Dextran successful carrier molecule for the delivery of NSAIDs with reduced gastrointestinal effect

The dextron ester polymeric prodrug of aceclofenac and mefenamic acid was synthesized through carbonyldiimidazole coupling agent, The prepared polymeric prodrug was characterized by UV IR. X-RD and Ill NAIR. The in vitro hydrolysis study was performed by HPLC and polymeric conjugate subjected for in vitro hydrolysis showed negligible hydrolysis in simulated gastric fluid pH 1.2 for 3 h. The half-life of the aceclofenac dextral( conjugate in simulated intestinal fluid (SIF) pH 7.4 and phosphate buffer solution (PBS) pH 9.0 was found to he 8.51 h and 33.72 min, respectively. The half-life 4.66 h and 25.4 min was found in STF pH 7.4 and PBS 9.0, respectively for mcienamic acid conjugates. Phe conjugate.s. were screened jbr biological activity such as anti-inflammatory, analgesic and ulcerogenic activity.Phe statistical data obtained from the biological experiment suggested that the value was Plaid to be significant willi respect to normal control.