Article
Biology
Allan Victor Ribeiro, Evelyn Giuliana Velasquez-Espedilla, Mirela Cesar de Barros, Leticia Lobo de Melo Simas, Flaviana Bombarda de Andrade
Summary: The aim of this study was to evaluate the influence of surface topography of gutta-percha (GP) cones and plasticized disks of GP on the initial adhesion of Enterococcus faecalis (E. faecalis). The roughness and waviness of the GP cones were higher compared to the plasticized disks. After contamination, bacterial accumulation was greater in cones, but the surface and topography became more homogeneous and smoother, with no differences between disks and cones. Plasticization of GP is recommended to reduce surface irregularities and bacterial retention.
Review
Engineering, Chemical
Joanna Dobrzanska, Lech B. Dobrzanski, Leszek A. Dobrzanski, Klaudiusz Golombek, Anna D. Dobrzanska-Danikiewicz
Summary: This paper confirms the importance of gutta-percha-based filling materials in endodontic treatment through literature review and experimental research, analyzing the methods of root canal preparation and obturation techniques. It emphasizes the impact of various technologies on treatment outcomes.
Article
Medicine, General & Internal
Ruth Perez-Alfayate, Montse Mercade, Juan Algar-Pinilla, Rafael Cisneros-Cabello, Federico Foschi, Stephen Cohen
Summary: This study evaluated the quality of root canal obturation in curved root canals filled with different techniques. The results showed variations in the performance of different filling materials at different levels in the canal, and the use of sonic activation of sealers did not reduce the presence of voids within obturation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Engineering, Chemical
Lara Dotto, Gabriel Kalil Rocha Pereira, Alvin Tomm, Atais Bacchi, Rafael Sarkis-Onofre
Summary: The choice of root canal irrigants affects the bond strength between endodontic sealers and root canal dentin. Using specific irrigant substances can improve the bond strength, while only using sodium hypochlorite or saline solution may weaken the bond strength.
JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Flavio R. F. Alves, Isabela N. Rocas, Jose C. Provenzano, Jose F. Siqueira
Summary: Complete removal of filling material is crucial for successful retreatment of root canals. Various techniques and supplementary approaches have shown promising results in enhancing root canal cleaning and disinfection.
APPLIED SCIENCES-BASEL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Davide Mancino, Naji Kharouf, Mauro Cabiddu, Frederic Bukiet, Youssef Haikel
Summary: GuttaCore and Thermafil groups showed significantly higher gutta-percha-filled areas and lower sealer-filled areas compared to the other groups at both 4 mm and 2 mm levels. There was also a significant improvement in obturation quality with the presence of gutta-percha tags in the GuttaCore and Thermafil groups compared to the other groups.
CLINICAL ORAL INVESTIGATIONS
(2021)
Review
Engineering, Biomedical
Lara Dotto, Rafael Sarkis-Onofre, Atais Bacchi, Gabriel Kalil Rocha Pereira
Summary: This scoping review aimed to explore the evidence on the use of solvents for gutta-percha dissolution during endodontic retreatments. Most studies suggested that solvents may complicate root canal cleanliness and facilitate gutta-percha remnants, recommending their avoidance except when necessary. High heterogeneity was observed, calling for further studies comparing different solvents in various clinical scenarios.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Review
Dentistry, Oral Surgery & Medicine
Chiara Pirani, Josette Camilleri
Summary: This systematic review aimed to investigate the impact of different obturation techniques and materials on the management of apical periodontitis (AP). The results showed that the obturation techniques and materials used did not affect the outcome of AP. Vertical compaction resulted in faster resolution of periapical lesions, while patients treated with lateral condensation had poorer oral health-related quality of life.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fernanda Clotilde M. Suassuna, Debora Ketley M. de Araujo, Ana Marly A. M. Amorim, Saulo Leonardo S. Melo, Richard J. Heck, Antonio Celso D. Antonino, Patricia M. Bento, Diego Filipe B. Silva, Daniela P. de Melo
Summary: This study assessed root temperature and volume of endodontic filling materials using infrared thermography and micro-computed tomography. The results showed that thermomechanical compaction had the highest increase in root temperature, while lateral condensation had the largest volume of filling materials.
JOURNAL OF ORAL SCIENCE
(2023)
Review
Engineering, Chemical
Leszek A. Dobrzanski, Joanna Dobrzanska, Lech B. Dobrzanski, Anna D. Dobrzanska-Danikiewicz, Klaudiusz Golombek
Summary: This review article provides an overview of commonly used endodontic filling materials, discussing their selection methods, experimental results, and importance in oral diseases. It also highlights the significance of developing root canals and obturation techniques in endodontics, emphasizing the role of gutta-percha and resilon materials.
Article
Multidisciplinary Sciences
Ines Ferreira, Pedro S. Babo, Ana Cristina Braga, Maria Ascensao Lopes, Manuela E. Gomes, Irene Pina-Vaz
Summary: This study compared the efficacy of XP-endo Finisher R and IrriSafe, with a solvent mixture of MEK/TCE, in removing root filling residues. The results showed that the final irrigation protocol with NaOCl and EDTA significantly reduced the volume of filling remnants, while the additional solvent mixture MEK/TCE increased the efficiency of reducing filling materials.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Multidisciplinary
Ines Ferreira, Irene Pina-Vaz
Summary: Non-surgical endodontic retreatment is a reliable conservative option for managing post-treatment apical periodontitis, but there is still uncertainty regarding effective microbial control. This article summarizes the current knowledge about specific solvent formulations targeting filling materials and highlights the advantages of additional irrigation steps to optimize disinfection.
APPLIED SCIENCES-BASEL
(2022)
Article
Materials Science, Multidisciplinary
K. Monisha, S. Antinate Shilpa, G. S. Hikku
Summary: Root canal treatment is the most effective method for treating pulpal damage, but bacterial infections are a major constraint. To combat this, an antibacterial coating of silver nanoparticles (Ag NPs) has been introduced onto gutta percha using a simple in-situ coating technique. The optimized coating duration results in a uniform coating, which has been characterized as face-centered cubic phase using XRD. Increasing the coating time increases the population of Ag NPs on gutta percha, enhancing its antibacterial activity as confirmed through zone of inhibition and colony counting studies. The antibacterial activity is attributed to the release of Ag+ ions from the coated gutta percha. The stability of the coating has been assessed and found to exhibit comparable antibacterial activity, validating its durability. This study demonstrates the potential of the developed coating system as an antibacterial coating for gutta percha.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Pediatrics
Claudia Adriana Rivera-Albarran, Veronica Morales-Dorantes, Jose Luis Ayala-Herrera, Mariana Castillo-Aguillon, Uriel Soto-Barreras, Claudia Veronica Cabeza-Cabrera, Ruben Abraham Dominguez-Perez
Summary: This study evaluated the efficacy of two common antimicrobial filling pastes on susceptible or resistant bacteria, finding that antibiotic resistance can impact the effectiveness of these pastes. The antimicrobial activity of the pastes depends on the antibiotic resistance profile of the strain.
Article
Agriculture, Dairy & Animal Science
Mohsen Hanifeh, Thomas Spillmann, Mirja Huhtinen, Yannes S. Sclivagnotis, Thomas Gronthal, Ulla Hynoenen
Summary: The study demonstrates that canine-derived Enterococcus faecalis and E. faecium strains adhere better to the duodenal mucosa of healthy beagles compared to chicken-derived strains, with canine E. faecalis showing the highest hydrophobicity levels. This suggests that both bacterial species and host origin may influence mucosal adhesion.
Article
Medical Laboratory Technology
Jesus Duque-Afonso, Miguel Waterhouse, Dietmar Pfeifer, Marie Follo, Justus Duyster, Hartmut Bertz, Juergen Finke
CLINICAL BIOCHEMISTRY
(2018)
Article
Biochemical Research Methods
Andreas R. Thomsen, Christine Aldrian, Peter Bronsert, Yi Thomann, Norbert Nanko, Nicolas Melin, Gerta Ruecker, Marie Follo, Anca L. Grosu, Gabriele Niedermann, Paul G. Layer, Anja Heseliche, Per G. Lund
Article
Oncology
Isabel Schulien, Birgit Hockenjos, Veerle van Marck, C. Korcan Ayata, Marie Follo, Robert Thimme, Peter Hasselblatt
Article
Pathology
Saskia Hussung, Marie Follo, Rhena F. U. Klar, Sandra Michalczyk, Kornelia Fritsch, Friederike Nollmann, Julian Hipp, Justus Duyster, Florian Scherer, Nikolas von Bubnoff, Melanie Boerries, Uwe Wittel, Ralph M. Fritsch
JOURNAL OF MOLECULAR DIAGNOSTICS
(2020)
Article
Biotechnology & Applied Microbiology
Annette Carola Anderson, Michael Rothballer, Markus Joerg Altenburger, Johan Peter Woelber, Lamprini Karygianni, Kirstin Vach, Elmar Hellwig, Ali Al-Ahmad
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Medicine, General & Internal
Julius Wehrle, Ulrike Philipp, Martina Jolic, Marie Follo, Saskia Hussung, Silvia Waldeck, Max Deuter, Michael Rassner, Jan Braune, Justyna Rawluk, Christine Greil, Cornelius F. Waller, Heiko Becker, Jesus Duque-Afonso, Anna L. Illert, Ralph M. Fritsch, Frank Meiss, Justus Duyster, Nikolas von Bubnoff, Florian Scherer
Article
Infectious Diseases
Christian Tennert, Yoana Zinovieva, Kalin Shishkov, Lamprini Karygianni, Makus Joerg Altenburger, Richard J. Wierichs, Ali Al-Ahmad
Article
Biochemistry & Molecular Biology
Juliane Strietz, Stella S. Stepputtis, Marie Follo, Peter Bronsert, Elmar Stickeler, Jochen Maurer
Summary: Primary breast cancer stem cell (BCSC) cultures isolated from TNBC specimens have been established and shown to grow as tumor spheres under anchorage-independent culture conditions in vitro, while reliably forming tumors in mice when transplanted in limiting dilutions in vivo. Additionally, these BCSC xenograft tumors exhibit similar architecture and gene expression to the original patient tumor, suggesting a promising model for researching BCSC biology and testing new treatment options for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Agazi Samuel Tesfai, Andreas Vollmer, Ali Caglar Ozen, Moritz Braig, Wiebke Semper-Hogg, Markus Jorg Altenburger, Ute Ludwig, Michael Bock
Summary: Accurate visualization of dental root canals is crucial for proper diagnosis and treatment. This study demonstrates the improvement of a new dental MRI coil in terms of signal-to-noise ratio and visibility. The results show that the intraoral flexible coil provides better image quality and visibility compared to conventional coils.
INVESTIGATIVE RADIOLOGY
(2022)
Article
Chemistry, Analytical
Kerstin Henkel, Miriam Klima, Volker Auwaerter, Markus J. Altenburger, Merja A. Neukamm
Summary: Non-mineralized dental biofilm has potential as a novel alternative matrix in forensic toxicology to prove drug use. The study found that the concentrations of methadone and morphine in plaque were related to the route of drug administration.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2022)
Article
Biology
Carla Regina, Ebrahem Hamed, Geoffroy Andrieux, Sina Angenendt, Michaela Schneider, Manching Ku, Marie Follo, Marco Wachtel, Eugene Ke, Ken Kikuchi, Anton G. Henssen, Beat W. Schafer, Melanie Boerries, Amy J. Wagers, Charles Keller, Simone Hettmer
Summary: The study shows that heterogeneous expression of PAX3:FOXO1 at the single cell level in rhabdomyosarcoma cells may provide a critical advantage during tumor progression.
LIFE SCIENCE ALLIANCE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Milena Kluge, Johanna Trueschler, Fadil Elamin, Annette Anderson, Elmar Hellwig, Markus Altenburger, Kirstin Vach, Annette Wittmer, Ali Al-Ahmad
Summary: This study evaluated the effect of passive ultrasonic irrigation (PUI) on microbial analysis of root canal-treated teeth with persistent or recurrent apical inflammation. The results showed that PUI significantly increased the total count of bacteria and the number of aerobic/facultative anaerobic microorganisms, leading to a more precise analysis of the etiology of persistent endodontic infections.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Biochemistry & Molecular Biology
Michael Rassner, Silvia Waldeck, Marie Follo, Stefanie Jilg, Ulrike Philipp, Martina Jolic, Julius Wehrle, Philipp J. Jost, Christian Peschel, Anna Lena Illert, Justus Duyster, Florian Scherer, Nikolas von Bubnoff
Summary: This study developed a set of ddPCR assays for the detection of cKIT mutations mediating resistance to cKIT kinase inhibitors in ctDNA. The assays showed good analytical sensitivity and specificity, and demonstrated high correlation with next generation sequencing results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Arpad Mihai Rostas, Loic Ledernez, Lisa Dietel, Lorenz Heidinger, Michael Bergmann, Markus Altenburger, Richard Bruch, Gerald Urban, Erik Schleicher, Stefan Weber
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2020)
Article
Dentistry, Oral Surgery & Medicine
J. P. Tchorz, M. Wolgin, L. Karygianni, K. Vach, M. J. Altenburger
INTERNATIONAL JOURNAL OF COMPUTERIZED DENTISTRY
(2018)