Journal
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 24, Issue 5, Pages 1148-1153Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756360802693890
Keywords
Pyrano[3,2-e]indoles; indole derivatives; von Pechmann reaction; coumarin derivatives; inhibition of NO production; antiproliferative effect
Ask authors/readers for more resources
The synthesis and the biological evaluation of pyrano[3,2-e]indoles and their reaction intermediates are described. The compounds prepared were evaluated for their inhibition of NO production, antioxidant activity and also for their ability to inhibit in vitro the growth of four human tumor cell lines: large lung carcinoma (COR-L23), alveolar basal epithelial carcinoma (A549), amelanotic melanoma (C32) and melanoma (A375). The two reaction intermediates, Sa and 5b, showed the highest inhibition of NO production in murine monocytic macrophage (IC50 = 1.1 mu M and IC50 = 23 mu M respectively). Compound 5a was the most active against melanotic melanoma (IC50 = 11.8 mu M) while the other compounds exhibited weak cytotoxicity with IC50 values >50 mu M on all cell lines.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available