PAR1 inhibition suppresses the self-renewal and growth of A2B5-defined glioma progenitor cells and their derived gliomas in vivo

The Emerging Role of the Thrombin Receptor (PAR-1) in Melanoma Metastasis - a Possible Therapeutic Target

(2015) Gabriel J. Villares et al.   Oncotarget

Protease-activated receptor-1 drives pancreatic cancer progression and chemoresistance

(2014) Karla C.S. Queiroz et al.   INTERNATIONAL JOURNAL OF CANCER

Overexpression of protease-activated receptor type 1 (PAR-1) in glioblastoma multiforme WHO IV cells and blood vessels revealed by NCAM-assisted glioblastoma border labeling

(2014) Susanne A. Kuhn et al.   NEUROLOGICAL RESEARCH

Comparative Expression Study of the Endo–G Protein Coupled Receptor (GPCR) Repertoire in Human Glioblastoma Cancer Stem-like Cells, U87-MG Cells and Non Malignant Cells of Neural Origin Unveils New Potential Therapeutic Targets

(2014) Marie Fève et al.   PLoS One

Proteinase-Activated Receptor 1 (PAR1) Regulates Leukemic Stem Cell Functions

(2014) Nicole Bäumer et al.   PLoS One

Prevalence and Clinicopathologic Characteristics of the Molecular Subtypes in Malignant Glioma: A Multi-Institutional Analysis of 941 Cases

(2014) Ning Lin et al.   PLoS One

Biased Signaling of Protease-Activated Receptors

(2014) Peishen Zhao et al.   Frontiers in Endocrinology

Proteinase-activated receptors (PARs) – focus on receptor-receptor-interactions and their physiological and pathophysiological impact

(2013) Frank Gieseler et al.   Cell Communication and Signaling

An Activated Protein C Analog Stimulates Neuronal Production by Human Neural Progenitor Cells via a PAR1-PAR3-S1PR1-Akt Pathway

(2013) H. Guo et al.   JOURNAL OF NEUROSCIENCE

Coagulation-related gene expression profile in glioblastoma is defined by molecular disease subtype

(2013) N. Magnus et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Transcriptional Differences between Normal and Glioma-Derived Glial Progenitor Cells Identify a Core Set of Dysregulated Genes

(2013) Romane M. Auvergne et al.   Cell Reports

Effect of cancer therapy on neural stem cells

(2012) Erin Gibson et al.   CURRENT OPINION IN ONCOLOGY

Targeting proteinase-activated receptors: therapeutic potential and challenges

(2012) Rithwik Ramachandran et al.   NATURE REVIEWS DRUG DISCOVERY

Thromboembolic disease in patients with high-grade glioma

(2012) J. R. Perry   NEURO-ONCOLOGY

The Association of Protease Activated Receptor 1 gene −506 I/D Polymorphism with Disease-Free Survival in Breast Cancer Patients

(2011) Aydan Eroğlu et al.   ANNALS OF SURGICAL ONCOLOGY

Direct thrombin inhibitors

(2011) Catherine J. Lee et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Use of dabigatran etexilate to reduce breast cancer progression

(2011) Karen DeFeo et al.   CANCER BIOLOGY & THERAPY

PAR-1 and Thrombin: The Ties That Bind the Microenvironment to Melanoma Metastasis

(2011) M. Zigler et al.   CANCER RESEARCH

Cancer stem cells in gliomas: Identifying and understanding the apex cell in cancer's hierarchy

(2011) Monica Venere et al.   GLIA

PAR1 plays a role in epithelial malignancies: Transcriptional regulation and novel signaling pathway

(2011) Rachel Bar-Shavit et al.   IUBMB LIFE

Correlation Between MMP1-PAR1 Axis and Clinical Outcome of Primary Gallbladder Carcinoma

(2011) X. Du et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Structure, function and pathophysiology of protease activated receptors

(2011) Mark N. Adams et al.   PHARMACOLOGY & THERAPEUTICS

Signal transduction by protease-activated receptors

(2010) Unice JK Soh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Non-Stem Cell Origin for Oligodendroglioma

(2010) Anders I. Persson et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer

(2010) Andrea Pia Elste et al.   JOURNAL OF MOLECULAR HISTOLOGY

Upregulation of matrix metalloproteinase-1 and proteinase-activated receptor-1 promotes the progression of human gliomas

(2010) Yan Zhang et al.   PATHOLOGY RESEARCH AND PRACTICE

Role of the tissue factor pathway in the biology of tumor initiating cells

(2010) Delphine Garnier et al.   THROMBOSIS RESEARCH

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Tissue Factor and Cancer Stem Cells

(2009) Chloe Milsom et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A2B5 Cells from Human Glioblastoma have Cancer Stem Cell Properties

(2009) Aurélie Tchoghandjian et al.   BRAIN PATHOLOGY

Thrombin-Activated Receptors: Promising Targets for Cancer Therapy?

(2009) M. Garcia-Lopez et al.   CURRENT MEDICINAL CHEMISTRY

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Clinical Pharmacokinetics and Pharmacodynamics of the Oral Direct Thrombin??Inhibitor Dabigatran Etexilate

(2008) Joachim Stangier   CLINICAL PHARMACOKINETICS

IDENTIFICATION OF A2B5+CD133− TUMOR-INITIATING CELLS IN ADULT HUMAN GLIOMAS

(2008) Alfred T. Ogden et al.   NEUROSURGERY

Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion

(2008) P Arora et al.   ONCOGENE