Article
Endocrinology & Metabolism
Albert Shieh, Arun S. Karlamangla, Mei-Hua Huang, Nitin Shivappa, Michael D. Wirth, James R. Hebert, Gail A. Greendale
Summary: An inflammatory diet during pre- and early perimenopause is associated with an increased risk of incident fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Albert Shieh, Gail A. Greendale, Jane A. Cauley, Carrie A. Karvonen-Gutierrez, Arun S. Karlamangla
Summary: This cohort study suggests that prediabetes in midlife women is associated with an increased risk of fracture. Future research should investigate whether treating prediabetes can reduce fracture risk.
Article
Endocrinology & Metabolism
Mia Q. Peng, Carrie A. Karvonen-Gutierrez, William H. Herman, Bhramar Mukherjee, Sung Kyun Park
Summary: This study examined the association between phthalate exposure and diabetes in midlife women and found that certain high-molecular-weight phthalate metabolites were potentially linked to a higher incidence of diabetes. However, the associations varied across racial/ethnic groups. Further investigation is needed to determine if phthalates cause diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Environmental Sciences
Xin Wang, Ning Ding, Sioban D. Harlow, John F. Randolph, Bhramar Mukherjee, Ellen B. Gold, Sung Kyun Park
Summary: Exposure to heavy metals may affect sex hormone levels in women. This study analyzed the association between urinary metal concentrations and serum levels of estradiol (E-2), follicle-stimulating hormone (FSH), testosterone, and sex hormone-binding globulin (SHBG) in a multi-ethnic group of women aged 45-56 years. The results showed that higher urinary metal concentrations were linked to lower E-2 levels for mercury and lead, higher FSH levels for lead, and higher SHBG levels for cadmium. However, no significant association was found between metals and testosterone levels.
ENVIRONMENTAL POLLUTION
(2023)
Article
Endocrinology & Metabolism
Sung Kyun Park, Xin Wang, Ning Ding, Carrie A. Karvonen-Gutierrez, Antonia M. Calafat, William H. Herman, Bhramar Mukherjee, Sioban D. Harlow
Summary: This study found a positive association between serum PFAS concentrations and incident diabetes risk, with specific PFAS such as n-PFOA and PFHxS potentially increasing the risk of diabetes. Reducing exposure to these chemicals may be crucial in lowering the risk of diabetes.
Article
Environmental Sciences
Xin Wang, Ning Ding, Sioban D. Harlow, John F. Randolph Jr, Bhramar Mukherjee, Ellen B. Gold, Sung Kyun Park
Summary: This study found associations between arsenic, lead, and metal mixtures with earlier natural menopause, which may be a risk factor for adverse health outcomes in later life.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Peripheral Vascular Disease
Xin Wang, Carrie A. Karvonen-Gutierrez, William H. Herman, Bhramar Mukherjee, Sioban D. Harlow, Sung Kyun Park
Summary: This study found that exposure to heavy metals may accelerate the increase in blood pressure in midlife women, especially for never smokers with high cadmium concentrations and women with higher concentrations of all four metals.
Article
Clinical Neurology
Carol A. Derby, Franya Hutchins, Gail A. Greendale, Karen A. Matthews, Barbara Sternfeld, Susan A. Everson-Rose, Rasa Kazlauskaite, Rachel A. Whitmer, Maria M. Brooks
Summary: Midlife cardiovascular risk factors such as diabetes, elevated fasting glucose, central obesity, and heart age greater than chronological age are associated with decline in processing speed, indicating the importance of intervening on these factors in midlife to prevent later life cognitive impairment and ADRD.
ALZHEIMERS & DEMENTIA
(2021)
Article
Endocrinology & Metabolism
Xin Wang, Carrie A. Karvonen-Gutierrez, Ellen B. Gold, Carol Derby, Gail Greendale, Xiangmei Wu, Joel Schwartz, Sung Kyun Park
Summary: The study found that exposure to fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O-3) was associated with adverse effects on body composition in midlife women, including higher fat mass, higher proportion of fat mass, and lower lean mass. These findings highlight the potential contribution of air pollution to obesity.
Article
Environmental Sciences
Seulbi Lee, Carrie Karvonen-Gutierrez, Bhramar Mukherjee, William H. H. Herman, Sung Kyun Park
Summary: Adipokines, which are secreted by adipose tissue, may be involved in obesity-related metabolic diseases. The impact of environmental phenols and parabens on racial disparities in metabolic disease burden is not well established and requires further investigation.
ENVIRONMENTAL POLLUTION
(2022)
Article
Geriatrics & Gerontology
Sylvia E. Badon, Kelley Pettee Gabriel, Carrie Karvonen-Gutierrez, Barbara Sternfeld, Ellen B. Gold, L. Elaine Waetjen, Catherine Lee, Lyndsay A. Avalos, Samar R. El Khoudary, Monique M. Hedderson
Summary: Most women in midlife exhibited low trajectories of physical activity and blood lipid levels. Although no clear association was found between long-term trajectories of physical activity and blood lipids in this study, the importance of promoting regular and sustained physical activity for midlife women to achieve cardiovascular and metabolic benefits was highlighted.
Article
Environmental Sciences
Xin Wang, Carrie A. Karvonen-Gutierrez, Bhramar Mukherjee, William H. Herman, Sung Kyun Park
Summary: The study found that urinary molybdenum was positively associated with adipokine levels, while cadmium, cesium, and lead were negatively associated with adipokine levels.
ENVIRONMENTAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Sheila A. Dugan, Kelly Karavolos, Yanyu Zhang, Elizabeth Avery, Imke Janssen, Mary Farhi, Sioban D. Harlow, Howard M. Kravitz
Summary: Research has shown a link between childhood sexual abuse (CSA) and lower urinary tract and sexual disorders in clinical settings. This study aimed to examine the association between CSA and two specific aspects of pelvic floor dysfunction (PFD) in community-dwelling women. The results revealed that in midlife women, pain with sexual activity was associated with a history of CSA, but urgency urinary incontinence was not.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Clinical Neurology
Di Li, Hongyun Zheng, Yongqing Tong, Yan Li
Summary: The intake of pro-vitamin A carotenoids may be inversely associated with depressive symptoms in premenopausal women, but not in early perimenopausal women.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Geriatrics & Gerontology
R. E. Koffer, R. C. Thurston, J. T. Bromberger, K. A. Matthews
Summary: This study examines the racial/ethnic differences in exposure to life events among midlife women and finds that these differences may contribute to health disparities in later life.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Brittney S. Lange-Maia, Carrie A. Karvonen-Gutierrez, Rasa Kazlauskaite, Elsa S. Strotmeyer, Kelly Karavolos, Bradley M. Appelhans, Imke Janssen, Elizabeth F. Avery, Sheila A. Dugan, Howard M. Kravitz
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Hematology
Saad Samargandy, Karen A. Matthews, Maria M. Brooks, Emma Barinas-Mitchell, Jared W. Magnani, Imke Janssen, Steven M. Hollenberg, Samar R. El Khoudary
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Endocrinology & Metabolism
Rasa Kazlauskaite, Imke Janssen, Robert S. Wilson, Bradley M. Appelhans, Denis A. Evans, Zoe Arvanitakis, Samar R. El Khoudary, Howard M. Kravitz
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Anesthesiology
John W. Burns, Imke Janssen, Teresa Lillis, Morgan Mulcahy, Yanina A. Purim-Shem-Tov, Stephen Bruehl, Helen J. Burgess, Alexandra Fischer, Katie Rim, Frances Aranda, Linzy Pinkerton, Stevan Hobfoll
Article
Cardiac & Cardiovascular Systems
Susan A. Everson-Rose, Emma J. M. Barinas-Mitchell, Samar R. El Khoudary, Hsin-Hui Huang, Qi Wang, Imke Janssen, Rebecca C. Thurston, Elizabeth A. Jackson, Melissa E. Lewis, Carrie Karvonen-Gutierrez, Peter Mancuso, Carol A. Derby
Summary: The menopausal transition is associated with increased cardiovascular risk, weight gain, and increased adiposity for many women. Adiponectin and leptin are two important inflammatory pathways that may contribute to adverse subclinical cardiovascular disease risk profiles in women at midlife, with lower adiponectin levels related to greater carotid artery intima-media thickness and wider adventitial diameter, and higher leptin levels associated with greater carotid artery intima-media thickness and wider adventitial diameter.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Imke Janssen, Lynda H. Powell, Susan A. Everson-Rose, Steven M. Hollenberg, Samar R. El Khoudary, Karen A. Matthews
Summary: Psychosocial well-being is associated with less progression of coronary artery calcium, especially in women with baseline CAC>0. Including psychological aspects in early prevention of cardiovascular disease may be beneficial in optimizing prevention strategies.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
Alexis Nasr, Karen Matthews, Imke Janssen, Maria M. Brooks, Emma Barinas-Mitchell, Trevor J. Orchard, Jeffrey Billheimer, Norman C. Wang, Dan McConnell, Daniel J. Rader, Samar R. El Khoudary
Summary: This study investigated the relationship between abdominal and cardiovascular fat with future HDL metrics in midlife women and the role of insulin resistance. The findings suggest that higher visceral fat volumes in midlife women predict lower HDL metrics in the future, possibly indicating future cardiovascular disease risk. Managing insulin resistance may help mitigate the unfavorable impact of visceral fat on HDL metrics.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Rebecca C. Thurston, Yuefang Chang, Karen A. Matthews, Sioban Harlow, Samar R. El Khoudary, Imke Janssen, Carol Derby
Summary: This study examined the relationship between interpersonal violence (including childhood abuse, adult abuse, and intimate partner violence) and the risk of cardiovascular disease (CVD) events in women. The results showed that childhood abuse, particularly sexual abuse, was associated with an increased risk of CVD in women. Intimate partner violence was also associated with CVD risk, with higher systolic blood pressure among IPV-exposed women being important in these associations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Chen Liang, Hsin-Fang Chung, Annette J. Dobson, Kunihiko Hayashi, Yvonne T. van der Schouw, Diana Kuh, Rebecca Hardy, Carol A. Derby, Samar R. El Khoudary, Imke Janssen, Sven Sandin, Elisabete Weiderpass, Gita D. Mishra
Summary: Infertility, recurrent miscarriage, and stillbirth are associated with an increased risk of stroke, with different risk patterns for different stroke subtypes. These findings contribute to the monitoring and prevention of stroke in women with a history of these conditions.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Samar R. El Khoudary, Alexis Nasr, Karen A. Matthews, Trevor J. Orchard, Maria M. Brooks, Jeffrey Billheimer, Dan McConnell, Imke Janssen, Susan A. Everson-Rose, Sybil Crawford, Daniel J. Rader
Summary: The study found that the associations between HDL metrics and CAC may vary by menopause stage and estradiol level. Different HDL subclasses may impact the likelihood of CAC presence and the stability of coronary plaque differently over the menopause transition.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Obstetrics & Gynecology
Saad Samargandy, Karen A. Matthews, Maria M. Brooks, Emma Barinas-Mitchell, Jared W. Magnani, Imke Janssen, Rasa Kazlauskaite, Samar R. El Khoudary
Summary: The study found that women experience an accelerated increase in abdominal visceral adipose tissue (VAT) starting 2 years before menopause, and this menopause-related increase in VAT is associated with a greater risk of subclinical atherosclerosis in the internal carotid artery.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
Article
Obstetrics & Gynecology
Karen A. Matthews, Yuefang Chang, Maria M. Brooks, Sybil L. Crawford, Imke Janssen, Hadine Joffe, Howard M. Kravitz, Rebecca C. Thurston, Samar R. El Khoudary
Summary: Through group-based multi-trajectory modeling, women were classified into five distinct groups based on shared levels and patterns of FSH, sleep maintenance problems, and frequent VMS across the menopause transition. Different race/ethnicity, premenopausal body mass index, depressive symptoms, and increasing depressive symptoms during the early phase of the transition predicted group membership characteristics.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
Article
Obstetrics & Gynecology
Gretchen Swabe, Karen Matthews, Maria Brooks, Imke Janssen, Norman Wang, Samar R. El Khoudary
Summary: The study found that the protective cardiovascular association of higher levels of high-density lipoprotein cholesterol (HDL-C) on aortic calcification was modified by estradiol but not by C-reactive protein (CRP) concentrations. Further investigation is needed to explore how estradiol might influence this association.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
Article
Geriatrics & Gerontology
Bradley M. Appelhans, Brittney S. Lange-Maia, Kelley Pettee Gabriel, Carrie Karvonen-Gutierrez, Kelly Karavolos, Sheila A. Dugan, Gail A. Greendale, Elizabeth F. Avery, Barbara Sternfeld, Imke Janssen, Howard M. Kravitz
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Obstetrics & Gynecology
Howard M. Kravitz, Karen A. Matthews, Hadine Joffe, Joyce T. Bromberger, Martica H. Hall, Kristine Ruppert, Imke Janssen
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2020)