Article
Oncology
Shangwei Hu, Jianhui Cai, Hua Fang, Zhen Chen, Jicai Zhang, Run Cai
Summary: RPS14 is found to be overexpressed in glioma, and its depletion can significantly suppress glioma cell proliferation and migration while promoting apoptosis. The effects of RPS14 knockdown on glioma may be closely associated with the p53 signaling pathway, and attenuation of these effects can be achieved by inhibiting the p53 pathway. Therefore, RPS14 may serve as a potential therapeutic target for gliomas.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Oncology
Chuntao Li, Bo Chen, Junxia Zhang, Jingxuan Yang, Muzi Guo, Yu Ren, Zhijun Zhou, Kar-Ming Fung, Min Li, Liyang Zhang, Zhixiong Liu
Summary: SEM1 is highly expressed in gliomas and correlated with malignant features and poor prognosis. SEM1 plays a critical role in the proliferation, apoptosis, invasion, and migration of glioma cells through regulating the PI3K-Akt pathway. The SEM1 malignant regulatory network shows significant importance for the prognosis and treatment of gliomas.
Article
Chemistry, Multidisciplinary
Lin-feng Zhan, Qi Zhang, Lu Zhao, Xue Dong, Xin-yu Pei, Li-li Peng, Xiao-wen Zhang, Bo Meng, Wen-di Shang, Zhen-wei Pan, Chao-qian Xu, Yan-jie Lu, Ming-yu Zhang
Summary: This study showed that lncRNA-6395 plays a crucial role in myocardial I/R injury by promoting cardiomyocyte apoptosis through inhibiting p53 degradation and facilitating its sub-cellular translocation. Overexpression of lncRNA-6395 led to cell apoptosis while knockdown attenuated apoptosis, highlighting its role as an endogenous pro-apoptotic factor in regulating cardiac function.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Oncology
Jie Sheng, Xin He, Wei Yu, Yingxi Chen, Yuxiang Long, Kejian Wang, Shujuan Zhu, Qian Liu
Summary: Glioma, the most prevalent intracranial tumor, is regulated by a positive feedback loop involving the p53/ST7-AS1/PTBP1 axis, which may serve as a promising therapeutic target for glioma treatment.
Article
Biotechnology & Applied Microbiology
Xiaojuan Zhang, Yuqing Cui, Xianfei Ding, Shaohua Liu, Bing Han, Xiaoguang Duan, Haibo Zhang, Tongwen Sun
Summary: Pediatric sepsis is a significant threat globally, and the pathogenesis remains unclear. This study identified differentially expressed mRNAs and lncRNAs associated with pediatric sepsis using the GEO database and conducted WGCNA to explore co-expression modules. Through GO and KEGG pathway analysis, the study revealed hub genes and their potential diagnostic markers for pediatric sepsis. The findings provide valuable insights for studying the molecular mechanisms of pediatric sepsis.
Article
Neurosciences
Zeyu Wu, Peng Lun, Tao Ji, Jiaojiao Niu, Xiuyan Sun, Xia Liu, Jian Xu
Summary: This study demonstrates that SNHG25 is upregulated in glioma cells and tissues, and its knockdown inhibits glioma cell proliferation and tumor growth. SNHG25 positively regulates MAPK signaling through sponging miR-579-5p and activating MAP2K2. Therefore, SNHG25 may serve as a potential target and biomarker for glioma.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Bo Xu, Yonggang Wei, Fei Liu, Lian Li, Siqi Zhou, Yufu Peng, Bo Li
Summary: The study has shown that CERS6-AS1 is highly expressed in HCC patients and is associated with poor prognosis. This lncRNA promotes cell growth, invasion, and glycolysis, and enhances MDM2 through sponging miR-30b-3p, ultimately leading to MDM2-mediated ubiquitin-dependent degradation of the p53 tumor suppressor.
CELL DEATH DISCOVERY
(2022)
Article
Chemistry, Medicinal
Jiayi Teng, Yu Chen, Shengnan Xiao, Tao Li, Guangyue Su, Guiyan Wang, Yuqing Zhao
Summary: In this study, 25 new panaxadiol derivatives were synthesized and their cytotoxicity against cancer cells was examined. The findings showed that the cyanopyrimidine derivatives had superior anti-proliferative effects, especially PM14 which exhibited the strongest inhibitory activity on human hepatoma cell lines.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Oncology
Hao Zhang, Huajun Sheng, Zhen Guo, Yu Xing, Qian Liu, Ziling Cai, Zihao Shen, Qingqian Xia, Shujuan Zhu
Summary: According to the study, AQP8 plays a significant role in the proliferation and growth of gliomas. Overexpression of AQP8 promotes cell proliferation, invasion, and migration, inhibits apoptosis, and affects the ROS/PTEN/AKT signaling pathway. Therefore, AQP8 may serve as a potential therapeutic target in gliomas.
Article
Biochemistry & Molecular Biology
Chao Song, Dongmei Shi, Kaiwen Chang, Xianghui Li, Qing Dong, Xia Ma, Xuefei Wang, Zhenhuan Guo, Yonglu Liu, Jundong Wang
Summary: Fluoride-induced pulmonary toxicity is related to cell apoptosis, with activation of caspase-8 and induction of DR5 playing critical roles. NOX4 and p53 mediate the expression of DR5 induced by NaF, influencing pulmonary apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Wenpeng Xie, Wenjie Chang, Xiaole Wang, Fei Liu, Xu Wang, Daotong Yuan, Yongkui Zhang
Summary: Allicin promotes oxidative stress and autophagy in osteosarcoma by inhibiting the expression of lncRNA MALAT1 and miR-376a, and inhibiting the Wnt/beta-catenin pathway, thereby suppressing tumor growth.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Zilin Liu, Xuezhong Wang, Jianping Li, Xiaoming Yang, Jun Huang, Chuang Ji, Xuyang Li, Lan Li, Jianlin Zhou, Yong Hu
Summary: This study found that GNA can trigger multiple cell death modalities, including ferroptosis and apoptosis, in human osteosarcoma cells, and inhibit cell growth and invasiveness. It was also found that GNA induces oxidative stress and affects the expression of certain genes involved in cell death regulation. In vivo experiments demonstrated that GNA can significantly delay tumor growth in a mouse model of osteosarcoma.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cell Biology
Yue Zhao, Dongsheng Bai, Jiaying Du, Haochuan Ren, Zhenguo Zhang, Cheng Jiang, Na Lu
Summary: CPUC002 inhibits proliferation and induces apoptosis in multiple myeloma cells by stabilizing p53 and inhibiting the STAT3 signaling pathway, suggesting potential therapeutic targets for multiple myeloma treatment.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaolei Yao, Mohamed AbdFatah El-Samahy, Xiaodan Li, Yongjin Bao, Jiahe Guo, Fan Yang, Zhibo Wang, Kang Li, Yanli Zhang, Feng Wang
Summary: This study identified a novel long non-coding RNA, lncRNA-412.25, which regulates granulosa cell proliferation and apoptosis in Hu sheep by binding to miR-346 and activating the LIF/STAT3 pathway. These findings provide novel insights into the mechanisms underlying prolificacy in sheep.
Article
Oncology
Yue-Feng Sun, Yuan Wang, Xiao-Dong Li, Hong Wang
Summary: This study reveals the association between the upregulation of small nucleolar RNA host gene 15 (SNHG15) and chemoresistance in osteosarcoma. The tumor suppressor p53 is found to downregulate SNHG15 expression and inhibit cisplatin-induced apoptosis and reactive oxygen species accumulation via the miR-335-3p/ZNF32 pathway.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Physics, Multidisciplinary
Jin-Yi Zhang, Chang-Rui Yi, Long Zhang, Rui-Heng Jiao, Kai-Ye Shi, Huan Yuan, Wei Zhang, Xiong-Jun Liu, Shuai Chen, Jian-Wei Pan
Summary: Floquet engineering allows for the creation of new topological states that cannot be achieved in static systems. In this study, we experimentally realize and characterize anomalous topological states using high-precision Floquet engineering for ultracold atoms trapped in a shaking optical Raman lattice.
PHYSICAL REVIEW LETTERS
(2023)
Article
Physics, Multidisciplinary
Hao-Tao Zhu, Yizhi Huang, Hui Liu, Pei Zeng, Mi Zou, Yunqi Dai, Shibiao Tang, Hao Li, Lixing You, Zhen Wang, Yu-Ao Chen, Xiongfeng Ma, Teng-Yun Chen, Jian-Wei Pan
Summary: In the past two decades, quantum key distribution networks based on telecom fibers have been implemented on metropolitan and intercity scales. One of the challenges is the exponential decay of the key rate with transmission distance. However, a recently proposed mode-pairing idea has allowed high-performance quantum key distribution without global phase locking, achieving improved key rates over conventional schemes in both metropolitan and intercity distances.
PHYSICAL REVIEW LETTERS
(2023)
Article
Pediatrics
Xinran Chu, Maoxiang Qian, Jin Yang, Dong Wu, Jing Gao, Lu Cao, Fang Fang, Jian Pan, Hui Zhang, Shaoyan Hu
Summary: The study aimed to evaluate the influence of GATA3 rs3824662 on pre-B-cell ALL susceptibility and long-term prognosis in Han Chinese children. The results showed that GATA3 rs3824662 was associated with susceptibility to pre-B-cell ALL and could be a risk factor for poor treatment response and treatment-related sepsis.
FRONTIERS IN PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Mei Yan, Jian Pan, Jie Huang, Changwei Liu, Xiaona Xia, Ting Zhu, Yuanyuan Wan, Yongjun Fang, Weibing Tang
Summary: This study evaluated the nutritional status of children who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) in the first 100 days. The study aimed to clarify the effect of weight loss on clinical outcomes and to analyze factors influencing weight loss. Data from 80 pediatric patients were collected and analyzed to investigate the factors affecting weight loss and the impact of weight loss on clinical outcomes.
FRONTIERS IN NUTRITION
(2023)
Article
Optics
Wei Li, Likang Zhang, Hao Tan, Yichen Lu, Sheng-Kai Liao, Jia Huang, Hao Li, Zhen Wang, Hao-Kun Mao, Bingze Yan, Qiong Li, Yang Liu, Qiang Zhang, Cheng-Zhi Peng, Lixing You, Feihu Xu, Jian-Wei Pan
Summary: This article reports a QKD system that can generate keys at a record high rate of 115.8 Mb/s over a 10 km standard optical fiber and distribute keys over up to 328 km of ultralow-loss fiber. These abilities are attributed to a multipixel superconducting nanowire single-photon detector with an ultrahigh counting rate, an integrated transmitter that can stably encode polarization states with low error, a fast post-processing algorithm for generating keys in real time, and the high system clock rate operation. The results demonstrate the feasibility of practical high-rate QKD with photonic techniques, thus opening its possibility for widespread applications.
Article
Physics, Multidisciplinary
Wei Li, Likang Zhang, Yichen Lu, Zheng-Ping Li, Cong Jiang, Yang Liu, Jia Huang, Hao Li, Zhen Wang, Xiang-Bin Wang, Qiang Zhang, Lixing You, Feihu Xu, Jian-Wei Pan
Summary: We propose and demonstrate a new method to achieve twin-field quantum key distribution (TF-QKD) without the need for phase locking. By separating the communication time into reference frames and quantum frames, we establish a global phase reference using the reference frames and reconcile the phase reference efficiently using a tailored algorithm based on fast Fourier transform. We successfully demonstrate no-phase-locking TF-QKD from short to long distances over standard optical fibers, achieving high secret key rates and repeaterlike key rates. Our work provides a scalable and practical solution to TF-QKD, representing an important step towards its wide applications.
PHYSICAL REVIEW LETTERS
(2023)
Article
Physics, Multidisciplinary
Jian Qin, Yu-Hao Deng, Han-Sen Zhong, Li-Chao Peng, Hao Su, Yi-Han Luo, Jia-Min Xu, Dian Wu, Si-Qiu Gong, Hua-Liang Liu, Hui Wang, Ming-Cheng Chen, Li Li, Nai-Le Liu, Chao-Yang Lu, Jian-Wei Pan
Summary: Quantum metrology aims to enhance measurement sensitivity by utilizing quantum resources. We propose and realize a novel quantum metrology scheme that combines unconventional nonlinear interferometers and stimulated emission of squeezed light. Our method achieves a scalable, unconditional, and robust quantum metrological advantage, outperforming ideal 5-N00N states. The demonstrated enhancement in Fisher information per photon, without discounting for imperfections or photon loss, makes our approach applicable in practical quantum metrology at low photon flux regime.
PHYSICAL REVIEW LETTERS
(2023)
Article
Physics, Multidisciplinary
Xue-Mei Gu, Liang Huang, Alejandro Pozas-Kerstjens, Yang-Fan Jiang, Dian Wu, Bing Bai, Qi-Chao Sun, Ming-Cheng Chen, Jun Zhang, Sixia Yu, Qiang Zhang, Chao-Yang Lu, Jian-Wei Pan
Summary: Nonlocality in networks composed of independent sources exhibits different phenomena compared to standard Bell scenarios. Network nonlocality in the entanglement-swapping scenario has been extensively studied, but previous violations of bilocality inequality could not certify the nonclassicality of their sources. We experimentally observe full network nonlocal correlations in a network where the loopholes of source-independence, locality, and measurement-independence are closed. Our experiment violates known inequalities for nonfull network nonlocal correlations by over 5 standard deviations, confirming the absence of classical sources.
PHYSICAL REVIEW LETTERS
(2023)
Article
Physics, Multidisciplinary
Li-Zheng Liu, Yue-Yang Fei, Yingqiu Mao, Yi Hu, Rui Zhang, Xu-Fei Yin, Xiao Jiang, Li Li, Nai-Le Liu, Feihu Xu, Yu-Ao Chen, Jian-Wei Pan
Summary: In this study, a full-period quantum phase estimation approach is proposed and demonstrated. The approach adopts Kitaev's phase estimation algorithm to eliminate phase ambiguity and uses GHZ states to obtain phase values. Through an eight-photon experiment, the estimation of unknown phases in a full period is achieved, and the phase super-resolution and sensitivity beyond the shot-noise limit are observed. This research provides a new way for quantum sensing and represents a solid step towards its general applications.
PHYSICAL REVIEW LETTERS
(2023)
Article
Physics, Multidisciplinary
Chong Ying, Bin Cheng, Youwei Zhao, He-Liang Huang, Yu-Ning Zhang, Ming Gong, Yulin Wu, Shiyu Wang, Futian Liang, Jin Lin, Yu Xu, Hui Deng, Hao Rong, Cheng-Zhi Peng, Man -Hong Yung, Xiaobo Zhu, Jian-Wei Pan
Summary: Although NISQ quantum computing devices are still limited in terms of qubit quantity and quality, quantum computational advantage has been experimentally demonstrated. Hybrid quantum and classical computing architectures have become the main paradigm for exhibiting NISQ applications, with the use of low-depth quantum circuits. This study demonstrates a circuit-cutting method for simulating quantum circuits with multiple logical qubits using only a few physical superconducting qubits, showcasing higher fidelity and scalability.
PHYSICAL REVIEW LETTERS
(2023)
Article
Physics, Multidisciplinary
Yu-Hao Deng, Si-Qiu Gong, Yi-Chao Gu, Zhi-Jiong Zhang, Hua-Liang Liu, Hao Su, Hao-Yang Tang, Jia-Min Xu, Meng-Hao Jia, Ming-Cheng Chen, Han-Sen Zhong, Hui Wang, Jiarong Yan, Yi Hu, Jia Huang, Wei -Jun Zhang, Hao Li, Xiao Jiang, Lixing You, Zhen Wang, Li Li, Nai-Le Liu, Chao -Yang Lu, Jian-Wei Pan
Summary: Gaussian boson sampling (GBS) is a protocol for demonstrating quantum computational advantage and is mathematically associated with graph-related and quantum chemistry problems. This study investigates the enhancement of GBS over classical stochastic algorithms on noisy quantum devices in the computationally interesting regime. Experimental results show the presence of GBS enhancement with a large photon-click number and robustness under certain noise, which may stimulate the development of more efficient classical and quantum-inspired algorithms.
PHYSICAL REVIEW LETTERS
(2023)
Article
Instruments & Instrumentation
Chao Yu, Tianyi Li, Xian-Song Zhao, Hai Lu, Rong Zhang, Feihu Xu, Jun Zhang, Jian-Wei Pan
Summary: In this study, a 4H-SiC single-photon avalanche diode (SPAD) based free-running ultraviolet single-photon detector (UVSPD) with ultralow afterpulse probability is reported. A beveled mesa structure is designed and fabricated for the 4H-SiC SPAD, which shows the characteristic of ultralow dark current. A readout circuit of passive quenching and active reset with a tunable hold-off time setting is further developed to significantly suppress the afterpulsing effect. The nonuniformity of photon detection efficiency (PDE) across the SPAD active area is investigated for performance optimization. The compact UVSPD shows a PDE of 10.3%, a dark count rate of 133 kcps, and an afterpulse probability of 0.3% at 266 nm, indicating its potential for practical ultraviolet photon-counting applications.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2023)
Article
Quantum Science & Technology
Xina Wang, Xufeng Jiao, Bin Wang, Yang Liu, Xiu-Ping Xie, Ming-Yang Zheng, Qiang Zhang, Jian-Wei Pan
Summary: This study demonstrates a low-noise quantum frequency conversion (QFC) process on the LNOI nanophotonic platform, achieving an internal conversion efficiency of 73% and an on-chip noise count of 900 counts per second (cps). The preservation of quantum statistical properties is also verified, indicating the potential applications of LNOI integrated circuits in quantum information. Additionally, an upconversion single-photon detector with a detection efficiency of 8.7% and a noise of 300 cps is constructed, paving the way for on-chip integrated single-photon detection.
NPJ QUANTUM INFORMATION
(2023)
Article
Physics, Multidisciplinary
Guo-Xian Su, Hui Sun, Ana Hudomal, Jean-Yves Desaules, Zhao-Yu Zhou, Bing Yang, Jad C. Halimeh, Zhen-Sheng Yuan, Zlatko Papie, Jian-Wei Pan
Summary: The ongoing quest for understanding nonequilibrium dynamics of complex quantum systems has led to the discovery of quantum many-body scarring. This phenomenon allows for the delay of thermalization by preparing the system in special initial states. In this study, the researchers demonstrate many-body scarring in a Bose-Hubbard quantum simulator, using previously unknown initial conditions. This work opens up new possibilities for exploring the relationship between scarring and various quantum phenomena.
PHYSICAL REVIEW RESEARCH
(2023)
Article
Optics
Jin Cao, Huan Yang, Zhen Su, Xin-Yao Wang, Jun Rui, Bo Zhao, Jian-Wei Pan
Summary: We have successfully prepared a quantum degenerate mixture of 23Na 40K molecules and 40K atoms. The atoms are highly degenerate with a large number ratio, while the molecules are in a moderately degenerate state. The elastic collisions between the atoms and molecules provide a thermalization mechanism, allowing the molecules to reach thermal equilibrium before significant losses occur. The degeneracy of the molecules is maintained for a sufficient time interval for further study and production of ultracold triatomic molecular gases.