Review
Biochemistry & Molecular Biology
Tasuku Matsuoka, Masakazu Yashiro
Summary: TGF-beta plays a crucial role in the development, invasion, and metastasis of gastrointestinal cancers. Understanding the mechanisms and functions of TGF-beta signaling is important for diagnosis, prognosis, and the development of targeted therapies.
Article
Engineering, Biomedical
Sirui Liu, Jingjing Sun, Shuai Yuan, Yanyu Yang, Yuping Gong, Ying Wang, Runying Guo, Xue Zhang, Yiming Liu, Hongyan Mi, Meiyue Wang, Mengzhe Liu, Rui Li
Summary: The study found that TDM can promote the odontogenic differentiation of human dental pulp stem cells, decrease the expression of GSK3 beta, and activate the Wnt/beta-catenin signaling pathway, thereby promoting the generation of new dentin.
BIOACTIVE MATERIALS
(2022)
Article
Cell Biology
Shuang Liu, Xiao Yan, Jing Guo, Hong An, Xingrui Li, Liying Yang, Xijiao Yu, Shu Li
Summary: PLAP-1/Asporin regulates the differentiation of osteoblasts and osteoclasts through the TGF-β1/Smad signaling pathway, providing a theoretical foundation for the study of the pathological mechanism underlying alveolar bone resorption and the prevention and treatment of periodontitis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Takashi Yamaguchi, Katsunori Yoshida, Miki Murata, Kanehiko Suwa, Koichi Tsuneyama, Koichi Matsuzaki, Makoto Naganuma
Summary: Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by fatty degeneration of the liver, insulin resistance, oxidative stress, lipotoxicity, adipokine secretion, endotoxins released by gut microbiota, and endoplasmic reticulum stress. NAFLD can progress to nonalcoholic steatohepatitis (NASH), fibrosis, and advanced liver diseases. Phosphorylated Smad isoforms play a crucial role in the early diagnosis of hepatocellular carcinoma (HCC) in NASH patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Li-Li Ren, Xiao-Jun Li, Ting-Ting Duan, Zheng-Hai Li, Jun-Zheng Yang, Ya-Mei Zhang, Liang Zou, Hua Miao, Ying-Yong Zhao
Summary: Fibrosis is the excessive deposition of extracellular matrix components in the processes of tissue repair, causing organ structural integrity and functional impairment. Transforming growth factor-beta (TGF-beta) is a key factor in promoting fibrosis by activating profibrotic signals. This review discusses the role of TGF-beta signaling in fibrotic organs, as well as potential therapeutic options for targeting tissue fibrosis through modulating TGF-beta signaling.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Chen-Pang Hou, Ke-Hung Tsui, Syue-Ting Chen, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Tsui-Hsia Feng, Horng-Heng Juang
Summary: GDF15 is a TGF beta-like cytokine that regulates target gene expression. TGF beta downregulates the expression of GDF15 through the activation of Smad signaling pathways. CAPE acts as an antagonist to block the effect of TGF beta on GDF15 expression.
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Dariusz Kajdaniuk, Dorota Hudy, Joanna Katarzyna Strzelczyk, Krystyna Mlynarek, Szymon Slomian, Andrzej Potyka, Ewa Szymonik, Janusz Strzelczyk, Wanda Foltyn, Beata Kos-Kudla, Bogdan Marek
Summary: This study found that the dysregulation of TGF beta/Smads pathway genes may play a role in the pathogenesis of kidney cancer. The expression of these genes was found to be altered in both the tumor tissues and the tumor microenvironment, which may impact the aggressiveness and spread of the tumor.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Urology & Nephrology
Aglaia Chalkia, Harikleia Gakiopoulou, Irini Theohari, Periklis G. Foukas, Dimitrios Vassilopoulos, Dimitrios Petras
Summary: This study investigated the expression of TGF-β1/Smad signaling in different types of glomerulonephritis and found that TGF-β1 expression is an independent risk factor for progression to chronic kidney disease. The co-expression pattern of pSmad3 and Smad7 in glomerulus is correlated with renal inflammation.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Medicine, Research & Experimental
Alex Boye
Summary: Early detection of cancer is crucial for cancer management and limited survival. Understanding cancer biology and key factors in cancer progression plays a significant role in cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Tsugumasa Toma, Hiroshi Tateishi, Kensaku Kawakami, Taha F. S. Ali, Masahiro Kamo, Kazuaki Monde, Yuta Nakashima, Mikako Fujita, Masami Otsuka
Summary: Metastasis is the main cause of mortality in solid tumors, but there are no available antimetastatic drugs on the market. This study focused on a synthetic compound called HPH-15, which showed anti-EMT and anti-cell migration activities in non-small-cell lung cancer cells. HPH-15 was found to inhibit downstream TGF-beta signaling and could potentially lead to the development of new antimetastatic drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Wenwen Ding, Danhua Zhou, Shimeng Zhang, Jiaping Qian, Lingxia Yang, Lei Tang
Summary: This study demonstrates that Trimetazidine (TMZ) can inhibit liver fibrosis and hepatic stellate cell proliferation induced by CCl4 and TGF-beta. TMZ exerts its effects by blocking the activation of TGF beta/Smad signaling pathway. These findings provide new insights into the potential application of TMZ in the treatment of liver fibrosis.
Article
Agriculture, Multidisciplinary
Qing Zhang, Die Qian, Dan-Dan Tang, Jia Liu, Lin-Yu Wang, Wenwen Chen, Chun-Jie Wu, Wei Peng
Summary: The study evaluated the anti-scarring effect of Gla extracted from Glycyrrhiza glabra in a rabbit ear hyperplastic scar model, demonstrating that Gla could reduce scar hyperplasia, inhibit inflammation, and decrease collagen production.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Immunology
Karthik Chandiran, Linda S. Cauley
Summary: Cytotoxic T lymphocytes (CTLs) are crucial for defense against intracellular pathogens and tumors, requiring efficient migration to locate and destroy infected cells in different regions of the body. The transforming growth factor-beta (TGF-beta) and canonical SMAD-dependent signaling pathways are essential for coordinating changes in homing receptor expression and ensuring successful migration of CTLs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Jitang Chen, Ze-yang Ding, Si Li, Sha Liu, Chen Xiao, Zifu Li, Bi-xiang Zhang, Xiao-ping Chen, Xiangliang Yang
Summary: Targeting TGF beta signaling for cancer therapy presents challenges and opportunities, as inhibitors can enhance chemotherapy efficacy but must also consider the dual role of TGF beta in normal tissues and tumors to avoid unwanted side effects.
Article
Engineering, Biomedical
Hsiao-Hua Chang, Mei-Chi Chang, Hsin-Hui Wang, Guay-Fen Huang, Yuan-Ling Lee, Yin-Lin Wang, Chiu-Po Chan, Sin-Yuet Yeung, Shuei-Kuen Tseng, Jiiang-Huei Jeng
ACTA BIOMATERIALIA
(2014)
Article
Dentistry, Oral Surgery & Medicine
Mei-Chi Chang, Hsiu-Pin Hung, Li-Deh Lin, Yow-Chyun Shyu, Tong-Mei Wang, Hsueh-Jen Lin, Chiu-Po Chan, Chih-Chia Huang, Jiiang-Huei Jeng
CLINICAL ORAL INVESTIGATIONS
(2015)
Article
Dentistry, Oral Surgery & Medicine
Yi-Ling Tsai, Mei-Chi Chang, Li-Deh Lin, Chiu-Po Chan, Chen-Ying Wang, Po-Shuan Lin, Jiiang-Huei Jeng
JOURNAL OF DENTAL SCIENCES
(2014)
Article
Dentistry, Oral Surgery & Medicine
Shuei-Kuen Tseng, Mei-Chi Chang, Ming-Lun Hsu, Cheng-Yao Su, Lin-Yang Chi, Wen-Chien Lan, Jiiang-Huei Jeng
JOURNAL OF DENTAL SCIENCES
(2014)
Article
Medicine, General & Internal
Yi-Jane Chen, Mei-Chi Chang, Chung-Chen Jane Yao, Hsiang-Hua Lai, Jenny Zwei-Chieng Chang, Jiiang-Huei Jeng
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2014)
Article
Medicine, General & Internal
Yen-Chun Chen, Cheing-Meei Liu, Jiiang-Huei Jeng, Chia-Chi Ku
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2014)
Article
Multidisciplinary Sciences
Mei-Chi Chang, Yi-Jane Chen, Hsiao-Hua Chang, Chiu-Po Chan, Chien-Yang Yeh, Yin-Lin Wang, Ru-Hsiu Cheng, Liang-Jiunn Hahn, Jiiang-Huei Jeng
Article
Multidisciplinary Sciences
Mei-Chi Chang, Hsiao-Hua Chang, Tong-Mei Wang, Chiu-Po Chan, Bor-Ru Lin, Sin-Yuet Yeung, Chien-Yang Yeh, Ru-Hsiu Cheng, Jiiang-Huei Jeng
Article
Cell Biology
Mei-Chi Chang, Bei-En Chang, Yu-Hwa Pan, Bor-Ru Lin, Yun-Chia Lian, Ming-Shu Lee, Sin-Yuet Yeung, Li-Deh Lin, Jiiang-Huei Jeng
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
M. C. Chang, H. H. Chang, W. C. Hsieh, W. L. Huang, Y. C. Lian, P. Y. Jeng, Y. L. Wang, S. Y. Yeung, J. H. Jeng
INTERNATIONAL ENDODONTIC JOURNAL
(2020)
Article
Dentistry, Oral Surgery & Medicine
Mei-Chi Chang, Tong-Mei Wang, Hua-Hong Chien, Yu-Hwa Pan, Yi-Ling Tsai, Po-Yuan Jeng, Li-Deh Lin, Jiiang-Huei Jeng
Summary: The study found that butyric acid inhibited cell viability, induced cellular apoptosis, stimulated ROS and HO-1 production, and increased ICAM-1 mRNA expression and protein synthesis in endothelial cells. Some inhibitors diminished the cell viability affected by BA, but none affected the increased sICAM-1 secretion stimulated by BA.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Health Care Sciences & Services
Wan-Chuen Liao, Chi-Hung Chen, Yu-Hwa Pan, Mei-Chi Chang, Jiiang-Huei Jeng
Summary: This article reviews the prevalence, characteristics, diagnosis and treatment methods of vertical root fractures in non-endodontically treated teeth and endodontically treated teeth. It found that most patients were over 40 years old, male patients had a higher prevalence in the non-endodontically treated group, and VRFNETT are more often observed in the Chinese population.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Yi-Ling Tsai, Chen-Ying Wang, Fu-Hsiung Chuang, Yu-Hwa Pan, Yan-Ru Lin, Kunaal Dhingra, Pai-Shien Liao, Fong-Shung Huang, Mei-Chi Chang, Jiiang-Huei Jeng
Summary: This study aimed to investigate the involvement of the PI3K/Akt signaling pathway in Porphyromonas gingivalis lipopolysaccharide (PgLPS)-induced inflammation in human dental pulp cells. The results showed that PgLPS upregulated the mRNA and protein levels of IL-6, IL-8, PI3K, and p-Akt, and pretreatment with LY294002 attenuated PgLPS-induced IL-6 and IL-8 mRNA expression. In conclusion, this study revealed that PgLPS promotes inflammation in dental pulp cells by dysregulating the PI3K/Akt signaling pathway.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Yi-Jie Jiang, Jiiang-Huei Jeng, Pin-Hsuan Wu, Hsiu-Wen Chien
Summary: This study focuses on the preparation of stretchable zwitterionic poly(sulfobetaine methacrylate) (PSBMA) hydrogels. A physical crosslinking method utilizing hydrophobic interactions is developed to improve the mechanical properties of the hydrogels. The PSBMA(phy) hydrogels exhibit greater flexibility, self-healing properties, and adhesive properties compared to the PSBMA(chem) hydrogels.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Ru-Hsiu Cheng, Yi-Ping Wang, Julia Yu-Fong Chang, Yu-Hwa Pan, Mei-Chi Chang, Jiiang-Huei Jeng
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
