Article
Oncology
Geno Guerra, Lucie McCoy, Helen M. Hansen, Terri Rice, Annette M. Molinaro, Joseph L. Wiemels, John K. Wiencke, Margaret Wrensch, Stephen S. Francis
Summary: A study found that the survival of adults with glioma is associated with the antibody levels of varicella-zoster virus (VZV) and Epstein-Barr virus (EBV), but not with cytomegalovirus (CMV) and herpes simplex virus 1/2 (HSV) antibody levels.
Article
Virology
Devin N. Fachko, Yan Chen, Rebecca L. Skalsky
Summary: It has been found that EBV miR-BHRF1-3 can suppress lytic replication by directly inhibiting Zta expression. Moreover, nucleotide variants that impact the function of miR-BHRF1-3 have been identified, which may contribute to specific EBV pathologies.
JOURNAL OF VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Faith Dickerson, Emily Katsafanas, Andrea Origoni, Theresa Newman, Kelly Rowe, Rita S. Ziemann, Kamal Bhatia, Emily Severance, Glen Ford, Robert Yolken
Summary: A study found that smoking is associated with increased levels of IgG antibodies to cytomegalovirus (CMV) and Epstein Barr virus (EBV), which may be related to chronic somatic disorders caused by these viruses.
Article
Biochemistry & Molecular Biology
Sho Yokoe, Akira Hasuike, Norihisa Watanabe, Hideki Tanaka, Hiroyuki Karahashi, Shin Wakuda, Osamu Takeichi, Takayuki Kawato, Hideki Takai, Yorimasa Ogata, Shuichi Sato, Kenichi Imai
Summary: Periodontitis is a common inflammatory condition that affects the supporting tissues of teeth. The role of Epstein-Barr virus (EBV) in the etiology of periodontitis is not well understood. This study found that inactivated EBV induces high levels of interleukin (IL)-6 and IL-8 in human gingival fibroblasts (HGFs), leading to inflammation and osteoclast differentiation, suggesting that EBV may contribute to the onset and progression of periodontitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Marisa Granato
Summary: EBV and KSHV, which are gamma-herpesviruses, are associated with various diseases. Therapeutics like bortezomib and CHOP are used, and nanotechnology shows promise in improving treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medical Laboratory Technology
Shaian Tavakolian, Hossein Goudarzi, Gita Eslami, Ilad Alavi Darazam, Golnaz Dehghan, Ebrahim Faghihloo
Summary: Despite medical advances, CNS diseases continue to strain the healthcare system, with infectious agents such as viruses playing a major role in accelerating conditions like meningitis. This study examined samples from 102 patients with symptoms of CNS infections, identifying a prevalence of EBV, HSV-1, and VZV, highlighting the need for further investigation into these viruses in meningitis cases.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Medicine, General & Internal
Noriaki Ito, Takeshi Masuda, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Kazuaki Chayama, Noboru Hattori
Summary: This case report describes a rheumatoid arthritis patient treated with MTX, who developed varicella pneumonia and meningoencephalitis due to VZV reinfection and EBV reactivation.
Article
Dentistry, Oral Surgery & Medicine
Alessio Buonavoglia, Fausto Zamparini, Gianvito Lanave, Francesco Pellegrini, Georgia Diakoudi, Andrea Spinelli, Maria Stella Lucente, Michele Camero, Violetta Iris Vasinioti, Maria Giovanna Gandolfi, Vito Marte, Carlo Prati
Summary: This study evaluated microbial communities in root canals using Nanopore sequencing and analyzed their relationship with peri-radicular inflammatory diseases. The results showed the presence of various microorganisms in root canals, which were closely related to clinical and endodontic conditions. Future studies should further evaluate these conditions and identify their role in inducing bone damage and local systemic diseases to better understand the relationship between microbes and endodontic pathologies.
JOURNAL OF ENDODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jaideep Mahendra, Little Mahendra, Dhana Divya, Paavai Ilango, Nalini Devarajan, Abirami Thanigaimalai
Summary: This study evaluates and compares the levels of lipocalin, adiponectin, and periodontal viruses in generalized periodontitis patients with and without diabetes mellitus. The results show that patients with diabetes and periodontitis have higher prevalence of EBV and CMV, as well as decreased levels of adiponectin, indicating an aggravation of the diabetic status among periodontitis patients and reinforcing the Periodontitis-DM continuum.
Review
Virology
Wayne L. Gray
Summary: This article discusses the similarities and differences between varicella zoster virus (VZV) and simian varicella virus (SVV) in causing chickenpox and herpes zoster, as well as their similarities and differences in genome. The gene expression during viral latency is also described, along with the evolutionary relationship between these two viruses.
Article
Multidisciplinary Sciences
Yoshimi Enose-Akahata, Limin Wang, Fahad Almsned, Kory R. Johnson, Yair Mina, Joan Ohayon, Xin Wei Wang, Steven Jacobson
Summary: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), and the cause of MS remains unknown. This study investigated the antibody responses against various viruses in the cerebrospinal fluid (CSF) and serum of MS patients, and found significant differences compared to healthy volunteers, as well as a pattern of antibody responses against multiple viruses, including Epstein-Barr virus. These findings indicate that virus-specific antibody signatures might reflect the disease-associated inflammatory milieu in the CSF of patients with neuroinflammatory diseases.
Article
Virology
Ravi Mahalingam, Brittany Feia, Colin Coleman, Kusala Anupindi, Pratush Saravanan, Amalia Luthens, Amalia Bustillos, Arpita Das, Eileen de Haro, Lara Doyle-Meyers, Jayme Looper, Andrew N. Bubak, Christy S. Niemeyer, Brent Palmer, Maria A. Nagel, Vicki Traina-Dorge
Summary: Nonhuman primates are valuable animal models for studying varicella zoster virus disease. This study found that both SVV DNA and antigens can be detected in skin lesions during varicella and zoster, providing the basis for further research on SVV skin pathogenesis.
Article
Immunology
Anne A. Gershon, Michael D. Gershon, Eugene D. Shapiro
Summary: The development and application of the varicella vaccine has brought significant health benefits to children and immunocompromised patients worldwide, reducing the incidence of varicella as well as decreasing the incidence of herpes zoster. Additionally, the vaccine provides protection against the varicella-zoster virus and offers an extra layer of prevention for susceptible adults.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Review
Virology
Ralph Tayyar, Dora Ho
Summary: Herpes simplex virus (HSV) and varicella zoster virus (VZV) are alpha herpesviruses that cause recurrent infections and significant complications, especially in immunocompromised hosts. Virus-specific tests are crucial in diagnosing atypical cases. Antiviral drugs like acyclovir and valacyclovir are commonly used, with foscarnet as an alternative for resistant cases. Prophylaxis should be considered for high-risk cancer patients, and vaccines are available for preventing varicella and zoster.