Article
Chemistry, Organic
Konstantin Lebedinskiy, Volodymyr Lobaz, Jindrich Jindrich
Summary: By synthesizing a series of β-cyclodextrin dimers with different spatial structures, this study analyzed their structure using 1H NMR and NOESY NMR, finding the dependence of molecular symmetry on spatial structure. The experiments on solubility showed that the synthesized dimers exhibited better effectiveness in increasing the solubility of tetracene compared to other supramolecular hosts.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Nazneen Akhtar, Sehresh Khan, Shafiq Ur Rehman, Zia Ur Rehman, Zia Ur Rehman Mashwani, Eui Shik Rha, Muhammad Jamil
Summary: The study found that lower concentrations of zinc oxide nanoparticles can increase bacterial growth rate and tolerance potential, helping them to resist heavy metal stress; while higher concentrations of zinc oxide nanoparticles may lead to the accumulation of heavy metals in bacterial cells, affecting bacterial morphology and cell membrane.
ADSORPTION SCIENCE & TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hay Man Saung Hnin Soe, Jatupol Junthip, Supakarn Chamni, Chaisak Chansriniyom, Patanachai Limpikirati, Thanundorn Thanusuwannasak, Rathapon Asasutjarit, Patamaporn Pruksakorn, Rinrapas Autthateinchai, Sirawit Wet-osot, Thorsteinn Loftsson, Phatsawee Jansook
Summary: In this study, water-soluble anionic beta-cyclodextrin derivatives were synthesized to improve the aqueous solubility of miconazole for the treatment of fungal keratitis. The results showed that the prepared complex significantly increased the solubility of miconazole and exhibited good antifungal efficacy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Zhanyao Hou, Werner M. Nau, Richard Hoogenboom
Summary: A new supramolecular hydrogel that can transform into a covalently crosslinked hydrogel upon UV irradiation was developed. The presence of a cationic charge on anthracene side chains enhanced the binding affinity, facilitating hydrogel formation at lower concentrations. UV irradiation at different wavelengths demonstrated the reversible conversion to a chemical hydrogel, losing the dynamic nature responsible for shear-thinning behavior.
Article
Agricultural Engineering
Jianhua Qu, Siqi Wang, Yihui Wang, Xue Tian, Zhao Jiang, Yue Tao, Lei Wang, Fengxia Deng, Ying Zhang
Summary: The magnetic hydrochar modified by 13-cyclodextrin showed excellent performance in the simultaneous removal of cadmium and anthracene. It exhibited fast adsorption equilibrium, high maximum monolayer binding capacity, and effective avoidance of competitive adsorption behavior between the two contaminants.
BIORESOURCE TECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Phatsawee Jansook, Hay Marn Hnin, Thorsteinn Loftsson, Einar Stefansson
Summary: This article discusses the use of carbonic anhydrase inhibitors to lower intraocular pressure in patients with glaucoma, and explores the enhancement of drug solubility and permeability using cyclodextrin complexes. It also examines the development of drugs targeting specific CA isoenzymes in ocular tissues and the potential of pharmaceutical nanotechnology platforms.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Environmental Sciences
Qiquan Li, Qian Deng, Hongyan Fang, Xuelian Yu, ZeMeng Fan, Zhengping Du, Meng Li, Qi Tao, Weiping Song, Bin Zhao, Chaoping Chen, Rong Huang, Dagang Yuan, Xuesong Gao, Bing Li, Changquan Wang, John P. Wilson
Summary: The study explored the key factors controlling Cd accumulation in the soil profile under actual field conditions, showing that phosphate fertilizer rates, parent material types, and precipitation affect Cd accumulation in agricultural soils. It was found that parent material is the decisive factor in determining the magnitudes and depths of exogenous Cd accumulation in the soil profile.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Environmental
Nan Guo, Hui Ling, Renkui Yu, Fei Gao, Yue Cao, Jun Tao
Summary: This study discovered a novel SsIRT9 gene from Sailx suchowensis that enhances Cd accumulation in willow roots. The expression of SsIRT9 in tobacco resulted in higher Cd levels in shoots, demonstrating its potential for enhancing Cd extraction from soils.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Environmental Sciences
Wanzheng Ma, Hong Wang, Xiaoliang Li, Yongbing Cai
Summary: This study investigated the effects of six leaching agents on chromium elution from contaminated soil, finding that citric acid and oxalic acid had higher removal efficiencies. The combined eluent of oxalic acid and citric acid showed the best elution efficiency, with a total chromium removal rate of 62.0%. Citric acid is an environmentally friendly eluent that can avoid secondary pollution.
WATER AIR AND SOIL POLLUTION
(2022)
Article
Chemistry, Medicinal
Ji-Hyun Kang, Ji-Eun Lee, So-Jeong Jeong, Chun-Woong Park, Dong-Wook Kim, Kwon-Yeon Weon
Summary: This study aims to improve the solubility of rivaroxaban (RIV) and develop a formulation that can be conveniently administered regardless of the meal, ensuring reproducibility of efficacy. The results show that the developed R-C-P complex formulation has higher solubility and better release performance compared to commercial products.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Zoltan-Istvan Szabo, Beata-Maria Benko, Agnes Bartalis-Fabian, Robert Ivanyi, Erzsebet Varga, Levente Szocs, Gergo Toth
Summary: A stereospecific capillary electrophoresis method was developed for the separation of the novel antipsoriatic agent, apremilast (APR). Six anionic cyclodextrin (CD) derivatives were tested and succinyl-beta-CD was found to exhibit chiral interactions, but with an unfavorable enantiomer migration order. However, by changing the direction of electroosmotic flow through dynamic coating, the migration order reversal was achieved, allowing for the determination of enantiomeric purity.
Article
Chemistry, Physical
A. A. Garibyan, E. S. Delyagina, M. L. Antipova, E. G. Odintsova, V. E. Petrenko, I. V. Terekhova
Summary: The solubilizing effect of beta-cyclodextrin on the immunosuppressant fingolimod is studied for the first time. The study reveals a possible 20x increase in the solubility of fingolimod due to its interaction with beta-cyclodextrin. H-1 NMR spectroscopy and computer modeling provide insights into the configuration and stability of the resulting inclusion complexes, suggesting the formation of hydrogen bonds between the two molecules.
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Article
Chemistry, Medicinal
Md. Khalid Anwer, Muzaffar Iqbal, Mohammad Muqtader Ahmed, Mohammed F. Aldawsari, Mohd Nazam Ansari, Essam Ezzeldin, Nasr Y. Khalil, Raisuddin Ali
Summary: The study reveals that poloxamer 188 may enhance the solubility of arbidol hydrochloride/beta-cyclodextrin complexes and significantly improve their bioavailability.
Article
Environmental Sciences
Hanghang Zhao, Peiyue Li, Xiaodong He
Summary: This study successfully synthesized a novel modified gangue material (MGE) from coal gangue and applied it to immobilize cadmium in contaminated soil. The results showed that the MGE had a large number of active groups on the surface, which facilitated the removal of Cd2+. Adsorption kinetics and isotherm models indicated that the adsorption behavior followed pseudo second-order and Langmuir models. Pot experiments demonstrated that the application of MGE significantly improved plant growth and reduced the content of available Cd2+ in the soil.
Article
Engineering, Environmental
Elham Einafshar, Zahra Khodadadipoor, Mojgan Nejabat, Mohammad Ramezani
Summary: A novel and facile route for the synthesis of cyclodextrin-conjugated graphene oxide (CDs-GO) nanocomposites was developed in this study. The study showed that different types of CDs-GO exhibited high adsorption capacity towards Cd2+ with the adsorption process following the pseudo-second-order and Freundlich isotherm models.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
