Review
Chemistry, Medicinal
Mussa E. Zholdasbayev, Gayane A. Atazhanova, Safol Musozoda, Ewa Poleszak
Summary: In this review, a comprehensive overview of the botany, extracting methods, chemical composition, and pharmacological activity of different parts of Prunella vulgaris L. (PV) extracts is presented. It was found that the chemical composition of PV varies depending on various factors. The review also highlights previously unused extraction methods that may have scientific interest, aiming to guide professionals and explore new solutions associated with PV plant.
Article
Plant Sciences
Zhihao Sun, Ya Wu, Pengyu Fan, Dengli Guo, Sanyin Zhang, Chi Song
Summary: This study reports the first complete mitochondrial genome of Prunella vulgaris, obtained by a hybrid assembly strategy using Nanopore and Illumina sequencing. The genome has two circular structures, a total length of 297,777 bp, a GC content of 43.92%, and 29 unique protein-coding genes. Comparative analysis with the chloroplast genome revealed 36 homologous fragments. This work provides valuable genetic information for further studies on Prunella vulgaris.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Jie Shen, Boying Liang
Summary: The sudden outbreak of COVID-19 had serious effects globally, but Traditional Chinese Medicine combined with regional characteristics has achieved remarkable results in China. A study found that Prunella vulgaris can extend the lifespan and improve endurance of fruit flies.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Plant Sciences
Yang-Qian-Nan Tang, Jing Deng, Li Li, Jing Yan, Li-Mei Lin, Ya-Mei Li, Yan Lin, Bo-Hoh Xia
Summary: The study demonstrated the favorable antibacterial, anti-inflammatory, and immunoregulatory effects of essential oil from Prunella vulgaris L., providing a reference for its application as food or drug.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Biochemical Research Methods
Zhimin Zhang, Bohou Xia, Yamei Li, Yan Lin, Jingchen Xie, Ping Wu, Limei Lin, Duanfang Liao
Summary: This study conducted quantitative proteome analysis on Prunella vulgaris L. during different growth stages, revealing changes in protein profiles and providing a scientific rationale for harvesting the plant in summer after it turns brownish red. This work lays a foundation for understanding the molecular mechanisms involved in quality development and emphasizes the importance of timing in harvesting traditional Chinese medicine.
JOURNAL OF PROTEOMICS
(2021)
Article
Plant Sciences
Ya-gang Song, Le Kang, Shuo Tian, Lin-lin Cui, Yan Li, Ming Bai, Xiao-yan Fang, Li-hua Cao, Kimberly Coleman, Ming-san Miao
Summary: The study found that the total flavonoids of Prunella vulgaris inhibited the activity of SMMC-7721 cells, reduced tumor volume and weight in H22 tumor-bearing mice, and increased the expressions of immune factors in serum and caspase content in tumor tissue homogenate. Prunella vulgaris total flavonoids have an obvious anti-hepatocarcinoma effect, which may be linked to the inhibition of autophagy and promotion of apoptosis in liver cancer cells. The inhibition of autophagy may be related to activation of the PI3K/Akt/mTOR pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Qingling Guo, Haili Qu, Hong Zhang, Xia Zhong
Summary: The bioactive compound in Prunella vulgaris L. was identified as rosmarinic acid, which can alleviate autoimmune thyroiditis by inhibiting HMGB1 signaling pathway, reducing inflammation and immune responses. It is the first study to demonstrate the role of Prunella vulgaris L. in attenuating Th1, Th2, and Th17 cells in AIT models, suggesting its potential therapeutic value in autoimmune diseases.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemical Research Methods
Fengwei Ma, Huayong Lou, Yonghui Ge, Jinyu Li, Chao Chen, Su Xu, Lei Tang, Weidong Pan
Summary: Vulgarisins, diterpenoids from Prunella vulgaris with rare ring skeleton, have attracted attention for their bioactivities. Analysis methods like mass spectrometry and chromatography were used to discover and characterize vulgarisins analogues in the plant extracts, facilitating further research on their medicinal properties.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zhan Chai, Yan-Jun Sun, Ru-Yi Pan, Chen Zhao, Rui-Jie Han, Hui Chen, Meng Li, Wei-Sheng Feng
Summary: Phytochemical investigation of the aerial parts of Gendarussa vulgaris led to the isolation of new triterpenoid derivative gvterpennoid B (1) and a new natural product 3-(2-hydroxy-4,5-dimethoxyphenyl)propanoic acid (9), along with known monoterpenoids (2-5) and phenylpropanoids (6-8). The structure elucidation was performed based on NMR data and MS, with known metabolites (2-8) isolated for the first time from the Acanthaceae family. The chemotaxonomic significance and plant distribution of the isolates were also discussed in the study.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2021)
Article
Environmental Sciences
Li Li, Li-mei Lin, Jing Deng, Xiu-lian Lin, Ya-mei Li, Bo-hou Xia
Summary: Significant oxidative damage induced by fluoride can be prevented by the natural antioxidant PV. PV exhibits antioxidant, anti-inflammatory, and hepatoprotective effects, improving metabolic disorders caused by fluoride and regulating metabolic pathways.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Min Kyoung Cho, Ling Jin, Jung Ho Han, Jung-Suk Jin, Se-Yun Cheon, Su Shin, Sung-Jin Bae, Jang-Kyung Park, Ki-Tae Ha
Summary: Endometriosis is a chronic inflammatory disorder with limited treatment options. However, recent studies have shown that Prunella vulgaris, a traditional herbal medicine with anti-estrogenic effects, may be a potential treatment for endometriosis. In this study, water-extracted Prunella vulgaris was found to alleviate endometriosis in mice by inducing apoptosis in endometrial cells through the regulation of aerobic glycolysis enzymes. These findings suggest that Prunella vulgaris may be a promising candidate for the prevention and treatment of endometriosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiao-xiong Gan, Lin-kun Zhong, Fei Shen, Jian-hua Feng, Ya-yi Li, Si-jing Li, Wen-song Cai, Bo Xu
Summary: The study utilized network pharmacology and molecular docking technology to investigate the bioactive ingredients and mechanisms of Prunella vulgaris in treating Hashimoto's thyroiditis. Luteolin and kaempferol were identified as key compounds that may play a crucial role in treating HT by regulating multiple signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jeonghyun Kim, Chang-Gun Lee, Seokjin Hwang, Seung-Hee Yun, Laxmi Prasad Uprety, Kang-Il Oh, Shivani Singh, Jisu Yoo, Hyesoo Jeong, Yoonjoong Yong, Subin Yeo, Eunkuk Park, Seon-Yong Jeong
Summary: This study investigated the anti-osteoarthritic effects of Prunella vulgaris (PV) and Gentiana lutea (GL) extract in vitro and in DMM-induced OA mice. The results showed that PV and GL extracts inhibited the mRNA expression of COX2 in chondrocytes and RAW 264.7 cells, and the optimal inhibitory effect was achieved with a PV and GL combination at an 8:2 ratio (PG). PG extracts also prevented the expression of catabolic factors and inflammatory mediator levels, and protected articular cartilage from destruction in DMM-induced OA mice. This study suggests that PG may be a potential alternative herbal medicine for treating OA.
Review
Pharmacology & Pharmacy
Junying Pan, Haoyu Wang, Yinghua Chen
Summary: Prunella vulgaris L. is a plant with both medicinal and edible value, and has a wide range of pharmacological activities. The major chemical constituents of Prunella vulgaris L. have been identified, and its pharmacological effects have been validated. However, there are still some shortcomings in the current research on Prunella vulgaris L., which need to be further strengthened.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Chemical
Ya Gao, Huan Chang, Dong Liang, Xing-yi Yang, Zhao-qiong Chen, Xin Liu
Summary: In this research, Prunella vulgaris L. residues were used as a novel adsorbent for the efficient removal of methylene blue and malachite green from aqueous solutions. The optimal conditions for the removal process were determined and the adsorption mechanisms were confirmed through various techniques. The findings suggest that Prunella vulgaris L. residues have the potential to be an effective adsorbent material for the removal of these hazardous dyes.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2023)