A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms

An Enhancer Composed of Interlocking Submodules Controls Transcriptional Autoregulation of Suppressor of Hairless

(2014) Feng Liu et al.   DEVELOPMENTAL CELL

Transcriptional enhancers: from properties to genome-wide predictions

(2014) Daria Shlyueva et al.   NATURE REVIEWS GENETICS

Rapid and Pervasive Changes in Genome-wide Enhancer Usage during Mammalian Development

(2013) Alex S. Nord et al.   CELL

Notch signaling represses p63 expression in the developing surface ectoderm

(2013) A. M. B. Tadeu et al.   DEVELOPMENT

Location of transient ectodermal progenitor potential in mouse development

(2013) L. Li et al.   DEVELOPMENT

Topology of mammalian developmental enhancers and their regulatory landscapes

(2013) Wouter de Laat et al.   NATURE

Chromatin and epigenetic features of long-range gene regulation

(2013) N. Harmston et al.   NUCLEIC ACIDS RESEARCH

Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET

(2013) R. Shalom-Feuerstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome

(2012) Giustina Ferone et al.   EMBO Molecular Medicine

 Np63  represses anti-proliferative genes via H2A.Z deposition

(2012) C. L. Gallant-Behm et al.   GENES & DEVELOPMENT

p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome

(2012) Giustina Ferone et al.   HUMAN MOLECULAR GENETICS

The accessible chromatin landscape of the human genome

(2012) Robert E. Thurman et al.   NATURE

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation

(2012) Simon S. McDade et al.   NUCLEIC ACIDS RESEARCH

Pluripotent Stem Cell Model Reveals Essential Roles for miR-450b-5p and miR-184 in Embryonic Corneal Lineage Specification

(2012) Ruby Shalom-Feuerstein et al.   STEM CELLS

Landscapes and archipelagos: spatial organization of gene regulation in vertebrates

(2012) Thomas Montavon et al.   TRENDS IN CELL BIOLOGY

ΔNp63is regulated by BMP4 signaling and is required for early epidermal development inXenopus

(2011) Celeste Tríbulo et al.   DEVELOPMENTAL DYNAMICS

p63 regulatesSatb1to control tissue-specific chromatin remodeling during development of the epidermis

(2011) Michael Y. Fessing et al.   JOURNAL OF CELL BIOLOGY

Interferon Regulatory Factor 6 Is Necessary, but Not Sufficient, for Keratinocyte Differentiation

(2011) Leah C. Biggs et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mapping and analysis of chromatin state dynamics in nine human cell types

(2011) Jason Ernst et al.   NATURE

Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas

(2011) E. Botti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skn-1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression

(2010) Anna Maria Lena et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis

(2010) R Shalom-Feuerstein et al.   CELL DEATH AND DIFFERENTIATION

Developmental gene regulation in the era of genomics

(2010) Julia Zeitlinger et al.   DEVELOPMENTAL BIOLOGY

Hdac1 and Hdac2 Act Redundantly to Control p63 and p53 Functions in Epidermal Progenitor Cells

(2010) Matthew LeBoeuf et al.   DEVELOPMENTAL CELL

A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias

(2010) Francesca Moretti et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional Repression of miR-34 Family Contributes to p63-Mediated Cell Cycle Progression in Epidermal Cells

(2010) Dario Antonini et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A unique chromatin signature uncovers early developmental enhancers in humans

(2010) Alvaro Rada-Iglesias et al.   NATURE

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Profiling of p63 DNA–Binding Sites Identifies an Element that Regulates Gene Expression during Limb Development in the 7q21 SHFM1 Locus

(2010) Evelyn N. Kouwenhoven et al.   PLoS Genetics

Transcriptional autoregulation in development

(2009) Stephen T. Crews et al.   CURRENT BIOLOGY

p63 Suppresses Non-epidermal Lineage Markers in a Bone Morphogenetic Protein-dependent Manner via Repression of Smad7

(2009) Laura De Rosa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic views of distant-acting enhancers

(2009) Axel Visel et al.   NATURE

ChIP-seq accurately predicts tissue-specific activity of enhancers

(2009) Axel Visel et al.   NATURE

C/EBPα and β couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation

(2009) Rodolphe G. Lopez et al.   NATURE CELL BIOLOGY

P-cadherin is a p63 target gene with a crucial role in the developing human limb bud and hair follicle

(2008) Y. Shimomura et al.   DEVELOPMENT

Disruption of epidermal specific gene expression and delayed skin development in AP-2γ mutant mice

(2008) Jillian Guttormsen et al.   DEVELOPMENTAL BIOLOGY

Multiple Roles of Notch Signaling in the Regulation of Epidermal Development

(2008) Mariko Moriyama et al.   DEVELOPMENTAL CELL

Direct targets of the TRP63 transcription factor revealed by a combination of gene expression profiling and reverse engineering

(2008) G. Della Gatta et al.   GENOME RESEARCH

AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis

(2008) Xuan Wang et al.   JOURNAL OF CELL BIOLOGY

Klf5 is involved in self-renewal of mouse embryonic stem cells

(2008) S. Parisi et al.   JOURNAL OF CELL SCIENCE

Tprg, a Gene Predominantly Expressed in Skin, Is a Direct Target of the Transcription Factor p63

(2008) Dario Antonini et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY