Article
Cell Biology
Yongjie Yang, Yanlin He, Hailan Liu, Wenjun Zhou, Chunmei Wang, Pingwen Xu, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Makoto Fukuda, Qingchun Tong, Jianming Xu, Zheng Sun, Bert W. O'Malley, Yong Xu
Summary: SRC-2 in POMC neurons is a key regulator of responses to fasting, with specific deletion leading to inadequate suppression of energy expenditure, impaired counterregulation, and insufficient refeeding. These mutant mice also show enhanced satiation, discoordination of anxiety and food-seeking behavior when food becomes available.
Article
Biochemistry & Molecular Biology
Alan Carlos Alves Fernandes, Franciane Pereira de Oliveira, Gimena Fernandez, Luane da Guia Vieira, Cristiane Gugelmin Rosa, Tais do Nascimento, Suzelei de Castro Franca, Jose Donato Jr, Kristen R. Vella, Jose Antunes-Rodrigues, Andre Mecawi, Mario Perello, Lucila Leico Kagohara Elias, Rodrigo Rorato
Summary: This study found that prolonged fasting in mice leads to increased plasma corticosterone levels and enhanced activity of CRFPVN neurons. Additionally, fasting also causes a decrease in plasma leptin levels and changes in the expression of Agrp and Pomc genes in the ARC. The fasting-induced decrease in plasma leptin partially modulates these responses through changes in the activity of ARC neurons. Furthermore, the study found that the chemogenetic activation of POMCARC neurons did not affect fasting-induced activation of the HPA axis, while the inhibition of AgRPARC neurons reduced the content of CRFPVN.
CELL AND BIOSCIENCE
(2022)
Article
Multidisciplinary Sciences
Maria M. Glavas, Queenie Hui, Ian Miao, Fan Yang, Suheda Erener, Kacey J. Prentice, Michael B. Wheeler, Timothy J. Kieffer
Summary: This study suggests that overconsumption of saturated fats may have negative impacts on body weight and glucose regulation in mice. A diet high in monounsaturated and omega-3 fats did not improve glucose dysregulation induced by early overnutrition, and may even increase weight gain, adiposity, and diabetes incidence in susceptible mice. It highlights the importance of considering the quantity, quality, and timing of fat intake for metabolic health outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Developmental
Olivia C. Robertson, Kristine Marceau, Kameron J. Moding, Valerie S. Knopik
Summary: This study outlines and extends the thrifty phenotype and fetal overnutrition hypotheses, highlighting their direct and indirect effects on child growth and pubertal timing. Further investigating these pathways can help identify adolescents at risk for earlier puberty and improve their health trajectories.
DEVELOPMENTAL REVIEW
(2022)
Article
Endocrinology & Metabolism
Katrien Benhalima, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick Van Den Bruel, Anne Loccufier, Annouschka Laenen, Caro Minschart, Roland Devlieger, Chantal Mathieu
Summary: The study aimed to determine the impact of mild fasting hyperglycemia in early pregnancy on pregnancy outcomes. It found that women with fasting plasma glucose levels of 5.1-5.5 mmol/L in early pregnancy may have a higher risk of adverse pregnancy outcomes later in pregnancy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Feng Zhu, Dawei Zhang, Fangfang Shen, Ke Xu, Xin Huang, Jue Liu, Jin Zhang, Yiqun Teng
Summary: The study indicates that pathological states in the early life environment, such as maternal obesity, can influence the offspring’s propensity for obesity and metabolic disorder later in life. Decreasing maternal Socs3 expression during pregnancy can mitigate obesity caused by the early life environment, potentially inspiring therapies to help obese mothers bear metabolically healthy children.
Article
Behavioral Sciences
Durdica Ignjatovic, Gordana Tovilovic-Kovacevic, Bojana Micic, Mirko Tomic, Ana Djordjevic, Djuro Macut, Danijela Vojnovic Milutinovic
Summary: Polycystic ovary syndrome (PCOS) is a complex disorder characterized by endocrine and metabolic abnormalities. This study investigated the effects of treating rats with 5α-dihydrotestosterone (DHT) and reducing litter size on spatial learning and memory in the striatum. The results showed that DHT treatment did not impair memory formation and may have a positive effect on synaptic strength.
HORMONES AND BEHAVIOR
(2023)
Review
Pharmacology & Pharmacy
Haneen S. Dwaib, Ibrahim AlZaim, Ali H. Eid, Omar Obeid, Ahmed F. El-Yazbi
Summary: Cardiometabolic syndrome (CMS) is a cluster of maladaptive disorders triggered by major shifts in lifestyle and dietary habits. Evidence suggests that diet-induced CMS is linked to adipose tissue inflammation, contributing to metabolic derangements and increased cardiovascular risk. Intermittent fasting has shown positive impacts on metabolic state, adipose tissue remodeling, and cardiovascular outcomes, potentially offering a novel approach to ameliorate inflammatory status in perivascular adipose tissue.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Aashita Batra, Lawrence M. M. Chen, Zihan Wang, Carine Parent, Irina Pokhvisneva, Sachin Patel, Robert D. D. Levitan, Michael J. J. Meaney, Patricia Pelufo Silveira
Summary: The study reveals that genetic background moderates the impact of early adversity on childhood impulsivity, with specific genes showing significant association with nervous system development and cognitive decline.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
E. Cosson, E. Vicaut, N. Berkane, T. L. Cianganu, C. Baudry, J-J Portal, J. Boujenah, P. Valensi, L. Carbillon
Summary: The study results suggest that initial care for women with early fasting hyperglycemia may help improve pregnancy outcomes, especially when FPG levels are >= 5.5 mmol/L. Women who received initial care during pregnancy were more likely to receive insulin treatment, gain less gestational weight, and had a lower rate of preeclampsia.
DIABETES & METABOLISM
(2021)
Article
Oncology
Wentao Hao, Kun Gao, Keting Li, Yin Li, Zongfei Wang, Haibo Sun, Wenqun Xing, Yan Zheng
Summary: This study investigated the feasibility of early oral feeding after neoadjuvant chemotherapy combined with non-tube no fasting-enhanced recovery after minimally invasive esophagectomy. The results showed that early oral feeding did not significantly increase complications, but significantly shortened the time to the first postoperative flatus/bowel movement and the postoperative length of stay.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Wentao Hao, Kun Gao, Keting Li, Yin Li, Zongfei Wang, Haibo Sun, Wenqun Xing, Yan Zheng
Summary: This study investigated the feasibility of early oral feeding (EOF) after neoadjuvant chemotherapy (nCT) combined with non-tube no fasting-enhanced recovery after minimally invasive esophagectomy (MIE). The results showed that EOF did not significantly increase complications, but significantly shortened the time to the first postoperative flatus/bowel movement and the postoperative length of stay.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Fei Guo, Yindi Liu, Zheng Ding, Yong Zhang, Chen Zhang, Jianxia Fan
Summary: The study found that increased maternal fasting plasma glucose levels in early pregnancy are closely related to fetal growth, and maternal characteristics may modify the relationship between glucose levels and fetal adiposity in late pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Orthopedics
Shanshan Xie, Changbiao Guan, Tingmo Huang, Yuqian Liu, Feifei Yuan, Daqi Xu
Summary: Intermittent fasting can promote the repair of rotator cuff injury in the early postoperative period by regulating the gut microbiota, while the influence of a certain strain may have a negative impact on the repair.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Endocrinology & Metabolism
Xiaomin Xie, Guirong Bai, Huili Liu, Li Zhang, YanTing He, Dan Qiang, Xiaoyan Zou
Summary: The study suggests that 25(OH)D may act as a protective factor in the early development of T2D, while TXNIP and FINS could serve as predictors for PD and T2D, respectively.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Neurosciences
Elena Alvarez-Salas, Aldo Gonzalez, Maria Isabel Amaya, Patricia de Gortari
Summary: The study demonstrates the important role of TRH in regulating hedonic feeding in stressed rats, with TRH downregulation increasing intake of palatable food while TRH injections reduce food intake. The findings indicate that accumbal TRH is downstream of glucocorticoid activity and specifically increases palatable food intake, suggesting potential therapeutic targets for controlling overeating.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
P. de Gortari, V Alcantara-Alonso, G. Matamoros-Trejo, M. Amaya, E. Alvarez-Salas
Article
Neurosciences
Cinthia Garcia-Luna, Graciela Sanchez-Watts, Myrtha Arnold, Guillaume de Lartigue, Nick DeWalt, Wolfgang Langhans, Alan G. Watts
Summary: Vagal and spinal sensory endings in the hepatic portal and superior mesenteric veins provide chemosensory information to the brain, primarily targeting medullary neurons. Neurons infected by PMV wall injections are mainly distributed in nodose ganglia and thoracic dorsal root ganglia. Direct sensory pathways into the DMX enable influences on visceral function without direct engagement of NTS neurons.
Review
Neurosciences
Elena Alvarez-Salas, Cinthia Garcia-Luna, Paulina Soberanes-Chavez, Patricia de Gortari
Summary: Thyrotropin-releasing hormone (TRH) has been found to play a role in regulating eating and mood through its actions on the hypothalamus and limbic regions of the brain. It can directly affect neurotransmitters and indirectly modulate their effects. Studies have shown the involvement of TRH in depressive and anxiety-like behaviors, as well as anorexia and hyperphagia. Various approaches, such as pharmacological studies and animal models, have been used to investigate the effects of TRH on mood and feeding parameters. Understanding the role of TRH expression could be beneficial for treating patients with eating disorders.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Article
Neurosciences
Jorge Chavez, Viridiana Alcantara-Alonso, Cinthia Garcia-Luna, Paulina Soberanes-Chavez, Dimitris Grammatopoulos, Patricia de Gortari
Summary: Among the modulatory functions of thyrotropin-releasing hormone (TRH), an anorectic behavior in rodents is observed when centrally injected. Hypothalamic paraventricular nucleus (PVN) neurons receive serotonergic inputs from dorsal raphe nucleus and express serotonin (5HT) receptors such as 5HT1A, 5HT2A/2C, 5HT6, which are involved in 5HT-induced feeding regulation.
Article
Biochemistry & Molecular Biology
Claudia Delgadillo-Puga, Ivan Torre-Villalvazo, Yonatan Y. Y. Carino-Cervantes, Cinthia Garcia-Luna, Paulina Soberanes-Chavez, Patricia de Gortari, Lilia G. G. Noriega, Claudia J. J. Bautista, Luis Cisneros-Zevallos
Summary: Cardamom seed modulates the neuroendocrine axis to regulate food intake, body weight, mitochondrial activity, and energy expenditure, resulting in weight loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Elena Alvarez-Salas, Cinthia Garcia-Luna, Patricia de Gortari
Summary: Thyrotropin-releasing hormone (TRH) is a tripeptide that regulates the neuroendocrine thyroid axis and acts as a neuromodulator of various behaviors. It has potential neuroprotective and mood-improving effects, but its limited permeability and degradation have restricted its therapeutic actions. However, new delivery strategies like intranasal delivery have renewed interest in TRH. TRH analogs have been proven safe and effective, and efforts are being made to prolong and facilitate their actions for better symptom management and disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
D. Islas-Preciado, C. Lopez-Rubalcava, E. Estrada-Camarena, P. de Gortari, M. Castro-Garcia
Summary: Premenstrual Dysphoric Disorder (PMDD) is a chronic stress-related disorder caused by an abrupt drop in progesterone and impairments in the HPA axis. This study investigated the effect of chronic unpredictable stress (CUS) on the gene expression of HPA axis activation in anxiety-prone WKY rats subjected to progesterone withdrawal (PW). The results showed that PW exacerbated anxiety-like behaviors and decreased the expression of Crh-PVN mRNA and Nr3c1-hippocampal mRNA. CUS also decreased Crh-PVN mRNA and Nr3c1 expression, and blunted the corticosterone and vasopressin levels in response to PW and BBT (systemic and psychogenic stressors).
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Cinthia Garcia-Luna, Ixchel Prieto, Paulina Soberanes-Chavez, Elena Alvarez-Salas, Ivan Torre-Villalvazo, Gilberto Matamoros-Trejo, Patricia de Gortari
Summary: Restrictive diet therapies for weight control have low adherence rates in obese patients, especially in stressed individuals. Intermittent fasting (IF) has emerged as an option to treat obesity and has shown positive effects on energy intake, adipocyte size, and hypothalamic-pituitary-thyroid axis function, leading to weight loss even in stressed rats.
Article
Neurosciences
E. Alvarez-Salas, F. Gama, G. Matamoros-Trejo, MI. Amaya, P. de Gortari
NEUROSCIENCE LETTERS
(2020)