-irradiated human fibroblasts

(2008) Kristin McNally et al.   DNA REPAIR

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols