Article
Urology & Nephrology
Anastasios D. Asimakopoulos, Gaia Colalillo, Roberto Miano, Enrico Finazzi Agro, Giuseppe Farullo, Andrea Fuschi, Antonio Luigi Pastore, Stefano Germani
Summary: This study presents a new technique for placing a DJ stent during laparoscopic transperitoneal ureterolithotomy. The technique is time-saving, safe, and eliminates the need for additional procedures or modified equipment.
Article
Medicine, General & Internal
Guo-Liang Lu, Xiao-Jin Wang, Bao-Xing Huang, Yang Zhao, Wei-Chao Tu, Xing-Wei Jin, Yuan Shao, Da-Wei Wang
Summary: Both MPCNL and RPLU have similar surgical success and stone clearance rates in treating impacted proximal ureteral stones larger than 15 mm. However, patients undergoing MPCNL experienced lower post-operative pain and faster recovery than those undergoing RPLU.
CHINESE MEDICAL JOURNAL
(2021)
Article
Andrology
Bo Jia, Jiayuan Liu, Bo Hu, Zhaohui Chen
Summary: A retrospective evaluation showed that retroperitoneal laparoscopic ureterolithotomy (RLU) is an effective method for treating large impacted upper ureteric calculi, with high success rate, low complication rate, and short operative time and hospital duration.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2022)
Article
Gastroenterology & Hepatology
Dao-Jian Gao, Jian-Feng Yang, Shu-Ren Ma, Jun Wu, Tian-Tian Wang, Hang-Bin Jin, Ming-Xing Xia, Ying-Chun Zhang, Hong-Zhang Shen, Xin Ye, Xiao-Feng Zhang, Bing Hu
Summary: Additional RFA may improve overall survival and quality of life in patients with inoperable primary extrahepatic biliary cancer compared to stent placement alone.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Medicine, General & Internal
Suraj Jayadeva Reddy, Bathi Sourabh Reddy, Arun Chawla, Jean J. M. C. H. de la Rosette, Pilar Laguna, Padmaraj Hegde, Abhijit Shah, Anupam Choudhary, Sanket Kankaria, Vivekanand Kedarlingayya Hiremath
Summary: Nonplacement of stents after uncomplicated URS can reduce stent-related symptoms and preserve the quality of life without increasing postoperative risks.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Sheng-Lin Gao, Hao Wu, Quan-Xin Su, Zi-Yi Zhang, Ze Zhang, Chao Lu, Li-Feng Zhang, Li Zuo
Summary: This study compared the efficacy of RPUL and URL in treating upper ureteral calculi. RPUL showed higher success rate and fewer complications compared to URL, making it a safe and effective laparoscopic method for treating patients with upper ureteral calculi.
Article
Urology & Nephrology
Toru Kanno, Go Kobori, Katsuhiro Ito, Hiromichi Nakagawa, Toshifumi Takahashi, Shigeki Koterazawa, Naoto Takaoka, Shinya Somiya, Kanji Nagahama, Masaaki Ito, Yuzuru Megumi, Yoshihito Higashi, Seiji Moroi, Toshiya Akao, Hitoshi Yamada
Summary: This study investigated the oncological outcomes and recurrence patterns in clinically node-negative patients with renal pelvic and/or upper or middle ureteral tumors after template-based RPLND in conjunction with LRNU. The study found that RPLND significantly improved the 5-year recurrence-free survival and reduced distant recurrences.
JOURNAL OF ENDOUROLOGY
(2022)
Article
Medicine, General & Internal
Lin Xiong, Kristine J. S. Kwan, Jian Hou
Summary: The successful removal of a unilateral upper ureteral stone and a smaller renal stone was reported using single-use digital flexible ureteroscopes for laparoscopic ureterolithotomy.
AMERICAN JOURNAL OF CASE REPORTS
(2023)
Article
Urology & Nephrology
Yuqing Zhang, Changqing Chen, Wei Hu, Simin Li, Yang Li, Rujian Zhu
Summary: This study compared the effectiveness of antireflux ureteral stents and standard ureteral stents in improving symptoms and quality of life in patients. The results showed that the antireflux ureteral stent group had significantly better outcomes in terms of flank and suprapubic pain, visual analog scale, analgesic use, back soreness during micturition, and quality of life, compared to the standard ureteral stent group.
JOURNAL OF ENDOUROLOGY
(2023)
Article
Urology & Nephrology
Makoto Taguchi, Kaneki Yasuda, Hidefumi Kinoshita
Summary: This study evaluated the correlation between the position of a ureteral stent and stent-related symptoms. The results showed that a ureteral stent crossing the bladder midline led to worse urinary symptoms. Choosing the appropriate stent length is important to minimize stent-related symptoms.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyo Jin Kim, Chang Jin Yoon, Seungjae Lee, Jae Hwan Lee, Won Seok Choi, Chong-Ho Lee
Summary: This study compares the technical success of antegrade uteral stent (AUS) and retrograde ureteral stent (RUS) placements in patients with malignant ureteral obstruction (MUO) and identifies the predictors of technical failure of RUS. The results show that AUS placement had a higher technical success rate compared to RUS placement, and age, ureteral orifice invasion, and extrinsic cancer were independent predictors of RUS technical failure.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Urology & Nephrology
Masahiko Sato, Yasuhiro Kaiho, Naoki Kawamorita, Shinichi Yamashita, Koji Mitsuzuka, Yoichi Arai, Akihiro Ito
Summary: This study found that retroperitoneal salvage surgery based on RLU is effective in addressing intractable urinary tract problems, avoiding intra-abdominal adhesions and ensuring sufficient ureteral length for subsequent reconstructions. The minimally invasive procedure contributes to improving patient quality of life.
JOURNAL OF ENDOUROLOGY
(2021)
Article
Oncology
Yucheng Xiang, Sinan Lu, Yufeng Li, Zhenghao Liu, Weilin Wang
Summary: This meta-analysis demonstrated that biliary stent placement with I-125 seeds showed lower risk of stent occlusion and better mean survival compared with stent placement alone in patients with malignant biliary obstruction. Additionally, there was no significant difference in adverse events between the two groups.
Article
Obstetrics & Gynecology
Morgan A. Scaglione, Amanda A. Allshouse, Dana R. Canfield, Hannah D. Mclaughlin, Ann M. Bruno, Ibrahim A. Hammad, D. Ware Branch, Kathryn A. Maurer, Robert L. Dood, Michelle P. Debbink, Robert M. Silver, Brett D. Einerson
Summary: This study aimed to evaluate the association between prophylactic ureteral stent placement and genitourinary injury during hysterectomy for placenta accreta spectrum. The results showed that prophylactic ureteral stent placement was associated with a decreased risk of genitourinary injury.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Urology & Nephrology
Ziye Huang, Tongxin Yang, Lishi Shao, Bowei Yang, Guang Wang, Pei Li, Shunhang Yang, Jiongming Li
Summary: This study evaluated the efficacy and safety of transperitoneal and retroperitoneal laparoscopic ureterolithotomy (TLU and RLU). A meta-analysis of 11 articles showed that RLU had better outcomes in terms of operative time, hospital stay, and the complication of paralytic ileus compared to TLU. However, more clinical trial data are needed to confirm these conclusions.
UROLOGIA INTERNATIONALIS
(2023)
Article
Biochemistry & Molecular Biology
Abdelsattar M. Omar, Anfal S. Aljahdali, Martin K. Safo, Gamal A. Mohamed, Sabrin R. M. Ibrahim
Summary: In this study, 114 phenylspirodrimanes from Stachybotrys chartarum were screened for their CB2 agonistic potential. Compound 56 exhibited the highest docking score and strong interactions with key amino acid residues in the CB2 receptor. These findings provide structural insights for the design of selective CB2 ligands.
Article
Biochemistry & Molecular Biology
Abdelsattar M. Omar, Khadijah A. Mohammad, Ikhlas A. Sindi, Gamal A. Mohamed, Sabrin R. M. Ibrahim
Summary: Compounds 34, 28, and 44 from the marine sponge D. elegans may be potential inhibitors of DHFR, with high binding affinity.
Review
Mycology
Sabrin R. M. Ibrahim, Hossam M. Abdallah, Gamal A. Mohamed, Sunil K. Deshmukh
Summary: Fungi are an abundant source of structurally unique bioactive metabolites. Aspergillus sclerotiorum, a fungus in the Aspergillaceae family, produces different enzymes with potential biotechnological and industrial applications. It also biosynthesizes various metabolites, including pyrazines, cyclic peptides, indole derivatives, diketopiperazines, butenolides, and lovastatin analogs, which exhibit diverse bioactivities. Diketopiperazines and butenolides are particularly bioactive metabolites with notable antimicrobial and cytotoxic properties. This review provides an overview of the metabolites produced by A. sclerotiorum, including their structures, bioactivities, proposed biosynthesis, and biotechnological applications from 1958 to September 2022, with a total of 104 metabolites and 91 references listed.
MYCOLOGICAL PROGRESS
(2023)
Article
Nutrition & Dietetics
Gamal A. A. Mohamed, Sabrin R. M. Ibrahim, Rawan H. H. Hareeri, Lenah S. S. Binmahfouz, Amina M. M. Bagher, Hossam M. M. Abdallah, Wael M. M. Elsaed, Dina S. S. El-Agamy
Summary: The study found that Garcinone E (GE), a xanthone derivative from Garcinia mangostana, effectively protects the liver from Con-A-induced damage by activating the Nrf2/HO-1 signaling pathway and suppressing oxidative stress, NF-kappa B, and TNF-alpha/JNK/apoptosis signaling pathways. These results suggest that GE has potential as a novel hepato-protective agent against autoimmune hepatitis.
Article
Medicine, Research & Experimental
Maan T. Khayat, Khadijah A. Mohammad, Gamal A. Mohamed, Dina S. El-Agamy, Wael M. Elsaed, Sabrin R. M. Ibrahim
Summary: gamma-Mangostin (gamma-MN) has a protective effect against cholestatic liver damage (CLI) by reducing hepatic injury parameters, improving pathological lesions, and exerting antioxidant and anti-inflammatory effects. This is achieved through the potentiation of Nrf2/HO-1 signaling and inhibition of NF-kappa B/NLRP3/Caspase-1/IL-1 beta/ GSDMD activation. gamma-MN may be a potential candidate for cholestatic patients.
Review
Chemistry, Medicinal
Sabrin R. M. Ibrahim, Kholoud F. Ghazawi, Samar F. Miski, Duaa Fahad ALsiyud, Shaimaa G. A. Mohamed, Gamal A. Mohamed
Summary: This study provides an up-to-date literature survey and comprehensive insight into the metabolites produced by the marine sponge genus Acanthella. A total of 226 metabolites were discussed based on published data from 1974 to the beginning of 2023, with 90 references. These metabolites include nitrogen-containing terpenoids, alkaloids, and sterols, with various structural characteristics and bioactivities. The study also covers their sources, biosynthesis, syntheses, and available biological activities.
Article
Biochemistry & Molecular Biology
Gamal A. Mohamed, Abdelsattar M. Omar, Dana F. AlKharboush, Mona A. Fallatah, Ikhlas A. Sindi, Dina S. El-Agamy, Sabrin R. M. Ibrahim
Summary: Through multiple docking studies on 235 depsidones, it was found that garcinisidone E and paucinervin Q may be potential CB2 receptor agonists, which deserve further in vivo and in vitro investigation.
Article
Pharmacology & Pharmacy
Gamal A. Mohamed, Ali A. Alqarni, Hossam M. Abdallah, Abdelsattar M. Omar, Sabrin R. M. Ibrahim
Summary: The purpose of this study was to investigate the cytotoxic and alpha-amylase inhibitory potential of methanol extract of T. minuta and its metabolites. Phytochemical investigation and analysis were conducted, and the structures of the isolated metabolites were determined. The metabolites were then assessed for cytotoxicity and alpha-amylase inhibitory potency. The results showed that T. minuta contains valuable anti-diabetic and cytotoxic metabolites, although further validation through in vivo and in vitro investigations is needed.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Kholoud F. Ghazawi, Sarah A. Fatani, Shaimaa G. A. Mohamed, Gamal A. Mohamed, Sabrin R. M. Ibrahim
Summary: Nowadays, the search for new microbial natural scaffolds has increased, providing potential compounds for pharmaceutical industries. Aspergillus nidulans Winter G. is a prolific source of structurally diverse bioactive metabolites with therapeutic significance, including terpenoids, benzophenones, sterols, alkaloids, xanthones, and polyketides. This work surveys the literature on A. nidulans, focusing on its metabolites, biosynthesis, bioactivities, and biotechnological potential, with over 200 metabolites listed.
FERMENTATION-BASEL
(2023)
Review
Chemistry, Medicinal
Sabrin R. M. Ibrahim, Shaimaa G. A. Mohamed, Baiaan H. Alsaadi, Maryam M. Althubyani, Zainab I. Awari, Hazem G. A. Hussein, Abrar A. Aljohani, Jumanah Faisal Albasri, Salha Atiah Faraj, Gamal A. Mohamed
Summary: Marine-derived fungi, such as Aspergillus sydowii, have been recognized as a valuable source of metabolites that have significant synthetic appeal and bioactivity. This review highlights the isolated metabolites from A. sydowii, including their structures, biological functions, biosynthesis, and the biotechnological and industrial significance of this fungus. More than 245 compounds and 134 relevant references published from 1975 to June 2023 were described in this review.
Article
Biochemistry & Molecular Biology
Tagyedeen H. Shoaib, Nihal Abdelmoniem, Rua M. Mukhtar, Amal Th. Alqhtani, Abdullah L. Alalawi, Razan Alawaji, Mashael S. Althubyani, Shaimaa G. A. Mohamed, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Hazem G. A. Hussein, Abdulrahim A. Alzain
Summary: This study evaluated the docking simulations of 120 lignans from Ferula sinkiangensis and Justicia procumbens on the MDM2 protein, and performed molecular dynamics simulations on three promising compounds. The results showed that these compounds have satisfactory pharmacokinetic properties and stable molecular dynamics profiles, making them potential starting points for further research.
Article
Biochemistry & Molecular Biology
Abdulrahim A. Alzain, Rua M. Mukhtar, Nihal Abdelmoniem, Tagyedeen H. Shoaib, Wadah Osman, Marwa Alsulaimany, Ahmed K. B. Aljohani, Sara A. Almadani, Baiaan H. Alsaadi, Maryam M. Althubyani, Shaimaa G. A. Mohamed, Gamal A. Mohamed, Sabrin R. M. Ibrahim
Summary: This study aimed to identify natural compounds capable of targeting KEAP1 using structure-based drug design methods. Ten compounds with superior binding energies compared to the reference compound were identified, and three compounds were chosen for further investigation. Ligand-residue interaction analysis revealed specific interactions between these compounds and key residues, indicating their stability within the binding site.
Article
Microbiology
Mohamed A. Hussain, Mohamed M. Hassan, Bashir Abdrhman Bashir, Tarig A. Gamar, Elmuaiz Gasmalbari, Ahmed Osman Mohamed, Wadah Osman, Asmaa E. Sherif, Abdelaziz Elgaml, Aisha A. Alhaddad, Kholoud F. Ghazawi, Samar F. Miski, Bayan E. Ainousah, Yusra Saleh Andijani, Sabrin R. M. Ibrahim, Gamal A. Mohamed, Ahmed Ashour
Summary: This study aimed to understand the behavior of SARS-CoV-2 through comparative genomic analysis with the closest coronavirus species that infect humans. The study revealed that SARS-CoV-2 is most similar to SARS-CoV, and the ORF8 protein of SARS-CoV-2 could be considered as a potential therapeutic target for stopping viral transmission.
Article
Biochemistry & Molecular Biology
Tagyedeen H. Shoaib, Mohammed A. Almogaddam, Yusra Saleh Andijani, Samaher Ahmad Saib, Najwa Mahmoud Almaghrabi, Abdulaziz Fahad Elyas, Rahmah Yasin Azzouni, Ehda Ahmad Awad, Shaimaa G. A. Mohamed, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Hazem G. A. Hussein, Wadah Osman, Ahmed Ashour, Asmaa E. Sherif, Abdulrahim A. Alzain
Summary: CDK5 plays a crucial role in various biological processes and is associated with cancer initiation and progression. In this study, a library of marine natural compounds was screened to assess their binding affinity with CDK5. Three promising compounds were identified as potential CDK5 inhibitors and showed stable interaction with the target during molecular dynamics simulations.
Article
Biology
Akaber T. Rizq, Alaa Sirwi, Dina S. El-Agamy, Hossam M. Abdallah, Sabrin R. M. Ibrahim, Gamal A. Mohamed
Summary: This study evaluated the potential protective efficacy of cepabiflas B and C (CBs) separated from Allium cepa against LPS-induced hepatic and kidney damage and its possible mechanistic pathways. CBs effectively protected the liver and the kidney against LPS-induced damage. CBs ameliorated oxidative damage and enhanced the Nrf2/HO-1 protective pathway, while counteracting the activation of NF-κB/downstream cytokines which attenuated LPS-induced inflammatory response and showed remarkable anti-apoptotic activity.