Journal
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 25, Issue 5, Pages 708-714Publisher
INFORMA HEALTHCARE
DOI: 10.3109/14756360903540292
Keywords
Potassium phenoxyaceto-hydroxamate; potassiumcinnamohydroxamate; non-oxovanadium (IV) complexes; spectral studies; antibacterial activity
Funding
- University Grant Commission, New Delhi
- Department of Science & Technology (DST), Government of India, New Delhi
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Complexes with a composition of VCl(2-n)(bzac)(2)(HL(1,2))(n) (I - IV) (where bzac=1-phenyl-1,3-butanedionate anion (C(6)H(5)COCHCOCH(3)(-)); HL(1)=C(6)H(5)OCH(2)C(O)NHO(-), HL(2)=C(6)H(5)CH=CHC(O)NHO(-), n=1 and 2) have been synthesised from the reactions of (VCl(2)(bzac)(2)) with equi- and bi-molar amounts of potassium phenoxyacetohydroxamate and cinnamohydroxamate (KHL(1,2)) in THF + MeOH solvent medium. The complexes have been characterised by elemental analyses, molar conductivity, magnetic measurements, IR, electronic and mass spectral studies. The physicochemical and spectral studies suggest a distorted octahedral geometry around vanadium in the complexes. The antibacterial activities of the newly synthesised complexes, vanadium precursor and ligands have been screened in vitro against six bacterial species. The complexes have shown higher antibacterial effect than the free ligands.
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