Article
Biochemistry & Molecular Biology
Ramkumar Thiyagarajan, Mary Taub
Summary: Cystinosis is a genetic disease that causes renal failure. Study using human-induced pluripotent stem cells found that the differentiation ability of cystinotic cells is impaired, which may lead to the malfunctioning of renal proximal tubule.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Bolin Jing, Lei Yan, Jiajia Li, Piaopiao Luo, Xiaoni Ai, Pengfei Tu
Summary: A high-throughput human renal proximal tubule model based on an integrated biomimetic array chip (iBAC) demonstrated improved epithelial polarization and membrane transporter activity, offering a more accurate prediction of nephrotoxicity.
Article
Chemistry, Medicinal
Marianne K. Vormann, Jelle Vriend, Henriette L. Lanz, Linda Gijzen, Angelique van den Heuvel, Simon Hutter, Jos Joore, Sebastiaan J. Trietsch, Christiaan Stuut, Tom T. G. Nieskens, Janny G. P. Peters, Daniela Ramp, Michaela Caj, Frans G. M. Russel, Bjoern Jacobsen, Adrian Roth, Shuyan Lu, Joseph W. Polli, Anita A. Naidoo, Paul Vulto, Rosalinde Masereeuw, Martijn J. Wilmer, Laura Suter-Dick
Summary: The Nephroscreen platform, using a combination of cell viability, LDH, and miRNA release, proved to be a robust and predictive method for detecting drug-induced kidney injury. It is compatible with automated pipetting, suitable for long-term experiments, and offers a valuable tool for replacing animal testing and supporting the 3Rs principles.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Takeshi Osonoi, Miyoko Saito, Mitsuru Hosoya, Satako Douguchi, Kensuke Ofuchi, Makoto Katoh
Summary: This study aims to evaluate the efficacy and safety of dotinurad in hyperuricemic patients with type 2 diabetic kidney disease. It will compare the levels of urate and indoxyl sulfate in the serum, plasma, and urine of patients before and after switching from febuxostat to dotinurad. The study hypothesizes that dotinurad can effectively lower serum urate levels without adversely affecting ABCG2.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Jasia King, Silvia M. Mihaila, Sabbir Ahmed, Roman Truckenmuller, Stefan Giselbrecht, Rosalinde Masereeuw, Aurelie Carlier
Summary: The research highlights the inadequacy of traditional dialysis for end-stage kidney disease and emphasizes the importance of computational models in developing alternative therapies. Experimental validation of the organic anionic transporter 1 model for indoxyl sulfate transport demonstrates the significant influence of transporter density and dissociation rate on toxin removal.
Article
Biochemistry & Molecular Biology
Rodrigo P. Silva-Aguiar, Douglas E. Teixeira, Rodrigo A. S. Peres, Sarah A. S. Alves, Carolina Novaes-Fernandes, Wagner B. Dias, Ana Acacia S. Pinheiro, Diogo B. Peruchetti, Celso Caruso-Neves
Summary: This study identified that in the early stage of diabetes, tubular sodium reabsorption impairment is due to SGLT2-mediated high glucose influx in proximal tubule epithelial cells (PTECs), leading to an increase in O-GlcNAcylation and a reduction in the expression and activity of ATPase (NKA).
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2023)
Article
Chemistry, Medicinal
Sumito Ito, Wooin Lee, Ji Eun Park, Masa Yasunaga, Ayano Mori, Sumio Ohtsuki, Yuichi Sugiyama
Summary: The study demonstrated the utility of transient, tunable transporter expression system in delineating the rate-determining process in hepatic elimination of compounds. It also revealed a proportional increase in biliary excretion clearance for taurocholate with the BSEP expression level. The inhibitory effects of rifampicin on BSEP and NTCP were quantitatively captured by kinetic modeling based on the extended clearance concept.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Toxicology
Annelies Noorlander, Sebastiaan Wesseling, Ivonne M. C. M. Rietjens, Bennard van Ravenzwaay
Summary: This study successfully incorporated active renal excretion via OCT2 transporter into a generic rat PBK model to predict the kinetics of MQ in rats using SA7K cells and MQ as the model compound. By applying a scaling factor to correct for differences in OCT2 activity and species variations, the model predictions improved significantly.
TOXICOLOGY LETTERS
(2021)
Article
Endocrinology & Metabolism
Zhongli Chen, Robin P. Peeters, Wesley Flach, Linda J. de Rooij, Sena Yildiz, Alexander Teumer, Matthias Nauck, Rosalie B. T. M. Sterenborg, Joost H. W. Rutten, Marco Medici, W. Edward Visser, Marcel E. Meima
Summary: This study identifies a novel group of transporters for (sulfated) iodothyronines in the organic anion transporter (OAT) subfamily of solute carrier (SLC) 22 family. These transporters play a critical role in the uptake of thyroid hormones and further research is needed to understand their relevance in thyroid hormone homeostasis and physiology.
EUROPEAN THYROID JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Milos Mihajlovic, Merle M. Krebber, Yi Yang, Sabbir Ahmed, Valeria Lozovanu, Daria Andreeva, Marianne C. Verhaar, Rosalinde Masereeuw
Summary: This study demonstrated that PBUTs induce inflammasome-mediated IL-1 beta production in proximal tubule cells via oxidative stress and NF-kappa B signaling, suggesting their involvement in disease-associated inflammatory processes.
Article
Pharmacology & Pharmacy
Stacey M. Tuey, Amandla Atilano-Roque, Georgia Charkoftaki, Joshua M. Thurman, Thomas D. Nolin, Melanie S. Joy
Summary: The study evaluated the effects of cholecalciferol and calcitriol on the expression and function of major vitamin D metabolizing enzymes and drug transport pathways in human kidney proximal tubule epithelial cells. Differential effects of uraemic serum and vitamin D treatment on the functional expression of CYPs and transporters in hPTECs were observed.
Article
Endocrinology & Metabolism
Marty K. S. Wong, Yoshio Takei
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2018)
Article
Biology
Ilan M. Ruhr, Kevin L. Schauer, Yoshio Takei, Martin Grosell
JOURNAL OF EXPERIMENTAL BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Yukitoshi Katayama, Tatsuya Sakamoto, Kazuhiro Saito, Hirotsugu Tsuchimochi, Hiroyuki Kaiya, Taro Watanabe, James T. Pearson, Yoshio Takei
SCIENTIFIC REPORTS
(2018)
Article
Fisheries
Makoto Kusakabe, Shigenori Nobata, Kaede Saito, Kiriko Ikeba, Sanae Ogasawara, Kiyoshi Tanaka, Yoshio Takei, Susumu Hyodo
Review
Physiology
Yukitoshi Katayama, Tatsuya Sakamoto, Keiko Takanami, Yoshio Takei
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Biology
Yoshio Takei, Marty K. S. Wong, Masaaki Ando
JOURNAL OF EXPERIMENTAL BIOLOGY
(2019)
Article
Zoology
Takashi Haramura, Taro Ikegami, Marty K. S. Wong, Yoshio Takei
ZOOLOGICAL SCIENCE
(2019)
Article
Multidisciplinary Sciences
Yukitoshi Katayama, Yoshio Takei, Makoto Kusakabe, Tatsuya Sakamoto
SCIENTIFIC REPORTS
(2019)
Editorial Material
Endocrinology & Metabolism
Akiyoshi Takahashi, Yoshio Takei
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2019)
Article
Zoology
Shigenori Nobata, Takashi Kitagawa, Kiyoshi Tanaka, Kosei Komatsu, Yoshinori Aoki, Katsufumi Sato, Yoshio Takei, Susumu Hyodo
ZOOLOGICAL SCIENCE
(2019)
Review
Endocrinology & Metabolism
Yoshio Takei
Summary: Guanylyl cyclase (GC) is an enzyme that produces cGMP, a second messenger for intracellular signal transduction. pGCs perceive environmental factors and transmit information into cells through cGMP, while sGC is a receptor for nitric oxide and carbon monoxide.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2022)
Review
Zoology
Yoshio Takei
Summary: Adaptation to a hypertonic marine environment is crucial for animal survival, with marine teleosts being able to compensate for water loss by absorbing water from the surrounding seawater. Eels, known for their euryhalinity, are commonly used in laboratories for osmoregulation research, providing insights into molecular mechanisms of ion and water transport in the digestive tract. Recent advancements in genome databases have enabled a better understanding of these mechanisms at the molecular level.
ZOOLOGICAL LETTERS
(2021)
Article
Cell Biology
Yukitoshi Katayama, Ami Saito, Maho Ogoshi, Yousuke Tsuneoka, Takao Mukuda, Morio Azuma, Makoto Kusakabe, Yoshio Takei, Takehiro Tsukada
Summary: The cloning of cnp genes from the brain of eel and zebrafish reveals different expressions of cnp4b and cnp4a in different brain regions. This suggests a subfunctionalization of duplicated cnp4s in ancestral teleosts, with cnp4b potentially involved in swallowing and respiration functions.
CELL AND TISSUE RESEARCH
(2022)
Article
Endocrinology & Metabolism
Yoshio Takei, Masaaki Ando, Marty K. S. Wong, Takehiro Tsukada
Summary: This study investigates the molecular mechanisms of transepithelial Cl- transport in the intestine of seawater-acclimated eels, and reveals that GN stimulates Cl- secretion. The DNDS-sensitive anion exchanger (AE) and Na+-HCO3- cotransporter (NBC) play a crucial role in Cl- uptake at the basolateral side, while an unknown DPC-sensitive Cl- channel (ClC) is responsible for Cl- secretion at the mucosal side.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2022)
Article
Biology
Shigenori Nobata, Yoshio Takei
Summary: In this study, it was found that isotocin is the potent dipsogenic hormone in eels, while vasopressin and oxytocin are not dipsogenic in mammals. Isotocin induces copious drinking through its action on the AP, while AngII may induce drinking through its action on a different circumventricular site.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)