Article
Endocrinology & Metabolism
Natalia Akkuratova, Louis Faure, Polina Kameneva, Maria Eleni Kastriti, Igor Adameyko
Summary: This study utilizes deep transcriptomic sequencing to investigate the individual cells in the developing sympatho-adrenal anlage of mice. The findings reveal the microheterogeneity and different developmental paths of embryonic chromaffin cells.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jose R. Lopez Ruiz, Stephen A. Ernst, Ronald W. Holz, Edward L. Stuenkel
Summary: This study continuously monitored the electrical activity of cortical chromaffin cells in the adrenal medulla, revealing the activity patterns and connections between cells under basal and physiological stress conditions. The results showed that adrenal medulla chromaffin cell networks have specific activation patterns under different stressors, reflecting the dynamic nature of neuroendocrine output.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Physiology
Johanna Guadalupe Pena del Castillo, Pedro Segura-Chama, Ruth Rincon-Heredia, Diana Millan-Aldaco, Yolanda Gimenez-Molina, Jose Villanueva, Luis Miguel Gutierrez, Arturo Hernandez-Cruz
Summary: The hypersecretory phenotype of adrenal chromaffin cells in early spontaneously hypertensive rats is mainly due to enhanced Ca2+-induced Ca2+-release. These abnormalities can be traced back to the prehypertensive stage, with an increase in catecholamine exocytosis in prehypertensive SHR compared to age-matched WKY rats. The mechanism responsible for the heterogeneous population of prehypertensive SHR chromaffin cells and the bias towards secreting more medium and large granules remains unexplained.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Antonio R. Artalejo, Marina Arribas-Blazquez, Maria Victoria Barahona, Celia Llorente-Saez, Luis Alcides Olivos-Ore
Summary: Maria Teresa Miras Portugal dedicated her scientific research to the study of purinergic signaling, primarily using chromaffin cells of the adrenal medulla. She identified diadenosine polyphosphates in these cells and further investigated the purinoceptors involved in adrenal chromaffin cell function. This short review focuses on Maria Teresa's seminal contributions to the understanding of purinoceptors in adrenal chromaffin cells.
PURINERGIC SIGNALLING
(2023)
Article
Oncology
Chao Liu, Jian-Ping Liang, Xiao-Lin Huang, Zhong Liu, An-Bing Zhang, Nian-Gen Deng, Zi-Feng Wei, Jun Wang
Summary: The presence of allergic rhinitis (AR) increases the risk of bronchial asthma (BA), and nerve growth factor (NGF) may play a key role in the inflammatory process in both conditions. However, the mechanism of progression from AR to BA is not well understood. This study aimed to investigate the role of NGF in nasobronchial interactions and explore the underlying molecular mechanisms. An AR mouse model was established and the histology of nasal mucosa tissue injury was examined. The expression levels of synaptophysin (SYP), STAT1, JAK1, p38, and ERK in NGF-treated and untreated adrenal medullary chromaffin cells (AMCCs) were analyzed. NGF was found to enhance SYP expression in AMCCs and decrease epinephrine (EPI) secretion through JAK1/STAT1, p38, and ERK signaling. These findings provide novel evidence for NGF's role in regulating neuroendocrine mechanisms.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Nataliya V. Yaglova, Sergey S. Obernikhin, Dibakhan A. Tsomartova, Valentin V. Yaglov, Svetlana V. Nazimova, Elina S. Tsomartova, Ekaterina P. Timokhina, Elizaveta V. Chereshneva, Marina Y. Ivanova, Tatiana A. Lomanovskaya
Summary: DDT is a potent endocrine disrupter affecting hormone production, including sex steroids, mineralocorticoids, glucocorticoids, and thyroid hormones. Exposure to low doses of DDT can result in decreased adrenal medulla growth and function, leading to lower epinephrine levels in rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Polina Kameneva, Artem V. Artemov, Maria Eleni Kastriti, Louis Faure, Thale K. Olsen, Jorg Otte, Alek Erickson, Bettina Semsch, Emma R. Andersson, Michael Ratz, Jonas Frisen, Arthur S. Tischler, Ronald R. de Krijger, Thibault Bouderlique, Natalia Akkuratova, Maria Vorontsova, Oleg Gusev, Kaj Fried, Erik Sundstrom, Shenglin Mei, Per Kogner, Ninib Baryawno, Peter V. Kharchenko, Igor Adameyko
Summary: Single-cell transcriptome profiling of human embryonic sympathoadrenal tissues reveals developmental transitions and suggests that intra-adrenal sympathoblasts from Schwann cell precursors may be potential neuroblastoma cell origins. The majority of extra-adrenal sympathoblasts appear to arise from migratory neural crest cells, while intra-adrenal sympathoblasts seem to be directly derived from nerve-associated Schwann cell precursors. This process persists during several weeks of development within the large intra-adrenal ganglia-like structures, potentially serving as reservoirs of originating cells in neuroblastoma.
Article
Medicine, Research & Experimental
N. Yaglova, S. S. Obernikhin, S. Nazimova, E. P. Timokhina, V. V. Yaglov
Summary: During the postnatal development of rat adrenal glands, the number of Oct4(+) chromaffin cells with nuclear localization increased as the proliferative activity decreased. All Oct4(+) cells were differentiated chromaffin cells. The expression of Oct4 in the adrenal medulla may serve as a potential source for physiological and reparative regeneration.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Medicine, General & Internal
Akbar Hussain, Sanjana Thota Kammili, Edilfavia Uy, Jonathan Piercy, Shyam Ganti, Dedeepya Gullapalli
Summary: This case highlights the rarity of pheochromocytomas and the importance of accurate diagnosis and effective management. Imaging techniques, such as CT and MRI, play a crucial role in localization, and complementary diagnostic methods contribute to a comprehensive understanding of different adrenal masses.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Physiology
Carmen Martinez-Ramirez, Irene Gil-Gomez, Antonio M. G. de Diego, Antonio G. Garcia
Summary: This study showed distinct effects of acute SERCA blockade on exocytosis in BCCs compared to MCCs upon pulsing with ACh, indicating different regulatory mechanisms in ACh-triggered secretion. The uptake of Ca2+ into the ER in BCCs may potentiate a Ca2+-induced Ca2+ release mechanism, while in MCCs, Ca2+ uptake via SERCA contributes to mitigating ACh-triggered secretion, demonstrating significant differences in the regulation of exocytosis at 37 degrees Celsius.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Physiology
Oscar J. Parada-Parra, Arturo Hernandez-Cruz
Summary: Intracellular Ca2+ signaling and catecholamine exocytosis from adrenal chromaffin cells vary between different mammalian species. The effects of cyclopiazonic acid (CPA) on catecholamine secretion and Ca2+ signals differ in mouse and bovine chromaffin cells. In rat chromaffin cells, CPA strongly inhibits voltage-gated exocytosis and Ca2+ transients. The suppression of endoplasmic reticulum Ca2+ uptake through CPA inhibits catecholamine secretion in rat chromaffin cells, similar to what is observed in bovine chromaffin cells.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Harisa Ferizovic, Natasa Spasojevic, Milica Jankovic, Bojana Stefanovic, Sladjana Dronjak
Summary: The study investigated the effects of the fatty acid amide hydrolase inhibitor URB597 on plasma catecholamine levels and their synthesis and degradation in the adrenal medulla of male and female rats under chronic unpredictable stress. Results showed that URB597 reduced catecholamine content and synthesis in stressed female rats, while females had higher adrenal weights and catecholamine levels before stress than males, and stress further increased these levels in females compared to males. Additionally, the inhibitor reduced plasma norepinephrine levels and restored content in the adrenal medulla in male rats under stress. The findings suggest a potential role for endocannabinoids in modulating stress response in both male and female subjects.
Article
Endocrinology & Metabolism
Jonathan Weber, Veeraya K. Tanawattanacharoen, Amy Seagroves, Mark C. Liang, Christina M. Koppin, Heather M. Ross, Tania A. S. S. Bachega, Mitchell E. Geffner, Monica Serrano-Gonzalez, Gagandeep Bhullar, Mimi S. Kim
Summary: The study found that lower epinephrine levels in infants with classical CAH are associated with increased risk of illness in the first year of life. Measuring epinephrine levels and assessing genotype may help predict acute illness in these infants.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, Research & Experimental
S. S. Obernikhin, N. V. Yaglova, E. P. Timokhina, S. V. Nazimova, V. V. Yaglov
Summary: This study investigated the regulation of morphogenetic processes during the postnatal development of the rat adrenal medulla. The findings showed that the termination of adrenal medulla growth was associated with decreased chromaffin cell proliferation, activation of the canonical Wnt signaling pathway, and enhanced expression of Sonic Hedgehog ligands. Additionally, highly differentiated chromaffin cells actively producing tyrosine hydroxylase were found to express Oct4 and Sonic Hedgehog.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Helena Hanschell, Salvador Diaz-Cano, Alfredo Blanes, Nadia Talat, Gabriele Galata, Simon Aylwin, Klaus Martin Schulte
Summary: In this study, a simple and reliable tool, the SIZEPASS criterion, was developed to predict the malignant behavior of PPGLs based on the size of the tumors. The SIZEPASS criterion showed high accuracy and sensitivity in predicting malignancy in PPGLs.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
D. A. Sufieva, V. V. Guselnikova, D. E. Korzhevskii
BIOLOGICHESKIE MEMBRANY
(2018)
Article
Biochemistry & Molecular Biology
E. T. Zakharova, A. V. Sokolov, N. N. Pavlichenko, V. A. Kostevich, I. N. Abdurasulova, A. V. Chechushkov, I. V. Voynova, A. Yu. Elizarova, N. N. Kolmakov, M. G. Bass, I. V. Semak, A. I. Budevich, P. M. Kozhin, N. K. Zenkov, V. M. Klimenko, O. V. Kirik, D. E. Korzhevskii, E. B. Menshchikova, V. B. Vasilyev
Article
Medicine, Research & Experimental
E. S. Petrova, E. N. Isaeva, E. A. Kolos, D. E. Korzhevskii
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2018)
Article
Multidisciplinary Sciences
T. Gupalova, G. Leontieva, T. Kramskaya, K. Grabovskaya, E. Bormotova, D. Korjevski, A. Suvorov
Article
Medicine, Research & Experimental
E. S. Petrova, E. A. Kolos
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2019)
Article
Medicine, General & Internal
V. V. Guselnikova, D. A. Sufieva, D. L. Tsyba, D. E. Korzhevskii
Summary: Fluorescence microscopy is increasingly used to identify amyloid deposits in human tissues, with Thioflavin T being the most effective stain for beta- and transthyretin amyloid. Congo red is effective for transthyretin amyloidosis but not for beta-amyloid plaques. Methyl violet can selectively bind to beta-amyloid and reduce autofluorescent background, making it a promising diagnostic tool for Alzheimer's-type pathology.
BULLETIN OF RUSSIAN STATE MEDICAL UNIVERSITY
(2021)
Article
Anatomy & Morphology
Aleksandr A. Veshchitskii, Olga Kirik, Dmitriy E. Korzhevskii, Natalia Merkulyeva
Summary: NeuN expression in sympathetic intermediolateral nucleus was investigated and compared with two neurochemical markers, nitric oxide synthase and calretinin, in this study. Results showed that NeuN was not expressed in nitric oxide synthase-labeled neurons, while it co-localized with calretinin, and the degree of co-localization varied with age.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2022)
Article
Medicine, General & Internal
Valeriia V. Guselnikova, Elena A. Fedorova, Alexandra Ja Gudkova, Michael M. Shavlovsky, Dmitrii E. Korzhevskii
Summary: This study compares the efficiency and specific features of different histological dyes in staining transthyretin amyloid and evaluates their suitability for diagnostic purposes. The results show that Congo red staining, combined with fluorescence or confocal microscopy, is the most reliable method for histological diagnosis of transthyretin amyloidosis.
TERAPEVTICHESKII ARKHIV
(2022)
Article
Medicine, General & Internal
V. V. Guselnikova, V. A. Razenkova, D. A. Sufieva, D. E. Korzhevskii
Summary: The study characterizes the microglia and macrophages of the subfornical organ in rats, focusing on their structural, cytochemical, and functional properties. Microglial cells were found to be the majority in this brain area, exhibiting a preactivated state. In addition to microglial cells, the subfornical organ also contains macrophages with specific expression of CD68.
BULLETIN OF RUSSIAN STATE MEDICAL UNIVERSITY
(2022)
Article
Geriatrics & Gerontology
E. A. Fedorova, D. A. Sufieva, I. P. Grigorev, D. E. Korzhevskii
ADVANCES IN GERONTOLOGY
(2019)
Proceedings Paper
Engineering, Biomedical
Andrey Belikov, Luidmila A. Ermolaeva, Dmitriy E. Korzhevsky, Elena S. Sergeeva, Yulia Semyashkina, Valeriia V. Gusel'nikova, Maria M. Antropova, Denis Y. Fedotov
SARATOV FALL MEETING 2018: OPTICAL AND NANO-TECHNOLOGIES FOR BIOLOGY AND MEDICINE
(2019)
Article
Cell Biology
D. A. Sufieva, V. V. Guselnikova, D. E. Korzhevskii
BIOCHEMISTRY MOSCOW SUPPLEMENT SERIES A-MEMBRANE AND CELL BIOLOGY
(2018)
Proceedings Paper
Optics
Andrey V. Belikov, Luidmila A. Ermolaeva, Dmitriy E. Korzhevsky, Elena S. Sergeeva, Yulia V. Semyashkina, Maria M. Antropova, Denis Y. Fedotov, Dina A. Sufieva
BIOPHOTONICS: PHOTONIC SOLUTIONS FOR BETTER HEALTH CARE VI
(2018)
Proceedings Paper
Biophysics
Andrey V. Belikov, Ludmila A. Ermolaeva, Dmitriy E. Korzhevsky, Elena S. Sergeeva, Yulia V. Semyashkina, Maria M. Antropova, Denis Y. Fedotov, Maria A. Zaitseva, Tatiana V. Kashina
SARATOV FALL MEETING 2017: OPTICAL TECHNOLOGIES IN BIOPHYSICS AND MEDICINE XIX
(2018)
Review
Medicine, Research & Experimental
I. P. Grigorev, D. E. Korzhevskii
SOVREMENNYE TEHNOLOGII V MEDICINE
(2018)
