Journal
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 30, Issue 5, Pages 737-745Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/14756366.2014.963072
Keywords
Carbonic anhydrase; fluorine; selectivity; superacid; tertiary benzenesulfonamides
Funding
- Universite de Poitiers
- CNRS
- @rtMolecule
- ANRT (CIFRE scholarship)
- EU
Ask authors/readers for more resources
A series of substituted pyrrolidines and piperidines were synthesized using superacid HF/SbF5 chemistry. Investigated as inhibitors of several human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, i.e. the cytosolic hCA I and II as well as the tumor-associated transmembrane isoforms hCA IX and XII, these compounds showed a never yet reported selectivity toward the human carbonic anhydrase hCA II. In the tertiary benzenesulfonamide family, this class of inhibitors points out a new mechanism of action for human carbonic anhydrase II inhibition.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available