Article
Neurosciences
Petra Heiden, Mauritius Hoevels, Dilruba Bayram, Juan C. Baldermann, Thomas Schueller, Daniel Huys, Veerle Visser-Vandewalle, Pablo Andrade
Summary: This study analyzed the connectivity profiles of different DBS targets for GTS and found significant differences in the connectivity profiles of standard targets. The pvGPi showed the strongest connection to the sensorimotor cortex, while the amGPi showed the strongest connection to the prefrontal cortex. Using probabilistic tractography based on patient data and a normative connectome revealed differences in connectivity profiles.
Article
Behavioral Sciences
Aijun Liu, Yongcheng Jiao, Shaohui Zhang, Haibo Kong
Summary: Bilateral posteroventral GPi DBS can significantly alleviate motor tics and depressive symptoms in GTS patients, but vocal tics and other psychiatric symptoms may worsen without statistical difference during the follow-up period.
BRAIN AND BEHAVIOR
(2022)
Article
Clinical Neurology
K. R. Mueller-Vahl, N. Szejko, A. Saryyeva, C. Schrader, D. Krueger, A. Horn, A. A. Kuehn, J. K. Krauss
Summary: This study compared the efficacy and safety of deep brain stimulation (DBS) in Gilles de la Tourette syndrome (GTS), finding that the initial effect of pvl GPi DBS was superior to thalamic DBS. While half of the patients discontinued treatment, some individuals continued to benefit from thalamic DBS after years.
Article
Psychiatry
Bina Kakusa, Sabir Saluja, Daniel A. N. Barbosa, Sam Cartmell, Flint M. Espil, Nolan R. Williams, Jennifer A. McNab, Casey H. Halpern
Summary: In this study, diffusion MRI tractography was used to investigate the structural connectivity of thalamic subregions associated with Gilles de la Tourette syndrome (GTS). The results revealed high streamline probability from the centromedian-parafascicular complex (CM) and the ventro-lateral thalamus (VLp) to various brain regions, suggesting that stimulating these areas could enhance symptom control for GTS patients.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Lulin Dai, Wenying Xu, Yunhai Song, Peng Huang, Ningfei Li, Barbara Hollunder, Andreas Horn, Yiwen Wu, Chencheng Zhang, Bomin Sun, Dianyou Li
Summary: This study found that STN-DBS treatment can significantly improve symptoms in patients with GTS, with minimal side effects. STN as a potential target for DBS modulates GTS symptoms through functional connectivity with other relevant brain areas.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Justyna Kaczynska, Piotr Janik
Summary: This study evaluated the prevalence, age of onset, and clinical correlates of blocking tics (BTs) in patients with Gilles de la Tourette syndrome (GTS). BTs represent early and common symptoms of GTS, associated with a more severe form of the syndrome.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neuroimaging
Alexander Muenchau, Lorenza S. Colzato, Azam AghajaniAfjedi, Christian Beste
Summary: This paper proposes an exploration of the characteristics and potential explanations of Tourette syndrome, focusing on neural noise and its adaptation in information processing. Through neurophysiological and imaging approaches, further investigation into the pathophysiology of Tourette syndrome is essential to pave the way for novel interventions targeting neural noise levels and patterns directly in Tourette syndrome.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Junghan Lee, Kyung Won Chang, Hyun Ho Jung, Dre Kim, Jin Woo Chang, Dong-Ho Song
Summary: This study retrospectively reviewed the outcomes of 20 patients with refractory TS who underwent DBS targeting the anteromedial globus pallidus internus in a single center in Korea. Improvement in tic symptoms was observed within 1 year after DBS, and initial responders showed larger treatment effects during the 1-year follow-up. Patients with serious self-injurious behaviors tended to show delayed responses.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Medicine, General & Internal
Piotr Janik, Anna Dunalska, Natalia Szejko, Andrzej Jakubczyk
Summary: Coprolalia and echophenomena repetition known as CTPh are rare in Gilles de la Tourette syndrome (GTS) patients, with a higher occurrence in adolescence and adulthood. As patients age, the severity of tics increases and anxiety disorder is significantly associated with CTPh, indicating that they may be part of the tic spectrum and are age-related symptoms of GTS.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Theresa Paulus, Lynn Wernecke, Annik Lundie, Julia Friedrich, Julius Verrel, Tina Rawish, Anne Weissbach, Christian Frings, Christian Beste, Tobias Baeumer, Alexander Muenchau
Summary: Research shows that inhibitory repetitive transcranial magnetic stimulation (rTMS) applied to the left BA40 is not effective in alleviating tic symptoms in GTS patients. The left BA40 does not appear to be a useful target for modulating tic symptoms in GTS.
Article
Psychiatry
Ryunosuke Goto, Natsumi Matsuda, Maiko Nonaka, Yu Hamamoto, Yosuke Eriguchi, Mayu Fujiwara, Akane Suzuki, Yukari Yokoyama, Yukiko Kano
Summary: This study provides evidence on the validity and reliability of the GTS-QOL scale in Japanese patients with GTS, making it an effective tool for measuring disease-specific HR-QOL in this population.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Zahra Aminzade, Sepand Tehrani Fateh, Reza Jalili Khoshnoud, Farzad Ashrafi, Mehri Salari
Summary: DBS procedure significantly improved OCD symptoms but had little effect on tics in a patient with refractory Gilles de la Tourette syndrome. Different adjustments led to variations in symptoms. It is suggested that pathways and circuits should be targeted for DBS treatment instead of single components.
CLINICAL CASE REPORTS
(2021)
Review
Clinical Neurology
Anna Latorre, Lorenzo Rocchi, Anna Sadnicka
Summary: This review showcases novel methods of neural stimulation for hyperkinetic movement disorders, focusing on both central and peripheral biomarkers and interventions. Current innovations are changing stimulation strategies by integrating technological advances and machine learning for optimization.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Ahmad Seif Kanaan, Dongmei Yu, Riccardo Metere, Andreas Schaefer, Torsten Schlumm, Berkin Bilgic, Alfred Anwandera, Carol A. Mathews, Jeremiah M. Scharf, Kirsten Mueller-Vahl, Harald E. Moeller
Summary: Quantitative susceptibility mapping (QSM) was performed on 28 patients with Gilles de la Tourette syndrome (GTS) and 26 matched controls, revealing significant reductions in brain iron content in GTS patients. Tic severity was negatively associated with striatal susceptibility. Correlations between susceptibility reductions and gene-expression patterns suggest disruptions in iron regulatory mechanisms are involved in GTS pathophysiology.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Genetics & Heredity
Amanda M. Levy, Peristera Paschou, Zeynep Tumer
Summary: GTS is a childhood-onset neurodevelopmental and psychiatric disorder that is often comorbid with OCD and ADHD. Genetic factors play a significant role in disease etiology, but identifying major susceptibility genes has been challenging due to the complex interplay between multiple genetic factors and environmental influences.
