4.6 Article

Urinary bisphenol A concentrations are associated with abnormal liver function in the elderly: a repeated panel study

Journal

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
Volume 68, Issue 4, Pages 312-317

Publisher

BMJ PUBLISHING GROUP
DOI: 10.1136/jech-2013-202548

Keywords

-

Funding

  1. Ministry of Environment, Republic of Korea [0411-20080013, 0411-20090007, 0411-20100016]

Ask authors/readers for more resources

Background Bisphenol A (4,40-isopropylidenediphenol, BPA) is known to adversely affect various organs. The liver is reported to be affected by BPA in animal studies. However, there are few studies in humans on the effects of BPA on the liver. Therefore, we evaluated the relationship between urinary BPA levels and liver function in elderly subjects using repeated measurements. Methods From 2008 to 2010, a total of 560 elderly subjects residing in Seoul were each evaluated up to three times. At the first visit, demographic data, environmental exposure and lifestyle information were obtained from a systemised questionnaire. At each visit, blood and urine samples were collected and stored for analysis. Linear mixed and GLIMMIX model analyses were performed after adjusting for age, sex, Body Mass Index, alcohol consumption, urinary cotinine concentrations, exercise frequency, and low-density lipoprotein cholesterol level. Results The mean urinary BPA concentration was 1.13 g/g creatinine. Significant relationships were observed between urinary BPA and aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transferase after adjusting for potential confounders (p<0.05). When subjects were grouped according to urinary BPA concentrations divided by the median value, higher urinary BPA concentrations were associated with increased abnormal liver function (OR 2.66; 95% CI 1.15 to 5.90). Conclusions Community-level exposure to BPA was associated with abnormal liver function in the elderly, indicating that more stringent control of BPA is necessary to protect susceptible populations.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Public, Environmental & Occupational Health

Age-specific effects of ozone on pneumonia in Korean children and adolescents: a nationwide time-series study

Kyoung-Nam Kim, Youn-Hee Lim, Sanghyuk Bae, In Gyu Song, Soontae Kim, Yun-Chul Hong

Summary: The study found that short-term exposure to ozone increases the risk of pneumonia in children aged 0-4 and 5-9. However, the association between ozone and hospital admissions due to pneumonia is not significant in the 10-14 and 15-19 age groups.

EPIDEMIOLOGY AND HEALTH (2022)

Article Environmental Sciences

Association between long-term exposure to particulate matter and childhood cancer: A retrospective cohort study

Jae Min Lee, Tae-Hee Lee, Soontae Kim, Minkyo Song, Sanghyuk Bae

Summary: This study found a positive association between long-term exposure to PM2.5 and childhood cancer, providing evidence for exploring the relationship between particulate matter and childhood cancer.

ENVIRONMENTAL RESEARCH (2022)

Article Construction & Building Technology

Association of indoor and outdoor short-term PM2.5 exposure with blood pressure among school children

Eunjin Oh, Kyung-Hwa Choi, Sung Roul Kim, Ho-Jang Kwon, Sanghyuk Bae

Summary: This study aimed to examine the association between personal short-term exposure to PM2.5 and blood pressure in children. In a panel study that comprehensively evaluated both indoor and outdoor exposures, a statistically significant association between blood pressure and PM2.5 exposure in children was observed, after accounting for time-activity.

INDOOR AIR (2022)

Article Environmental Sciences

Modification Effect of PARP4 and ERCC1 Gene Polymorphisms on the Relationship between Particulate Matter Exposure and Fasting Glucose Level

Jin Hee Kim, Seungho Lee, Yun-Chul Hong

Summary: This study found a correlation between PMs exposure and an increase in fasting glucose levels, and genetic polymorphisms of PARP4 and ERCC1 may modify this relationship, making the elderly more susceptible to the effects of PMs exposure.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Review Immunology

EGFR-Based Targeted Therapy for Colorectal Cancer-Promises and Challenges

Balakarthikeyan Janani, Mayakrishnan Vijayakumar, Kannappan Priya, Jin Hee Kim, D. S. Prabakaran, Mohammad Shahid, Sameer Al-Ghamdi, Mohammed Alsaidan, Nasraddin Othman Bahakim, Mohammad Hassan Abdelzaher, Thiyagarajan Ramesh

Summary: Colorectal carcinoma is a common and lethal form of cancer, with a high rate of metastasis. Targeted nanotherapy, particularly targeting EGFR, has the potential to improve surgical control and reduce tumor-related mortality. Antibodies conjugated with drug-loaded carriers can increase drug effectiveness and quantity delivered to the target site.

VACCINES (2022)

Article Biochemistry & Molecular Biology

Predicting High Blood Pressure Using DNA Methylome-Based Machine Learning Models

Thi Mai Nguyen, Hoang Long Le, Kyu-Baek Hwang, Yun-Chul Hong, Jin Hee Kim

Summary: In this study, DNA methylome data was used in combination with machine learning algorithms, including deep learning, to successfully detect high blood pressure. A correlation model between DNA methylome and high blood pressure was established. This method provides a new approach for early detection of high blood pressure in clinical practices.

BIOMEDICINES (2022)

Article Public, Environmental & Occupational Health

Effect modification of consecutive high concentration days on the association between fine particulate matter and mortality: a multi-city study in Korea

Hyungryul Lim, Sanghyuk Bae, Jonghyuk Choi, Kyung-Hwa Choi, Hyun-Joo Bae, Soontae Kim, Mina Ha, Ho-Jang Kwon

Summary: This study investigated the effect of prolonged exposure to high concentrations of PM2.5 on mortality risk. The results showed that for every 10ug/m3 increase in PM2.5 concentration, there was a 0.33% increase in all-cause mortality, a 0.47% increase in respiratory disease mortality, and a 0.26% increase in cardiovascular disease mortality. The risk of all-cause mortality significantly increased when exposure to high PM2.5 concentrations persisted for more than 4 days.

EPIDEMIOLOGY AND HEALTH (2022)

Article Environmental Sciences

Association of long-term exposure to PM2.5 and survival following ischemic heart disease

Jongmin Oh, Sangbum Choi, Changwoo Han, Dong-Wook Lee, Eunhee Ha, Soontae Kim, Hyun-Joo Bae, Wook Bum Pyun, Yun-Chul Hong, Youn-Hee Lim

Summary: A study in South Korea found that long-term exposure to PM2.5 increases the risk of cardiovascular morbidity and mortality among patients with ischemic heart disease, particularly those aged 65-74 years.

ENVIRONMENTAL RESEARCH (2023)

Article Environmental Sciences

Effects of mercury exposure on fetal body burden and its association with infant growth

Seungho Lee, Jin Hee Kim, Hyo-Bang Moon, Jeongim Park, Guyuyeon Choi, Sungkyoon Kim

Summary: This study estimated the fetal body burden of mercury in pregnant women and analyzed its effects on infant growth. Cord blood mercury levels were positively correlated with length at birth and the high cord blood group showed faster growth rates. Pregnant women are advised to mitigate mercury exposures, especially from diet. Further research is suggested to investigate the relationship between infant growth and mercury levels, considering fish consumption, diet information, and other environmental pollutants.

ENVIRONMENTAL RESEARCH (2023)

Article Endocrinology & Metabolism

Increased Morbidity in Males Diagnosed With Gynecomastia: A Nationwide Register-based Cohort Study

Cecilie S. Uldbjerg, Youn-Hee Lim, Elvira Braeuner, Anders Juul

Summary: There is a lack of evidence on the long-term and general health of males with gynecomastia. This study found that males with idiopathic gynecomastia have a higher risk of future disease, especially endocrine diseases.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2023)

Article Environmental Sciences

Prenatal paraben exposures and birth size: Sex-specific associations in a healthy population- A study from the Odense Child Cohort

Elvira V. Brauner, Cecilie S. Uldbjerg, Astrid L. Beck, Youn-Hee Lim, Henriette Boye, Hanne Frederiksen, Anna-Maria Andersson, Tina K. Jensen

Summary: This study investigated the relationship between maternal paraben concentrations in second trimester urine and birth size of the offspring, specifically looking at sex-specific associations. The findings revealed that higher maternal exposure to n-butylparaben was associated with lower birth size in female offspring, while no significant relationship was observed in male offspring.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

Article Agricultural Engineering

Optimization of photosynthetically active radiation, temperature, and urea deprivation for increasing neutral lipids and fatty acids in Scenedesmus obliquus and Chlorella vulgaris as biodiesels

Rasiravathanahalli Kaveriyappan Govindarajan, Rekha Thiruvengadam, Amer M. Alanazi, Saravanan Pandiaraj, Krishnamurthy Mathivanan, Muthu Thiruvengadam, Jin Hee Kim

Summary: The present study investigated the impact of photosynthetically active radiation (PAR), culture temperature, and urea addition on the biomass, total lipid, lipidomic profile, and fatty acid productivity in Scenedesmus obliquus (S. obliquus) and Chlorella vulgaris (C. vulgaris) for sustainable biodiesels. Results showed that both S. obliquus and C. vulgaris exhibited high cell densities and lipid contents. The optimal parameters for biomass yields were a PAR of 60 μmol/m2/sec and a temperature of 27 degrees Celsius. Urea deprivation and a PAR of 60 μmol/m2/sec resulted in the highest proportions of unsaturated fatty acids in both species.

BIOMASS & BIOENERGY (2023)

Article Environmental Sciences

Mediation of daily ambient ozone concentration on association between daily mean temperature and mortality in 7 metropolitan cities of Korea

Sanghyuk Bae, Youn-Hee Lim, Jongmin Oh, Ho-Jang Kwon

Summary: This study examined the mediation of ozone on the association between temperature and daily mortality, and estimated the excess mortality due to climate change. The findings revealed that increased temperature led to higher ozone concentration, which in turn affected daily mortality. Both direct and indirect effects of temperature and ozone were found to contribute to excess deaths.

ENVIRONMENT INTERNATIONAL (2023)

Article Public, Environmental & Occupational Health

Impact of Radiofrequency Exposure from Mobile Phones on the Risk of Developing Brain Tumors in Korean and Japanese Adolescents: A MOBI-Kids Case-Control Study

Noriko Kojimahara, Yong-Han Lee, Ae-Kyoung Lee, Sanghyuk Bae, Ho-Jang Kwon, Mina Ha, Yasuto Sato, Masao Taki, J. Wiart, C. E. Langer, Elisabeth Cardis

Summary: This study aimed to investigate the association between mobile phone use and the risk of brain tumors in young people in Korea and Japan. The results showed no evidence of a causal association between mobile phone use and risk of brain tumors as a whole or glioma specifically.

JOURNAL OF EPIDEMIOLOGY (2023)

Article Medicine, General & Internal

Latent Tuberculosis Cascade of Care Among Healthcare Workers: A Nationwide Cohort Analysis in Korea Between 2017 and 2018

Jinsoo Min, Hyung Woo Kim, Joon Young Choi, Ah Young Shin, Ji Young Kang, Yunhee Lee, Jun-Pyo Myong, Hyunsuk Jeong, Sanghyuk Bae, Hyeon-Kyoung Koo, Sung-Soon Lee, Jae Seuk Park, Hyeon Woo Yim, Ju Sang Kim

Summary: Using the cascade of care model, we evaluated the performance of Korea's nationwide latent tuberculosis infection project among healthcare workers. Only one third of participants completed treatment. Age, occupation, treatment center, and initial regimen were significantly related to treatment performance indicators.

JOURNAL OF KOREAN MEDICAL SCIENCE (2022)

No Data Available