Strategies on the nuclear-targeted delivery of genes

A Comparison of DNA Compaction by Arginine and Lysine Peptides: A Physical Basis for Arginine Rich Protamines

(2013) Jason DeRouchey et al.   BIOCHEMISTRY

The effect of a nuclear localization sequence on transfection efficacy of genes delivered by cobalt(II)–polybenzimidazole complexes

(2012) Jun Yin et al.   BIOMATERIALS

Development of a novel histone H1-based recombinant fusion peptide for targeted non-viral gene delivery

(2012) Fatemeh Soltani et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Ternary Complexes with Core-Shell Bilayer for Double Level Targeted Gene Delivery: In Vitro and In Vivo Evaluation

(2012) Ying Fan et al.   PHARMACEUTICAL RESEARCH

Enhanced Nuclear Import and Transfection Efficiency of TAT Peptide-Based Gene Delivery Systems Modified by Additional Nuclear Localization Signals

(2011) Wen-Jie Yi et al.   BIOCONJUGATE CHEMISTRY

Quantitative Analysis of Tat Peptide Binding to Import Carriers Reveals Unconventional Nuclear Transport Properties

(2011) Francesco Cardarelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor

(2011) Jun Li et al.   JOURNAL OF CONTROLLED RELEASE

Systemic Delivery of siRNA via LCP Nanoparticle Efficiently Inhibits Lung Metastasis

(2011) Yang Yang et al.   MOLECULAR THERAPY

Efficient Gene Transfection by Histidine-Modified Chitosan through Enhancement of Endosomal Escape

(2010) Kai-Ling Chang et al.   BIOCONJUGATE CHEMISTRY

Intranuclear DNA Release Is a Determinant of Transfection Activity for a Non-viral Vector: Biocleavable Polyrotaxane as a Supramolecularly Dissociative Condenser for Efficient Intranuclear DNA Release

(2010) Yuma Yamada et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Biotinylated transferrin/avidin/biotinylated disulfide containing PEI bioconjugates mediated p53 gene delivery system for tumor targeted transfection

(2010) Xuan Zeng et al.   BIOMATERIALS

Acid-transforming polypeptide micelles for targeted nonviral gene delivery

(2010) Min Suk Shim et al.   BIOMATERIALS

Targeted minicircle DNA delivery using folate–poly(ethylene glycol)–polyethylenimine as non-viral carrier

(2010) Chao Zhang et al.   BIOMATERIALS

Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery

(2010) Makoto Oba et al.   BIOMATERIALS

Endosome-disruptive peptides for improving cytosolic delivery of bioactive macromolecules

(2010) Ikuhiko Nakase et al.   BIOPOLYMERS

Cyclic stretch of alveolar epithelial cells alters cytoskeletal micromechanics

(2010) Mootaz Eldib et al.   BIOTECHNOLOGY AND BIOENGINEERING

Enhanced growth inhibition of metastatic lung tumors by intravenous injection of ATRA-cationic liposome/IL-12 pDNA complexes in mice

(2010) P Charoensit et al.   CANCER GENE THERAPY

Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

(2010) I Goldstein et al.   CANCER GENE THERAPY

Pericentrin contains five NESs and an NLS essential for its nucleocytoplasmic trafficking during the cell cycle

(2010) Qinying Liu et al.   CELL RESEARCH

Identification of two functional nuclear localization signals mediating nuclear import of liver receptor homologue-1

(2010) Feng-Ming Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Exceptional structural and mechanical flexibility of the nuclear pore complex

(2010) Ivan Liashkovich et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Folate mediated in vitro targeting of depolymerised trimethylated chitosan having arginine functionality

(2010) Viola B. Morris et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

Controlled nonviral gene delivery and expression using stable neural stem cell line transfected with a hypoxia-inducible gene expression system

(2010) Meng-Lu Liu et al.   JOURNAL OF GENE MEDICINE

Structure and Function of a Genetically Engineered Mimic of a Nonenveloped Virus Entry Intermediate

(2010) M. Banerjee et al.   JOURNAL OF VIROLOGY

Imaging multiple intermediates of single-virus membrane fusion mediated by distinct fusion proteins

(2010) Kye-Il Joo et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Learning from the Viral Journey: How to Enter Cells and How to Overcome Intracellular Barriers to Reach the Nucleus

(2009) Diky Mudhakir et al.   AAPS Journal

Identification of a nuclear localization signal in the polo box domain of Plk1

(2009) Moon-Sing Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cytosolic Targeting of Macromolecules Using a pH-Dependent Fusogenic Peptide in Combination with Cationic Liposomes

(2009) Sachiko Kobayashi et al.   BIOCONJUGATE CHEMISTRY

Transferrin Receptor-Targeted Liposomes Encapsulating anti-BCR-ABLsiRNA or asODN for Chronic Myeloid Leukemia Treatment

(2009) Liliana S. Mendonça et al.   BIOCONJUGATE CHEMISTRY

All-trans-retinoic acid (ATRA)-grafted polymeric gene carriers for nuclear translocation and cell growth control

(2009) Kyong Mi Park et al.   BIOMATERIALS

Masking and triggered unmasking of targeting ligands on nanocarriers to improve drug delivery to brain tumors

(2009) Kathleen M. McNeeley et al.   BIOMATERIALS

Multi-layered nanoparticles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process

(2009) Hidetaka Akita et al.   BIOMATERIALS

Cell-penetrating macromolecules: Direct penetration of amphipathic phospholipid polymers across plasma membrane of living cells

(2009) Tatsuro Goda et al.   BIOMATERIALS

Fusogenic activity of cationic lipids and lipid shape distribution

(2009) Caroline Lonez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nucleolar targeting: the hub of the matter

(2009) Edward Emmott et al.   EMBO REPORTS

Flexible Gates: Dynamic Topologies and Functions for FG Nucleoporins in Nucleocytoplasmic Transport

(2009) Laura J. Terry et al.   EUKARYOTIC CELL

High mobility group box 1 protein enhances polyethylenimine mediated gene delivery in vitro

(2009) Yuan Shen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Enhancement of gene transfection into human dendritic cells using cationic PLGA nanospheres with a synthesized nuclear localization signal

(2009) Takanori Kanazawa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape

(2009) Ayman El-Sayed et al.   JOURNAL OF CONTROLLED RELEASE

Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection

(2009) Richard N. Cohen et al.   JOURNAL OF CONTROLLED RELEASE

Missing pieces in understanding the intracellular trafficking of polycation/DNA complexes

(2009) You-Yeon Won et al.   JOURNAL OF CONTROLLED RELEASE

Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives

(2009) Eun Ju Oh et al.   JOURNAL OF CONTROLLED RELEASE

Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA

(2009) Swati Koppu et al.   JOURNAL OF CONTROLLED RELEASE

Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery

(2009) Jun Li et al.   JOURNAL OF CONTROLLED RELEASE

The efficiency of nuclear plasmid DNA delivery is a critical determinant of transgene expression at the single cell level

(2009) Dominic J. Glover et al.   JOURNAL OF GENE MEDICINE

Combinatorial Evaluation of Cations, pH-sensitive and Hydrophobic Moieties for Polymeric Vector Design

(2009) Sharon Y Wong et al.   MOLECULAR THERAPY

Fabrication of a Novel Core-Shell Gene Delivery System Based on a Brush-Like Polycation of α, β–Poly (L-Aspartate-Graft-PEI)

(2009) Jia-Hui Yu et al.   PHARMACEUTICAL RESEARCH

Characterization of a multifunctional PEG-based gene delivery system containing nuclear localization signals and endosomal escape peptides

(2008) Nicole M. Moore et al.   Acta Biomaterialia

Extracellular barriers in respiratory gene therapy

(2008) Niek Sanders et al.   ADVANCED DRUG DELIVERY REVIEWS

Simultaneous and bidirectional transport of kinesin-coated microspheres and dynein-coated microspheres on polarity-oriented microtubules

(2008) Ryuji Yokokawa et al.   BIOTECHNOLOGY AND BIOENGINEERING

Expression, purification and characterization of TAT-high mobility group box-1A peptide as a carrier of nucleic acids

(2008) Kyunghwa Kim et al.   BIOTECHNOLOGY LETTERS

Polymer-Based Gene Delivery: A Current Review on the Uptake and Intracellular Trafficking of Polyplexes

(2008) Patrick Midoux et al.   CURRENT GENE THERAPY

Cell-specific nuclear import of plasmid DNA in smooth muscle requires tissue-specific transcription factors and DNA sequences

(2008) A M Miller et al.   GENE THERAPY

Octaarginine- and Octalysine-modified Nanoparticles Have Different Modes of Endosomal Escape

(2008) Ayman El-Sayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Six Classes of Nuclear Localization Signals Specific to Different Binding Grooves of Importin α

(2008) Shunichi Kosugi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes

(2008) D AUGUSTE et al.   JOURNAL OF CONTROLLED RELEASE