Article
Cell Biology
Amrita Salvi, Alexandria N. Young, Andrew C. Huntsman, Melissa R. Pergande, Melissa A. Korkmaz, Rathnayake A. Rathnayake, Brittney K. Mize, A. Douglas Kinghorn, Xiaoli Zhang, Kiira Ratia, Markus Schirle, Jason R. Thomas, Scott M. Brittain, Claude Shelton, Leslie N. Aldrich, Stephanie M. Cologna, James R. Fuchs, Joanna E. Burdette
Summary: PHY34 is a synthetic small molecule with potent anticancer activity against ovarian cancer cells. It induces apoptosis in these cells by inhibiting late-stage autophagy. CAS protein is identified as a likely target of PHY34, and its elevated expression in HGSOC is associated with worse clinical outcomes. Additionally, PHY34 interacts with ATP6V0A2 subunit and induces cell death.
CELL DEATH & DISEASE
(2022)
Review
Genetics & Heredity
Sivasubramanian Ramani, Sungkwon Park
Summary: Doxorubicin, an anthracycline derivative anti-cancer drug, shows anti-cancer activity but can cause cardiotoxicity, which may be prevented by administering cardioprotectants. Hsp27 has shown potential as a cardioprotectant, but further research, particularly in primary cell lines and animal models, is needed to confirm its efficacy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Engineering, Environmental
Hao Cheng, Zijun Jiang, Chenkai Sun, Zhen Wang, Guochen Han, Xin Chen, Tianyi Li, Zhechen Fan, Feng Zhang, Xiaoyu Yang, Lingyu Lv, Huaqing Zhang, Jianping Zhou, Yang Ding
Summary: A novel nanoparticle drug delivery platform was developed in this study to prevent cancer metastasis post-chemotherapy, improving treatment effectiveness. This platform utilizes a combination of chemotherapy drugs and gene interference to achieve controlled release within tumor cells.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Asma Rafiq, Sabreena Aashaq, Iqra Jan, Mushtaq A. Beigh
Summary: Sine Oculis Homeobox 1 (SIX1) is a vital member of the homeobox transcription factor family, playing crucial roles in organismal development and differentiation. Its aberrant expression has been linked to hearing impairment, renal anomalies, and tumorigenesis, highlighting its importance in various pathological conditions. As a transcription factor, SIX1 primarily regulates cellular functions by controlling the expression of different proteins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Medicine, Research & Experimental
Bruna Stefane Alves de Oliveira, Ana Carolina Correa de Assis, Natalia Melo Souza, Luiz Fernando Romanholo Ferreira, Renato Nery Soriano, Muhammad Bilal, Hafiz M. N. Iqbal
Summary: Cancer is projected to become the leading cause of mortality worldwide in the future, with tumorigenesis being a complex process involving cancer stem cells playing a significant role. Research on targeting CSCs in cancer treatment is on the rise, showing promising results in pathways and CSC-surface markers targeting.
Review
Pharmacology & Pharmacy
Anjali Phour, Vidit Gaur, Ahana Banerjee, Jayanta Bhattacharyya
Summary: This review discusses the development of advanced recombinant protein polymers designed for the delivery of chemotherapeutics, and highlights their importance in overcoming the limitations of conventional chemotherapy and improving the therapeutic index.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Physical
Aritra Kumar Dan, Bari Aamna, Soumik De, Miguel Pereira-Silva, Raghaba Sahu, Ana Claudia Paiva-Santos, Sagarika Parida
Summary: Sericin nanoparticles have emerged as a promising drug delivery vector in cancer treatment, offering enhanced efficacy, stability, and targeted delivery of chemotherapeutic drugs. This review provides a comprehensive summary of the current research status and synthesis techniques of sericin nanoparticles, highlighting their potential in cancer mitigation.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Oncology
H. C. Lin, J. Li, D. D. Cheng, X. Zhang, T. Yu, F. Y. Zhao, Q. Geng, M. X. Zhu, H. W. Kong, H. Li, M. Yao
Summary: The study identified that CSE1L is upregulated in non-small cell lung cancer (NSCLC) and is associated with poor prognosis. CSE1L promotes tumor cell proliferation and inhibits apoptosis in NSCLC by activating the NF-kappa B/MAPK signaling pathway.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Review
Oncology
Manqiu Ding, Yongqiang Chen, Yue Lang, Li Cui
Summary: Prion protein has two isoforms, PrP(C) and PrPSc. PrPSc is the pathological aggregated form that plays a role in neurodegenerative diseases, while PrP(C) is a membrane-anchored protein expressed in neurons and peripheral organs. Studies have revealed the involvement of PrP(C) in various aspects of cancer biology.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hardeep Singh Tuli, Prangya Rath, Abhishek Chauhan, Seema Ramniwas, Kanupriya Vashishth, Mehmet Varol, Vivek Sheel Jaswal, Shafiul Haque, Katrin Sak
Summary: This review article discusses the diverse therapeutic properties of phloretin, including its anticancer, antioxidant, anti-inflammatory, and antidiabetic activities. The focus is on its anticancer potential, specifically its antiproliferative, proapoptotic, antimetastatic, and antiangiogenic activities in preclinical cancer models. The article also analyzes the effects of phloretin on cellular signaling pathways and proteins, enzymes, and its co-effects with conventional anticancer drugs.
Article
Nanoscience & Nanotechnology
Mahaveer P. Purohit, Aditya K. Kar, Manisha Kumari, Debabrata Ghosh, Satyakam Patnaik
Summary: Combining antiangiogenic and chemotherapeutic drugs within multimodal nanocarriers has shown promising clinical benefits in inhibiting tumor growth and progression. The study reports the combinatorial efficacy of heparin, selenium NPs, and doxorubicin in inhibiting cancer cell viability and inducing apoptosis. The nanocarriers demonstrated excellent water dispersity and strong anticancer potential in in vitro assays, while in vivo imaging highlighted their tumor targeting ability. Overall, these results qualify the nanocarriers as a potential clinical therapeutic candidate.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Virology
Zhang Chengcheng, Hu Jiashu, Wang Xiuling, Wang Yuyang, Guo Mengjiao, Zhang Xiaorong, Wu Yantao
Summary: This study demonstrated that avian reovirus infection induces cell apoptosis through the unfolded protein response (UPR) pathway, with ATF6 playing a critical role upstream of caspase in this process. Inhibition of UPR or knockdown of ATF6 attenuated the apoptosis induction caused by ARV infection.
Review
Biochemistry & Molecular Biology
Jitender K. Bhardwaj, Prerna Bikal, Som Nath Sachdeva
Summary: The success of cancer treatment has improved the survival rate, but there are adverse consequences in female reproductive system due to chemotherapy. Ovarian tissue is sensitive to chemotherapeutic drugs-induced toxicity. Commonly used drugs like doxorubicin, cyclophosphamide, cisplatin and paclitaxel can cause ovarian damage and decline fertility potential in females. Understanding the different toxicity mechanisms will be helpful for developing therapeutic interventions for preserving declining female fertility among cancer survivors.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Mahmoudi Gomari, Shadi Abkhiz, Taha Ghantab Pour, Ehsan Lotfi, Neda Rostami, Fatemeh Nafe Monfared, Babak Ghobari, Mona Mosavi, Behruz Alipour, Nikolay V. Dokholyan
Summary: The low efficiency of cancer treatment strategies is a major obstacle in developing cancer inhibitors. Peptidomimetics, a new class of agents, have been introduced to overcome the limitations of peptides and have shown effectiveness in inhibiting metastasis, angiogenesis, and cancerous cell growth.
MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Jie Xiong, Hongmei Yuan, Hongge Wu, Jing Cheng, Shengli Yang, Ting Hu
Summary: The study developed a multifunctional black phosphorus nanoagent that effectively targeted primary tumors and metastatic lung tumors by conjugating with ginsenoside Rg3. When paired with near-light irradiation, the nanoagent showed superior controllable photothermal therapy synergistic therapeutics, significantly increasing tumor ablation effectiveness. The findings supported the biocompatibility of the nanoagent for lung cancer metastasis control.
