Hope and fear for new classes of type 2 diabetes drugs: is there preclinical evidence that incretin-based therapies alter pancreatic morphology?

One year of sitagliptin treatment protects against islet amyloid-associated β-cell loss and does not induce pancreatitis or pancreatic neoplasia in mice

(2013) Kathryn Aston-Mourney et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression

(2013) Rachel E. Stamateris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Incretin Therapy and Islet Pathology: A Time for Caution

(2013) S. E. Kahn   DIABETES

Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors

(2013) A. E. Butler et al.   DIABETES

Comment on: Butler et al. Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors. Diabetes 2013;62:2595-2604

(2013) S. S. Engel et al.   DIABETES

Comment on: Butler et al. Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors. Diabetes 2013;62:2595-2604

(2013) R. J. Heine et al.   DIABETES

Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls

(2013) D. J. Drucker   DIABETES

A Critical Analysis of the Clinical Use of Incretin-Based Therapies: The benefits by far outweigh the potential risks

(2013) M. A. Nauck   DIABETES CARE

An Analysis of Characteristics of Subjects Examined for Incretin Effects on Pancreatic Pathology

(2013) Evis Harja et al.   Diabetes Technology & Therapeutics

Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin in an advanced-aged diet-induced obesity mouse model

(2013) B. A. Omar et al.   DIABETOLOGIA

Glucagon-like peptide-1 receptor agonist treatment reduces beta cell mass in normoglycaemic mice

(2013) J. H. Ellenbroek et al.   DIABETOLOGIA

Models of Acute and Chronic Pancreatitis

(2013) Markus M. Lerch et al.   GASTROENTEROLOGY

GLP-1 based agents and acute pancreatitis

(2013) E. A. M. Gale   BMJ-British Medical Journal

Glucagonlike Peptide 1–Based Drugs and Pancreatitis: Clarity at Last, but What About Pancreatic Cancer?

(2013) Belinda Gier et al.   JAMA Internal Medicine

Glucagonlike Peptide 1–Based Therapies and Risk of Hospitalization for Acute Pancreatitis in Type 2 Diabetes Mellitus

(2013) Sonal Singh et al.   JAMA Internal Medicine

The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis

(2012) Niels Vrang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Both sitagliptin analogue & pioglitazone preserve the β-cell proportion in the islets with different mechanism in non-obese and obese diabetic mice

(2012) Jin-A Yeom et al.   BMB Reports

Chronic GLP-1 Receptor Activation by Exendin-4 Induces Expansion of Pancreatic Duct Glands in Rats and Accelerates Formation of Dysplastic Lesions and Chronic Pancreatitis in the KrasG12DMouse Model

(2012) Belinda Gier et al.   DIABETES

The Human GLP-1 Analog Liraglutide and the Pancreas

(2012) Niels C.B. Nyborg et al.   DIABETES

No evidence of drug-induced pancreatitis in rats treated with exenatide for 13 weeks

(2012) K. Tatarkiewicz et al.   DIABETES OBESITY & METABOLISM

Studies in rodents with the dipeptidyl peptidase-4 inhibitor vildagliptin to evaluate possible drug-induced pancreatic histological changes that are predictive of pancreatitis and cancer development in man

(2012) S. J. Busch et al.   DIABETES OBESITY & METABOLISM

Cardiovascular Biology of the Incretin System

(2012) John R. Ussher et al.   ENDOCRINE REVIEWS

Impact of the Dipeptidyl Peptidase-4 Inhibitor Vildagliptin on Glucose Tolerance and β-Cell Function and Mass in Insulin Receptor Substrate-2-Knockout Mice Fed a High-Fat Diet

(2012) Koichiro Sato et al.   ENDOCRINOLOGY

Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats

(2012) Wataru Inaba et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Discovery and development of exenatide: the first antidiabetic agent to leverage the multiple benefits of the incretin hormone, GLP-1

(2012) David G Parkes et al.   Expert Opinion on Drug Discovery

DPP4 inhibitor vildagliptin preserves β-cell mass through amelioration of endoplasmic reticulum stress in C/EBPB transgenic mice

(2012) Shinobu Shimizu et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The association of pancreatitis with antidiabetic drug use: gaining insight through the FDA pharmacovigilance database

(2011) E. Raschi et al.   ACTA DIABETOLOGICA

Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice

(2011) J. Shirakawa et al.   DIABETES

Incretin-Based Therapy and the Quest for Sustained Improvements in  -Cell Health

(2011) D. J. Drucker   DIABETES CARE

Effects of Exenatide on Measures of  -Cell Function After 3 Years in Metformin-Treated Patients With Type 2 Diabetes

(2011) M. C. Bunck et al.   DIABETES CARE

Effect of sitagliptin plus metformin on β-cell function, islet integrity and islet gene expression in Zucker diabetic fatty rats

(2011) Seung Jin Han et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice

(2011) Y. Takeda et al.   DIABETOLOGIA

Pancreatitis, Pancreatic, and Thyroid Cancer With Glucagon-Like Peptide-1–Based Therapies

(2011) Michael Elashoff et al.   GASTROENTEROLOGY

Protective Effects of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor against Increased β Cell Apoptosis Induced by Dietary Sucrose and Linoleic Acid in Mice with Diabetes

(2011) Jun Shirakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice

(2011) Benjamin J. Lamont et al.   JOURNAL OF CLINICAL INVESTIGATION

Exenatide does not evoke pancreatitis and attenuates chemically induced pancreatitis in normal and diabetic rodents

(2010) Krystyna Tatarkiewicz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sitagliptin prevents the development of metabolic and hormonal disturbances, increased β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal rats

(2010) Bárbara Maiztegui et al.   CLINICAL SCIENCE

 -Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide-Induced UCH-L1 Deficiency

(2010) S. Costes et al.   DIABETES

Patients with type 2 diabetes mellitus have higher risk for acute pancreatitis compared with those without diabetes

(2010) C. J. Girman et al.   DIABETES OBESITY & METABOLISM

Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes

(2010) A. Garber et al.   DIABETES OBESITY & METABOLISM

Effects of chronic administration of alogliptin on the development of diabetes and β-cell function in high fat diet/streptozotocin diabetic mice

(2010) X. Zhang et al.   DIABETES OBESITY & METABOLISM

The DPP-4 inhibitor vildagliptin increases pancreatic beta cell mass in neonatal rats

(2010) Alokesh Duttaroy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glucagon-Like Peptide-1 Receptor Activation Modulates Pancreatitis-Associated Gene Expression But Does Not Modify the Susceptibility to Experimental Pancreatitis in Mice

(2009) J. A. Koehler et al.   DIABETES

Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes: Interactions With Metformin

(2009) A. V. Matveyenko et al.   DIABETES

Age-Dependent Decline in  -Cell Proliferation Restricts the Capacity of  -Cell Regeneration in Mice

(2009) S.-I. Tschen et al.   DIABETES

Adaptive  -Cell Proliferation Is Severely Restricted With Advanced Age

(2009) M. M. Rankin et al.   DIABETES

Increased Risk of Acute Pancreatitis and Biliary Disease Observed in Patients With Type 2 Diabetes: A retrospective cohort study

(2009) R. A. Noel et al.   DIABETES CARE

Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas

(2009) J. S. Nachnani et al.   DIABETOLOGIA

Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress

(2009) R. L. Hull et al.   DIABETOLOGIA

Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes

(2009) James Mu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Differential Importance of Glucose-Dependent Insulinotropic Polypeptide vs Glucagon-Like Peptide 1 Receptor Signaling for Beta Cell Survival in Mice

(2009) Adriano Maida et al.   GASTROENTEROLOGY

Pancreatic Duct Glands Are Distinct Ductal Compartments That React to Chronic Injury and Mediate Shh-Induced Metaplasia

(2009) Oliver Strobel et al.   GASTROENTEROLOGY

Exendin-4 Potentiates Insulinotropic Action Partly via Increasing β-Cell Proliferation and Neogenesis and Decreasing Apoptosis in Association With the Attenuation of Endoplasmic Reticulum Stress in Islets of Diabetic Rats

(2009) Dae Young Kwon et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Incretin-based therapies for type 2 diabetes mellitus

(2009) Julie A. Lovshin et al.   Nature Reviews Endocrinology

Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin

(2008) K. Aston-Mourney et al.   DIABETOLOGIA

Acute Dipeptidyl Peptidase-4 Inhibition Rapidly Enhances Insulin-Mediated Suppression of Endogenous Glucose Production in Mice

(2008) Hélène Duez et al.   ENDOCRINOLOGY

An Albumin-Exendin-4 Conjugate Engages Central and Peripheral Circuits Regulating Murine Energy and Glucose Homeostasis

(2008) Laurie L. Baggio et al.   GASTROENTEROLOGY