Article
Biochemistry & Molecular Biology
Alok Mishra, Anshuman Srivastava, Ankit Pateriya, Manendra Singh Tomar, Anand Kumar Mishra, Ashutosh Shrivastava
Summary: Breast cancer is the most common cancer among females, and endocrine therapy for ER-positive breast cancer can result in acquired resistance. The metabolic state of cancer cells plays a crucial role in their susceptibility to chemotherapeutic drugs, and understanding metabolic pathway alterations in TAMR cancer may offer potential therapeutic strategies.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Shaimaa Hamza, Ekaterina E. E. Garanina, Mohammad Alsaadi, Svetlana F. F. Khaiboullina, Gulcin Tezcan
Summary: NLRP3 may contribute to the growth and propagation of breast cancer, and the effects of ER-alpha, PR, and HER2 on NLRP3 activation in breast cancer are still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Friederike Steifensand, Julia Gallwas, Gerd Bauerschmitz, Carsten Gruendker
Summary: Increased glucose requirement and upregulated glutaminolysis play crucial roles in cancer cell survival, making combined metabolic treatments a potentially effective strategy for improving therapy outcomes in estrogen receptor alpha-positive breast cancer.
Article
Oncology
Yuanqin Zhang, Xiangwei Fang, Jiuhui Wang, Daotai Nie
Summary: TMEM97/sigma 2 receptor is highly expressed in ER-positive breast tumors and correlated with ERs and PRs. High expression of TMEM97 is associated with reduced overall survival of patients and increased resistance to tamoxifen treatment in breast cancer cells, as well as enhanced cell growth and ERα activity.
Article
Medicine, Research & Experimental
Sheila Almaraz Postigo, Juan Carlos Montero
Summary: In this study, the researchers found that Neuregulins (NRGs) regulate estrogen receptor α (ERα) in breast cancer cells through multiple mechanisms. NRGs activate the PI3K/AKT/mTOR, ERK1/2, and ERK5 pathways, leading to phosphorylation of ERα and down-regulation of its expression. NRGs also confer resistance to fulvestrant in breast cancer cells. However, this resistance can be reversed by simultaneously inhibiting these three pathways.
Review
Oncology
Nivida Shete, Jordan Calabrese, Debra A. Tonetti
Summary: Estrogen is a key driver of estrogen-receptor-positive breast cancers, and drugs that block estrogen signaling are commonly used for treatment. Surprisingly, estrogen was previously used to treat breast cancer before the introduction of tamoxifen. This review focuses on the insights, molecular mechanisms, and potential clinical application of this counterintuitive therapeutic approach.
Article
Medicine, Research & Experimental
Coralie Poulard, Thuy Ha Pham, Youenn Drouet, Julien Jacquemetton, Ausra Surmielova, Loay Kassem, Benoite Mery, Christine Lasset, Jonathan Reboulet, Isabelle Treilleux, Elisabetta Marangoni, Olivier Tredan, Muriel Le Romancer
Summary: Endocrine therapies targeting estrogen signaling have improved management of estrogen receptor alpha (ERα)-positive breast cancers. However, resistance to treatment remains a challenge. This study identifies nuclear PRMT5 expression as a predictive marker of sensitivity to tamoxifen in breast cancer patients, and reveals the mechanism of tamoxifen stimulating ERα methylation by PRMT5. This biomarker could be used to enhance response to tamoxifen in ERα-positive breast tumors.
EMBO MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Faten Shehadeh-Tout, Heloisa H. Milioli, Suraya Roslan, Patric J. Jansson, Mahendiran Dharmasivam, Dinny Graham, Robin Anderson, Tharushi Wijesinghe, Mahan Gholam Azad, Des R. Richardson, Zaklina Kovacevic
Summary: This study investigates a new class of anti-cancer agents for the treatment of ER-positive breast cancer. These agents inhibit multiple growth factor receptors and down-stream signaling, leading to decreased expression of hormone receptors and key resistance pathways. In vivo experiments demonstrate that these agents effectively inhibit ER-positive breast cancer growth. This represents an innovative non-hormonal, multi-modal therapeutic approach.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Oncology
Xuemiao Zhang, Linfei Huang, Jing Sun, Jialong Liu, Yulong Zong, Luming Wan, Xiaopan Yang, Xue Yan, Yanhong Zhang, Ruzhou Zhao, Jing Liu, Hui Zhong, Congwen Wei, Xiaoli Yang, Yanhong Tai, Yue Han, Yanhai Wang
Summary: This study reveals the role of Mps1 kinase in tamoxifen resistance in breast cancer and suggests it as a potential therapeutic approach to overcome tamoxifen resistance.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Endocrinology & Metabolism
Partha Das, Aritra Gupta, Kartiki V. Desai
Summary: High expression of JMJD6 is associated with poor prognosis and resistance to endocrine therapy in ER+ breast cancer. JMJD6 upregulates genes related to cell proliferation and downregulates ER target genes. Blocking ER alone may not eliminate proliferation of JMJD6-expressing ER+ cells. Immunostaining for JMJD6 could be developed as a potential marker for predicting endocrine therapy resistance.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chih-Jung Chen, Ting-Hao Chen, Jason Lei, Ji-An Liang, Po-Sheng Yang, Chiun-Sheng Huang, Chia-Ming Hsieh, Ling-Ming Tseng, Liang-Chih Liu, Skye Hung-Chen Cheng, Kuan-Hui Shih
Summary: This study compared the biomarker expression and breast cancer subtyping results obtained by immunohistochemistry (IHC) and reverse transcriptase-polymerase chain reaction (RT-PCR). The results showed concordance between the two methods, and RT-PCR performed similarly to IHC in predicting 5-year survival.
BIOSCIENCE REPORTS
(2022)
Editorial Material
Endocrinology & Metabolism
Michael B. Stout, Rebecca L. Scalzo, Elizabeth A. Wellberg
Summary: Tamoxifen, a selective estrogen receptor modulator, is commonly used in preclinical studies and treatment of ER-positive breast cancer. Activation of Cre-ER transgenes in mice requires tamoxifen administration through various methods and doses, leading to inconsistent metabolic effects compared to anecdotal reports and expected outcomes.
Article
Oncology
Javier A. Menendez, Adriana Papadimitropoulou, Travis Vander Steen, Elisabet Cuyas, Bharvi P. Oza-Gajera, Sara Verdura, Ingrid Espinoza, Luciano Vellon, Inderjit Mehmi, Ruth Lupu
Summary: The study highlights the critical role of fatty acid synthase (FASN) in HER2-driven tamoxifen resistance and suggests that FASN inhibition could be a novel therapeutic approach to restore tamoxifen sensitivity in endocrine-resistant breast cancer.urther research using next-generation FASN inhibitors may be therapeutically relevant in countering resistance to tamoxifen in FASN-overexpressing ER+/HER2+ breast carcinomas.
Article
Multidisciplinary Sciences
Tomoka Hisada, Naoto Kondo, Yumi Wanifuchi-Endo, Satoshi Osaga, Takashi Fujita, Tomoko Asano, Yasuaki Uemoto, Sayaka Nishikawa, Yusuke Katagiri, Mitsuo Terada, Akiko Kato, Hiroshi Sugiura, Katsuhiro Okuda, Hiroyuki Kato, Masayuki Komura, Satoshi Morita, Satoru Takahashi, Tatsuya Toyama
Summary: Co-expression of LLGL2 and SLC7A5 mRNA has a significant impact on predicting prognosis and response to tamoxifen therapy in ER alpha-positive breast cancer patients, making it a promising biomarker for early breast cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Ingrid Espinoza, Lin Yang, Travis Vander Steen, Luciano Vellon, Elisabet Cuyas, Sara Verdura, Lester Lau, Javier A. Menendez, Ruth Lupu
Summary: CCN1 promotes angiogenesis, tumor growth, and chemoresistance in endothelial and breast cancer cells by binding to its integrin receptor α(v)β(3). It also controls tissue regeneration by engaging its integrin receptor α(6)β(1) to induce fibroblast senescence. In estrogen receptor-positive breast cancer cells, CCN1 drives an endocrine resistance phenotype through its interaction with ER α.
Article
Cell Biology
Lucas Solla Mathias, Bruna Moretto Rodrigues, Bianca Mariani Goncalves, Fernanda Cristina Fontes Moretto, Regiane Marques Castro Olimpio, Igor Depra, Maria Teresa De Sibio, Helena Paim Tilli, Celia Regina Nogueira, Miriane de Oliveira
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Cell Biology
Miriane de Oliveira, Lucas Solla Mathias, Bruna Moretto Rodrigues, Bianca Goncalves Mariani, Jones Bernardes Graceli, Maria Teresa De Sibio, Regiane Marques Castro Olimpio, Fernanda Cristina Fontes Moretto, Igor Carvalho Depra, Celia Regina Nogueira
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Cell Biology
Miriane de Oliveira, Maria Teresa De Sibio, Lucas Solla Mathias, Bruna Moretto Rodrigues, Marna Eliana Sakalem, Celia Regina Nogueira
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Pharmacology & Pharmacy
Miriane de Oliveira, Lucas Solla Mathias, Maria Teresa de Sibio, Jose Bernardo Noronha-Matos, Maria Adelina Costa, Celia Regina Nogueira, Paulo Correia-de-Sa
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Cell Biology
Sarah Maria Barneze Costa, Georgia Silva Feltran, Vickeline Namba, Tabata Marilda Silva, Raghavendra Lakshmana Shetty Hallur, Patricia Pinto Saraiva, Willian Fernando Zambuzzi, Celia Regina Nogueira
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Review
Endocrinology & Metabolism
Renata Aparecida de Oliveira Lima, Gabriela Andrade Piemonte, Celia Regina Nogueira, Vania dos Santos Nunes-Nogueira
Summary: Exercise interventions can improve balance, fear of falling, and mental quality of life in patients with diabetic peripheral neuropathy, but the impact on the risk of falls is inconclusive.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Celia Nogueira, Lisbeth Silva, Ana Marcao, Carmen Sousa, Helena Fonseca, Hugo Rocha, Teresa Campos, Elisa Leao Teles, Esmeralda Rodrigues, Patricia Janeiro, Ana Gaspar, Laura Vilarinho
Summary: The study highlights the importance of RNA studies for a definitive molecular diagnosis of MADD patients, expands the background of ETFDH mutations, and will be important in providing accurate genetic counseling and prenatal diagnosis for the affected families.
Article
Biochemistry & Molecular Biology
Juliana R. B. Martins, Leonardo N. Moraes, Sarah S. Cury, Juliana Capannacci, Robson Francisco Carvalho, Celia Regina Nogueira, Newton Key Hokama, Paula O. M. Hokama
Summary: Chronic myeloid leukemia (CML) is a hematopoietic neoplasm caused by the BCR-ABL1 oncogene, and treatment mainly involves TKIs and HSCT-allo transplantation, though the latter presents challenges and risks. Studying miRNAs in CML patients can provide insights into disease prognosis and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Flavia Bessi Constantino, Sarah Santiloni Cury, Celia Regina Nogueira, Robson Francisco Carvalho, Luis Antonio Justulin
Summary: This study analyzed the potential non-canonical cell-entry mediators of SARS-CoV-2 infection and replication in placenta cells, showing high levels of DPP4 and CTSL as potential non-canonical mediators in cells.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Bruna Moretto Rodrigues, Lucas Solla Mathias, Igor de Carvalho Depra, Sarah Santiloni Cury, Miriane de Oliveira, Regiane Marques Castro Olimpio, Maria Teresa De Sibio, Bianca Mariani Goncalves, Celia Regina Nogueira
Summary: This study provides new directions for elucidating the mechanisms of T3 action on osteoblast metabolism, with potential future implications for the treatment of endocrine-related bone pathologies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Reproductive Biology
Bianca M. Goncalves, Jones B. Graceli, Paula B. da Rocha, Helena P. Tilli, Ester M. Vieira, Maria T. de Sibio, Vinicius V. Peghinelli, Igor C. Depra, Lucas S. Mathias, Regiane M. C. Olimpio, Virginia C. Belik, Celia R. Nogueira
Summary: The placenta is a temporary organ that plays critical roles at the maternal-fetal interface. Its normal development and function depend on hormonal signaling pathways, which also make it vulnerable to endocrine disrupting chemicals. New placental models have been developed to assess and prevent developmental toxic harm caused by these chemicals. This review focuses on discussing the newest in vitro models for understanding the maternal-fetal interface and predicting placental development, physiology, and dysfunction.
REPRODUCTIVE TOXICOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Jose Augusto Sgarbi, Celia Regina Nogueira, Gabriela Brenta, Marco Antonio Campinho
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lucas Solla Mathias, Carina Herman-de-Sousa, Sarah Santiloni Cury, Celia Regina Nogueira, Paulo Correia-de-Sa, Miriane de Oliveira
Summary: The anti-obesity hormones T3 and irisin have been found to stimulate thermogenesis and energy consumption, while reducing lipid accumulation. This study investigated their effects on the purinergic signaling pathway in adipocytes, and found that T3 and irisin differentially regulate the transcription of purinergic signaling markers. These findings may offer new insights into the treatment of obesity and related metabolic disorders.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Biology
Roberto Jorge da Silva Franco, Jose Antonio Vieira Filho, Douglas Inomata Cardoso da Silva, Luis Cuadrado Martin, Bruno Alves Silva, Silmeia Garcia Zanati Bazan, Pasqual Barretti, Celia Regina Nogueira
Summary: The objective of this study was to assess the value of abnormal circadian blood pressure pattern in predicting abnormal albuminuria in normotensive and normoalbuminuric DM1 patients. The study found that patients with a normal circadian blood pressure pattern did not develop elevated albuminuria during the follow-up period, while only 22% of non-dippers were free of albuminuria at the same time, suggesting that abnormal systolic blood pressure circadian pattern predicts the evolution to incipient nephropathy in these patients.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Glaucia Maria Ferreira da Silva Mazeto, Jose Augusto Sgarbi, Helton Estrela Ramos, Danilo Glauco Pereira Villagelin Neto, Celia Regina Nogueira, Mario Vaisman, Hans Graf, Gisah Amaral de Carvalho
Summary: This position statement prepared by experts from the Brazilian Society of Endocrinology and Metabolism provides guidance on the management of three special situations of hypothyroidism. The authors conducted a search on various databases and selected articles with the best evidence quality to present information on the current approach to patients in these special situations.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2022)