Article
Multidisciplinary Sciences
Mona Mohamed Taha, Heba Mahdy-Abdallah, Eman Mohamed Shahy, Mona Adel Helmy, Lamia Samir ElLaithy
Summary: Diabetic nephropathy (DN) is the main cause of chronic kidney disease in patients with type 2 diabetes mellitus (T2DM). This study assessed potential biomarkers, including cystatin-c and hemeoxygenase, as well as genetic factors, ACE I/D polymorphism and ACE G2350A genotypes, in predicting kidney disease susceptibility in T2DM patients. The results showed significant elevations in cystatin-c and hemeoxygenase levels in diabetic groups compared to controls, and an association between G2350A genotype of ACE gene and increased cystatin-c and hemeoxygenase levels.
SCIENTIFIC REPORTS
(2023)
Article
Virology
Anna Papadopoulou, Paraskevi C. Fragkou, Eirini Maratou, Dimitra Dimopoulou, Antonis Kominakis, Ioanna Kokkinopoulou, Christos Kroupis, Athina Nikolaidou, Georgios Antonakos, Vasiliki Papaevangelou, Apostolos Armaganidis, Argirios Tsantes, Eftychia Polyzogopoulou, Sotirios Tsiodras, Anastasia Antoniadou, Paraskevi Moutsatsou
Summary: Accumulated data suggests a role of the renin-angiotensin system in COVID-19 pathogenesis, with the ACE insertion/deletion polymorphism potentially increasing the risk for severe disease. A retrospective study found that COVID-19 patients with the DD genotype and D allele carriers had a higher risk of developing severe disease, associated with lower ACE activity. This highlights the need for further research on ACE genotype-based therapies in COVID-19 patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sergej Nadalin, Sanja Devic Pavlic, Vjekoslav Peitl, Dalibor Karlovic, Lena Zatkovic, Smiljana Ristic, Alena Buretic-Tomljanovic, Hrvoje Jakovac
Summary: We investigated the impact of a functional insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) on antipsychotic treatment. The results showed that the ACE-I/D polymorphism was significantly associated with changes in PANSS psychopathology, with a weak gender-specific effect and no association with metabolic-syndrome-related parameters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Mitra Rezaei, Hadiseh Mohammadpour, Mahya Eftekhari, Mihan Pourabdollah, Farinaz Nasr Azadani, Payam Tabarsi, Majid Marjani, Seyed Ali Ziai
Summary: This study aimed to investigate the correlation between angiotensin I converting enzyme (ACE) insertion/deletion polymorphism and the severity of symptoms in COVID-19 patients. The study found that the ACE D allele was associated with an increased risk of disease severity.
FRONTIERS IN GENETICS
(2022)
Review
Medicine, Research & Experimental
Hamid Tanzadehpanah, Elham Lotfian, Amir Avan, Sahar Saki, Sima Nobari, Roghaye Mahmoodian, Mohsen Sheykhhasan, Mohamad Hosein Shafiee Froutagh, Farzaneh Ghotbani, Raoufeh Jamshidi, Hanie Mahaki
Summary: The novel coronavirus SARS-CoV-2 presents a global challenge due to its high infectivity and rapid transmission. It can invade epithelial cells and may worsen the condition of patients with pre-existing vascular diseases by causing endothelial damage and intravascular thrombosis. ACE2, the enzyme involved in the renin-angiotensin aldosterone system, is used by SARS-CoV-2 as a receptor for viral entry. Understanding the mechanism of SARS-CoV-2 infection and its impact on the vascular system is crucial for effective management in patients with vascular diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Malik Nassan, Iyas Daghlas, Ignazio S. Piras, Emily Rogalski, Lianne M. Reus, Yolande Pijnenburg, Leah K. Cuddy, Richa Saxena, M-Marsel Mesulam, Matt Huentelman
Summary: This study used genetic approaches to find that angiotensin-converting enzyme (ACE) inhibition is associated with Alzheimer's disease and frontotemporal dementia, but not with Lewy body dementia or vascular dementia. These results provide evidence for further research on the neurocognitive effects of ACE inhibition.
ALZHEIMERS & DEMENTIA
(2023)
Article
Food Science & Technology
Jingjing Dong, Shen Wang, Xiaoyao Yin, Min Fang, Zhiyong Gong, Yongning Wu
Summary: This study investigated the antihypertensive effect of rice peptide (RP) and revealed its mechanism of action. The results demonstrated that RP could effectively reduce systolic blood pressure in hypertensive rats, potentially through regulating the renin-angiotensin system and nitric oxide release.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biochemistry & Molecular Biology
Fatih Aydin, Vedat Turkoglu, Zehra Bas
Summary: The study successfully purified ACE enzyme from sheep lungs in one step and determined that captopril, a specific ACE inhibitor, has a significant inhibitory effect with a very low IC50 value of 0.51 nM.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Neurosciences
Ankit Goyal, Alvee Saluja, Kallur N. Saraswathy, Priya Bansal, Rajinder K. Dhamija
Summary: The study demonstrates a strong association between ACE insertion/deletion polymorphism and the risk of acute ischemic stroke (AIS), with the DD genotype independently associated with an increased risk. This finding suggests the potential of ACE polymorphism as a genetic risk factor for AIS.
Article
Biochemistry & Molecular Biology
Se Yeong Park, Eun Woo Jeong, Yun Sun Yang, Hyun-Joo Kim, Gwang-woong Go, Hyeon Gyu Lee
Summary: Finger millet ethanol extracts (FEs) exhibit lipid-lowering, antioxidant, renin-angiotensin system-controlling, and vascular remodeling-improving effects in spontaneously hypertensive rats (SHRs), significantly reducing systolic blood pressure.
Article
Pharmacology & Pharmacy
Hichem Bouchenaki, Amandine Bernard, Flavien Bessaguet, Simon Frachet, Laurence Richard, Franck Sturtz, Laurent Magy, Sylvie Bourthoumieu, Claire Demiot, Aurore Danigo
Summary: Ramipril has the potential to prevent paclitaxel-induced peripheral neuropathy, and the neuroprotective role of ramipril in this condition is mediated through the involvement of the AT2 receptor.
Article
Public, Environmental & Occupational Health
Guillaume Butler-Laporte, Tomoko Nakanishi, Vincent Mooser, Alessandra Renieri, Sara Amitrano, Sirui Zhou, Yiheng Chen, Vincenzo Forgetta, J. Brent Richards
Summary: Mendelian randomization using genetic determinants of serum-ACE levels found no association between genetically decreased ACE levels and susceptibility to, or severity of, COVID-19, suggesting that individuals taking ACE inhibitors should not discontinue therapy during the pandemic.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Virology
Nahid Alimoradi, Moein Sharqi, Dena Firouzabadi, Mohammad Moein Sadeghi, Mohammad Iman Moezzi, Negar Firouzabadi
Summary: This study investigated the impact of RAS gene polymorphisms ACE1 and ACE2 on the susceptibility and severity of COVID-19 infection. The results found that certain genotypes were associated with the susceptibility and severity of COVID-19 infection.
Article
Food Science & Technology
Mingzhe Ma, Yinghui Feng, Yulu Miao, Qiang Shen, Shuting Tang, Juan Dong, John Z. H. Zhang, Lujia Zhang
Summary: Chronic diseases, such as hypertension, have detrimental effects on human health. Conventional drugs for treatment often come with significant side effects. Food-sourced ACE inhibitory peptides provide a safer alternative, with fewer side effects. However, the lack of a systematic and effective screening method and understanding of the sequence characteristics and molecular mechanisms hinder the development of ACE inhibitory peptides.
Article
Biochemistry & Molecular Biology
Yu-Hang Zhang, Wen-Yu Wang, Xiao-Cong Pang, Zhi Wang, Cheng-Zhuo Wang, Hang Zhou, Bo Zheng, Yi-Min Cui
Summary: The study revealed that thymosin-alpha 1 prevents COVID-19 by binding with ACE and reducing ACE2 expression in human lung epithelial cells, suggesting its potential clinical applications in preventing SARS-CoV-2 infection.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Health Care Sciences & Services
Juan Luis Gonzalez-Pascual, Margarita G. Marquez, Rocio Rodriguez-Rey, Edurne Zabaleta-del-Olmo, Marta Raurell-Torreda, Angel Romero-Collado, Beatriz Hidalgo-Sanz
Summary: This study translated and validated the Spanish version of the Interprofessional Socialization and Valuing Scale (ISVS), a tool used to measure interprofessional socialization. The results showed that the Spanish version of the ISVS-21 has adequate psychometric properties in terms of construct validity (structural validity and convergent validity) and internal consistency.
JOURNAL OF INTERPROFESSIONAL CARE
(2022)
Review
Cell Biology
Juan-Jose Zamora-Sanchez, Ana-Maria Urpi-Fernandez, Meritxell Sastre-Rus, Iris Lumillo-Gutierrez, Vicente Gea-Caballero, Lina Jodar-Fernandez, Ivan Julian-Rochina, Edurne Zabaleta-del-Olmo
Summary: This review critically appraises and summarizes the measurement properties of the Tilburg Frailty Indicator (TFI). The findings indicate moderate sufficient evidence for TFI's content validity and construct validity, although its comprehensiveness of items is still insufficient. The evidence for TFI's internal consistency and test-retest reliability is inconsistent. TFI shows high sufficient concurrent validity with the comprehensive geriatric assessment. Evidence for the predictive validity of TFI for adverse frailty-related outcomes is mostly insufficient. There is a lack of studies assessing the responsiveness of TFI scores.
AGEING RESEARCH REVIEWS
(2022)
Review
Health Care Sciences & Services
Marina Gonzalez-del-Rio, Carme Bertran-Noguer, Lluis Ramio-Torrenta, Edurne Zabaleta-del-Olmo
Summary: This review summarized the evaluation of available disease-related knowledge measurement instruments in people with multiple sclerosis. The results showed that two instruments can be recommended for use, two are not recommended, and five have the potential to be recommended but require further research.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Psychology, Clinical
Irene Gomez-Gomez, Isabel Benitez, Juan Bellon, Patricia Moreno-Peral, Barbara Olivan-Blazquez, Ana Claveria, Edurne Zabaleta-del-Olmo, Joan Llobera, Maria J. Serrano-Ripoll, Olaya Tamayo-Morales, Emma Motrico
Summary: The Patient Health Questionnaire (PHQ) is a valuable tool for detecting major depression in primary health care (PHC) patients in Spain. The PHQ-8 and PHQ-9 versions showed high internal consistency and the results confirmed the expected relationship with anxiety, social support, and health-related quality of life. The PHQ has good discrimination power when compared to the CIDI interview, with optimal cut-off values of >2 for PHQ-2, >7 for PHQ-8, and >8 for PHQ-9.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Oncology
Ruben Martin-Payo, Andrea Martinez-Urquijo, Edurne Zabaleta-del-Olmo, Maria del Mar Fernandez-Alvarez
Summary: This study evaluated the effectiveness of an educational intervention using a web-app based on the Behaviour Change Wheel model to improve knowledge of breast cancer risk factors and symptoms, as well as adherence to healthy eating and physical activity among women without a breast cancer diagnosis. The results suggest that the web-app intervention significantly increased adherence to healthy behaviors and improved the identification of risk factors and symptoms among the intervention group compared to the control group. Overall, the study highlights the potential of using a web-app to enhance breast cancer prevention in women without a previous diagnosis.
CANCER CAUSES & CONTROL
(2023)
Article
Nutrition & Dietetics
Maria Del Mar Fernandez-Alvarez, Edurne Zabaleta-Del-Olmo, Judit Cachero-Rodriguez, Ruben Martin-Payo
Summary: This study describes and classifies the nutritional quality and information of processed foods and alcoholic and non-alcoholic beverages advertised near schools in three cities in the north of Spain. The findings show that the advertisements promote products of low nutritional value, high in fat, saturated fat, and sugars, which can contribute to childhood obesity.
NUTRITION BULLETIN
(2023)
Article
Public, Environmental & Occupational Health
Montse Martinez-Marcos, Edurne Zabaleta-del-Olmo, Esperanza-Luisa Gomez-Duran, Anna Rene-Rene, Carmen Cabezas-Pena
Summary: This study aimed to assess the impact of lockdown measures during the COVID-19 pandemic on childhood vaccination coverage rates in Catalonia, Spain, and the recovery of these rates after the partial lifting of restrictions. The results showed a decline in vaccination coverage rates in the post-lockdown period compared to the pre-lockdown period, with significant reductions in measles-mumps-rubella and diphtheria-tetanus-acellular pertussis vaccination coverage rates. Immediate and long-term support strategies are necessary to restore and sustain routine childhood vaccination.
Article
Gerontology
Maria Jesus Megido, Montserrat Celdran, Assumpta Ferrer, Montserrat Roca, Enriqueta Pujol-Ribera, Edurne Zabaleta-del-Olmo
Summary: The aim of this study was to understand the impact of Alzheimer's disease on the relationship between grandparents and grandchildren aged 6 to 13. Qualitative interviews were conducted with 25 grandchildren living in Catalonia, Spain. The findings revealed changes in roles, activities, and emotional wellbeing, as well as sleeping problems among grandchildren living with their grandparents. The study highlights the need for information and resources to support grandchildren and their families in dealing with the disease.
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2023)
Article
Health Care Sciences & Services
Marcus Heumann, Gundula Roehnsch, Edurne Zabaleta-del-Olmo, Beatriz Rosana Goncalves de Oliveira Toso, Ligia Giovanella, Kerstin Haemel
Summary: This study investigated the barriers and enablers to promoting the participation of chronically ill patients in their care within the primary health care (PHC) setting. Through interviews with 34 PHC nurses and 23 key informants, it was found that establishing bonds with patients, cooperation with relatives and families, communication and cooperation within the PHC team, and the work environment are important factors in enabling or hindering patient participation.
HEALTH EXPECTATIONS
(2023)
Review
Computer Science, Information Systems
Lucia A. Carrasco-Ribelles, Jose Llanes-Jurado, Carlos Gallego-Moll, Margarita Cabrera-Bean, Monica Monteagudo-Zaragoza, Concepcion Violan, Edurne Zabaleta-del-Olmo
Summary: The objective of this study is to describe and evaluate the use of artificial intelligence techniques in handling longitudinal data from electronic health records to predict health-related outcomes. The review included 81 studies and found heterogeneity in reporting methodology and results, as well as a lack of public EHR datasets and code sharing, making replication of the research complex.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Review
Nursing
Edurne Zabaleta-Del-Olmo, Rosalia Santesmases-Masana, Ruben Martin-Payo, Angel Romero-Collado, Juan-Jose Zamora-Sanchez, Ana-Maria Urpi-Fernandez, Marina Gonzalez-Del-Rio, Iris Lumillo-Gutierrez, Meritxell Sastre-Rus, Lina Jodar-Fernandez, Elvira Hernandez-Martinez-Esparza
Summary: This scoping review aimed to establish the quantity and type of research undertaken on missed nursing care during the COVID-19 pandemic. The review found that current studies mainly focused on nurses-based prevalence surveys, highlighting the urgent need for longitudinal and intervention studies, as well as broadening the research focus.
WORLDVIEWS ON EVIDENCE-BASED NURSING
(2023)
Article
Public, Environmental & Occupational Health
Lucia A. Carrasco-Ribelles, Margarita Cabrera-Bean, Marc Danes-Castells, Edurne Zabaleta-del-Olmo, Albert Roso-Llorach, Concepcion Violan
Summary: This study aimed to assess how the inclusion of frailty contributes to identifying and characterizing multimorbidity patterns in people aged 65 years or older. The results suggest that frailty should be considered when studying multimorbidity patterns in older adults. This helps in tailoring social and health care to the specific needs of older people.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Medicine, General & Internal
Lucia A. Carrasco-Ribelles, Albert Roso-Llorach, Margarita Cabrera-Bean, Anna Costa-Garrido, Edurne Zabaleta-del-Olmo, Pere Toran-Monserrat, Francesc Orfila Pernas, Concepcion Violan
Summary: This study examined the dynamics of multimorbidity and frailty as individuals age and their associations with health-related outcomes. The findings revealed that frailty increases significantly with age and is characterized by disability and symptoms rather than diseases. Concurrent diseases contribute more to mortality, while frailty-related deficits are associated with the need for specialized care.
Meeting Abstract
Public, Environmental & Occupational Health
M. Heumann, G. Roehnsch, E. Zabaleta-del-Olmo, B. Rosana Goncalves de Oliveira Toso, L. Giovanella, K. Haemel
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Marcus Heumann, Edurne Zabaleta-del-Olmo, Gundula Roehnsch, Kerstin Haemel
Summary: This study investigates the adaptation of Spanish PHC nurses' approaches to supporting the participation of patients living with chronic illness during the COVID-19 pandemic. The study found that nurses faced a high workload related to COVID-19, reduced health promotion and chronic care, increased digital and telephone communication, and fewer in-person consultations. Nurses felt challenged in supporting the participation of vulnerable groups.