Article
Oncology
Francois Lallemand, Natacha Leroi, Silvia Blacher, Mohamed Ali Bahri, Evelyne Balteau, Philippe Coucke, Agnes Noel, Alain Plenevaux, Philippe Martinive
Summary: Significant changes in perfusion-related parameters were observed on day 6 in a neoadjuvant radiotherapy model using SCID mice, which correlated with an increase in perfused vessels and metastasis spreading after surgery. This observation suggests the potential for personalized treatment by adjusting the timing of surgery based on MRI functional data, especially tumor perfusion.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shun Kishimoto, Jeffrey R. Brender, Gadisetti V. R. Chandramouli, Yu Saida, Kazutoshi Yamamoto, James B. Mitchell, Murali C. Krishna
Summary: The study demonstrates that evofosfamide not only kills the hypoxic regions in tumors, but also improves oxygenation in remaining tumor regions, providing a rationale for combination therapies with radiation and antiproliferatives. Monitoring changes in pO(2) following treatment may offer insight into treatment response.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Oncology
Mengjie Ma, Jianye Liang, Dong Zhang, Xi Xu, Qingqing Cheng, Zeyu Xiao, Changzheng Shi, Liangping Luo
Summary: Anti-angiogenic therapy combined with hypoxia-activated prodrugs effectively inhibits tumor growth. IVIM-DWI and BOLD-MRI can be utilized noninvasively to monitor the tumor microenvironment, including perfusion, hypoxia, cell apoptosis, and proliferation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
John Virostko, Anna G. Sorace, Kalina P. Slavkova, Anum S. Kazerouni, Angela M. Jarrett, Julie C. DiCarlo, Stefanie Woodard, Sarah Avery, Boone Goodgame, Debra Patt, Thomas E. Yankeelov
Summary: This study aimed to determine if advanced quantitative MRI could be used in community settings to predict the response of breast cancer to neoadjuvant therapy. Analysis showed that quantitative MRI could accurately predict the response, leading to the potential incorporation of these parameters into standard care and increasing clinical community sites participation in drug trials requiring quantitative MRI.
BREAST CANCER RESEARCH
(2021)
Article
Oncology
Roberta Fusco, Vincenza Granata, Mauro Mattace Raso, Paolo Vallone, Alessandro Pasquale De Rosa, Claudio Siani, Maurizio Di Bonito, Antonella Petrillo, Mario Sansone
Summary: The study aimed to differentiate benign and malignant breast lesions by combining BOLD-MRI, DCE-MRI, and DW-MRI, but found that the combined use of these imaging techniques did not provide a significant improvement compared to using DCE-MRI alone. An interesting result was the negative correlation between R-2* and D.
Article
Radiology, Nuclear Medicine & Medical Imaging
Inna Gertsenshteyn, Boris Epel, Amandeep Ahluwalia, Heejong Kim, Xiaobing Fan, Eugene Barth, Marta Zamora, Erica Markiewicz, Hsiu-Ming Tsai, Subramanian Sundramoorthy, Lara Leoni, John Lukens, Mohammed Bhuiyan, Richard Freifelder, Anna Kucharski, Mihai Giurcanu, Brian B. Roman, Gregory Karczmar, Chien-Min Kao, Howard Halpern, Chin-Tu Chen
Summary: This study compared FMISO PET images with pO(2) EPRI in mouse models to identify the optimal FMISO threshold for locating tumor hypoxia, showing a high overall hypoxia similarity between the two imaging methods. Additionally, the correlations between PET/EPRI hypoxia images and vascular permeability and extracellular-extravascular space from DCE-MRI were evaluated.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Alan W. L. Mui, Anne W. M. Lee, Victor H. F. Lee, W. T. Ng, Varut Vardhanabhuti, Shei S. Y. Man, Daniel T. T. Chua, Stephen C. K. Law, X. Y. Guan
Summary: Nasopharyngeal carcinoma is an aggressive head and neck malignancy, and radiotherapy is the main treatment. Functional magnetic resonance imaging shows promise as an early prognostic and monitoring tool.
MAGNETIC RESONANCE IMAGING
(2021)
Article
Chemistry, Medicinal
Ka-Loh Li, Daniel Lewis, Xiaoping Zhu, David J. Coope, Ibrahim Djoukhadar, Andrew T. King, Timothy Cootes, Alan Jackson
Summary: This study developed a new DCE-MRI processing technique that combines LEGATOS with multi-kinetic models to evaluate tumor microvascular changes and predict antiangiogenic therapy response. The technique enables high spatial resolution interrogation of flow and permeability effects.
Article
Multidisciplinary Sciences
Seung Eun Lee, Joon-Yong Jung, Yoonho Nam, So-Yeon Lee, Hyerim Park, Seung-Han Shin, Yang-Guk Chung, Chan-Kwon Jung
Summary: The study found that using diffusion-weighted imaging (DWI) for radiomics analysis did not provide additional diagnostic value compared to conventional DWI in differentiating benign and malignant soft tissue tumors, with no significant difference between the two in practical application.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Roberta Fusco, Vincenza Granata, Paolo Pariante, Vincenzo Cerciello, Claudio Siani, Maurizio Di Bonito, Marika Valentino, Mario Sansone, Gerardo Botti, Antonella Petrillo
Summary: The study aimed to evaluate the use of BOLD-MRI and DW-MRI in differentiating benign and malignant breast lesions. The study found that using the standard deviation value of S0 as a BOLD parameter led to significant discrimination between the two types of lesions. The best classification result was achieved using the LDA method with an AUC of 0.83, demonstrating good sensitivity and specificity.
MAGNETIC RESONANCE IMAGING
(2021)
Article
Biochemical Research Methods
Angela M. Jarrett, Anum S. Kazerouni, Chengyue Wu, John Virostko, Anna G. Sorace, Julie C. DiCarlo, David A. Hormuth, David A. Ekrut, Debra Patt, Boone Goodgame, Sarah Avery, Thomas E. Yankeelov
Summary: This protocol outlines a comprehensive pipeline for using quantitative MRI data to predict the response of locally advanced breast cancer to neoadjuvant therapy, involving image acquisition, segmentation, and mathematical modeling. Successful application of the protocol results in personalized predictions for individual patients' tumor responses to therapy.
Article
Oncology
Jon-Vidar Gaustad, Einar K. Rofstad
Summary: K (trans) maps are strongly correlated with hypoxic fraction and can predict disease-free and overall survival in cervical carcinoma patients, while v (e) maps do not provide relevant information on hypoxia status or patient outcome.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Neeraj Kumar, Mini Sharma, Neeti Aggarwal, Sanjiv Sharma, Malay Sarkar, Balraj Singh, Navneet Sharma
Summary: This study evaluated diffusion and dynamic contrast-enhanced MRI parameters in differentiating malignant from benign pulmonary lesions. Among the parameters, K-trans showed the highest diagnostic accuracy, while mean ADC and K-trans had similar sensitivity in predicting malignancy.
CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stig P. Cramer, Henrik B. W. Larsson, Maria H. Knudsen, Helle J. Simonsen, Mark B. Vestergaard, Ulrich Lindberg
Summary: This study investigates the reproducibility of DCE-MRI in healthy controls and evaluates the impact of arterial input function selection and manual region of interests delineation versus automated global segmentation. The results show excellent reproducibility of pharmacokinetic variables derived from DCE-MRI in healthy controls.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Medicine, General & Internal
Akane Ohashi, Masako Kataoka, Mami Iima, Maya Honda, Rie Ota, Yuta Urushibata, Marcel Dominik Nickel, Masakazu Toi, Sophia Zackrisson, Yuji Nakamoto
Summary: This study evaluates the agreement in morphological information obtained from malignant breast mass lesions between ultrafast dynamic contrast-enhanced (DCE) MRI and conventional DCE-MRI. The results show high agreement between the two methods, suggesting that ultrafast DCE-MRI may replace conventional DCE-MRI to evaluate the morphological information of malignant breast mass lesions.
