Article
Chemistry, Multidisciplinary
Shan He, Wei Pang, Xiaoyu Wu, Yang Yang, Wenjun Li, Hang Qi, Chongling Sun, Xuexin Duan, Yanyan Wang
Summary: This study proposes a hydrodynamic intracellular delivery system based on the gigahertz acoustic streaming effect, which allows for tunable delivery range by adjusting the acoustic streaming radius. With the assistance of acoustic streaming, AuNRs with different modifications can be targetedly delivered to specific organelles. Additionally, the large quantities of AuNRs introduced via acoustic streaming demonstrate a photothermal effect, which has the potential to shorten the treatment cycle of photothermal therapy. This efficient hydrodynamic technology provides a new idea for precise medical treatment.
Article
Chemistry, Multidisciplinary
Cristina Ana Mocanu, Elena Valeria Fuior, Geanina Voicu, Daniela Rebleanu, Florentina Safciuc, Mariana Deleanu, Ioana Madalina Fenyo, Virginie Escriou, Ileana Manduteanu, Maya Simionescu, Manuela Calin
Summary: The newly developed Psel-lipo/shRAGE lipoplexes reduce the inflammatory processes associated with RAGE signaling and the progression of atherosclerosis in ApoE-deficient mice. Downregulation of RAGE employing these lipoplexes may represent a promising new targeted therapy to block atherosclerosis progression.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Ines Beekers, Simone A. G. Langeveld, Bram Meijlink, Antonius F. W. van der Steen, Nico de Jong, Martin D. Verweij, Klazina Kooiman
Summary: This study investigated the interaction between microbubbles and endothelial cells during drug delivery. It found that targeted microbubbles were internalized by the cells, leading to changes in microbubble oscillation and resulting membrane perforation. The study provides important insights into the mechanisms of microbubble-mediated drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Materials Science, Biomaterials
Sensen Zhou, Cheng Li, Yang Yuan, Lei Jiang, Weizhi Chen, Xiqun Jiang
Summary: This study reports a novel tumor-targeted liposome based on the protein-anchored cell membrane architecture. The liposome, called dtDLP, was constructed through the electrostatic interaction between dendritic lipopeptide liposomes and a dual-targeted recombinant protein, and it demonstrated superior tumor homing, cellular endocytotic, and penetration abilities.
BIOMATERIALS SCIENCE
(2022)
Review
Biotechnology & Applied Microbiology
Haoyue Song, Xiaohang Chen, Yujia Hao, Jia Wang, Qingpeng Xie, Xing Wang
Summary: This review comprehensively summarizes the potential and challenges of natural endogenous extracellular vesicles (EVs) in precision medicine drug delivery systems. The strategies to improve targeting specificity, such as nanoengineering techniques to modify source cells and EVs surfaces, as well as auxiliary strategies to change the external environment, are discussed. The lack of a gold standard for assessing targeting efficiency in contemporary issues is also highlighted.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Anshuman Dasgupta, Tao Sun, Elena Rama, Alessandro Motta, Yongzhi Zhang, Chanikarn Power, Diana Moeckel, Stecia-Marie Fletcher, Mirjavad Moosavifar, Roman Barmin, Celine Porte, Eva Miriam Buhl, Celine Bastard, Roger M. Pallares, Fabian Kiessling, Nathan Mcdannold, Samir Mitragotri, Twan Lammers
Summary: This study demonstrates the design and application of a novel microbubble (MB) system that can better penetrate the blood-brain barrier (BBB) and deliver drugs effectively by altering the shape and surface modification. In vitro and in vivo experiments show that rod-shaped MBs efficiently bind to BBB endothelium and generate stronger cavitation effects compared to traditional spherical MBs, resulting in enhanced drug delivery.
ADVANCED MATERIALS
(2023)
Article
Hematology
Eilam Yeini, Ronit Satchi-Fainaro
Summary: Cell adhesion molecules play a critical role in cellular interactions, and P-Selectin (SELP) is particularly involved in thrombosis and cancer progression.
THROMBOSIS RESEARCH
(2022)
Article
Engineering, Biomedical
Alina Zenych, Charlene Jacqmarcq, Rachida Aid, Louise Fournier, Laura M. Forero Ramirez, Frederic Chaubet, Thomas Bonnard, Denis Vivien, Didier Letourneur, Cedric Chauvierre
Summary: The development of fucoidan-functionalized hydrogel polysaccharide submicroparticles as a nanocarrier for targeted thrombolysis using alteplase has shown promising results in vitro and in vivo, demonstrating improved clot dissolution and reduced post-ischemic cerebral infarct lesions and blood-brain barrier permeability in a murine model of acute thromboembolic ischemic stroke.
Review
Pharmacology & Pharmacy
J. Angel Navarro-Becerra, Mark A. Borden
Summary: Microbubbles, with a diameter of 1-10 & mu;m, are gas-filled particles stabilized by a phospholipid monolayer shell. They can be used as targeted ultrasound imaging probes and carriers for drug and cell delivery. This review summarizes current targeted microbubble (tMB) formulations and their applications in ultrasound-targeted delivery. The review also discusses different strategies to enhance local delivery, improve therapeutic efficacy, and minimize side effects, as well as future directions for improving tMB performance in diagnostic and therapeutic applications.
Article
Biochemistry & Molecular Biology
Nikita Yabbarov, Elena Nikolskaya, Maria Sokol, Mariia Mollaeva, Margarita Chirkina, Irina Seregina, Mikhail Gulyaev, Yury Pirogov, Rem Petrov
Summary: This study demonstrates a dual-targeting drug delivery strategy that enhances the therapeutic efficacy by simultaneously targeting tumor endothelium and cell surface receptors. By functionalizing the nanodevice with selectin ligand and alpha-fetoprotein receptor-binding peptide, the strategy increases the accumulation and antitumor effect of the drug in tumor tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jayoung Kim, Hannah J. Vaughan, Camila G. Zamboni, Joel C. Sunshine, Jordan J. Green
Summary: A new high-throughput method has been developed to evaluate polymeric nanoparticle libraries for tissue-specific gene delivery in vivo. Nanoparticles were found to mainly accumulate in clearance organs, with transfection efficiency not necessarily correlating with tissue accumulation levels. This study validates the effectiveness of the new method in accurately assessing systemic gene delivery.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Rui Li, Yiming Zhou, Yijia Liu, Xingpeng Jiang, Wenlong Zeng, Zhuoran Gong, Gang Zheng, Desheng Sun, Zhifei Dai
Summary: In this study, a targeted silicon phthalocyanine was synthesized and modified to achieve high accumulation in TNBC cells. In vitro experiments showed significant apoptosis of tumor cells with the targeted silicon phthalocyanine, while the non-targeted photosensitizer exhibited no such effect. This study indicates that the targeted silicon phthalocyanine has great potential for TPDT treatment of TNBC.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Chemistry, Multidisciplinary
Mike Bismuth, Michal Eck, Tali Ilovitsh
Summary: Ultrasound insonation of microbubbles can form transient pores in cell membranes, which can be utilized to deliver non-permeable molecules to cells. By reducing the size of microbubbles to the nanometer range, the extravasation of nanobubbles into tumors can be enhanced, providing a noninvasive sonoporation platform. Coupling nanobubbles with low frequency ultrasound can achieve high amplitude oscillations, facilitating low energy sonoporation of cancer cells. This method offers potential for noninvasive cancer treatment and gene therapy applications.
Article
Chemistry, Multidisciplinary
Roman A. Barmin, Mirjavad Moosavifar, Anshuman Dasgupta, Andreas Herrmann, Fabian Kiessling, Roger M. Pallares, Twan Lammers
Summary: Ultrasound (US) is widely used for diagnostic imaging and treatment, and polymeric materials with cavitation nuclei properties can enhance US imaging and promote local drug delivery. This review discusses engineered polymeric materials, such as microbubbles and gas-releasing nanoparticles, that respond to US and their formulation aspects. It focuses on microbubbles and explores the chemical toolbox to enhance their performance in US imaging and drug delivery. The review also summarizes the emerging applications of polymeric microbubbles in molecular imaging, sonopermeation, and gas and drug delivery, highlighting their potential in US imaging and therapy.
Review
Pharmacology & Pharmacy
Prashant Kesharwani, Rahul Chadar, Afsana Sheikh, Waleed Y. Rizg, Awaji Y. Safhi
Summary: Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in various solid tumors. It plays a significant role in cell proliferation, cell-to-cell interaction, cellular migration, inflammation, and immune responses. Nanocarriers have been developed to target the CD44 receptor and improve the efficacy of chemotherapy. Hyaluronic acid (HA) also plays a crucial role in cancer therapy and interacts with CD44, providing a potential approach for targeted therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Benjamin B. Kasten, Patsy G. Oliver, Harrison Kim, Jinda Fan, Soldano Ferrone, Kurt R. Zinn, Donald J. Buchsbaum
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Romone M. Fancy, Harrison Kim, Tiara Napier, Donald J. Buchsbaum, Kurt R. Zinn, Yuhua Song
JOURNAL OF CELLULAR BIOCHEMISTRY
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin B. Kasten, Abhishek Gangrade, Harrison Kim, Jinda Fan, Soldano Ferrone, Cristina R. Ferrone, Kurt R. Zinn, Donald J. Buchsbaum
NUCLEAR MEDICINE AND BIOLOGY
(2018)
Article
Oncology
Christos Vaklavas, Kurt R. Zinn, Sharon L. Samuel, Zheng Meng, William E. Grizzle, Hyoungsoo Choi, Scott W. Blume
Article
Biochemistry & Molecular Biology
Kiel D. Neumann, Joseph E. Blecha, Thomas R. Hayes, Tony Huynh, Chih-Kai Chao, Nicolas Guilloteau, Kurt R. Zinn, Henry F. VanBrocklin, Charles M. Thompson, John M. Gerdes
ACS CHEMICAL NEUROSCIENCE
(2018)
Review
Biochemistry & Molecular Biology
Benjamin B. Kasten, Soldano Ferrone, Kurt R. Zinn, Donald J. Buchsbaum
CURRENT MEDICINAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Christopher M. Gentile, Anton V. Borovjagin, Jillian R. Richter, Aditi H. Jani, Hongju Wu, Kurt R. Zinn, Jason M. Warram
Article
Multidisciplinary Sciences
Thomas R. Hayes, Joseph E. Blecha, Chih-Kai Chao, Tony L. Huynh, Henry D. VanBrocklin, Kurt R. Zinn, Palmer W. Taylor, John M. Gerdes, Charles M. Thompson
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jacqueline Pei, Georgina Juniper, Nynke S. van den Berg, Naoki Nisho, Trevor Broadt, Anthony R. Welch, Grace S. Yi, Roan C. Raymundo, Stefania U. Chirita, Guolan Lu, Giri Krishnan, Yu-Jin Lee, Shrey Kapoor, Quan Zhou, A. Dimitrios Colevas, Natalie S. Lui, George A. Poultsides, Gordon Li, Kurt R. Zinn, Eben L. Rosenthal
Summary: The study demonstrated that Panitumumab-IRDye800CW was safe and stable to administer over a 54-month window with a low rate of adverse events (7.4%), which is consistent with the rate associated with Panitumumab alone. This data supports re-purposing therapeutic antibodies as diagnostic imaging agents with limited preclinical toxicology studies.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Chemistry, Medicinal
Thomas R. Hayes, Chih-Kai Chao, Joseph E. Blecha, Tony L. Huynh, Kurt R. Zinn, Charles M. Thompson, John M. Gerdes, Henry F. VanBrocklin
Summary: The study focused on developing molecular imaging tools using radiolabeled OP analog tracers to assess reactivated AChE activity in vivo. Carbon-11 and fluorine-18 radiolabeled analog tracers of VX and sarin OP agents were prepared and evaluated in normal rats. The [18F]VX analog tracer showed the most favorable values for various metrics, making it the optimal tracer for future OP exposure and reactivation studies.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Nathan Kauffman, Satyendra Kumar Singh, James Morrison, Kurt R. Zinn
Summary: This study demonstrates the successful inhibition of breast cancer growth (4T1 and EO771) using radiolabeled macroaggregated albumin particles (Bi-212-MAA) as a form of radiation therapy, which showed stable biodistribution in vivo. The potential of this approach can be extended and applied in larger animal models and human clinical trials.
FRONTIERS IN CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Nathan Kauffman, James Morrison, Kevin O'Brien, Jinda Fan, Kurt R. Zinn
Summary: A paradigm shift is occurring in cancer diagnosis and therapy with radiopharmaceuticals. This strategy involves using diagnostic imaging to measure tumor uptake of radioactive agent X to select patients for therapy with radioactive agent Y. X-Y pairs, known as radiotheranostics, are being evaluated for intra-arterial dosing to enhance tumor targeting and improve imaging and therapy. Clinical trials are underway to assess these new therapeutic approaches, including the use of alpha-particle therapy with short-lived radioisotopes.
Article
Chemistry, Analytical
Monica J. Jacobs, Morgan K. Geiger, Suzanne E. Summers, Charles P. DeLuca, Kurt R. Zinn, Dana M. Spence
Summary: The glycation of serum albumin affects the binding of C-peptide and Zn2+ to red blood cells (RBCs), as well as the subsequent release of ATP. This has implications for C-peptide therapy in individuals with type 1 diabetes.
ACS MEASUREMENT SCIENCE AU
(2022)
Article
Biochemical Research Methods
Yueli Liu, Laura E. Hesse, Morgan K. Geiger, Kurt R. Zinn, Timothy J. McMahon, Chengpeng Chen, Dana M. Spence
Summary: A set of 3D-printed analytical devices were developed to investigate the effects of different storage solutions on erythrocytes in transfusion medicine. The results showed that hyperglycemic conditions permanently alter erythrocyte deformability and reduce ATP release. However, normal glycemic storage can mitigate the storage lesion.
Article
Chemistry, Multidisciplinary
Seyedmehdi Hossaini Nasr, Zahra Rashidijahanabad, Sherif Ramadan, Nate Kauffman, Narayanan Parameswaran, Kurt R. Zinn, Chunqi Qian, Ripla Arora, Dalen Agnew, Xuefei Huang