Article
Veterinary Sciences
Diego E. Gomez, Lynna Li, Hanne Goetz, Jennifer MacNicol, Lisa Gamsjaeger, David L. Renaud
Summary: Diarrhea is the leading cause of morbidity, mortality, and antimicrobial drug use in calves during the first month of age. This study investigated the alterations in the fecal bacterial communities of diarrheic calves and their association with changes in blood pH and anion gap (AG). The results showed that diarrhea in calves is associated with a shift in the gut microbiota, expansion of lactate-producing bacteria, and acid-base disorders. These findings highlight the importance of the gastrointestinal microbiota in the pathophysiological changes observed in diarrheic calves.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Medicine, General & Internal
Samantha R. Wray, Puja P. Patel, Christopher D. Jackson
Summary: Hypertriglyceridemia causing unexplained hypobicarbotinemia and elevated anion gap is a rare condition. This case involves a 33-year-old woman who developed a high anion gap after a subacute gastrointestinal illness. Arterial blood gas analysis showed normal bicarbonate levels, but a lipid panel revealed extremely high triglyceride levels. Treatment involved using triglyceride-lowering agents, which led to normalization of the patient's serum bicarbonate levels.
JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
(2023)
Article
Obstetrics & Gynecology
Aaron M. Dom, Rebecca Royzer, Courtney Olson-Chen
Summary: Acetaminophen use can lead to 5-oxoprolinemia and metabolic acidosis, caution should be taken during pregnancy. N-acetylcysteine may be an effective antidote for pregnant women with high anion gap metabolic acidosis.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Debargha Basuli, Sasmit Roy
Summary: Acetone poisoning, although rare, can cause a variety of symptoms. High levels of serum acetone can be due to external exposure or internal production. Unlike certain alcohol toxicities, acetone does not lead to high anion gap metabolic acidosis. Clinicians need to be able to determine and manage such metabolic disturbances and associated toxicities.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Urology & Nephrology
Jun-Ya Kaimori, Yusuke Sakaguchi, Sachio Kajimoto, Yuta Asahina, Tatsufumi Oka, Koki Hattori, Yohei Doi, Yoshitaka Isaka
Summary: Metabolic acidosis is a common complication of chronic kidney disease (CKD) and is associated with disease progression and functional impairments. Recent studies have highlighted the importance of considering blood pH and anion gap for diagnosing and treating metabolic acidosis in CKD patients. High anion gap acidosis has been identified as a prognostic factor, and there is evidence that it can be improved with specific treatments. Reevaluation of the clinical approach to diagnosing and treating metabolic acidosis in CKD may be necessary.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Urology & Nephrology
Michael Emmett
Summary: This article briefly reviews the mechanisms of metabolic acidosis and categorizes them based on mechanism and the presence or absence of an increased anion gap. It emphasizes the importance of identifying the primary causative etiology as quickly as possible. When the etiology is not obvious, determining whether the metabolic acidosis is of the hyperchloremic or high-anion-gap type can be helpful in ordering appropriate diagnostic studies.
ADVANCES IN CHRONIC KIDNEY DISEASE
(2022)
Article
Pediatrics
Farahnak Assadi
Summary: Measuring urine anion gap can help differentiate between chronic respiratory alkalosis and metabolic acidosis, especially when arterial blood gas is not available.
PEDIATRIC PULMONOLOGY
(2023)
Article
Medicine, General & Internal
Michael R. Wiederkehr, Raul Benevides, Carol A. Santa Ana, Michael Emmett
Summary: Pseudohyperchloremia can be caused by salicylate poisoning, affecting the measurement of blood chloride concentration. Different manufacturers of Cl-ISEs can generate varying levels of artifactual chloride concentrations. Physicians should consider salicylate poisoning when a combination of hyperchloremia and a very small or negative anion gap is reported in the laboratory.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Dariusz Uczkowski, Rani Gundavarapu
Summary: 5-oxoprolinemia is a rare metabolic disorder that can cause severe anion gap metabolic acidosis. This case report describes a 59-year-old female who presented with elevated anion gap metabolic acidosis, with no apparent classical cause, but was later diagnosed with 5-oxoprolinemia along with chronic acetaminophen use and severe hypothyroidism. Treatment involved correcting the acidosis, providing IV fluids, prescribing oral levothyroxine, and advising against further acetaminophen use. This case underscores the importance of monitoring the use of over-the-counter medications and recognizing metabolic conditions that can lead to metabolic acidosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Suvika Patel, Falguni Parikh, Niranjan Kulkarni
Summary: High anion gap metabolic acidosis is a common acid-base disorder in hospitalized patients, with lactate, ketones, and urea accumulation being the most common causes. Prompt recognition and discontinuation of offending agents can lead to rapid recovery and reduce the length of hospital stay.
INDIAN JOURNAL OF MEDICAL SPECIALITIES
(2022)
Review
Pharmacology & Pharmacy
Y. Ahmad, S. Kissling, C. Torrent, J. -D. Chiche, L. Liaudet, Z. Ltaief
Summary: Ethylene glycol poisoning can lead to severe complications such as central nervous system depression, cardiorespiratory instability, and renal failure. Proper diagnosis and timely treatment are crucial to prevent lethal consequences.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Infectious Diseases
Julia Elisabeth Lenz, Volker Alt, Thomas Dienemann
Summary: This report describes a case of severe metabolic acidosis in a 64-year-old female patient, and the cause of the metabolic derailment was found to be inhibition of 5-oxoprolinase by flucloxacillin.
JOURNAL OF BONE AND JOINT INFECTION
(2022)
Article
Nutrition & Dietetics
Qiong Wu, Jiankang Li, Jinghan Zhu, Xiaohui Sun, Di He, Jun Li, Zongxue Cheng, Xuhui Zhang, Yuying Xu, Qing Chen, Yimin Zhu, Maode Lai
Summary: This study identified the association between Gamma-Glu-Leu and 4 SNPs, and revealed the causal-effect relationships between Gamma-Glu-Leu and cardio-metabolic risk factors.
FRONTIERS IN NUTRITION
(2022)
Article
Immunology
Shifeng Sheng, Su Yan, Jingfeng Chen, Yuheng Zhang, Youxiang Wang, Qian Qin, Weikang Li, Tiantian Li, Meng Huang, Suying Ding, Lin Tang
Summary: It is predicted that by 2035, metabolic syndrome will be found in nearly more than half of our adult population, seriously affecting the health of our body. The gut microbiota is involved in metabolic syndrome, but the correlation between gut microbiota and metabolic syndrome with elevated gamma-glutamyl transpeptidase (GGT) has not been comprehensively studied. A recent study found significant changes in the gut microbiome composition in men with metabolic syndrome and abnormal GGT levels.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Naonori Kumagai, Tomomi Kondoh, Yuji Matsumoto, Yohei Ikezumi
Summary: Type 3 renal tubular acidosis is a rare pathological condition characterized by a combination of distal and proximal renal tubular acidosis. This case report presents a 5-year-old boy with cyclic vomiting syndrome and type 3 renal tubular acidosis. After treatment, the patient's symptoms improved and laboratory test results returned to normal.
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
