Journal
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
Volume 32, Issue 7, Pages 1041-1045Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/01932691.2010.488497
Keywords
FITC-insulin; intestinal uptake; SLN
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Funding
- Italian Government (MIUR)
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Insulin-loaded solid lipid nanoparticles (SLN) were prepared according to a solvent dilution method from O/W emulsions using isovaleric acid as organic phase. Insulin was derivatized with fluorescein isothyocianate (FITC) obtaining a fluorescent marker to be used in in vivo experiments. FITC-insulin and native insulin-loaded SLN were quite similar with regard to their mean sizes and encapsulation efficiency. SLN intestinal uptake was then investigated administering FITC-insulin loaded SLN on healthy male Wistar rats. Significant drug accumulation within intestinal lymphatic system was recovered, but the immune system seems to play an important role in SLN degradation: further studies are necessary to improve the results on blood glucose level.
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