Article
Dermatology
Rakhavi P. Manimaran, Sivaranjini Ramassamy, Medha Rajappa, Laxmisha Chandrashekar
Summary: This study evaluated the effectiveness of DPCP in alopecia areata and identified prognostic factors and biomarkers associated with clinical response. The results showed that DPCP can reduce levels of specific cytokines and promote hair regrowth.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Maryam Nasimi, Robabeh Abedini, Narges Ghandi, Fatememasume Manuchehr, Amirmasoud Kazemzadeh Houjaghan, Safoura Shakoei
Summary: The study found that most alopecia areata (AA) patients perceive their disease as long-lasting and having a timely variable, negatively affecting their lives. Patients relatively accepted their illness but the disease had significant negative effects on their emotions.
DERMATOLOGIC THERAPY
(2021)
Review
Dermatology
Kun-Wei Lai, Tsen-Fang Tsai
Summary: Contact immunotherapy plays a significant role in the treatment of skin diseases, including extensive alopecia areata, melanoma, infectious, neoplastic, and inflammatory conditions. This review summarizes the current evidence and discusses the mechanism, prognosis prediction, efficacy, and safety of contact immunotherapy.
DERMATOLOGY AND THERAPY
(2022)
Article
Medicine, Research & Experimental
Pejman Kokhabi, Sahar Dadkhahfar, Reza M. Robati
Summary: Alopecia areata is an autoimmune and inflammatory hair follicle disorder. Metformin, with its anti-inflammatory and immunomodulatory properties, has shown efficacy in managing autoimmune conditions and promoting hair growth. Therefore, topical application of metformin may be beneficial in treating alopecia areata.
MEDICAL HYPOTHESES
(2023)
Review
Chemistry, Medicinal
Thipprapai Mahasaksiri, Chaninan Kositkuljorn, Tanaporn Anuntrangsee, Poonkiat Suchonwanit
Summary: Treatment of extensive or recalcitrant alopecia areata remains a major clinical challenge, with no FDA-approved medication available yet. Topical immunotherapy, including substances like dinitrochlorobenzene, squaric acid dibutylester, and diphenylcyclopropenone, has shown efficacy in treatment, but the mechanism and clinical outcomes are still not well-understood.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Dermatology
Eirini Kyrmanidou, Zoi Apalla, Triantafyllia Koletsa, Eleni Sotiriou, Demetrios Ioannides, Christina Fotiadou, Stavros Chatzopoulos, Christina Kemanetzi, Elisavet Lazaridou
Summary: Topical immunotherapy with DPCP is effective for treating alopecia areata, with a response rate associated with perifollicular infiltrate of T regulatory cells.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Marta Muscianese, Francesca Magri, Pierpaolo Leoncini, Maria Caterina Fortuna, Gemma Caro, Alfredo Rossi
Summary: The study evaluated the safety and efficacy of brevilin A in treating AA patients, showing potential benefits in multifocal AA patients but no significant improvement in overall severity of AA patients. Further studies are needed to explore the potential of brevilin A as an effective treatment for multifocal AA forms.
DERMATOLOGIC THERAPY
(2021)
Article
Multidisciplinary Sciences
Anna Waskiel-Burnat, Anna Niemczyk, Paulina Chmielinska, Marta Muszel, Michal Zaremba, Adriana Rakowska, Malgorzata Olszewska, Lidia Rudnicka
Summary: This study compares the levels of adipokines lipocalin-2 and visfatin, as well as metabolic markers, between patients with alopecia areata and healthy controls. The results show significantly higher levels of lipocalin-2, insulin, and other markers in patients with alopecia areata, and a positive correlation with the number of hair loss episodes and body mass index.
Article
Multidisciplinary Sciences
Anna Stochmal, Anna Waskiel-Burnat, Sylwia Chrostowska, Michal Zaremba, Adriana Rakowska, Joanna Czuwara, Lidia Rudnicka
Summary: The study found significantly lower concentrations of adiponectin and resistin in patients with alopecia areata compared to healthy controls, with a negative correlation between adiponectin levels and hair loss severity. Adiponectin concentrations were significantly lower in patients with alopecia universalis than in those with patchy alopecia areata. The results suggest that adiponectin may serve as a marker of hair loss severity in patients with alopecia areata.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Amany Nassar, Mona Elradi, Mona Radwan, Waleed Albalat
Summary: This study compared the efficacy of three different treatments for localized alopecia areata, and found that the combination of vitamin D analogues with potent steroids was more effective and had less side effects compared to superpotent steroids. This suggests that combined treatment with vitamin D analogues and potent steroids is a more convenient and beneficial approach for localized alopecia areata.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Chemistry, Medicinal
Breno N. Matos, Ana Luiza Lima, Camila O. Cardoso, Marcilio Cunha-Filho, Tais Gratieri, Guilherme M. Gelfuso
Summary: This study prepared polymeric and lipidic nanoparticles (PNPs and NLCs) co-entrapping minoxidil and betamethasone for follicular drug delivery. The nanoparticles showed suitable size and thermal stability, significantly increasing the penetration of minoxidil and betamethasone into the hair follicles and delivering higher concentrations of betamethasone. The nanoparticles are suitable for topical therapy and effectively target the hair follicles.
Article
Dermatology
Hesham Ali Shokeir, Anas Yousry, Shady Mahmoud Attia Ibrahim
Summary: A study comparing the effects of fractional Er:YAG laser with topical steroids against alopecia areata found significant clinical improvement in both treatment modalities, with a more pronounced reduction in SALT score observed in the laser-steroid group. Dermoscopy findings also showed a significant reduction in all dermoscopic features of alopecia areata in both treatment modalities. Combining fractional Er:YAG laser with topical steroids was found to be a safe and more effective treatment modality for alopecia areata.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Review
Dermatology
Sarah Benton, Ronda Farah, Rebecca Freese, Maria Hordinsky
Summary: This study evaluated the safety and efficacy of off-label use of tofacitinib in treating alopecia areata. The results showed that tofacitinib was safe, effective, and practical for the cohort of 35 patients, with most experiencing significant scalp regrowth.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Dalia Mahmoud Toma, Rabie Bedir Atallah, Ramadan Mohamed Eldahshan
Summary: This study evaluated the efficacy of 1% methotrexate gel and 5% minoxidil gel in treating localized alopecia areata (AA). The results showed no significant difference between the two treatments based on clinical and dermoscopic examination, indicating that both topical methotrexate gel and topical minoxidil gel are effective in treating localized AA.
DERMATOLOGIC THERAPY
(2022)
Review
Dermatology
Jiaping Zhu, Rui Qiao, Yufen Li, Xuemei Lan, Xiangdong Gong, Yiqun Jiang
Summary: Diphenylcyclopropenone topical immunotherapy is an effective treatment for various types of alopecia areata, with a high rate of hair regrowth and acceptable common side effects.
DERMATOLOGIC THERAPY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Amira Abdelwhab, Olfat Shaker, Reham Lotfy Aggour
Summary: This study evaluated the expression level of mucin1 in saliva and its correlation with clinical and histological variables in oral potentially malignant disorders and oral squamous cell carcinoma patients. The results showed that mucin1 expression in saliva was significantly elevated in both oral potentially malignant disorders and oral squamous cell carcinoma patients compared with controls, and it correlated with the severity and metastasis of the diseases. These findings suggest that mucin1 in saliva may serve as a potential biomarker for diagnosing these oral diseases.
Article
Multidisciplinary Sciences
Samy A. Abdelazim, Olfat G. Shaker, Yehya Aly Hussein Aly, Mahmoud A. Senousy
Summary: This study aimed to explore serum miR-17, miR-363, MALAT-1, and HOTAIR as potential biomarkers of preeclampsia (PE) risk, onset, and severity. The results showed that miR-17, miR-363, and MALAT-1 could be new biomarkers for PE diagnosis, and miR-363 may be associated with early-onset PE, while downregulation of MALAT-1 correlates with PE severity.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Ebtsam Hamed Khalil, Olfat G. Shaker, Nabil A. Hasona
Summary: Cancer is a major public health issue globally, and this study aimed to investigate the role of LncRNA H-19 rs2107425 and miR-200a in colorectal cancer susceptibility and correlation in patients with CRC.
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2023)
Article
Cell Biology
Rana Aldabbas, Olfat G. Shaker, Manal F. Ismail, Nevine Fathy
Summary: This study identified the downregulation of miRNA-559 and upregulation of MTDH in psoriatic patients. The levels of PTEN, AKT, and FOXO1 were also found to be significantly altered in psoriasis. miRNA-559 and MTDH may serve as potential diagnostic biomarkers for psoriasis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Letter
Dermatology
Mohammed Hussein Medhat EL-Komy, Khadiga S. S. Sayed, Wedad Z. Z. Mostafa, Olfat Shaker, Nada Nasser, Mohammed Hassan
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ghada Ayeldeen, Olfat G. Shaker, Ahmed M. Khairy, Asharef Y. Elfert, Nabil A. Hasona
Summary: Obesity is associated with a higher risk of colorectal cancer, and chronic inflammation plays a role in this association. The study examines the clinical relevance of microRNA expression and TGF-beta/IL-6 axis in obesity-related colorectal cancer. Diseased individuals showed increased expression of IL-6 and TGF-beta, as well as tumor biomarkers. Obese patients with colorectal cancer had lower expression of microRNAs and a negative correlation with BMI.
NON-CODING RNA RESEARCH
(2023)
Article
Multidisciplinary Sciences
Christine Raouf George Mikhail, Abeer Abd El Maksoud Mohamed, Olfat Gamil Shaker, Eman EL Desouky, Rania Hassan Shalaby
Summary: This study suggests that middle income, previous history of H. pylori, and clinical symptoms of dyspepsia are risk factors for oral H. pylori infection. The prevalence of H. pylori infection in Egypt has declined.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Sameh Fayek GamalEl Din, Olfat Gamil Shaker, Ahmad Fawzy Megawer, Mohamed Ahmed Abdel Salam, Abdelhalim Nabil Abdelhalim, Ahmed Adel
Summary: This study compared the levels of Gal-1 and Gal-3 in seminal plasma and serum between azoospermic patients and fertile men. The results showed significantly higher levels of Gal-1 and Gal-3 in the serum and seminal fluid of azoospermic patients. In healthy individuals, there were significant correlations between these levels and age and reproductive hormones.
ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA
(2023)
Article
Chemistry, Multidisciplinary
Abeer Abd Elmoneam Ali, Salwa M. El-Hallouty, Mohammed Ali El-Desouky
Summary: This study aimed to investigate the role of Punica granatum and Persea Americana extracts in decreasing the neurodegenerative effects of AlCl3 toxicity. The results showed that the treatment with Punica granatum and Persea Americana extracts alleviated the adverse effects of AlCl3 and enhanced dopamine levels while reducing apoptotic markers.
EGYPTIAN JOURNAL OF CHEMISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Naglaa Mohamed El-Wakeel, Zienab Farid Shalaby, Rania Farouk Abdulmaguid, Sally Said Abd Elhamed, Olfat Shaker
Summary: This study aimed to investigate the levels of prolactin (PRL) in gingival crevicular fluid (GCF), synovial fluid, and serum in patients with moderately active rheumatoid arthritis (RA) with and without periodontitis (P). The study found that patients with periodontitis had higher levels of PRL in GCF and serum, and non-surgical periodontal treatment could reduce these levels.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Medicine, Research & Experimental
Maysa M. Haroon, Gehan A. Hegazy, Mohammed A. Hassanien, Olfat Shaker, Wafaa H. Hussein
Summary: IL23 levels are significantly elevated in SLE patients compared to healthy individuals and are positively correlated with disease activity and parameters of nephritis. Further research is needed to explore its exact role in SLE pathogenesis and its potential as a biomarker or therapeutic target.
BIOLOGICS-TARGETS & THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Elsayed Fouad, Mohamed Abd El-Moneim, Mahmoud El-Desouky, W. I. El-Dougdoug
Summary: New chitosan derivatives were synthesized and evaluated as corrosion inhibitors for mild steel in acidic medium. The inhibition efficiency of these derivatives was found to be high and they were capable of forming a protective film to reduce the corrosion rate.
EGYPTIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ahmed Abdel-Aziz, Mahmoud El-Fransawy, Mahmoud El-Desouky, Rasha A. El-Sadany
Summary: This study investigates the effects of gamma radiation on normal weight concrete and heavyweight concrete, as well as the possibility of replacing steel bars with carbon glass fiber reinforced polymer bars. The results show that heavyweight concrete mixed with barite and ilmenite has better radiation properties than normal weight concrete, and carbon glass fiber bars can safely replace steel bars in structures exposed to gamma radiations.
EGYPTIAN JOURNAL OF CHEMISTRY
(2023)