Article
Endocrinology & Metabolism
Jenny Riley, Christina Antza, Punith Kempegowda, Anuradhaa Subramanian, Joht Singh Chandan, Krishna Gokhale, Neil Thomas, Christopher Sainsbury, Abd A. Tahrani, Krishnarajah Nirantharakumar
Summary: Social deprivation is an independent risk factor for the development of DFD, PN, FU, PVD, LLA, and gangrene in newly diagnosed patients with type 2 diabetes. Strategies targeting patients in socially deprived areas are needed to reduce health inequalities considering the high individual and economic burdens of DFD.
Article
Endocrinology & Metabolism
Afnan Mansour, Mira Mousa, Dima Abdelmannan, Guan Tay, Ahmed Hassoun, Habiba Alsafar
Summary: This study conducted an Exome-Wide Association Study (EWAS) on Emirati individuals with type 2 diabetes mellitus (T2DM) to identify susceptibility loci associated with T2DM-related complications. The results showed associations between various genes and each complication category. The study also highlighted the limitations of the current genotyping arrays in representing diverse populations, emphasizing the need for better representation in future studies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Christine M. Embury, Grace H. Lord, Andjela T. Drincic, Cyrus Desouza, Tony W. Wilson
Summary: Poor glycemic control in type 2 diabetes is associated with age-related cognitive decline, and this study aims to investigate its impact on the neural dynamics serving working memory. The results show that individuals with poorer glycemic control exhibit diminished neural responses in specific brain regions during encoding and maintenance phases of working memory, as well as enhanced activity in other regions. The activity in these regions significantly predicts task performance, with longer reaction times associated with poorer glycemic control. These findings highlight the importance of glycemic control for working memory and its underlying neural mechanisms.
Article
Clinical Neurology
Farsad Afshinnia, Evan L. Reynolds, Thekkelnaycke M. Rajendiran, Tanu Soni, Jaeman Byun, Masha G. Savelieff, Helen C. Looker, Robert G. Nelson, George Michailidis, Brian C. Callaghan, Subramaniam Pennathur, Eva L. Feldman
Summary: This study found that differences in serum lipidomic profiles were associated with neuropathy in type 2 diabetes. Changes in abundance of medium-chain acylcarnitines and total free fatty acids, as well as phosphatidylcholines and lysophosphatidylcholines, were observed 10 years prior to the development of neuropathy. These findings suggest that lipid profiles early in the disease course may be useful in identifying individuals at risk for neuropathy in type 2 diabetes.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Rianneke de Ritter, Simone J. S. Sep, Carla J. H. van der Kallen, Marleen M. J. van Greevenbroek, Marit de Jong, Rimke C. Vos, Michiel L. Bots, Jos P. H. Reulen, Alfons J. H. M. Houben, Carroll A. B. Webers, Tos T. J. M. Berendschot, Pieter C. Dagnelie, Simone J. P. M. Eussen, Miranda T. Schram, Annemarie Koster, Sanne A. E. Peters, Coen D. A. Stehouwer
Summary: The study investigated the associations between diabetes and microvascular complications in a population-based cohort, finding that men with type 2 diabetes had higher risks of certain microvascular complications compared to men with normal glucose metabolism, while women did not show significant sex differences.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Lorraine E. Levitt Katz, Neil H. White, Laure El Ghormli, Christine L. Chan, Kenneth C. Copeland, Terri H. Lipman, Marsha D. Marcus, Philip Zeitler
Summary: This study examined the development of diabetic peripheral neuropathy (DPN) in youth with type 2 diabetes and its relationship with glycemic control, sex, race/ethnicity, BMI, and other type 2 diabetes-associated factors.
Article
Endocrinology & Metabolism
Rossella Messina, Marica Iommi, Paola Rucci, Chiara Reno, Maria Pia Fantini, Carlotta Lunghi, Mattia Altini, Francesca Bravi, Simona Rosa, Antonio Nicolucci, Paolo Di Bartolo
Summary: The study revealed a high incidence of depression in type 2 diabetes, with predictors including female sex, age over 65, living in rural areas, and comorbid diseases. Depression was associated with significantly increased risks of acute complications, long-term complications, and mortality in type 2 diabetes patients.
ACTA DIABETOLOGICA
(2022)
Article
Biochemistry & Molecular Biology
Amy E. Rumora, Bhumsoo Kim, Eva L. Feldman
Summary: Peripheral neuropathy (PN) is the most prevalent complication of diabetes and prediabetes, characterized by progressive sensory loss due to nerve damage. Dyslipidemia, a component of metabolic syndrome, is strongly associated with PN in type 2 diabetes (T2D) and prediabetes. Fatty acids (FAs) have been implicated in PN pathogenesis, with saturated and unsaturated FAs showing differential effects on nerve lipid profile and function.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xin Wang, Lei Luo, Jianming Xing, Jianliang Wang, Bimin Shi, Yin-Min Li, Yong-Gang Li
Summary: The study demonstrated that DTI is effective in evaluating the diagnostic accuracy of diabetic peripheral neuropathy and can effectively differentiate between axonal injury and demyelination, showing correlations with electrophysiology parameters.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Pharmacology & Pharmacy
Shih-Ting Huang, Pei-Jane Bair, Shih-Sheng Chang, Yu-Nong Kao, San-Ni Chen, I-Kang Wang, Chih-Wei Chiu, Chi-Tzung Chang, Ying-Hsiu Shih, Chi-Yuan Li, Tung-Min Yu
Summary: This study found that the risk of diabetic retinopathy (DR) was significantly lower in patients receiving sodium-glucose cotransporter 2 inhibitors (SGLT2is) compared to those receiving dipeptidyl peptidase 4 inhibitors (DPP4is).
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Cecile Reynes, Jean-Baptiste Beaume, Francoise Latil-Plat, Houda Ennaifer, Laure Rocher, Sophie Antoine-Jonville, Eric Benamo, Yannick Knapp, Agnes Vinet
Summary: This study found that peripheral neuropathy, at any stage, altered the microvascular response to exercise through impaired endothelial and neurogenic mechanisms.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Yuanjue Wu, Ting Xiong, Xiao Tan, Liangkai Chen
Summary: This study aimed to evaluate the association of pre-frailty and frailty with diabetic microvascular complications (DMC) in patients with type 2 diabetes (T2D). The results showed that both pre-frailty and frailty were associated with an increased risk of DMC in T2D patients.
Article
Clinical Neurology
Roshan Dhanapalaratnam, Tushar Issar, Ann M. Poynten, Kerry-Lee Milner, Natalie C. G. Kwai, Arun Krishnan
Summary: This study found that peripheral nerve ultrasound can serve as a marker for the presence and severity of peripheral neuropathy in type 2 diabetes, with high sensitivity and specificity. The tibial nerve CSA correlates with neuropathy severity.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Tushar Issar, Natalie C. G. Kwai, Ann M. Poynten, Ria Arnold, Kerry-Lee Milner, Arun V. Krishnan
Summary: This study assessed the effect of exenatide, DPP-IV inhibitors, and SGLT-2 inhibitors on peripheral nerve excitability in patients with type 2 diabetes. Patients treated with exenatide showed improvements in nerve excitability, whereas those receiving DPP-IV or SGLT-2 inhibitors exhibited abnormalities in nerve function.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Camelia Oana Iatcu, Aimee Steen, Mihai Covasa
Summary: The gut microbiota plays a crucial role in the development of obesity, metabolic syndrome, and type 2 diabetes. Modulating the gut microbiota through probiotics, prebiotics, synbiotics, and fecal microbial transplantation shows potential in treating diabetes and its complications. The severity of gut microbiota dysbiosis is associated with disease severity, and restoration of the gut microbiota through probiotic administration can improve symptoms and disease progression.
Article
Cell Biology
Katrin Brandt, Jacob Grunler, Kerstin Brismar, Jing Wang
GROWTH HORMONE & IGF RESEARCH
(2015)
Article
Cell Biology
Vivekananda Gupta Sunkari, Folke Lind, Ileana Ruxandra Botusan, Abad Kashif, Zhao-Jun Liu, Seppo Yla-Herttuala, Kerstin Brismar, Omaida Velazquez, Sergiu-Bogdan Catrina
WOUND REPAIR AND REGENERATION
(2015)
Article
Oncology
Norhashimah Abu Seman, Wan Nazaimoon Wan Mohamud, Claes-Goran Ostenson, Kerstin Brismar, Harvest F. Gu
CLINICAL EPIGENETICS
(2015)
Article
Endocrinology & Metabolism
Lisa Arnetz, Neda Rajamand Ekberg, Kerstin Brismar, Michael Alvarsson
ENDOCRINE CONNECTIONS
(2015)
Review
Endocrinology & Metabolism
Lisa Arnetz, Mozhgan Dorkhan, Michael Alvarsson, Kerstin Brismar, Neda Rajamand Ekberg
ACTA DIABETOLOGICA
(2014)
Article
Endocrinology & Metabolism
Yatao Du, Huihui Zhang, Sergio Montano, Jesper Hegestam, Neda Rajamand Ekberg, Arne Holmgren, Kerstin Brismar, Johanna S. Ungerstedt
ACTA DIABETOLOGICA
(2014)
Article
Urology & Nephrology
Norhashimah Abu Seman, Bing He, Juha R. M. Ojala, Wan Nazaimoon Wan Mohamud, Claes-Goran Ostenson, Kerstin Brismar, Harvest F. Gu
AMERICAN JOURNAL OF NEPHROLOGY
(2014)
Article
Medicine, General & Internal
Malin Almgren, Richard L. Atkinson, Agneta Hilding, Jia He, Kerstin Brismar, Martin Schalling, Claes-Goran Ostenson, Catharina Lavebratt
ANNALS OF MEDICINE
(2014)
Article
Biochemistry & Molecular Biology
Magnus Bentinger, Magdalena Kania, Witold Danikiewicz, Ewa Kaczorowska, Jacek Wojcik, Kerstin Brismar, Gustav Dallner, Tadeusz Chojnacki, Ewa Swiezewska, Michael Tekle
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2014)
Article
Endocrinology & Metabolism
Camilla Hage, Kerstin Brismar, Pia Lundman, Anna Norhammar, Lars Ryden, Linda Mellbin
DIABETES & VASCULAR DISEASE RESEARCH
(2014)
Article
Endocrinology & Metabolism
Kyriakoula Marinou, Leanne Hodson, Senthil K. Vasan, Barbara A. Fielding, Rajarshi Banerjee, Kerstin Brismar, Michael Koutsilieris, Anne Clark, Matt J. Neville, Fredrik Karpe
Article
Biochemistry & Molecular Biology
Noah Moruzzi, Marianna Del Sole, Romana Fato, Jantje M. Gerdes, Per-Olof Berggren, Christian Bergamini, Kerstin Brismar
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2014)
Article
Endocrinology & Metabolism
Senthil K. Vasan, Fredrik Karpe, Harvest F. Gu, Kerstin Brismar, Caroline H. Fall, Erik Ingelsson, Tove Fall
Article
Multidisciplinary Sciences
Mats Halldin, Kerstin Brismar, Per Fahlstadius, Max Vikstrom, Ulf de Faire, Mai-Lis Hellenius
Article
Oncology
Tianwei Gu, Henrik Falhammar, Harvest F. Gu, Kerstin Brismar
CLINICAL EPIGENETICS
(2014)