Article
Pharmacology & Pharmacy
Sahebgowda Sidramagowda Patil, Helena Hernandez-Cueryo, Jutaro Fukumoto, Sudarshan Krishnamurthy, Muling Lin, Matthew Alleyn, Mason Breitzig, Venkata Ramireddy Narala, Ramani Soundararajan, Richard F. Lockey, Narasaiah Kolliputi, Lakshmi Galam
Summary: Acute lung injury (ALI) is a leading cause of mortality in older adults, and oxygen therapy is a common treatment method. Alda-1 protects against oxidative stress by enhancing ALDH2 activity, and also shows protective effects against ischemic reperfusion injury, heart failure, and other conditions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Romina Deza-Ponzio, Paula A. Albrecht, Lucia E. Fernandez-Hubeid, Tuany Eichwald, Romina B. Cejas, Yohana C. Garay, Mario Rivera-Meza, Alexandra Latini, Fernando J. Irazoqui, Miriam B. Virgolini
Summary: Combined exposure to Pb and EtOH impairs ALDH2 functionality, leading to mitochondrial dysfunction and increased oxidative stress. NAD+ or an ALDH2 enhancer can restore ALDH2 activity and alleviate the detrimental effects.
Article
Engineering, Biomedical
Xiaolei Sun, Rifeng Gao, Wenjia Li, Yongchao Zhao, Heng Yang, Hang Chen, Hao Jiang, Zhen Dong, Jingjing Hu, Jin Liu, Yunzeng Zou, Aijun Sun, Junbo Ge
Summary: ALDH2 activation in mitochondrial transplantation shows potential for treating myocardial I/R injury. Activation of ALDH2 and treatment with Alda-1 promote oxygen consumption rate and mechanical function of cardiomyocytes after mitochondrial transplantation. Mitochondrial transplantation inhibits cardiomyocyte apoptosis induced by hypoxia-reoxygenation, while promotion of mechanical function is observed only after mitochondrial Alda-1 treatment and transplantation.
BIOACTIVE MATERIALS
(2021)
Article
Nutrition & Dietetics
Ahmed Ismaeel, Joseph A. Laudato, Emma Fletcher, Evlampia Papoutsi, Abigail Tice, Lara S. Hwa, Dimitrios Miserlis, Athanasios Z. Jamurtas, Jennifer Steiner, Panagiotis Koutakis
Summary: This study aimed to assess the concurrent effect of chronic heavy alcohol consumption and consumption of a high-fat diet on skeletal muscle oxidative stress and mitochondrial dysfunction. The results showed that a high-fat diet may exacerbate the negative effects of alcohol on skeletal muscle mitochondrial health and oxidative stress.
Article
Cell Biology
Mushfiquddin Khan, Fei Qiao, Pavan Kumar, S. M. Touhidul Islam, Avtar K. Singh, Jeseong Won, Inderjit Singh
Summary: This study found that enhancing the activity of ALDH2 can alleviate the 4-HNE load induced by spinal cord injury, suppress neuroinflammation and neurodegeneration, promote neurorepair process, and improve functional recovery. The results suggest that Alda-1 may have therapeutic potential for the treatment of human spinal cord injury.
NEURAL REGENERATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Che-Hong Chen, Benjamin R. Kraemer, Lucia Lee, Daria Mochly-Rosen
Summary: Human ALDH is a multigene family with 19 functional members involved in detoxification and biotransformation. Genetic mutations can lead to toxic aldehyde accumulation and human pathologies. The physiological functions and substrate specificity of many ALDH genes are still unknown.
Article
Biochemistry & Molecular Biology
Yu-Feng Hu, Chih-Hsun Wu, Tsung-Ching Lai, Yu-Chan Chang, Ming-Jing Hwang, Ting-Yung Chang, Ching-Hui Weng, Peter Mu-Hsin Chang, Che-Hong Chen, Daria Mochly-Rosen, Chi-Ying F. Huang, Shih-Ann Chen
Summary: The ALDH2*2 mutation was found to increase susceptibility to atrial fibrillation by decreasing retinoic acid signals and SCN5A expression, and causing dysregulation in mitochondrial bioenergetics pathways. Treatment with Coenzyme Q10 protected against AF attack in mutant ALDH2*2 mice by mitigating mitochondrial oxidative stress and preserving bioenergetics.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Agriculture, Dairy & Animal Science
M. Wiebke, B. Hensel, E. Nitsche-Melkus, M. Jung, M. Schulze
Summary: This review provides an overview of current techniques for cooled storage of semen from livestock animals, including the state of the art, factors influencing quality, and recent advances. The potential of large-scale use of boar sperm and the trend towards higher-temperature storage for stallion sperm are discussed. Liquid storage of sperm in bulls has potential for applications in breeding programs worldwide.
ANIMAL REPRODUCTION SCIENCE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Jolanta Floryszak-Wieczorek, Ewa Sobieszczuk-Nowicka, Magdalena Arasimowicz-Jelonek
Summary: Nitroxyl (HNO), a one-electron reduced and protonated congener of nitric oxide (NO), has been recently discovered in Arabidopsis thaliana. Due to its distinct chemical properties, further studies are needed to determine the impacts of HNO on physiological processes.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Article
Reproductive Biology
Camilo Hernandez-Aviles, Luisa Ramirez-Agamez, Charles C. Love, Macy Friedrich, Mariah Pearson, Dale E. Kelley, Anne M. N. Beckham, Sheila R. Teague, Katrina A. LaCaze, Steven P. Brinsko, Dickson D. Varner
Summary: This study demonstrates that glucose optimizes stallion sperm quality in a skim milk-based semen extender at storage temperatures of 10 or 20 degrees C. Substrates supporting oxidative phosphorylation, such as pyruvate or lactate, did not improve sperm quality compared to glucose alone, and may have deleterious effects over time.
Article
Biochemistry & Molecular Biology
Roger S. Holmes
Summary: ALDH4A1 and ALDH4A2 are genes that encode mitochondrial enzymes involved in the metabolism of proline and ornithine to glutamate. The sequences and structures of ALDH4A1 are highly conserved in vertebrates and invertebrates. The human ALDH4A1 gene is more highly expressed in the liver and kidney cortex. Most vertebrates have a single ALDH4A1 gene, but there are exceptions.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Reproductive Biology
Maria Kareskoski, Johanna Vakkamaki, Kirsi Laukkanen, Mari Palviainen, Anders Johannisson, Terttu Katila
Summary: This study aimed to evaluate the association between MMP-2 and MMP-9 levels in stallion ejaculates and semen quality, as well as sperm survival. The results showed that MMP-2 and MMP-9 were positively correlated with sperm concentration and count, but did not affect sperm longevity during cooled storage.
Article
Agriculture, Dairy & Animal Science
Alexandra Usuga, Victor Gutierrez, Maria Elisa Lopez, Luisa Fernanda Perez, Lorena Jaramillo, Benjamin Rojano, Giovanni Restrepo
Summary: This study evaluated the effect of different drugs on the quality of cooled stallion semen and found that thymol and isospintanol can be used as natural antifungals in semen extenders for refrigeration.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Reproductive Biology
M. S. Ferrer, I. F. Canisso, G. Podico, R. E. Ellerbrock, D. J. Hurley, R. Palomares
Summary: The presence of sperm-bound antisperm antibodies (ASAs) is associated with poor cryosurvival of stallion sperm, leading to lower post-thaw sperm motility, velocity, and higher percentage of apoptotic sperm. Stallions with ASAs show higher levels of IgG- and IgA-bound sperm and are more likely to have poor sperm cryosurvival. Evaluating stallions for the presence of ASAs before freezing may provide an indicator of their prognosis for cryosurvival.
Article
Food Science & Technology
Hua Cao, Tuoyu Zhou, Haibo Tang, Pengya Feng, Gohar Ali, Pu Liu, Xiangkai Li
Summary: The genetically modified EcN has shown effectiveness in detoxifying ethanol metabolites in liver disease models, restoring liver function, inhibiting oxidative stress, lipid peroxidation, and inflammation, as well as promoting the recovery of gut microbiota homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Biochemistry & Molecular Biology
Leila Rashki Ghaleno, AliReza Alizadeh, Joel R. Drevet, Abdolhossein Shahverdi, Mojtaba Rezazadeh Valojerdi
Summary: Oxidative stress is a major cause of male infertility due to its destructive effects on sperm structures and functions. Sperm DNA is highly susceptible to oxidative damage, particularly leading to single- or double-strand DNA breaks, which is a significant issue in male infertility. While methods to detect sperm DNA fragmentation have become important diagnostic tools, there is still no clear consensus on their prognostic value.
Article
Cell Biology
Samaneh Faraji, Leila Rashki Ghaleno, Mohsen Sharafi, Maryam Hezavehei, Mehdi Totonchi, Abdolhossein Shahverdi, Rouhollah Fathi
Summary: The study evaluated the effects of cryopreservation on the expressions of SPAG genes in human sperm, finding a decrease in the expression of certain SPAG genes during freezing. This suggests that the freezing procedure could negatively affect gene expression in human spermatozoa.
BIOPRESERVATION AND BIOBANKING
(2021)
Article
Reproductive Biology
Maryam Khodadi, Mohammad Jafari Atrabi, Tahoura Torkzadeh, Mohaddese Fazli, Vahid Akbarinejad, Rouhollah Fathi
Summary: This study investigated the effects of different culture medium preparations and nutrient supplements on the formation and activation of primordial follicles in neonatal mouse ovaries. The results showed that the base medium containing knock-out serum replacement (KSR) had better support for follicle formation than the granulosa cells conditioned medium (GCCM). However, the base medium with KSR did not promote follicular activation as effectively as the GCCM prepared with KSR did.
REPRODUCTIVE BIOLOGY
(2022)
Article
Cell Biology
Maryam Jazayeri, Poopak Eftekhari-Yazdi, Mohammad Ali Sadighi Gilani, Mohsen Sharafi, Abdolhossein Shahverdi
Summary: High rates of infertility in type 2 diabetic men have led to attempts to understand the mechanisms involved. This study found that T2DM alters the methylation profile and epigenetic programming in spermatozoa of humans and may ultimately influence the fertility status of men with diabetes.
Article
Andrology
Vahid Esmaeili, Morteza Zendehdel, Abdolhossein Shahverdi, AliReza Alizadeh
Summary: Obesity is associated with male infertility, and little is known about the relationship between obesity-related markers and sperm parameters. This study found that obese men had higher waist circumference, hip circumference, waist to hip ratio, body fat mass, skeletal muscle, resting metabolism, and visceral fat compared to normal-weight and overweight men. In normal-weight men, body fat mass and visceral adiposity index were positively correlated with sperm progressive motility. In obese men, sperm progressive motility was positively correlated with height and negatively correlated with waist to hip ratio. The study also found that the association between serum testosterone levels, testosterone/estradiol ratios, and semen parameters depended on obesity-related markers.
Review
Agriculture, Dairy & Animal Science
Mohsen Sharafi, Seyyed Mohsen Borghei-Rad, Maryam Hezavehei, Abdolhossein Shahverdi, James D. Benson
Summary: This comprehensive review examines the mechanisms of damage caused by cryopreservation and highlights classical and novel strategies to reduce this damage and improve sperm survival. Cryopreservation is an important method for preserving germplasm in various fields, but the current methods only yield about 50% viable spermatozoa after cryopreservation. Various sperm components, including the plasma membrane, nucleus, mitochondria, proteins, mRNAs, and microRNAs, can be damaged during the process. Conventional strategies using chemical additives have been employed, but they are not completely effective in preventing damage.
Article
Agriculture, Dairy & Animal Science
Iman Allahyari, Faramarz Gharagozlou, Mehdi Vojgani, Poorya Pooladzadeh, Emadeddin Mobedi, Vahid Akbarinejad
Summary: Unlike GnRH, estradiol can induce the emergence of a new follicular wave regardless of follicle size. This study aimed to investigate whether replacing the first GnRH with estradiol in the breeding protocol of the Double Ovsynch program could enhance fertility. The results showed that including estradiol in the Double Ovsynch protocol as a replacement for the first GnRH could improve fertility, especially in cows with a CL at the initiation of EPG.
ANIMAL REPRODUCTION SCIENCE
(2023)
Article
Cell Biology
Shahab Mirshahvaladi, Tohid Rezaei Topraggaleh, Mustafa Numan Bucak, Pegah Rahimizadeh, Abdolhossein Shahverdi
Summary: Asthenozoospermia, characterized by low sperm motility, is a common cause of male infertility. This study identified and quantified a total of 2140 proteins in the sperm tails of asthenozoospermic patients and controls, with 409 differentially expressed proteins. Bioinformatics analysis further revealed alterations in mitochondrial energy production, stress response, and other biological processes in asthenozoospermic sperm tails.
CELL AND TISSUE RESEARCH
(2023)
Article
Andrology
Parisa Yazdanpanah Ghadikolaei, Leila Rashki Ghaleno, Samira Vesali, Ehsan Janzamin, Mohammad Ali Sadighi Gilani, Hesamoddin Sajadi, Ahmad Vosough Taghi Dizaj, Abdolhossein Shahverdi, Joel R. Drevet, AliReza Alizadeh Moghadam Masouleh
Summary: This study analyzed nearly 1200 sperm samples to evaluate the sperm DNA fragmentation index and its association with factors such as age, body mass index, season of sperm collection, geographical location, medical history, and addictive behaviors. The results showed that the sperm DNA fragmentation index increased with age, was higher in spring and summer samples, was not correlated with body mass index, and was higher in rural and epileptic patients. Overall, age was found to be the strongest factor associated with the sperm DNA fragmentation index.
Article
Agriculture, Dairy & Animal Science
Navid Jahan Roshan, Massoud Talebkhan Garoussi, Vahid Akbarinejad
Summary: The study investigated the effect of melatonin implantation in rams and administration of 400 IU eCG (E400) versus 300 IU eCG (E300) in ewes on reproductive performance of Lacaune sheep breed during non-breeding season. Results showed that melatonin implantation improved the reproductive performance of rams, while an increase in dose of eCG enhanced synchronization of estrus and fertility in ewes.
ANIMAL REPRODUCTION SCIENCE
(2023)
Article
Multidisciplinary Sciences
Elnaz Zand, Elias Rajablou, Seyedeh Fatemeh Siadat, Bahare Beiki, Vahid Akbarinejad, Christiani Andrade Amorim, Mojtaba Rezazadeh Valojerdi, Leila Alsadat Tahaei, Rouhollah Fathi
Summary: This study investigated the effects of Human Wharton's Jelly (HWJ) hydrogel on mouse ovarian follicles in vitro culture and auto-transplantation. The results demonstrated that the composite of Wharton's jelly hydrogel and Alginate showed positive effects on the development and survival of the follicles.
Article
Reproductive Biology
Mohammad Bafandeh, Mohammad Javad Mozaffari Makiabadi, Faramarz Gharagozlou, Mehdi Vojgani, Emadeddin Mobedi, Vahid Akbarinejad
Summary: Multiparous dams have been found to produce offspring with greater fertility and higher AMH concentration. However, it is unclear if this phenomenon still applies to old multiparous cows. This study aims to evaluate the performance of offspring with different maternal parities.
Article
Reproductive Biology
Hafez Sadeghi, Faramarz Gharagozlou, Mehdi Vojgani, Emadeddin Mobedi, Mohammad Bafandeh, Vahid Akbarinejad
Summary: This research explored the association between maternal average monthly somatic cell count (SCC) and the reproduction, anti-Mullerian hormone (AMH) concentration, udder health status, and milk production of the offspring. The study found that elevated maternal SCC could result in offspring with inferior reproductive performance, smaller ovarian reserves, and lower milk production during the first lactation period.
Article
Reproductive Biology
Mohammad Javad Mozaffari Makiabadi, Mohammad Bafandeh, Faramarz Gharagozlou, Mehdi Vojgani, Emadeddin Mobedi, Vahid Akbarinejad
Summary: Maternal exposure to heat stress during early gestation stage may have a more significant negative impact on offspring's milk production and ovarian reserves. However, an evident temporal pattern for the adverse effect of maternal heat stress on offspring's reproductive performance was not found.
Article
Veterinary Sciences
Adel K. Auth, Guy J. Hinnigan, Meredith A. Smith, Kathryn R. Owen
Summary: This study investigated the low-field magnetic resonance imaging (MRI) findings and lesion distribution in nonracehorses with MCP/MTPJ region pain. The results showed that soft tissue injuries were more common, with suspensory ligament branch injuries being the most frequent. In terms of osseous pathology, the subchondral bone (SCB) was most frequently affected, with the majority of lesions located on the dorsal aspect of the bone. The main limitations of the study were the lack of standardized diagnostic analgesia pattern and the absence of bilateral MRI sequences in all limbs.
JOURNAL OF EQUINE VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Humberto B. Magalhaes, Jose Antonio Dell'Aqua Jr, Igor F. Canisso
Summary: This study assessed luteolysis and side effects in jennies receiving standard horse-recommended doses of cloprostenol and dinoprost. The results showed that both dinoprost and cloprostenol effectively induced luteolysis, but with different side effects.
JOURNAL OF EQUINE VETERINARY SCIENCE
(2024)
