Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice

Genomic analysis of primordial dwarfism reveals novel disease genes

(2014) R. Shaheen et al.   GENOME RESEARCH

RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair

(2014) Tingting Li et al.   JOURNAL OF CELL SCIENCE

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks

(2014) Elda Cannavo et al.   NATURE

PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways

(2014) Carole Beck et al.   NUCLEIC ACIDS RESEARCH

Inactivating UBE2M Impacts the DNA Damage Response and Genome Integrity Involving Multiple Cullin Ligases

(2014) Scott Cukras et al.   PLoS One

BRCA1 Accelerates CtIP-Mediated DNA-End Resection

(2014) Andrés Cruz-García et al.   Cell Reports

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

(2013) Sara L. Poulsen et al.   JOURNAL OF CELL BIOLOGY

RNF111-Dependent Neddylation Activates DNA Damage-Induced Ubiquitination

(2013) Teng Ma et al.   MOLECULAR CELL

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

New Tools to Study DNA Double-Strand Break Repair Pathway Choice

(2013) Daniel Gomez-Cabello et al.   PLoS One

Prognostic value of CtIP/RBBP8 expression in breast cancer

(2013) Isabel Soria-Bretones et al.   Cancer Medicine

Novel DNA Damage Checkpoints Mediating Cell Death Induced by the NEDD8-Activating Enzyme Inhibitor MLN4924

(2012) J. L. Blank et al.   CANCER RESEARCH

The p21-Dependent Radiosensitization of Human Breast Cancer Cells by MLN4924, an Investigational Inhibitor of NEDD8 Activating Enzyme

(2012) Dong Yang et al.   PLoS One

Structural regulation of cullin-RING ubiquitin ligase complexes

(2011) David M Duda et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

COP9 signalosome function in the DDR

(2011) Ronny Hannß et al.   FEBS LETTERS

Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924

(2011) Hua Liao et al.   MOLECULAR & CELLULAR PROTEOMICS

Tracking genome engineering outcome at individual DNA breakpoints

(2011) Michael T Certo et al.   NATURE METHODS

CtIP Mutations Cause Seckel and Jawad Syndromes

(2011) Per Qvist et al.   PLoS Genetics

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA resection in eukaryotes: deciding how to fix the break

(2010) Pablo Huertas   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

(2009) Pablo Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification

(2009) Danny T. Huang et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Targeted therapy for cancer using PARP inhibitors

(2008) Christopher J Lord et al.   CURRENT OPINION IN PHARMACOLOGY

Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

(2008) Ali Jazayeri et al.   EMBO JOURNAL

Function and regulation of protein neddylation. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Gwénaël Rabut et al.   EMBO REPORTS

CDK targets Sae2 to control DNA-end resection and homologous recombination

(2008) Pablo Huertas et al.   NATURE

A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

(2008) Aude Dupré et al.   Nature Chemical Biology

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS

MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings

(2008) Mitch McVey et al.   TRENDS IN GENETICS

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics