Article
Environmental Sciences
Xue Wen, Man Zhu, Zehua Li, Tao Li, Xuewen Xu
Summary: This study explores the effects of BPA on wound repair and finds that dietary intake of BPA delays wound healing, while wound application of BPA accelerates skin regeneration. This is because BPA up-regulates the expression of ERβ in the wound area, and enhances the function of fibroblasts to promote wound repair. For diabetic patients, application of BPA on wounds significantly speeds up wound healing without significant adverse effects on ovarian hormone levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Francesca Rossi, Giada Magni, Francesca Tatini, Martina Banchelli, Federica Cherchi, Michele Rossi, Elisabetta Coppi, Anna Maria Pugliese, Duccio Rossi degl'Innocenti, Domenico Alfieri, Francesco S. Pavone, Roberto Pini, Paolo Matteini
Summary: Studies have shown that blue LED light can be used to modulate the metabolism and proliferation of human fibroblasts and play a significant role in wound healing, particularly in co-cultures of fibroblasts and keratinocytes.
Article
Cell Biology
Pattawika Lertpatipanpong, Chanin Sillapachaiyaporn, Garam Oh, Yeong-Hun Kang, Cheol-Yong Hwang, Seung Joon Baek
Summary: Cold atmospheric microwave plasma (CAMP) is a promising therapeutic option for skin infection and wound treatment, and it promotes wound healing through regulating cellular migration, invasion, gene expression, and signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mario Migliario, Preetham Yerra, Sarah Gino, Maurizio Sabbatini, Filippo Reno
Summary: The innate immune system is composed of anatomical barriers and effector cells, among other components, providing defense against pathogens and initiating wound repair. This study investigated the ability of laser biostimulation to modulate the production of hBD-1 and hBD-2 in human keratinocytes, and found that these antimicrobial peptides were significantly increased after laser stimulation, in an energy-dependent manner. The study also showed that the production of hBD-1 and hBD-2 was oxidative-stress-dependent.
Review
Oncology
Tapan K. Mukherjee, Parth Malik, John R. Hoidal
Summary: ERRα overexpression in NSCLC promotes tumor metastasis through mechanisms such as EMT and Slug activation. It has a distinct impact on NSCLC progression and may be a target for therapy alone or in combination with antiER in treating NSCLC complications.
Article
Pharmacology & Pharmacy
Danielle Twilley, Oleg Reva, Debra Meyer, Namrita Lall
Summary: This study suggests that mupirocin promotes wound healing not only through its antibacterial activity, but also by stimulating human keratinocyte proliferation and enhancing the production of various growth factors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Amani Hassan, Edward T. Bagu, Shunmoogum A. Patten, Sirinart Molidperee, Stefan Parent, Soraya Barchi, Isabelle Villemure, Andre Tremblay, Florina Moldovan
Summary: Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional spinal deformity with a higher incidence in females. The Centriolar protein gene POC5 has been identified as a causative gene of AIS, but its hormonal regulation is still unknown.
Article
Biochemistry & Molecular Biology
Masaru Takada, Daisuke Fukuhara, Toshihiko Takiura, Yukino Nishibori, Masashi Kotani, Zentaro Kiuchi, Akihiko Kudo, Olga Beltcheva, Noriko Ito-Nitta, Kazuhiro R. Nitta, Toru Kimura, Jun-Ichi Suehiro, Tomohisa Katada, Hiromu Takematsu, Kunimasa Yan
Summary: Spermatid production is regulated by hormonal control and apoptosis, with hormones like gonadotrophins, sex hormones, and glucocorticoid playing a role in the apoptotic process. The specific pathways and mechanisms involved in apoptosis during spermatogenesis are not well understood.
Article
Biology
Yu Yamanoi, Jing Lei, Yasunori Takayama, Shigekuni Hosogi, Yoshinori Marunaka, Makoto Tominaga
Summary: The chloride channel anoctamin1 is activated by calcium influx through transient receptor potential vanilloid 3 (TRPV3), leading to chloride influx and enhancement of wound healing in keratinocytes.
COMMUNICATIONS BIOLOGY
(2023)
Article
Food Science & Technology
Jianan Song, Byunggook Kim, Oksu Kim, Ying Yang, Danyang Liu, Wenqi Fu, Guowu Ma, Young Kim, Okjoon Kim
Summary: This study suggests that coffee components caffeine and chlorogenic acid may have anti-inflammatory and antioxidant effects in alleviating periodontitis through various mechanisms. Coffee consumption may help reduce the symptoms of periodontitis.
Article
Dentistry, Oral Surgery & Medicine
Sabrina Himmelsbach, Thorsten Steinberg, Pascal Tomakidi, Manuel Garcia-Kaufer, Elmar Hellwig, Olga Polydorou
Summary: Grinding dental composite materials generates particles of different sizes. The particle size distribution is more influenced by the suspending medium than the material itself. While cell growth is not affected by the particles, an upregulation of fibronectin expression in the intercellular space suggests an increase in cell migration and mobility.
Article
Genetics & Heredity
Zhonghua Fu, Zhengying Jiang, Xincheng Liao, Mingzhuo Liu, Guanghua Guo, Xin Wang, Guangping Yang, Zhiyu Zhou, Long Hu, Zhenfang Xiong
Summary: In this study, the upregulation of circRNA-080968 in DFU was found to induce the degradation of miR-326 and miR-766-3p, which further repressed the migration and increased the proliferation of keratinocytes.
Article
Biochemistry & Molecular Biology
Sun-Hye Choi, Kyung-Jong Won, Rami Lee, Han-Sung Cho, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study demonstrates that gintonin promotes wound healing by enhancing migration and proliferation of skin cells, as well as increasing vascular endothelial growth factor release, possibly through activation of LPA receptors and downstream signaling pathways involving VEGF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Michael Singh, Serhat Akkaya, Mark Preuss, Franziska Rademacher, Mersedeh Tohidnezhad, Yusuke Kubo, Peter Behrendt, Jan-Tobias Weitkamp, Thilo Wedel, Ralph Lucius, Regine Glaeser, Juergen Harder, Andreas Bayer
Summary: The study found that treatment with PRGF can induce the expression of genes encoding paracrine factors associated with wound healing in human keratinocytes, and this effect is transduced via the IL-6 receptor pathway. Additionally, treatment with PRGF also induces the expression of these genes in ex vivo skin explants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yali Li, Kyung Jong Won, Do Yoon Kim, Ha Bin Kim, Hye Min Kang, Su Yeon Lee, Hwan Myung Lee
Summary: The absolute extracted from Smilax china flowers was found to promote skin cell activities, accelerate keratinocyte migration and proliferation, enhance collagen synthesis, and increase skin barrier protein synthesis. It suggests that it may have positive effects on skin wound healing and barrier repair.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Biochemistry & Molecular Biology
Claudia G. Fresta, Annamaria Fidilio, Giacomo Lazzarino, Nicolo Musso, Margherita Grasso, Sara Merlo, Angela M. Amorini, Claudio Bucolo, Barbara Tavazzi, Giuseppe Lazzarino, Susan M. Lunte, Filippo Caraci, Giuseppe Caruso
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Sara Merlo, Juan Pablo Luaces, Simona Federica Spampinato, Nicolas Toro-Urrego, Grazia Ilaria Caruso, Fabio D'Amico, Francisco Capani, Maria Angela Sortino
Article
Pharmacology & Pharmacy
Simona Federica Spampinato, Sara Merlo, Yasuteru Sano, Takashi Kanda, Maria Angela Sortino
Summary: Sphingosine 1 phosphate (S1P) is a bioactive sphingolipid with important physiological and pathological functions. The drug siponimod (BAF-312) has been approved for secondary progressive MS treatment by targeting S1P1 and S1P5 receptors, showing potential to strengthen BBB properties and provide additional effects for MS treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Grazia Ilaria Caruso, Simona Federica Spampinato, Giuseppe Costantino, Sara Merlo, Maria Angela Sortino
Summary: Microglia show an early defensive response to Aβ42, involving SIRT1-mediated BDNF upregulation, which can be externally modulated by melatonin. Prolonged exposure to Aβ42 leads to changes in microglial features, with increased inflammatory markers, while melatonin exhibits protective effects by preventing NF-kB nuclear translocation and acetylation.
Article
Neurosciences
Simona F. Spampinato, Sara Merlo, Giuseppe Costantino, Yasuteru Sano, Takashi Kanda, Maria Angela Sortino
Summary: The study demonstrates that BAF-312 can reduce the migration of peripheral blood mononuclear cells through endothelial cells under inflammatory conditions by controlling astrocyte activation, adhesion molecule expression, and proinflammatory cytokines and chemokines levels, highlighting the importance of astrocytes in mediating drug effects on BBB function.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Sara Merlo, Simona Federica Spampinato, Dmitry Lim
Article
Medicine, Research & Experimental
Fabio D'Amico, Giuseppe Costantino, Lucia Salvatorelli, Alice Ramondetta, Rocco De Pasquale, Maria Angela Sortino, Sara Merlo
Summary: This study found that SIRT1 expression was significantly downregulated while NAMPT expression was upregulated in the skin of psoriatic patients, suggesting their involvement in the pathogenesis and inflammation of psoriasis. These findings provide direction for exploring novel pharmacological targets in the treatment of psoriasis.
ADVANCES IN MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Simona Federica Spampinato, Giuseppe Costantino, Sara Merlo, Pier Luigi Canonico, Maria Angela Sortino
Summary: Modulating S1P receptors in microglia may contribute to the reinforcement of the endothelial barrier at the blood-brain barrier, suggesting an additional effect of the drug in the treatment of multiple sclerosis.
Review
Biochemistry & Molecular Biology
Giorgia Serena Gullotta, Giuseppe Costantino, Maria Angela Sortino, Simona Federica Spampinato
Summary: Microglia are intrinsic immune cells in the central nervous system that have immune surveillance function and modulating effect on neuronal synaptic development and function. Upon injury, microglia are activated and change their morphology to ameboid phenotype with pro- or anti-inflammatory features. This article describes the specific crosstalk of microglia with different cellular components of the blood-brain barrier, and focuses on the involvement of microglia in the modulation of blood-brain barrier function in neuroinflammatory conditions associated with acute events or slow neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sara Merlo, Grazia Ilaria Caruso, Dhwani Sunil Korde, Alla Khodorovska, Christian Humpel, Maria Angela Sortino
Summary: Melatonin exerts neuroprotective effects on neuronal and glial cells, with its effects on microglia mediated by MT1 receptor and dependent on SIRT1 activation. In this study, the effects of melatonin on hippocampal microglia in a 3D context were compared to a single cell type context using the HMC3 cell line. Melatonin showed anti-inflammatory effects against LPS-induced inflammation, including the regulation of NF-kB expression, and these effects were mediated by SIRT1. The multicellular context is important for the full activity of melatonin, especially in a preventive view, and organotypic brain cultures can be used as a favorable model to study inflammatory responses.
Review
Chemistry, Medicinal
Simona Federica Spampinato, Grazia Ilaria Caruso, Rocco De Pasquale, Maria Angela Sortino, Sara Merlo