Article
Chemistry, Applied
Hamidulla B. Tukhtaev, Stanislav I. Bezzubov, Elena A. Tarasenko, Mikhail Ya. Melnikov, Konstantin L. Ivanov, Ekaterina M. Budynina
Summary: A new method was developed for the design of diastereodivergent approach to phosphazenopyrrolines by switching step order within a cascade process. The strategy relies on the multifaceted roles of phosphazene intermediates in cascade transformation, providing a stereodivergent route to synthesize biorelevant compounds with different stereoisomers.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Ebenezer Ametsetor, Spencer Farthing, Richard A. Bunce
Summary: This article reports a new method for the synthesis of a novel compound, successfully producing the target product under specific conditions through a series of reaction steps. Key steps of the method include aza-Michael addition, SNAr ring closure, and oxidation to form indoles.
Article
Chemistry, Multidisciplinary
Daniela Pinheiro, Marta Pineiro, J. Sergio Seixas de Melo
Summary: The study introduces an aqueous all-organic redox flow battery with sulfonated tryptanthrin as an anolyte solution, reaching a high cell voltage of 0.94 V and maintaining stability during at least 50 working cycles.
COMMUNICATIONS CHEMISTRY
(2021)
Article
Engineering, Environmental
Qin Guo, Yang Zhou, Su-Yan Pang, Yuan Gao, Jiebin Duan, Juan Li, Jin Jiang
Summary: This study evaluated the transformation and detoxification of sulfamethoxazole (SMX) by permanganate (Mn(VII)) in the presence of humic constituents (HCs). The results showed that the presence of catechol (CAT) could rapidly degrade SMX, while alkaline conditions and excess Mn(VII) were unfavorable for SMX degradation. The transformation products of SMX had less acute toxicity than the parent compound, providing an efficient strategy for detoxifying SMX in water treatment.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Organic
Zhen-yu Lu, Wei-qiao Lan, Fang-yi Liu, Jun-yi Wang, Xiao-mei Zhang, Li-hua Liao
Summary: An efficient catalytic asymmetric [3 + 2] cyclization of 3-substituted indoles with p-benzoquinones has been achieved using binol-chiral phosphoric acid. A variety of C3 substituted benzofuroindolines compounds were synthesized in moderate to high yields (up to 91% yield) and excellent enantioselectivities (up to 94% ee).
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Organic
Jiaming Zou, Lei Xu, Yurong Tang, Wentao Wang, Yunfei Cai
Summary: The asymmetric synthesis of bridged tetrahydrobenzo[b]azepine and oxepine derivatives has been achieved through chiral Bri nsted acid catalyzed asymmetric aza-Piancatelli rearrangement/Michael addition sequence. The reaction proceeds under mild reaction conditions to afford the final bridged cyclic products in good yields with excellent enantio- and diastereoselectivities.
Article
Pharmacology & Pharmacy
Ilma Nugrahani, Muhammad Ramadhan Sulaiman, Chiaki Eda, Hidehiro Uekusa, Slamet Ibrahim
Summary: Recently, solid-state engineering has emerged as a promising method to enhance the stability and effectiveness of antibiotics. This study focuses on using antioxidant dihydroxybenzoic acid (DHBA) to react with Levofloxacin (LF) in order to produce a more stable compound and improve potency. Through screening and phase diagrams, two potential DHBA isomers, 2,6-DHBA and 3,5-DHBA, are identified as antioxidants that can react with LF in a (1:1) molar ratio. Multicomponent systems are prepared and their structures are confirmed through various analyses. The resulting salts, LF-26 and LF-35, show improved stability and approximately double the antibiotic potency compared to LF.
Article
Physics, Applied
Yuji Nakabayashi, Heisuke Sakai, Akio Miyazato, Chiko Shijimaya, Ryoichi Suzuki, Satoru Yamada
Summary: DHB crystal layers were formed using mist deposition, leading to the accurate analysis of lipid components such as cholesterols, diacylglycerides, and triglycerides. Using mass spectrometry imaging, these compounds were detected successfully with clearer mass images compared to conventional aerosol spray methods.
APPLIED PHYSICS EXPRESS
(2021)
Article
Chemistry, Physical
Ajay S. Bangwal, Manisha Chauhan, Prabhakar Singh
Summary: A series of double perovskite oxide materials were synthesized and their catalytic activity in alkaline medium was investigated. The results show that these materials exhibit catalytic activity for both oxygen evolution reaction (OER) and oxygen reduction reactions (ORR). Among them, Pr0.90Ba1.10Co2O6-δ shows the best activity in OER.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Chemistry, Multidisciplinary
Jie Ouyang, Rajat Maji, Markus Leutzsch, Benjamin Mitschke, Benjamin List
Summary: Here, we report the design of a highly enantioselective, catalytic (4 + 3) cycloaddition reaction enabled by strong and confined IDPi Lewis acids. This reaction allows the synthesis of novel compounds with multiple stereocenters from gem-dialkyl 2-indolylalcohols and dienolsilanes. The method exhibits broad substrate scope and versatile downstream chemical modifications. Density functional theory-supported mechanistic studies reveal the significance of the in-situ generated silylium species in an overall concerted yet asynchronous cycloaddition.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Applied
Deliang Meng, Xiaowei Huang, Zongyu Feng, Meng Wang, Juanyu Yang, Chao Xia, Yanyan Zhao, Yuqing Wei
Summary: This study designed an electrochemical experiment to monitor the reaction between Ce(4+) ions and Cl- ions at the electron level. The influences of Ce4+ ion concentration, temperature, and F- ion on the reduction peak potential of Ce4+ ion were investigated. The results showed that the reaction between Ce4+ ion and Cl- ion is irreversible without any intermediate products, and the diffusion during the electrode reaction is the rate-determining step. The temperature and Ce4+ ion concentration have negligible effects on the reduction peak potential, but a higher molar ratio of F- to Ce4+ promotes the reduction of Ce4+ ion to Ce(3+) ion. Furthermore, thiourea preferentially reduces Ce(4+) ions and inhibits the oxidation of Cl- ions to Cl2 by forming a complex with Cl- ions.
JOURNAL OF RARE EARTHS
(2022)
Article
Chemistry, Physical
Sundus Azhar, Khuram Shahzad Ahmad, Isaac Abrahams, Shaan Bibi Jaffri, Tenzin Ingsel, Ram K. Gupta, Daoud Ali
Summary: The study investigates the role of phyto-metabolites of Amaranthus viridis in the development of energy-active nanocomplex. The synthesis of doped nanocomplexes using a green route shows economic viability and ecological friendliness. The biomimetically prepared nanoparticles with different doping concentrations exhibit a bandgap range of 2.5 to 3.2 eV. XRD analysis reveals average crystallite sizes of 13.97, 19.64, 16.11, and 11.16 nm for doping concentrations of 2.5, 5, 7.5, and 10%, respectively. The synthesized doped nanoparticles have a porous sheet-like morphology. The material shows promising potential for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) with overpotential values of 154 mV and 445 mV, respectively. Cyclic voltammetry demonstrates the highest capacitance of 287 F/g at 2 mV/s.
Article
Chemistry, Analytical
Zeynep Ozyildiz, Dilan Gezer, Nahide Gulsah Deniz, Zeliha Gokmen, Ozlem Uguz Neli, Atif Koca
Summary: The class of quinone compounds is important in biologically redox-active compounds as they play significant roles in the bioactivation, metabolism/catabolism, and ligand-target interactions of redox-active drugs. This study focuses on the electrochemical and photoelectrochemical properties of amino(substituted)-1,4-naphthoquinone (NQ) derivatives. The synthesized NQ derivatives exhibit two reductions and one oxidation processes, with the reversibility of the redox processes being influenced by the substituent environments of the NQ structure.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Jia Chen Qian, Dan Liu, Li Ping Lin, Wen Jing Zhu, Ren Xiang Tan
Summary: This study demonstrates the presence of a family of low-abundance high-order indole oligomers in kimchi, derived from cruciferous vegetables. One of the indole tetramers exhibits significant toxicity towards tumor cells. The findings provide valuable information about kimchi and may inspire the development of indole-based molecules.
Article
Chemistry, Analytical
Geetika Bhardwaj, Randeep Kaur, Navneet Kaur, Narinder Singh
Summary: A new receptor R1 was synthesized and prepared as nanoparticles to detect azidothymidine. The nanoparticle probe showed better sensing performance for azidothymidine in various techniques such as cyclic voltammetry.
Article
Chemistry, Analytical
Razzagh Rahimpoor, Abdulrahman Bahrami, Davood Nematollahi, Farshid Ghorbani Shahna, Maryam Farhadian
Summary: In this study, a magnetic-dispersive solid-phase extraction (DSPE) method was developed for the extraction and desorption of muconic acid from real urine samples. Fe3O4-SiO2-NH2@ UiO-66 was used as a Metal-Organic Framework (MOF) in the DSPE for extraction followed by HPLC analysis. The method showed good detection limit, wide linear dynamic range, and high correlation coefficient, indicating its efficiency for the extraction and analysis of muconic acid from urine samples.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Faezeh Amri, Ali Niazi, Atisa Yazdanipour
Summary: This study introduces an analytical procedure for determining diazinon, malathion and chlorpyrifos in tomato samples using a pressure variation in-syringe dispersive liquid-phase microextraction method coupled with gas chromatography-mass spectrometry. The proposed method utilizes chloroform as the extraction solvent and employs experimental design methods. The calibration curves are linear and the determination coefficients are high for all three pesticides. The method also demonstrates good precision and low detection limits.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Maryam Kazemi, Ali Niazi, Atisa Yazdanipour
Summary: The study compared the efficiency of ultrasound-assisted extraction and microwave-assisted extraction for obtaining essential oils from Satureja rechingeri, and optimized the extraction parameters using response surface methodology. The results showed that both methods achieved high extraction yields of essential oils from S. rechingeri, with no significant difference between predicted and experimental data, indicating the models were highly capable of predicting extraction outcomes.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2022)
Article
Chemistry, Analytical
Mahmood Masoudi Khoram, Niloofar Mohamadighader, Davood Nematollahi, Sadegh Khazalpour, Hossein Masoumi, Hojjat Alizadeh
Summary: A green electrochemical method was developed for the synthesis of new spiro and dispiro pyrimidine derivatives. The reactivity of the nucleophile (barbituric acids) was found to be crucial in determining the type of product. The synthesized compounds showed good antibacterial performance against gram-positive bacteria.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Zahra Souri, Mahmood Masoudi Khoram, Davood Nematollahi, Mohammad Mazloum-Ardakani, Hojjat Alizadeh
Summary: Electrochemical oxidation of imipramine in aqueous solutions was studied, showing a complex behavior at different pH values. The oxidation of imipramine at a pH of about 5 led to the formation of a unique dimer, which was fully characterized. A possible reaction mechanism for the oxidation process was proposed. The synthesized dimer exhibited fluorescence activity and good antibacterial performance.
SCIENTIFIC REPORTS
(2022)
Article
Electrochemistry
Faezeh Zivari-Moshfegh, Davood Nematollahi
Summary: A new derivative of desloratadine (DQ-TBC complex) was synthesized for the first time using a green electrochemical method. The electrooxidation of 4-tert-butylcatechol (TBC) in the presence of desloratadine (DES) was investigated to optimize the synthesis conditions of DQ-TBC complex. The results suggest that the electrooxidation of TBC in the presence of DES leads to DQ through an ECE mechanism. The synthesized compound showed promising antibacterial activity against Bacillus cereus and Staphylococcus aureus.
ELECTROCHIMICA ACTA
(2022)
Article
Electrochemistry
Heydar Hameed Salman Arkwazee, Niloofar Mohamadighader, Davood Nematollahi, Arash Rabiee, Hojjat Alizadeh
Summary: This article describes a method for synthesizing new sulfonamide derivatives using electrochemical methods without toxic reagents, and finds that these products have good antibacterial performance against bacteria.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Electrochemistry
Niloofar Mohamadighader, Davood Nematollahi, Mahnaz Saraei
Summary: Electrochemical oxidation of phenothiazine in an acetonitrile/water mixture was investigated, revealing that the oxidation pathway varies with respect to pH. The results led to the synthesis of two new types of PTZ dimer and provided insights into the oxidation mechanism of PTZ.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Razzagh Rahimpoor, Ali Firoozichahak, Saber Alizadeh, Houman Serkan, Davood Nematollahi
Summary: This paper synthesized an aluminum-based metal-organic framework and utilized it in high-performance liquid chromatography for the reliable determination of cyclophosphamide in urine samples. By optimizing various parameters, satisfactory measurement results and recovery rates were obtained.
Article
Electrochemistry
Mohammad Reza Talebi, Davood Nematollahi, Ahmad Reza Massah
Summary: The electrochemical oxidation of N-(4-aminophenyl) and N-(4-hydroxyphenyl)benzenesulfonamide derivatives was investigated at different pH values and concentrations. The oxidation potential and mechanism of these compounds were found to be pH dependent. The oxidation products were found to undergo hydroxylation and/or dimerization reactions. The adsorption behavior and oxidation products under conditions similar to the human body were also studied.
ELECTROCHIMICA ACTA
(2023)
Article
Electrochemistry
Faezeh Zivari-Moshfegh, Fereshteh Javanmardi, Davood Nematollahi
Summary: The electrochemical behavior of rifampicin, an anti-tuberculosis drug, was studied in a water/ethanol mixture. The drug was found to undergo two-step oxidation, with the first step being a reversible oxidation of the hydroquinone moiety and the second step being an irreversible oxidation of the phenolic ring. The adsorption activity and diffusion coefficient of rifampicin were also determined, indicating that the first oxidation step is diffusion-controlled and the second step is a diffusion/adsorption control process. The oxidation of rifampicin was found to be complex and highly pH-dependent, with different rates of reaction observed for different drugs used in combination therapy.
ELECTROCHIMICA ACTA
(2023)
Article
Chemistry, Applied
Masoomeh Naseri, Ali Niazi, Kowsar Bagherzadeh, Elahe Konoz, Hamid Reza Samadikhah
Summary: An ultrasensitive electrochemical aptasensor based on modified glassy carbon electrode was developed to detect tetracycline in food samples. Molecular docking and molecular dynamic simulations were used to study the affinity and stability of antibiotics-aptamers complexes. The aptasensor, using kanamycin-specific aptamer, achieved a wide dynamic linear range and low limit of detection for tetracycline in milk samples.
Article
Electrochemistry
Faezeh Zivari-Moshfegh, Davood Nematollahi
Summary: This study investigates the toxic metabolites formed from the oxidation of rifampicin and acetaminophen in the body. It provides strong evidence of a catalytic reaction between vitamin C and the oxidized form of rifampicin. Additionally, contrary to previous reports, this study discovers another catalytic reaction between oxidized acetaminophen and rifampicin.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Electrochemistry
Zahra Godini, Davood Nematollahi, Faezeh Zivari-Moshfegh
Summary: In this study, the electrochemical complexation of five azole antifungal drugs with silver, copper and zinc cations was conducted in an undivided electrolytic cell. Twenty complexes were synthesized using a simple method in water/ethanol mixtures with high yield and purity. The applied current and acid concentration were found to have no significant effects on the yield and purity of the complexes, but they did affect the cell voltage and energy consumption.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Pouria Patoghi, Ali Sadatnabi, Davood Nematollahi
Summary: In this study, a new convergent paired electro-organic synthesis method for sulfonamide derivatives was introduced, which follows the principles of green chemistry and does not require catalysts, oxidants, halogens, or amines. Instead of using toxic amine compounds, an innovative mechanism based on the reduction of nitro compounds and in-situ production of amine compounds was used. The mechanism involves cathodic reduction of nitro compounds to hydroxylamine compounds and anodic oxidation of hydroxylamine compounds to nitroso compounds.
SCIENTIFIC REPORTS
(2023)
