Review
Biochemistry & Molecular Biology
Fabio Lobefaro, Giulio Gualdi, Sergio Di Nuzzo, Paolo Amerio
Summary: Atopic dermatitis is a common chronic skin disorder that negatively impacts the quality of life for patients. The diagnosis and management of atopic dermatitis still face several challenges. This paper presents the main clinical features of atopic dermatitis and the unmet needs that need to be addressed in future research.
Article
Immunology
Xiaoxiao Fan, Tianzi Zang, Jiamiao Dai, Ni Wu, Chloe Hope, Jinbing Bai, Yanqun Liu
Summary: This study investigated the relationship between maternal-offspring gut microbiota and the development of atopic dermatitis in infants and toddlers. The results showed that mothers of infants and toddlers with atopic dermatitis had higher abundance of certain bacteria during pregnancy, and the infants and toddlers themselves had higher abundance of certain bacteria at different time points. Additionally, the study found a lower abundance of a specific bacteria in mothers of infants and toddlers with atopic dermatitis. These findings support a correlation between gut microbiota and the development of pediatric atopic dermatitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Allergy
Andreas Wollenberg, Simon Francis Thomsen, Jean-Philippe Lacour, Xavier Jaumont, Slawomir Lazarewicz
Summary: Immunoglobulin E (IgE) is important in allergic diseases, and omalizumab is the primary biologic anti-IgE therapy available in clinical use. Limited studies show inconclusive efficacy of omalizumab in atopic dermatitis (AD), but it may be effective in certain patients. Further robust clinical studies are needed to establish the role of omalizumab in AD.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Article
Allergy
Inge Kortekaas Krohn, Fariza Mishaal Saiema Badloe, Nadine Herrmann, Laura Maintz, Shauni De Vriese, Johannes Ring, Jan CK-CARE Study Group, Thomas Bieber, Jan Gutermuth
Summary: Autoreactive IgE antibodies to self-peptides within the epidermis have been identified in patients with atopic dermatitis (AD). The presence of IgE autoantibodies seems to be associated with atopic comorbidities and environmental factors. These findings suggest the potential value of IgE autoantibodies as a predictive biomarker for the course of AD and the atopic march.
Article
Chemistry, Medicinal
Tae-Kyeong Lee, Dae Won Kim, Ji Hyeon Ahn, Choong-Hyun Lee, Jae-Chul Lee, Soon Sung Lim, Il Jun Kang, Seongkweon Hong, Soo Young Choi, Moo-Ho Won, Joon Ha Park
Summary: Topical administration of laminarin improved oxazolone-induced atopic dermatitis-like skin lesions in Balb/c mice by reducing swelling, decreasing epidermal and dermal thickness, inhibiting mast cell infiltration, and lowering IgE levels. It also suppressed the expression of proinflammatory cytokines in the skin lesion, suggesting laminarin's potential as a candidate for atopic dermatitis treatment.
Article
Immunology
Pei-Yun Shih, Chia-Jung Li, Su-Boon Yong
Summary: Atopic dermatitis is a chronic inflammatory skin disease characterized by immune function imbalance and impaired epidermal barrier function. The JAK/STAT signaling pathway plays a critical role in its pathogenesis, and JAK inhibitors offer a novel therapeutic approach.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Allergy
Hywel C. Williams, Jochen Schmitt, Kim S. Thomas, Phyllis Spuls, Eric L. Simpson, Christian J. Apfelbacher, Joanne R. Chalmers, Masutaka Furue, Norito Katoh, Louise A. A. Gerbens, Yael A. Leshem, Laura Howells, Jasvinder A. Singh, Maarten Boers
Summary: Core outcome sets are crucial in atopic dermatitis research, providing a standardized approach to measuring outcomes and improving clinical practice.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Sul-Hee Lee, Youin Bae, Young-Lip Park
Summary: This study found a negative correlation between serum adiponectin levels and disease severity and pruritus in AD patients. However, no significant effects were observed with biologic treatment for AD. Therefore, adiponectin may serve as a potential biomarker for severity assessment in AD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Jinqiu Jiang, Shi Yan, Xiaoying Zhou, Jinghua Zhou, Xiaoming Bai, Qi Tan, Yunqiu Xia, Hua Wang, Xiaoyan Luo
Summary: The study found that the percentage of IL-10-producing Breg cells is significantly lower in children with extrinsic AD, and it correlates negatively with increased Tfh cell responses and disease activity. Co-culture experiments showed that Breg cells from patients with extrinsic AD cannot effectively inhibit the differentiation of Tfh cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Dongwon Kim, Younbyoung Chae, Hi-Joon Park, In-Seon Lee
Summary: Research on atopic dermatitis has been increasing in quantity over the years, with a focus on topics such as asthma, food allergies, skin barrier, and epidemiology. Keywords such as 'allergic rhinitis', 'child(ren)', 'quality of life', and 'probiotics' have become more commonly used in recent years. The research is predominantly led by countries like the USA, Germany, and the UK, with recommendations for global collaborations and more holistic research approaches.
Review
Immunology
Peck Y. Ong
Summary: Atopic dermatitis is a chronic inflammatory skin disease characterized by barrier defects and immune dysregulations. Epithelial cells, especially keratinocytes, play an important role in the innate immunity of the skin and are involved in the pathogenesis of atopic dermatitis. Filaggrin mutations have been established as an important factor in the development of atopic dermatitis. Current therapeutic approaches focus on targeting cytokines produced by T cells in the adaptive immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Xin Ma, Yi Ru, Ying Luo, Le Kuai, Qi-Long Chen, Yun Bai, Ye-Qiang Liu, Jia Chen, Yue Luo, Jian-Kun Song, Mi Zhou, Bin Li
Summary: This review summarizes the knowledge of different types of post-translational protein modifications in the pathogenesis of atopic dermatitis and discusses opportunities for disease management.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Dermatology
Zhen Zhang, Jiawen Chen, Yijun Yang, Ruoqu Wei, Peiyi Sun, Wenqing Zhang, Wange Zhou, Yifeng Guo, Zhirong Yao
Summary: Intravenous immunoglobulin (IVIG) therapy has shown efficacy and safety in children with severe atopic dermatitis (AD). Treatment response was seen in 60% of patients, with significant improvement in Scoring Atopic Dermatitis index. Furthermore, baseline total serum IgE levels and eosinophil counts decreased significantly after treatment.
DERMATOLOGIC THERAPY
(2022)
Article
Microbiology
Hsin-Yu Chen, Yung-Tsung Chen, Kuan-Yi Li, Hsiao-Wen Huang, Yu-Chun Lin, Ming-Ju Chen
Summary: Through experiments in a house dust mite (HDM) extraction-induced atopic dermatitis (AD) mouse model, it was found that administration of a mixture of heat-killed Lactococcus lactis subsp. cremoris MP01 and Lactobacillus paracasei subsp. paracasei MP02 relieved AD symptoms, decreased serum IgE concentration, and rebalanced the population of Th1/Th2 cells in the spleen.
Review
Immunology
Anni Xie, Ailing Chen, Yuqing Chen, Zichen Luo, Shanyu Jiang, Daozhen Chen, Renqiang Yu
Summary: Atopic dermatitis is a chronic inflammatory skin disease with itching and swelling. Probiotics, especially certain strains of Lactobacillus, can provide a safe and effective way to treat and prevent AD by regulating the immune system and improving gut health.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)