Assessing the association between homocysteine and cognition: reflections on Bradford Hill, meta-analyses, and causality

Reply to Garrard and Jacoby and Smith et al.

(2015) et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Homocysteine lowering, B vitamins, and cognitive aging

(2015) A David Smith et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

B-vitamin trials meta-analysis: less than meets the eye

(2015) Peter Garrard et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The Worldwide Challenge of the Dementias: A Role for B Vitamins and Homocysteine?

(2015) A. David Smith   FOOD AND NUTRITION BULLETIN

Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals

(2014) Robert Clarke et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism

(2014) Nafisa M. Jadavji et al.   BIOCHEMICAL JOURNAL

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

(2014) Johannes Attems et al.   BMC Medicine

Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis

(2014) May A Beydoun et al.   BMC PUBLIC HEALTH

Homocysteine levels in schizophrenia and affective disorders—focus on cognition

(2014) Ahmed A. Moustafa et al.   Frontiers in Behavioral Neuroscience

Plasma homocysteine, Alzheimer and cerebrovascular pathology: a population-based autopsy study

(2013) Babak Hooshmand et al.   BRAIN

The role of NMDA and mGluR5 receptors in calcium mobilization and neurotoxicity of homocysteine in trigeminal and cortical neurons and glial cells

(2013) Polina A. Abushik et al.   JOURNAL OF NEUROCHEMISTRY

Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment

(2013) Gwenaëlle Douaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum homocysteine and dementia: Meta-analysis of eight cohort studies including 8669 participants

(2011) David S. Wald et al.   Alzheimers & Dementia

Cognitive function after supplementation with B vitamins and long-chain omega-3 fatty acids: ancillary findings from the SU.FOL.OM3 randomized trial

(2011) Valentina A Andreeva et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial

(2011) Celeste A. Jager et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study

(2011) B. Hooshmand et al.   JOURNAL OF INTERNAL MEDICINE

Effects of Homocysteine-Lowering With Folic Acid Plus Vitamin B12vs Placebo on Mortality and Major Morbidity in Myocardial Infarction Survivors

(2010)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Homocysteine, Another Risk Factor for Alzheimer Disease, Impairs Apolipoprotein E3 Function

(2010) Hirohisa Minagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial

(2010)   LANCET NEUROLOGY

Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial

(2010) A. David Smith et al.   PLoS One

Age-associated cognitive decline

(2009) I. J. Deary et al.   BRITISH MEDICAL BULLETIN

Midlife homocysteine and late-life dementia in women. A prospective population study

(2009) Dimitri E. Zylberstein et al.   NEUROBIOLOGY OF AGING

A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease

(2008) Jae Hee Kang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

High-Dose B Vitamin Supplementation and Cognitive Decline in Alzheimer Disease

(2008) Paul S. Aisen   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION