IMPACT OF A 21-KM RUN ON CARDIAC BIOMARKERS IN ADOLESCENT RUNNERS

Post exercise cardiac biomarker release has been widely reported in adult athlete groups but limited data is available for adolescents We assessed the impact of a 21 km run on cardiac biomarkers in adolescent athletes and uniquely assessed N terminal pro brain natriuretic peptide (NT pro BNP) and its potential association with serum cardiac troponin T (cTnT) appearance NT pro BNP and cTnT were measured in 17 male adolescent runners (age 16 5 +/- 1 6 years) before immediately after and 4 hours after a 21 km run Post exercise both cTnT (median range 0 12 <0 01-1 33 ng mL(-1)) and NT pro BNP (median range 132 6 738-370 6 pg mL(-1)) were elevated (p <0 05) compared to pre exercise (median range cTnT <0 01 <0 01-0 02 ng mL(-1) NT pro BNP 113 8 39 1-240 6 pg mL(-1)) There was no significant correlation between delta NT pro BNP with peak post exercise cTnT (r = 0 29 p>0 05) Further there was no significant difference in peak post exercise cTnT levels (median range 0 10 0 02-1 33 vs 0 13 0 02-0 35 ng mL(-1) respectively p>0 05) between the subjects with higher delta pre-post NT pro BNP values (range 62 9-186 1 pg mL(-1) n=8) and the other subjects with lower delta pre-post NT pro BNP values (range 83-55 3 pg mL(-1) n=9) The findings suggest that during recovery from a 21 km run both serum cTnT and NT pro BNP were elevated in adoles cent athletes but no significant relationship existed between increases in both biomarkers This supports the contention that exercise induced cTnT and NT pro BNP release are largely independently mediated phenomena [J Exerc Sci Fit . Vol 8 . No 2 . 61-66 . 2010]