Article
Neurosciences
Yu Wu, Zhuwei Zhang, Xiaoou Sun, Jing Wang, Haitao Shen, Xue Sun, Zhong Wang
Summary: This study found that inhibition of SDF-1/CXCR4 complex formation can rescue the inflammatory response and alleviate neurobehavioral dysfunction after intracerebral hemorrhage (ICH). Pharmacological inhibition with AMD3100 reduced the upregulation of SDF-1/CXCR4 and decreased levels of TNF-alpha and IL-1 beta. These findings suggest that SDF-1/CXCR4 may serve as a therapeutic target for ICH.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Fisheries
Zhaosheng Sun, Yuting Qin, Danjie Liu, Bangjie Wang, Zhao Jia, Junya Wang, Qian Gao, Jun Zou, Yue Pang
Summary: Chemokines are soluble peptides that guide cell migration in development and immune defense. The CXC chemokine system in lamprey has been found to have diversified, showing variations in gene organization and expression patterns in different tissues, indicating an evolutionary adaptation in jawless fish.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xinxin Huang, Juncheng Hao, Yan Qin Tan, Tao Zhu, Vijay Pandey, Peter E. Lobie
Summary: Patients with epithelial ovarian cancer are often diagnosed at an advanced stage, leading to poor overall prognosis. This review summarizes the functional significance of CXCL/CXCR chemokines in modulating EOC progression and discusses the current status and prospects of CXCR/CXCL-based theranostic strategies in EOC management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Bo Yao, Xiaogang Cheng, Xiaohan Mei, Jun Qiu, Beidi Zhang, Jueyu Wang, Qing Yu, Min Xiao
Summary: This study investigated the differential expression of lncRNAs in DPSCs after SDF-1 alpha induction and identified AC080037.1 as an important regulator of odontogenic differentiation. Knockdown of AC080037.1 suppressed DPSCs migration and Rho GTPase expression, and affected mineralized nodule formation and the expression of key genes in odontogenic differentiation. AC080037.1 may be a potential target for regenerative endodontics.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rongzhang He, Xingyu Zheng, Jian Zhang, Bo Liu, Qijie Wang, Qian Wu, Ziyan Liu, Fangfang Chang, Yabin Hu, Ting Xie, Yongchen Liu, Jun Chen, Jing Yang, Shishan Teng, Rui Lu, Dong Pan, You Wang, Liting Peng, Weijin Huang, Velislava Terzieva, Wenpei Liu, Youchun Wang, Yi-Ping Li, Xiaowang Qu
Summary: The study found that spike-specific CXCR3(+) T-FH cells play a crucial role in antibody maintenance and recall responses after SARS-CoV-2 infection and vaccination, exhibiting a more durable response and better ability to induce antibody secretion.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Environmental Sciences
Fuyu Jin, Yaqian Li, Xuemin Gao, Xinyu Yang, Tian Li, Shupeng Liu, Zhongqiu Wei, Shifeng Li, Na Mao, Heliang Liu, Wenchen Cai, Hong Xu, Haibo Zhang
Summary: Exercise training has the potential to mitigate the progression of silicosis by suppressing the SRB/NLRP3 and TLR4 pathways. Macrophage-derived IL-17A plays a key role in silica-induced pulmonary inflammation and fibrosis. Exercise training effectively inhibits the IL-17A-CXCL5-CXCR2 axis in silicotic mice, reducing collagen deposition and preserving elastic fibers, ultimately slowing down pulmonary fibrosis advancement and improving lung function post silica exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Dentistry, Oral Surgery & Medicine
B. Michot, S. M. Casey, J. L. Gibbs
Summary: Mediators released by DPSCs, stimulated with CGRP, induce neuronal sensitization through the CXCR2 receptor, likely contributing to pain symptoms that develop in pulpitis.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Immunology
Lin Gao, Yan-Mei Jiao, Ping Ma, Lijun Sun, Hongxin Zhao, An-Liang Guo, Xing Fan, Chao Zhang, Jin-Wen Song, Ji-Yuan Zhang, Fengmin Lu, Fu-Sheng Wang
Summary: This study aimed to investigate the characteristics and distribution of HIV-infected cells in semen, in order to improve strategies for exposure prevention and assisted reproduction for HIV-infected partners. The results showed that HIV-infected spermatozoa were mainly CD4 negative, and p24-positive cells in semen were predominantly spermatozoa. Additionally, the study confirmed that motile spermatozoa could carry HIV into peripheral blood mononuclear cells of healthy men.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Biochemistry & Molecular Biology
Mio Yamaguchi, Kiyoshi Takagi, Koki Narita, Yasuhiro Miki, Yoshiaki Onodera, Minoru Miyashita, Hironobu Sasano, Takashi Suzuki
Summary: Chemokines, particularly CCL5, secreted from stromal cells play crucial roles in interaction with carcinoma cells and regulating tumor progression. In human breast carcinoma tissues, the expression of CCL5 and CCR3 is significantly correlated with aggressive phenotype, and patients with positive CCL5 and CCR3 but negative CCR1 and CCR5 have a higher risk of recurrence. These findings suggest that the CCL5-CCR3 axis may contribute to a worse prognosis in breast cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Zhao Zhu, Guoxiu Zhang, Dahuan Li, Xiaojun Yin, Tianzhong Wang
Summary: In septic myocardial injury, SP1 regulates inflammation and cell apoptosis through CXCR4 and the NF-kB signaling pathway.
Article
Anatomy & Morphology
Jiaqian Feng, Tao Han, Yuexing Zhang, Bing Zhang, Dexiang Huang, Tianming Wang, Jingwen Yang
Summary: The study revealed the elevated expression of MsCXCR1 in head kidney, spleen, and liver of largemouth bass infected with N. seriolae, indicating its involvement in immune response and potential impact on digestive function of the species.
Review
Medicine, Research & Experimental
Nerea Cuesta-Gomez, Gerard J. Graham, John D. M. Campbell
Summary: Multipotent mesenchymal stromal cells (MSCs) are promising cellular therapeutics for treating inflammatory and degenerative disorders due to their anti-inflammatory, immunomodulatory, and regenerative potentials. MSCs can be obtained from various tissues, with bone marrow being the most commonly used starting material for clinical applications. Understanding the expression of chemokine receptors and ligands by MSCs from different tissues is crucial for predicting their therapeutic potential.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Weina Kong, Gang Zhao, Haixia Chen, Weina Wang, Xiaoqian Shang, Qiannan Sun, Fan Guo, Xiumin Ma
Summary: In this study, the role of CXC chemokines in the tumor microenvironment of cervical cancer was investigated using public databases. It was found that transcriptional levels of certain CXC chemokines were significantly altered in CC tissues, with some showing associations with patient overall survival. The study provides insights into the potential use of CXC chemokines as immunotherapeutic targets and prognostic biomarkers for cervical cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Pediatrics
Mengrou Xu, Bin Hu, Jiarui Chen, Limin Zhao, Jing Wang, Xiaoyan Li
Summary: This study investigated the function of CXC chemokine receptor-7 (CXCR7) in fibroblasts derived from laryngotracheal stenosis (LTS). The findings showed that LTS had increased expression of CXCR7 and decreased expression of E-cadherin. Activation of CXCR7 promoted migration of LTS-derived fibroblasts and inhibited E-cadherin expression via the NF-& kappa;B signaling pathway.
TRANSLATIONAL PEDIATRICS
(2023)
Article
Pediatrics
Mengrou Xu, Bin Hu, Jiarui Chen, Limin Zhao, Jing Wang, Xiaoyan Li
Summary: LTS is a disease that can obstruct the airways in children and has high risk of restenosis with traditional treatments. This study shows that CXCR7 is highly expressed in LTS and its activation promotes fibroblast migration by inhibiting E-cadherin expression through the NF-KB signaling pathway.
TRANSLATIONAL PEDIATRICS
(2023)