Review
Biochemistry & Molecular Biology
Chengli Wen, Nathupakorn Dechsupa, Zehui Yu, Xu Zhang, Sicheng Liang, Xianying Lei, Tao Xu, Xiaolan Gao, Qinxue Hu, Phattarawadee Innuan, Jiraporn Kantapan, Muhan Lu
Summary: Pentagalloyl glucose (PGG) is a natural compound found in various plants and herbs that exhibits broad-spectrum anticancer properties and acts on multiple molecular targets and signaling pathways. It inhibits cancer growth, angiogenesis, and metastasis, and can enhance the efficacy of chemotherapy and radiotherapy. However, further research is needed to investigate the pharmacokinetics and safety profile of PGG to determine its clinical application in cancer therapy.
Article
Biochemistry & Molecular Biology
Jingxiang Zhao, Zhiqiang Zhao, Wanting Hou, Yue Jiang, Guobin Liu, Xuelian Ren, Kun Liu, Hong Liu, Kaixian Chen, He Huang
Summary: This study identified potential binding targets and non-canonical mechanisms of Hydroxychloroquine (HCQ) in the treatment of diseases such as pancreatic cancer. HCQ may target autophagy-related proteins and regulate gene expression to exert its therapeutic effects. These findings contribute to a better understanding of HCQ's role in the treatment of diseases.
Review
Pharmacology & Pharmacy
Javad Sharifi-Rad, Cristina Quispe, Amirhossein Rahavian, Joara Nalyda Pereira Carneiro, Janaina Esmeraldo Rocha, Antonio Linkoln Alves Borges Leal, Maria Flaviana Bezerra Morais Braga, Henrique Douglas Melo Coutinho, Anahita Ansari Djafari, Pedro Alarcon-Zapata, Miquel Martorell, Gizem Antika, Tugba Boyunegmez Tumer, Natalia Cruz-Martins, Pawel Helon, Paulina Paprocka, Wojciech Koch, Anca Oana Docea, Daniela Calina
Summary: This review provides updated information on the use of natural bioactive compounds for the prevention and treatment of sexually transmitted infections, highlighting their potential as adjuvant drugs in the pharmacotherapeutic management of STDs. The study emphasizes the biological effects of natural compounds against various microorganisms and suggests the need for extensive clinical trials and developments in pharmaceutical nanotechnologies for enhanced therapeutic efficacy.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Integrative & Complementary Medicine
Jin-Fang Chen, Shi-Wei Wu, Zi-Man Shi, Bing Hu
Summary: Colorectal cancer is a complex disease with a high risk of metastasis and involvement of multiple signaling pathways. Traditional Chinese medicine has a long history of preventing and treating this type of cancer by regulating various signaling pathways. This paper systematically summarizes the main signaling pathways and potential targets of traditional Chinese medicine in the treatment of colorectal cancer, providing a theoretical basis for its use and suggesting new ideas for further research and development of anti-cancer drugs for colorectal cancer.
Review
Plant Sciences
Fan Meng, Bin Guo, Yi-qing Ma, Kun-wei Li, Feng-ju Niu
Summary: Puerarin has been widely studied for its therapeutic role in eye diseases, exploring its diverse biological activities, clinical applications, and toxicity, with potential to improve treatment of diabetic retinopathy, retinal vascular occlusion, glaucoma and other ocular diseases.
Review
Pharmacology & Pharmacy
Zhi-Hua Yang, Bin Wang, Qian Ma, Lin Wang, Ya-Xin Lin, Hai-Feng Yan, Zi-Xuan Fan, Hao-Jia Chen, Zhao Ge, Feng Zhu, Hui-Jie Wang, Bao-Nan Zhang, Hai-Dong Sun, Li-Min Feng
Summary: COVID-19 is an emergent infectious pneumonia caused by SARS-CoV-2, and Chinese patent medicines have played an important role in prevention and treatment with significant therapeutic efficacy. This study focuses on analyzing the potential targets, drug composition, and mechanisms of Chinese patent medicines to provide valuable information for their clinical application in COVID-19 treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Mathieu Gauthe, Paul Sargos, Eric Barret, Gaelle Fromont-Hankard, Jean-Baptiste Beauval, Laurent Brureau, Gilles Crehange, Raphaele Renard-Penna, Charles Dariane, Gaelle Fiard, Romain Mathieu, Guilhem Roubaud, Alain Ruffion, Morgan Roupret, Guillaume Ploussard
Summary: Besides PSMA, there are other potential targets for prostate cancer theranostics in nuclear medicine, such as GRPR and androgen receptor, which may have greater potential in treating early-stage and low-grade prostate cancer. Theranostics in nuclear medicine will continue to develop, with promising molecules like radiolabeled fibroblast activation protein inhibitors requiring specific studies to assess their interest in prostate cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, Research & Experimental
Lu Ding, Hongyu Qi, Yisa Wang, Zepeng Zhang, Qing Liu, Chen Guo, Jiaqi Liu, Zhaoqiang Chen, Jing Li, JinJin Chen, Qingxia Huang, Daqing Zhao, Zeyu Wang, Xiangyan Li
Summary: This review summarizes the therapeutic effects and molecular mechanisms of ginsenosides in respiratory diseases. Ginsenosides, including Rb1, Rg1, Rg3, Rh2, and CK, have been shown to ameliorate pneumonia, fibrosis, and inhibit tumor progression through targeting various pathways. This review provides valuable insights for future research on ginsenosides for the treatment of respiratory diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Parina Asgharian, Abbas Pirpour Tazekand, Kamran Hosseini, Haleh Forouhandeh, Tohid Ghasemnejad, Maryam Ranjbar, Muzaffar Hasan, Manoj Kumar, Sohrab Minaei Beirami, Vahideh Tarhriz, Saiedeh Razi Soofiyani, Latipa Kozhamzharova, Javad Sharifi-Rad, Daniela Calina, William C. Cho
Summary: This article discusses the anticancer properties of quercetin as a natural bioactive compound. Quercetin inhibits tumor proliferation, invasion, and metastasis by modulating multiple signaling pathways and miRNA expression. Understanding the anticancer mechanisms of quercetin can help prevent and manage various types of cancer.
CANCER CELL INTERNATIONAL
(2022)
Review
Pharmacology & Pharmacy
Mahyar Ostadkarampour, Edward E. Putnins
Summary: Chronic inflammatory diseases have a significant impact on patients' quality of life and financial burden. Monoamine oxidase (MAO) inhibitor drugs have been shown to have anti-inflammatory effects, not only in CNS-associated diseases, but also in various non-CNS tissues. Understanding the mechanism(s) of action of MAO inhibitors is critical for their development as anti-inflammatories.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ruifeng Wang, Xin Shi, Kaikai Li, Alex Bunker, Chunmei Li
Summary: One distinguishing feature of the persimmon is its high proanthocyanidins content, known as persimmon tannin (PT), which has many health benefits. This review aims to summarize the literature on the relationship between PT structure and activity, as well as the potential mechanisms underlying its health benefits. The unique structure of PT and its conversion into oligomeric proanthocyanidins, along with its effects on lipogenic and inflammatory signaling pathways, fatty acid oxidation, gut microbiota, and absorption properties, contribute to its multiple health benefits.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Hardeep Singh Tuli, Ruchira Joshi, Diwakar Aggarwal, Ginpreet Kaur, Jagjit Kaur, Manoj Kumar, Nidarshana Chaturvedi Parashar, Md Asaduzzaman Khan, Katrin Sak
Summary: Plant-derived butein exhibits diverse anticancer effects, including antiangiogenic and antimetastatic activities. It interacts with multiple cellular targets and regulates various intracellular signal transduction pathways.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Immunology
Yongbiao Huang, Ye Yuan, Sheng Chen, Duo Xu, Lingyan Xiao, Xi Wang, Wan Qin, Bo Liu
Summary: This study aimed to investigate the therapeutic effects and underlying action mechanisms of vitamin D in COVID-19 and HCC. Through bioinformatics and network pharmacology analyses, we identified target genes and analyzed their prognostic significance in HCC patients. We developed a risk score model to evaluate the prognosis of HCC patients with COVID-19 and identified seven potential pharmacological targets of vitamin D. We also revealed the biological functions, signaling pathways, and TF-miRNA coregulatory network of vitamin D in COVID-19/HCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Shaojie Yang, Wanlin Dai, Jingnan Wang, Xiaolin Zhang, Yuting Zheng, Shiyuan Bi, Liwei Pang, Tengqi Ren, Ye Yang, Yang Sun, Zhuyuan Zheng, Shuodong Wu, Jing Kong
Summary: Cancer is a global health problem with high incidence and mortality rates. Osthole, a coumarin compound extracted from Cnidium monnieri (L.) Cuss., has shown promising anticancer effects. Studies have revealed that osthole inhibits cancer cell proliferation, induces apoptosis, suppresses migration and invasion, inhibits angiogenesis, enhances sensitivity to chemotherapy drugs, and reverses multidrug resistance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Minjee Kim, Hanul Choi, Young Bong Kim
Summary: This study focused on curcumin as a potential therapeutic agent for Zika virus, identifying TNF as the target with the strongest binding. In vitro experiments confirmed the anti-Zika effects of curcumin, indicating its promise for the treatment of ZIKV infections.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
