Article
Chemistry, Analytical
Dalton L. Glasco, Nguyen H. B. Ho, Art Matthew Mamaril, Jeffrey G. Bell
Summary: This technical note introduces a method for fabricating ion-selective membranes using 3D printing technology for potentiometric sensing, demonstrating high stability and reproducibility in different electrode configurations. The versatile approach allows for the seamless translation of these membranes into reliable sensors for various applications, highlighting the advantages of mass production and reduced time and cost associated with sensor fabrication.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Nam-Hui Yim, Eunhee Park, Won-Kyung Cho, Yeoun-Hee Kim, Jin Yeul Ma
Summary: This study investigated the effects of two extracts from Acer palmatum leaves on dry eye. The results showed that the extracts increased tear production, reduced inflammation and cell death, and alleviated dry eye symptoms. Topical administration of KIOM-2015EE demonstrated better therapeutic effects compared to oral administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yanlin Zhong, Xie Fang, Xuemei Wang, Yu-An Lin, Huping Wu, Cheng Li
Summary: This study found that the bacterial communities on the ocular surface changed significantly after the use of sodium hyaluronate eye drops. Regardless of the presence of preservatives, eye drops have an impact on the bacterial communities on the ocular surface.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Giuseppe Suanno, Philippe Fonteyne, Giulio Ferrari
Summary: This study used a mouse model of dry eye disease induced by BAK to examine its stability and the presence of neurosensory abnormalities. The results showed that BAK treatment significantly increased corneal fluorescein staining, ocular pain, leukocyte infiltration, and reduced corneal sensitivity and tear secretion. Moreover, discontinuation of BAK treatment improved corneal epithelial damage. Therefore, BAK is an important factor contributing to DED.
EXPERIMENTAL EYE RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Andelka Racic, Danina Krajisnik
Summary: Dry eye syndrome and allergic conjunctivitis are common inflammatory disorders of the eye surface. The use of biopolymers in liquid ophthalmic preparations has advantages such as increasing tear film viscosity, exhibiting bioadhesive properties, and improving therapeutic effects. Methods for assessing mucoadhesiveness have been suggested, and this review provides an overview of the development of mucoadhesive liquid ophthalmic formulations for treating dry eye and allergic conditions.
Article
Ophthalmology
Nobuo Takeda, Masamichi Fukuda, Hiroshi Sasaki, Kazuhisa Sugiyama
Summary: The study showed that preservative-free ophthalmic solutions such as dorzolamide/timolol without BAK did not significantly affect corneal electrical resistance, while solutions with low concentrations of BAK had a significant impact. Fluorescein staining was unable to detect corneal epithelium changes that were detected by CRDs.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Chemistry, Analytical
Huda Alghamdi, Majidah Alsaeedi, Alyah Buzid, Jeremy D. Glennon, John H. T. Luong
Summary: The study utilized GC and BDD electrodes for the detection of BAK homologs in a non-aqueous medium, with BDD showing better reproducibility and a detection limit of 0.4 μg/mL, in agreement with manufacturer specifications.
Article
Pharmacology & Pharmacy
Xiaolin Li, Xunchan Jiang, Xiaolei Zhou, Yanju Cheng, Feng Cao
Summary: In this study, DEX quaternary CD aggregate suspension eye drops containing HP gamma CD as solubilizing CD, gamma CD as aggregating CD and poloxamer 407 were developed for efficient drug delivery from the ocular surface to posterior segment of the eye. These eye drops showed better permeability and maintained higher concentrations of DEX in the choroid-retina compared to the ternary CD eye drops. Furthermore, the quaternary CD aggregate eye drops remained stable for 6 months, indicating their potential for large-scale production.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Veterinary Sciences
Michael Stucki, Clarissa D. Voegel, Tina M. Binz, Thomas Kraemer, Arnold Lavaud, Katrin Voelter
Summary: This study investigated the detectability of dexamethasone and prednisolone in equine serum and urine samples during and after treatment with eye drops. The results showed that both drugs can induce measurable drug levels in samples during treatment, potentially leading to a positive doping result. However, all samples tested negative for both drugs one day to one week after treatment cessation.
EQUINE VETERINARY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Velmurugan Shanmugham, Ravi Subban
Summary: Dry eye disease (DED) is a complex ocular surface inflammatory disease that varies widely in its occurrence worldwide. The use of benzalkonium chloride in ocular drops worsens DED conditions, and the Covid-19 pandemic has resulted in an increase in DED cases. The study found that capsanthin from Capsicum annum can effectively manage DED by reducing intraocular pressure and inflammation.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Thorsteinn Loftsson, Einar Stefansson
Summary: Topical drug delivery to the eye is challenging, with only a small percentage of the dose reaching the desired target. Invasive drug administration methods are currently used for retinal diseases. This study explores a cyclodextrin-based aqueous eye drop microsuspension as a potential solution, which successfully overcomes barriers to drug permeation and delivers therapeutic drug concentrations to the retina. Results show that the efficacy of this eye drop microsuspension is comparable to that of a intravitreal insert.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Ophthalmology
Sara De Lima, Nejla Erdal, Karin Adolfsson, Minna Hakkarainen, Maria Kugelberg
Summary: The study found that contact lenses used by infants treated with dexamethasone eye drops after congenital cataract surgery had ruptured surfaces, but no accumulation of dexamethasone or benzalkonium chloride was detected in the lenses. It is recommended to replace contact lenses monthly during the course of anti-inflammatory eye drop treatment to maintain comfort and reduce the risk of microbial adhesion.
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Hongwei Lu, Yongqing Guan, Yudan Su, Na Nan, Yazhen Yuan
Summary: The combination of sodium hyaluronate eye drops with other medications improves the treatment outcome of patients with dry eye after phacoemulsification, reducing corneal fluorescein staining and inflammatory factor levels.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Zhi-Hui Duan, Yi-Fei Tang
Summary: In the treatment of dry eye after phacoemulsification of cataract, sodium hyaluronate eye drops and polyethylene glycol eye drops showed better clinical efficacy, significantly reducing dry eye symptoms and the incidence of ocular irritation.
Article
Nanoscience & Nanotechnology
Qi Lou, Lu Pan, Shengjin Xiang, Yueting Li, Jiahui Jin, Jingyang Tan, Baoshan Huang, Kaihui Nan, Sen Lin
Summary: In this study, TAT-MT liposomes were developed to inhibit BAC-induced dry eye disease (DED). It was found that TAT-MT liposomes significantly alleviated DED symptoms by suppressing tissue inflammation and preventing the loss of corneal epithelium and conjunctival goblet cells. The study also revealed a new mechanism of BAC-induced corneal epithelial pyroptosis mediated by NLRP3/Caspase-1/GSDMD, and suggested the potential of TAT-MT liposomes as a new treatment for DED.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Phatsawee Jansook, Hay Marn Hnin, Pitsiree Praphanwittaya, Thorsteinn Loftsson, Einar Stefansson
Summary: This study aimed to increase the aqueous solubility of angiotensin II receptor blockers (ARBs) by forming cyclodextrin inclusion complexes and determine their chemical stability in aqueous solutions. The results showed that the solubility of drugs increased by forming inclusion complexes with gamma-cyclodextrin and by increasing their intrinsic solubility in phosphate buffer. The formation of inclusion complexes was confirmed by molecular docking. Salt formation using various organic salts enhanced the solubilization of drugs with gamma-cyclodextrin, but chemical instability was observed at high salt concentrations.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Phyo Darli Maw, Phatsawee Jansook
Summary: The solubility of amphotericin B (AmB) and the effect of cyclodextrins (CDs) on the complex formation of medium chain triglyceride (MCT) oils and AmB were investigated prior to the development of CD stabilized Pickering nanoemulsions (NEs) for fungal keratitis therapy. The inclusion complexes of MCT oil/alpha-cyclodextrin (alpha CD), AmB/gamma cyclodextrin (gamma CD), and AmB/2-hydroxypropyl-gamma cyclodextrin (HP gamma CD) were characterized using various techniques. The MCT oil/alpha CD complexes were found to be suitable for stabilizing Pickering NEs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hay Man Saung Hnin Soe, Suppakan Sripetch, Thorsteinn Loftsson, Einar Stefansson, Phatsawee Jansook
Summary: The combination of Soluplus(R) with gamma-cyclodextrin (gamma CD) was found to significantly enhance the aqueous solubility of irbesartan and candesartan cilexetil, forming stable complex nanoaggregates which could potentially serve as a platform for drug delivery systems.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hay Marn Hnin, Einar Stefansson, Thorsteinn Loftsson, Thanyada Rungrotmongkol, Phatsawee Jansook
Summary: The study found that the inclusion complex formed by the ACE inhibitor losartan potassium and cyclodextrins has potential application value in the treatment of glaucoma.
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Phatsawee Jansook, Thorsteinn Loftsson
Summary: Cyclodextrins, particularly gamma-cyclodextrin, have been extensively used in pharmaceutical products to improve the solubility and bioavailability of drugs. They can self-assemble to form nano- and microparticles, increasing drug solubility and permeability. Clinical studies have shown their potential in enhancing drug delivery to the eye.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Phyo Darli Maw, Prompong Pienpinijtham, Patamaporn Pruksakorn, Phatsawee Jansook
Summary: In this study, cyclodextrin-stabilized, amphotericin B-loaded Pickering and non-Pickering nano-emulsions were developed. These emulsions showed acceptable physicochemical properties and exhibited good stability and antifungal activity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Dileep Urimi, Maja Hellsing, Najet Mahmoudi, Christopher Soderberg, Ronja Widenbring, Lars Gedda, Katarina Edwards, Thorsteinn Loftsson, Nicolaas Schipper
Summary: Lipid nanocapsules (LNCs) with core-shell structure were studied using various techniques, and it was found that drug loading does not alter the overall structure of LNCs. However, the presence of the drug leads to an increase in the thickness of the shell while the core size remains unchanged.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Hay Marn Hnin, Einar Stefansson, Thorsteinn Loftsson, Rathapon Asasutjarit, Dusadee Charnvanich, Phatsawee Jansook
Summary: This study developed a chemically stable niosomal eye drop containing fosinopril for lowering intraocular pressure. The optimal formulation exhibited high entrapment efficiency, negative zeta potential, controlled release profile, and protection against hydrolytic degradation.
Review
Pharmacology & Pharmacy
Phatsawee Jansook, Thorsteinn Loftsson
Summary: Glaucoma is a major cause of irreversible blindness globally, and prostaglandin analogues (PGAs) are the first-line treatment. However, the stability and adverse effects of PGAs in eye drop formulations have been challenging for formulation scientists.
Article
Biochemistry & Molecular Biology
Hay Man Saung Hnin Soe, Khanittha Kerdpol, Thanyada Rungrotmongkol, Patamaporn Pruksakorn, Rinrapas Autthateinchai, Sirawit Wet-osot, Thorsteinn Loftsson, Phatsawee Jansook
Summary: This study aimed to improve the aqueous solubility and chemical stability of voriconazole eye drops by using cyclodextrin and water-soluble polymers. The results showed that sulfobutyl ether beta-cyclodextrin greatly enhanced the solubility of voriconazole, and the addition of polyvinyl alcohol had a synergistic effect on solubilization and stabilization. The developed voriconazole eye drops containing cyclodextrin and polyvinyl alcohol exhibited high mucoadhesion, sustained release, good permeability, and no irritation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Hay Man Saung Hnin Soe, Phyo Darli Maw, Thorsteinn Loftsson, Phatsawee Jansook
Summary: Fungal infections are a serious health issue, especially for patients with weakened immune systems. The low solubility of most antifungal agents can limit their effectiveness. However, their solubility and bioavailability can be improved through complexation with cyclodextrins (CDs). CD-based nanocarriers, such as nanoparticles and liposomes, offer a promising solution for delivering antifungal drugs. These systems have synergistic effects, enhancing drug loading, stability, and permeability through membranes, thereby increasing the bioavailability of antifungals.
Review
Pharmacology & Pharmacy
Thorsteinn Loftsson, Einar Stefansson
Summary: Topical drug delivery to the eye is challenging, with only a small percentage of the dose reaching the desired target. Invasive drug administration methods are currently used for retinal diseases. This study explores a cyclodextrin-based aqueous eye drop microsuspension as a potential solution, which successfully overcomes barriers to drug permeation and delivers therapeutic drug concentrations to the retina. Results show that the efficacy of this eye drop microsuspension is comparable to that of a intravitreal insert.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Physical
Thorsteinn Loftsson, Hakon Hrafn Sigurdsson, Phatsawee Jansook
Summary: Cyclodextrins (CDs) are widely used in pharmaceutical products as solubilizing complexing agents and organic cosolvents. They can self-assemble to form nanoparticles in aqueous solutions, which may cause misinterpretations of experimental results. CDs can enhance drug permeation through membranes without affecting the membrane barrier. This review discusses some unexpected findings encountered during studies of CDs as pharmaceutical excipients.
Article
Pharmacology & Pharmacy
Hay Man Saung Hnin Soe, Phyo Darli Maw, Rathapon Asasutjarit, Thorsteinn Loftsson, Phatsawee Jansook
Summary: In this study, the aqueous solubility of Tacrolimus (TAC) was increased by complexation with hydroxypropyl-beta-cyclodextrin (HP beta CD), and a promising eye drop formulation for retinal disease treatment was developed using Zein nanoparticles (ZnNP) and nanoemulsions (NE) stabilized by ZnNP.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xueliang Xiu, Shichao Ma, Zhiyong Li, Zhipeng Li, Xuemei Li, Yangtao Ruan, Dezhao Li, Jianwei Wang, Fengsen Ma
Summary: Liposomes are promising delivery vehicles for drugs and vaccines. The use of microfluidic chips for liposome preparation is an effective method. However, traditional liposome preparation technologies hinder their industrial production and clinical application. This study presents a novel three-dimensional integrated microfluidic device for continuous liposome preparation and purification, which shows potential for industrial production of nano-pharmaceutical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2024)