Journal
JOURNAL OF ELECTRON MICROSCOPY
Volume 60, Issue 1, Pages 95-99Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jmicro/dfq071
Keywords
active targeting liposome; colloidal gold; electron microscopy; arthritis; tumor; drug delivery
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Funding
- Japan Society for the Promotion of Science (JSPS) [20659232, 22591686]
- Grants-in-Aid for Scientific Research [20659232, 22591686, 23390348] Funding Source: KAKEN
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Active targeting of the liposome is an attractive strategy for drug delivery and in vivo bio-imaging. We previously reported the specific accumulation of Sialyl Lewis X (SLX) liposome to inflamed tissue in arthritic model mice or tumor-bearing mice. SLX-liposome encapsulation with fluorescent substances allows for the visualization of these liposomes by the time-dependent transvascular accumulation of fluorescent signals in the histological sections. In the present study, we developed a new SLX-liposome encapsulated with colloidal gold for transmission electron microscopic observation. We herein describe the characterization of the colloidal gold-loaded SLX-liposomes and demonstrate its specific targeting to the endothelial cells of tumor blood vessels in tumor-bearing mice.
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