Article
Cardiac & Cardiovascular Systems
Zhuoxuan Yang, Tianjie Wang, Ying Dong, Long Liu, Xuan Xue, Jine Wu, Liuyi Hao, Jiansong Yuan, Jingang Cui, Shubin Qiao, Weixian Yang
Summary: FT3 can serve as an independent predictor for postoperative myocardial infarction, recurrent ISR, and target vessel revascularization in patients with ISR. When FT3 level is below 2.785 pmol/L, the incidence of postoperative myocardial infarction, recurrent ISR, and TVR significantly increases in ISR patients.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Erfan Razavi, Akam Ramezani, Asma Kazemi, Armin Attar
Summary: This systematic review and meta-analysis evaluated the impact of colchicine on acute coronary syndrome (ACS). The results showed that colchicine has a marginal effect on reducing high-sensitivity C-reactive protein (hs-CRP) levels and promisingly reduces the risk of stroke. However, there was no difference in the occurrence of myocardial infarction (MI) or the primary composite endpoint between the colchicine and non-colchicine groups. Additionally, low-dose consumption of colchicine can help avoid gastrointestinal (GI) adverse events.
CARDIOVASCULAR THERAPEUTICS
(2022)
Review
Biology
Tommaso Gori
Summary: Coronary stents are widely implanted medical devices with various mechanical and biochemical characteristics. Inflammatory reactions are a major cause of complications following stent implantation, highlighting the importance of understanding and comparing these reactions across different generations of stents.
Review
Cardiac & Cardiovascular Systems
Ming Yi, Lu Wu, Xiao Ke
Summary: This meta-analysis study shows that higher levels of baseline hs-CRP are not associated with an increased risk of ISR in stented patients. However, an increased risk of ISR was associated with hs-CRP levels at 6 to 12 months of follow-up, particularly in studies involving diabetic patients and the elderly.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Environmental Sciences
Shichao Han, Fen Zhang, Hongmei Yu, Jing Wei, Lina Xue, Zhizhou Duan, Zhiping Niu
Summary: Long-term exposure to air pollution is associated with an increased prevalence of metabolic syndrome (MetS), which may be enhanced by systemic inflammation. Measures should be taken to improve air quality and reduce systemic inflammation, considering the rapidly aging society and heavy burden of MetS.
ENVIRONMENTAL RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Ascension M. de los Reyes-Garcia, Laura Zapata-Martinez, Sonia Aguila, Maria L. Lozano, Constantino Martinez, Rocio Gonzalez-Conejero
Summary: Atrial fibrillation is a complex disease and microRNAs play a crucial role in the development of major adverse cardiovascular events (MACE) in these patients. MicroRNAs have been investigated as potential biomarkers for various diseases, including cardiovascular diseases. Some studies have associated certain microRNAs in plasma with the occurrence of MACE in atrial fibrillation. However, the lack of standardization in the purification and detection of microRNAs has produced contradictory results. Additionally, microRNAs have a functional impact on MACE in atrial fibrillation through the dysregulation of immunothrombosis, suggesting their potential use as therapy against thromboinflammatory processes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Luis M. Blanco-Colio, Nerea Mendez-Barbero, Ana Maria Pello Lazaro, Alvaro Acena, Nieves Tarin, Carmen Cristobal, Juan Martinez-Milla, Oscar Gonzalez-Lorenzo, Jose Luis Martin-Ventura, Ana Huelmos, Carlos Gutierrez-Landaluce, Marta Lopez-Castillo, Andrea Kallmeyer, Ester Canovas, Joaquin Alonso, Lorenzo Lopez Bescos, Jesus Egido, Oscar Lorenzo, Jose Tunon
Summary: The study found that MCP-1 plasma concentration is associated with recurrent cardiovascular events in patients with persistent inflammation, while NT-proBNP and MCP-1 are not associated with primary outcome in patients with low inflammation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Michael Y. Henein, Ibadete Bytyci, Rachel Nicoll, Rafik Shenouda, Sherif Ayad, Federico Vancheri, Matteo Cameli
Summary: The study assessed the prevalence of COVID-19 among Coptic priests, with higher rates in Northern Egypt. Obesity was identified as the most powerful independent predictor of major adverse events related to COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Jessie Clare, Justin Ganly, Christina A. Bursill, Huseyin Sumer, Peter Kingshott, Judy B. de Haan
Summary: This review focuses on the mechanisms of inflammation and redox stress in the context of stent design and discusses whether targeted mechanistic approaches can lead to improved outcomes for patients.
Article
Cardiac & Cardiovascular Systems
Niveditta Ramkumar, Philip P. Goodney, Mark A. Creager, Stanislav Henkin
Summary: Therapeutic anticoagulation after peripheral endovascular intervention is associated with a higher risk of major adverse limb events and all-cause mortality. Patients receiving anticoagulation had a higher prevalence of acute or chronic limb ischemia and were less likely to receive antiplatelet agents after the intervention.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Psychology, Multidisciplinary
Ana Cecilia de Menezes Galvao, Raissa Nobrega Almeida, Geovan Menezes de Sousa, Mario Andre Leocadio-Miguel, Fernanda Palhano-Fontes, Draulio Barros de Araujo, Bruno Lobao-Soares, Joao Paulo Maia-de-Oliveira, Emerson Arcoverde Nunes, Jaime Eduardo Cecilio Hallak, Felipe Barreto Schuch, Jerome Sarris, Nicole Leite Galvao-Coelho
Summary: The study found that patients with first episode MDD had higher levels of CAR and SC compared to controls, while patients with treatment-resistant depression had lower levels of SC and CAR but higher levels of mBDNF and CRP than controls. The severity of depressive symptoms and poor sleep quality were associated with low levels of SC and CAR, and high levels of mBDNF. These findings suggest a strong relationship between clinical stages of MDD and changes in relevant biological markers.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Laura Orsolini, Simone Pompili, Silvia Tempia Valenta, Virginio Salvi, Umberto Volpe
Summary: This study reviewed the literature on the association between C-Reactive Protein (CRP) and depression. Evidence suggested dysregulation in the inflammation system in individuals with depression, with higher blood CRP levels being associated with greater symptom severity and worse treatment response. Some depressed patients showed a low-grade inflammatory state, suggesting a distinct subgroup within major depressive disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Maxime Boidin, Gregory Y. H. Lip, Alena Shantsila, Dick Thijssen, Eduard Shantsila
Summary: We investigated the association between dynamic changes in monocyte subset counts, phagocytic activity, and NF kappa B activity with major adverse cardiovascular events (MACE) and left ventricular ejection fraction (LVEF) in patients with ST-elevation myocardial infarction (STEMI). Multivariate Cox regression analysis revealed that a more significant reduction in Mon2 by week 1 was independently associated with fewer MACE events. Additionally, a less prominent reduction in Mon2 at 1 month was predictive of better 6-month LVEF. This study highlights the importance of dynamic changes in Mon2 and their potential significance for MACE risk and cardiac recovery.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Ying Yu, Long Yan, Yake Lou, Rongrong Cui, Kaijiang Kang, Lingxian Jiang, Dapeng Mo, Feng Gao, Yongjun Wang, Xin Lou, Zhongrong Miao, Ning Ma
Summary: This study aimed to identify predictors of intracranial in-stent restenosis (ISR) after stent placement in symptomatic intracranial atherosclerotic stenosis (ICAS). The study found that elevated high-sensitivity C-reactive protein (hs-CRP) level, Mori type B and C, coronary artery disease (CAD), neutrophil/lymphocyte ratio (NLR), residual stenosis, and concurrent intracranial tandem stenosis were the main predictors of intracranial ISR. Elevated hs-CRP level was crucially associated with recurrent stroke in patients with symptomatic ICAS after intracranial stent implantation.
JOURNAL OF NEUROSURGERY
(2022)
Review
Biochemistry & Molecular Biology
Mihaela-Andreea Podeanu, Adina Turcu-Stiolica, Mihaela Simona Subtirelu, Mioara Desdemona Stepan, Claudiu-Marinel Ionele, Dan-Ionut Gheonea, Bianca Stefanita Vintilescu, Raluca Elena Sandu
Summary: The study suggests that C-reactive protein (CRP) is a reliable marker for detecting inflammation in pediatric patients with metabolic syndrome (MetS). However, it may not be very accurate in distinguishing between patients with MetS and those who are obese.
Article
Medical Laboratory Technology
Paula Breitenbach Renz, Mayana Kieling Hernandez, Joiza Lins Camargo
CLINICA CHIMICA ACTA
(2018)
Article
Medical Laboratory Technology
Julia Dauernheimer Machado, Eduardo Guimaraes Camargo, Roberta Boff, Lais da Silva Rodrigues, Joiza Lins Camargo, Ariana Aguiar Soares, Sandra Pinho Silveiro
CLINICAL BIOCHEMISTRY
(2018)
Review
Medical Laboratory Technology
Paula B. Renz, Fernando C. Chume, Joao R. T. Timm, Ana L. Pimentel, Joiza L. Camargo
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2019)
Article
Endocrinology & Metabolism
L. C. Pinto, C. K. Kramer, J. L. Camargo, L. H. Canani, J. L. Gross, C. B. Leitao
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2020)
Article
Multidisciplinary Sciences
Fernando Chimela Chume, Mayana Hernandez Kieling, Priscila Aparecida Correa Freitas, Gabriela Cavagnolli, Joiza Lins Camargo
Article
Multidisciplinary Sciences
Leticia de Almeida Brondani, Ariana Aguiar Soares, Mariana Recamonde-Mendoza, Angelica Dall'Agnol, Joiza Lins Camargo, Karina Mariante Monteiro, Sandra Pinho Silveiro
SCIENTIFIC REPORTS
(2020)
Review
Medical Laboratory Technology
Fernando C. Chume, Priscila A. C. Freitas, Luisa G. Schiavenin, Ana L. Pimentel, Joiza Lins Camargo
Summary: Glycated albumin (GA) shows good overall diagnostic accuracy for diabetes, with an optimal threshold of 17.1% for diagnosing previously undiagnosed individuals.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Genetics & Heredity
Cristine Dieter, Leticia de Almeida Brondani, Natalia Emerim Lemos, Ariell Freires Schaeffer, Caroline Zanotto, Denise Taurino Ramos, Eliandra Girardi, Felipe Mateus Pellenz, Joiza Lins Camargo, Karla Suzana Moresco, Lucas Lima da Silva, Mariana Rauback Aubin, Mayara Souza de Oliveira, Tatiana Helena Rech, Luis Henrique Canani, Fernando Gerchman, Cristiane Bauermann Leitao, Daisy Crispim
Summary: Although age, sex, and comorbidities play a role in the severity of COVID-19, genetic polymorphisms in ACE1, ACE2, DPP9, IFIH1, IFNAR2, IFNL4, TLR3, TMPRSS2, and TYK2 also contribute to the variation in disease severity. This study found that specific genotypes and alleles in these genes are associated with increased risk of ICU admission and death in COVID-19 patients, especially among females and non-white individuals. Moreover, interactions between these polymorphisms further increase the risk of worse outcomes.
Article
Multidisciplinary Sciences
Priscila Bellaver, Larissa Schneider, Ariell F. Schaeffer, Lilian Rodrigues Henrique, Joiza Lins Camargo, Fernando Gerchman, Cristiane B. Leitao, Tatiana H. Rech
Summary: This study investigates the association of diabetes mellitus (DM) and stress-induced hyperglycemia at ICU with mortality in COVID-19 patients. The results show that DM, hyperglycemia, and glycemic variability are associated with increased mortality in critically ill patients with severe COVID-19, but do not increase the rates of other clinical outcomes.
Letter
Endocrinology & Metabolism
Fernando Chimela Chume, Joiza Lins Camargo
Article
Parasitology
Daiana de Lima-Morales, Priscila Lamb Wink, Fabiana Caroline Zempulski Volpato, Joiza Lins Camargo, Fernanda de-Paris, Afonso Luis Barth
Summary: Monitoring the viral RNA shedding period of 29 healthcare workers revealed that over 50% remained RT-qPCR positive after 14 days, with one healthcare worker showing positive results 95 days after the first positive test, indicating heterogeneity in sequential RT-qPCR results and unique viral RNA shedding periods for individuals.
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2021)
Article
Endocrinology & Metabolism
Fernando Chimela Chume, Paula Breitenbach Renz, Mayana Kieling Hernandez, Priscila Aparecida Correa Freitas, Joiza Lins Camargo
Summary: This study aimed to assess the clinical utility of glycated albumin (GA) in diagnosing gestational diabetes mellitus (GDM) in 149 Brazilian women. The results showed that GA at 24-28 weeks of gestation did not have the ability to accurately discriminate between those with and without GDM.
Article
Medical Laboratory Technology
Ana Laura Pimentel, Mayana Kieling Hernandez, Priscila Aparecida Correa Freitas, Fernando Chimela Chume, Joiza Lins Camargo
CLINICA CHIMICA ACTA
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Fabian Juliao, Oriana M. Damas, Mateo Arrubla, Omar J. Calixto, Jose Lyn Camargo, Lina Cruz, Juan Hurtado, Absalon Clavijo, Jorge Donado, Maria T. Abreu
Article
Medical Laboratory Technology
Ana Laura Pimentel, Joiza Lins Camargo
CLINICAL BIOCHEMISTRY
(2017)