Review
Rheumatology
Eleni Papachristodoulou, Loukas Kakoullis, Eleni Tiniakou, Konstantinos Parperis
Summary: The study reviewed different treatment modalities for Cutaneous polyarteritis nodosa (CPAN) and found limited evidence on the management of CPAN patients. Current treatment mainly involves the use of systemic corticosteroids and immunosuppressive agents in combination, but further research is needed to evaluate their impact on disease remission, relapses, and mortality.
Article
Dermatology
Thomas Bettuzzi, Marie Jachiet, Emilie Sbidian, Laure Frumholtz, Florence Cordoliani, Luc Mouthon, Francois Chasset, Romain Paule, Jean-David Bouaziz, Loic Guillevin, Benjamin Terrier, Selim Aractingi, Nicolas Dupin, Alexis Regent
Summary: This study retrospectively analyzed the treatment efficacy and safety in patients with cutaneous polyarteritis nodosa. The results showed that colchicine and glucocorticoids + azathioprine were effective treatment options, while patients with peripheral sensory neuropathy had a lower treatment response.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Athanassios Kolivras, Curtis Thompson
Summary: Macular arteritis (MA) is characterized by a discordance between clinical presentation of hyperpigmented macules and histopathologic findings of lymphocytic arteritis, primarily affecting middle-aged women's legs, sometimes with a more severe variant. Despite similar histologic features, there is no evidence of progression from MA to lymphocytic thrombophilic arteritis in terms of disease course.
CLINICS IN DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Louis Wolff, Alice Horisberger, Laura Moi, Maria P. Karampetsou, Denis Comte
Summary: Polyarteritis nodosa is a form of necrotizing vasculitis that primarily affects medium-sized vessels, but can also involve smaller vessels. It has a wide range of clinical manifestations, with common symptoms including shortness of breath, fever, and weight loss. The skin, nervous system, and gastrointestinal tract are frequently affected. While it was historically linked to hepatitis B virus, recent research has found associations with genetic syndromes and neoplasms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Ian Liang, Mariya Hamid, Deshan Sebaratnam, Nick Manolios
Summary: This article presents two cases illustrating the various manifestations of cutaneous polyarteritis nodosa, including one case with delayed diagnosis resulting in permanent nerve deficit and scarring.
CLINICAL CASE REPORTS
(2022)
Review
Rheumatology
Shun Nomura, Yasuhiro Shimojima, Yasufumi Kondo, Dai Kishida, Yoshiki Sekijima
Summary: HP is a rare neurological disorder characterized by thickening of the dura mater, commonly leading to symptoms such as headache and cranial neuropathies. This case study presented a patient with HP following a diagnosis of PAN, who showed improvement with corticosteroid and cyclophosphamide treatment. Subsequent maintenance therapy with methotrexate helped maintain remission and reduce prednisolone dosage. Only two cases of HP in PAN patients have been reported in English literature, indicating its rarity as a complication of PAN.
CLINICAL RHEUMATOLOGY
(2022)
Review
Rheumatology
Benzeeta Pinto, Prateek Deo, Susmita Sharma, Arshi Syal, Aman Sharma
Summary: Deficiency of adenosine deaminase 2 (DADA2) is a monogenic disease caused by biallelic mutations in the ADA2 gene, resulting in a wide spectrum of clinical manifestations including vasculitis, autoinflammatory, immunological and hematological disorders. Treatment options currently include tumor necrosis factor inhibitors and hematopoietic stem cell transplantation. Further research is needed to fully understand the pathogenesis and clinical aspects of the disease for early diagnosis and prompt treatment.
CLINICAL RHEUMATOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Hong Huang, Yanjun Gong, Li Guo, Zhuoli Zhang
Summary: This case report presents a 22-year-old male patient with polyarteritis nodosa (PAN) who developed insidious occlusion of three main coronary arteries after 7 years of stable PAN. Treatment with a stent implantation and anti-angina medications alleviated the chest pain.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Immunology
Julien Rohmer, Yann Nguyen, Ludovic Trefond, Christian Agard, Jean Sebastien Allain, Alice Berezne, Pierre Charles, Pascal Cohen, Guillaume Gondran, Matthieu Groh, Tessa Huscenot, Carole Lacout, Estibaliz Lazaro, Jonathan London, Francois Maurier, Arsene Mekinian, Rafik Mesbah, Isabelle Nubourgh, Laurent Perard, Xavier Puechal, Gregory Pugnet, Mathieu Puyade, Viviane Queyrel, Arthur Rouxw, Diane Rouzaud, Cecile-Audrey Durel, Loic Guillevin, Benjamin Terrier
Summary: The landscape of PAN has changed in the last decades, with the disappearance of HBV-related PAN and the emergence of secondary PAN. The relapse rate remains high, especially in older patients with gastrointestinal and skin necrosis. The 1-, 5-, and 10-year overall survival rates were 93%, 87%, and 81%, respectively.
JOURNAL OF AUTOIMMUNITY
(2023)
Review
Immunology
Edoardo Conticini, Jurgen Sota, Paolo Falsetti, Arianna Lamberti, Clelia Miracco, Andrea Guarnieri, Bruno Frediani, Luca Cantarini
Summary: The use of biologic drugs, particularly TNF-alpha inhibitors, shows promise in treating PAN and DADA2, although further research is needed to fully understand their role in these conditions.
AUTOIMMUNITY REVIEWS
(2021)
Article
Dermatology
Kazuki Mitsuru Matsuda, Ayumi Yoshizaki, Hirohito Kotani, Ai Kuzumi, Maiko Fukayama, Satoshi Ebata, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Shinichi Sato
Summary: The treatment response of cutaneous arteritis can be predicted by a combination of sex, presence of skin ulcers, and serum levels of C-reactive protein.
JOURNAL OF DERMATOLOGY
(2021)
Article
Rheumatology
Jerome Hadjadj, Alice Canzian, Omer Karadag, Anne Contis, Francois Maurier, Sebastien Sanges, Silvia Sartorelli, Laure Denis, Claire de Moreuil, Cecile-Audrey Durel, Stephane Durupt, Marie Jachiet, Diane Rouzaud, Carlo Salvarani, Roberto Padoan, Lorenzo Dagna, Fabrice Bonnet, Christian Agard, Thomas Moulinet, Marion Hermet, Raluca Sterpu, Alexandre Thibault Jacques Maria, Jeremy Keraen, Loic Guillevin, David Jayne, Benjamin Terrier
Summary: This study investigates the effectiveness and safety of biologics, particularly TCZ, in treating relapsing and/or refractory polyarteritis nodosa (PAN) patients. The results suggest that TCZ may be effective in managing PAN, but further research is needed to confirm these findings.
Article
Medicine, General & Internal
Mya Abousy, Angel Byrd, Farah Succaria, Michelle Kerns, Julie Caffrey
Summary: This case report describes a severe case of cutaneous polyarteritis nodosa (cPAN) with atypical presentation, which was managed with surgical excision and drug therapy. As non-burn wound admissions to burn centers increase, it is crucial for burn specialists to familiarize themselves with severe presentations of vasculitides, including cPAN, for timely diagnosis and treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Medicine, General & Internal
Takaharu Ikeda
Summary: Cutaneous polyarteritis nodosa (cPAN) is a skin-limited vasculitis with histopathological features indistinguishable from PAN. The revised Chapel Hill Classification recognized cutaneous arteritis (CA) as the same disease as cPAN and discovered that some CA cases were related to deficiency of adenosine deaminase 2 (DADA2). CA can be classified as an immune complex-mediated vasculitis, and the main skin manifestations include livedo racemosa, subcutaneous nodules, and ulcers. Cases with ulcers or sensory neuropathies may require more intensive therapies.
FRONTIERS IN MEDICINE
(2022)
Article
Dermatology
Eun Hye Hong, Joon Woo Jung, Eun Joo Park, Kwang Joong Kim, Kwang Ho Kim
Summary: A 10-year-old boy presented with erythematous skin lesions on his extremities and abdominal pain, later diagnosed with Crohn's disease associated with cutaneous polyarteritis nodosa. This rare case highlights the importance of recognizing extraintestinal manifestations in pediatric Crohn's disease.
ANNALS OF DERMATOLOGY
(2021)