Journal
JOURNAL OF EMERGENCY MEDICINE
Volume 39, Issue 1, Pages 89-94Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jemermed.2009.07.021
Keywords
sepsis; lactic acid; infection; mortality; risk assessment
Categories
Funding
- National Institutes of Health/National Institute of Heart, Lung, and Blood [1R01HL091757-01A1]
- National Institute of General Medical Sciences [1P50GM076659-01]
- National Institutes of Health/National Institute of General Medical Sciences [K23GM083211]
- Novo Nordisk
- Eli Lilly
- Inverness
- Abbot Point of Care
- Hutchinson technologies
- American Heart Association [0735533T]
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Background: Prior studies show that lactate is a useful prognostic marker in sepsis. Objective: To study the feasibility and accuracy of a point-of-care (POC) analyzer capable of performing bedside serum lactate measurements; and to determine if other measurements (pH, base excess) are predictive of mortality. Methods: Design: prospective cohort study of adult (age 18 years or older) Emergency Department (ED) patients with suspected infection during the study period of May 2006 through March 2007. Setting: A 55,000-annual-visit urban tertiary care ED. Intervention: A point-of-care device (i-STAT, Abbott Point of Care Inc., Princeton, NJ) was deployed using a standardized training and quality assurance process. Using POC testing, we measured serum lactate, pH, and base excess, as well as concomitant lactate measurement via a central laboratory. Statistics: Area under the curve (AUC) for receiver operator characteristic curve, Bland-Altman statistics along with a correlation coefficient, and relative risk with 95% confidence intervals reported. Results: There were 699 patients enrolled, of whom 34 (4.9%) died. The AUCs for mortality prediction were: POC lactate 0.72, laboratory lactate 0.70, pH measurement 0.60, and base excess 0.60. Bland-Altman showed that POC lactate was, on average, 0.32 (95% confidence interval -0.35-0.98) lower than laboratory lactate, with agreement kappa = 0.97. Conclusions: A point-of-care testing device provides a reliable and feasible way to measure serum lactate at the bedside. The pH and base excess were less helpful. (C) 2010 Elsevier Inc.
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