Article
Dermatology
Alexander Hines, Richard Butterfield, Blake Boudreaux, Puneet Bhullar, Kevin J. Severson, Robert D. McBane, Mark D. P. Davis, Mark R. Pittelkow, Aaron R. Mangold, Afsaneh Alavi
Summary: Ulcerated NL is more likely to be painful, develop lesion-associated malignancy, and be larger in size compared to non-ulcerated NL. There were no statistically significant differences in venous insufficiency, arterial Doppler/ankle brachial index, or TcPO2 values between ulcerated and non-ulcerated NL patients, however, a significant portion of the cohort demonstrated abnormal vascular studies, particularly on TcPO2 and venous insufficiency testing.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Emma Johnson, Meera H. Patel, Caitlin M. Brumfiel, Kevin J. Severson, Puneet Bhullar, Blake Boudreaux, Richard J. Butterfield, David J. DiCaudo, Steven A. Nelson, Mark R. Pittelkow, Aaron R. Mangold
Summary: This study reveals that there are distinct histopathologic features of necrobiosis lipoidica (NL) in patients with and without diabetes mellitus (DM). Diabetic patients are more likely to have epidermal acanthosis, while non-diabetic patients are more likely to have naked granulomas and eosinophil infiltration.
JOURNAL OF CUTANEOUS PATHOLOGY
(2022)
Review
Dermatology
Anna Schiefer-Niederkorn, Birgit Sadoghi, Barbara Binder
Summary: Necrobiosis lipoidica (NL) is a rare chronic granulomatous disease characterized by plaques on the shins. NL in children is extremely rare, but treatment can be challenging due to resistance to therapy and other complications. This review analyzed 29 reports of NL in children aged <18 years and found that potent topical steroids are the first-line treatment. For refractory cases, tacrolimus and phase-adapted wound care may be used. Further treatment options include hyperbaric oxygenation, photochemotherapy, and systemic treatments. The treatment failure rate for NL in childhood is 40%, indicating the need for further research.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Review
Dermatology
Aman Nihal, Avrom S. Caplan, Misha Rosenbach, William Damsky, Aaron R. Mangold, Bridget E. Shields
Summary: This review provides a comprehensive summary of recently published treatments for NL. The existing data comes predominantly from case reports and series, and more randomized controlled trials are needed to evaluate treatment efficacy.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Maryellen Blevins
Summary: Necrobiosis lipoidica is a granulomatous skin condition commonly associated with diabetes, with a low incidence rate. The cause of the disease is still unclear, and although topical steroids are widely accepted for treatment, the effect of glucose control is still debated.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Review
Medicine, General & Internal
Samir Shrestha, Natalia Spierings, Suchana Marahatta
Summary: The traditional method for diagnosing NL is through Histopathological Examination (HPE). This case report suggests an alternative noninvasive approach using dermoscopy to confirm the condition and differentiate it from other granulomatous skin conditions.
CLINICAL CASE REPORTS
(2021)
Article
Dermatology
Cornelia Erfurt-Berge, Veronika Heusinger, Finja Reinboldt-Jockenhofer, Joachim Dissemond, Regina Renner
Summary: This study evaluated the therapeutic approaches and efficacy for 98 patients with NL. Common comorbidities included diabetes and thyroidal disorders. Topical steroids were predominantly used, while systemic application of fumaric acid esters and dapsone showed remarkable efficacy as alternatives to the use of steroids.
Review
Medicine, General & Internal
Mina Saber, Fatemeh Mohaghegh, Parisa Mohammadian
Summary: Perforating necrobiosis lipoidica is a rare variant of the disease that mainly affects diabetic patients and can be easily identified using dermoscopy.
CLINICAL CASE REPORTS
(2023)
Article
Dermatology
Hamideh Moravej, Ali Forghanian, Sahar Dadkhahfar, Nikoo Mozafari
Summary: Comparing the safety and efficacy of intralesional triamcinolone and bleomycin in the treatment of hypertrophic scars and keloids, the study found no significant difference in clinical improvement and level of lesion flattening between the two treatments, but bleomycin had more adverse events.
DERMATOLOGIC THERAPY
(2022)
Review
Engineering, Biomedical
Ali Rajabi-Estarabadi, Divya J. Aickara, Melanie Hirsch, Natalie M. Williams, Eric L. Maranda, Evangelos Van Badiavas
Summary: Necrobiosis lipoidica (NL) is a rare skin disorder involving collagen degeneration. Various light and laser therapies have been used for its treatment, with PUVA, ALA-PDT, and MAL-PDT being the most widely studied modalities and pulsed dye laser showing consistent successful outcomes.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Dermatology
Enayat Attwa, Mohamed H. Khater, Heba M. Selim, Reham Essam
Summary: This study compared the efficacy and safety of intralesional triamcinolone and 5-FU in the treatment of plaque psoriasis, finding that intralesional triamcinolone may be more effective with less side effects than 5-FU.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Samantha J. Palomares, Aaron S. Farberg
Summary: Necrobiosis lipoidica (NL) is a chronic granulomatous disorder of the skin that commonly causes red papules and plaques on the lower extremities. NL is associated with diabetes mellitus, but the exact cause is unknown. NL is difficult to treat, and options often rely on limited case reports. We present a successful case of treating NL using tapinarof cream, a novel anti-inflammatory agent targeting multiple pathways without serious adverse reactions.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Review
Pharmacology & Pharmacy
L. di Bartolomeo, L. Macca, A. Motolese, C. Guarneri, F. Guarneri
Summary: Necrobiosis lipoidica is a rare chronic skin disease, mostly associated with diabetes mellitus, characterized by typical plaques on the shins, with ulcerative forms seen in some cases. A case with atypical presentation prompted a review of relevant literature.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Dermatology
Niti Tawaranurak, Pitchaya Pliensiri, Krongthong Tawaranurak
Summary: The combination of fractional CO2 laser with topical triamcinolone (TA) has a similar therapeutic effect on keloids compared to intralesional TA. However, the combination treatment can better reduce scar volume and significantly decrease Vancouver Scar Scale (VSS) scores. It is an alternative and effective option for the treatment of keloids.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Dermatology
Sarah N. Rimmer, Rithi J. Chandy, Danyaal Khan, Steven R. Feldman
Summary: Hypertrophic scars and keloids are pathologic scars caused by genetic and inflammatory factors. Various methods are used to treat these scars, including intralesional agents, cryotherapy, surgical excision, pressure dressings, topical agents, laser resurfacing, radiotherapy, and investigational therapies. Combination therapy using intralesional agents, such as triamcinolone, 5-fluorouracil, verapamil, bleomycin, and botulinum toxin, has shown superior results compared to monotherapy.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lijia Cheng, Ahmad Taha Khalaf, Tianchang Lin, Ling Ran, Zheng Shi, Jun Wan, Xin Zhou, Liang Zou
Article
Biotechnology & Applied Microbiology
Ahmad Taha Khalaf, Yonghong Sun, Fang Wang, Minmin Sheng, Yan Li, Xiaoming Liu
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Education, Scientific Disciplines
Lifeng Wang, Ahmad Taha Khalaf, Dongyu Lei, Mengke Gale, Jing Li, Ping Jiang, Jing Du, Xuehereti Yinayeti, Mayinuer Abudureheman, Yuanyuan Wei
ADVANCES IN PHYSIOLOGY EDUCATION
(2020)
Article
Multidisciplinary Sciences
Lijia Cheng, Tianchang Lin, Ahmad Taha Khalaf, Yamei Zhang, Hongyan He, Liming Yang, Shuo Yan, Jiang Zhu, Zheng Shi
Summary: The study developed an artificial bone material with excellent mechanical properties and good osteogenic capability, which showed better bone tissue regeneration and repair effects in mice compared to the control group. The CTC composites have proven to be a promising option for orthopedic patients.
SCIENTIFIC REPORTS
(2021)
Review
Biotechnology & Applied Microbiology
Ahmad Taha Khalaf, Yuanyuan Wei, Sadiq Jaafir Aziz Alneamah, Sarmad Ghazi Al-Shawi, Samiah Yasmin Abdul Kadir, Jamaludin Zainol, Xiaoming Liu
Summary: Nutraceuticals are gaining significance for their safety and potential nutritional benefits, with pharmaceutical and dietary companies seeking financial success while promoting healthier consumer choices like heart-oriented value-added products. Despite claims of therapeutic benefits, many nutraceuticals lack substantial evidence to support their advantages, and further research is needed to validate their potential health benefits. Studies indicate that functional foods contain physiologically active components that offer various health benefits, with some foods playing a key role in the primary prevention of diseases and conditions that may lead to the identification of functional foods. Further research and studies are needed to establish the relationship between diet and health and validate the health benefits of various functional foods yet to be clinically proven.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Integrative & Complementary Medicine
Yuanyuan Wei, Ahmad Taha Khalaf, Peng Ye, Wei Fan, Junyi Su, Wanlu Chen, Hao Hu, Rashid Menhas, Lifeng Wang, Zahraa Oglah
Summary: Pomegranate flower extract is beneficial for hyperglycemia and has a vasodilatory effect. It works by enhancing the synthesis of nitric oxide (NO), blocking potassium ion (K+) channels, and inhibiting the entry of extracellular calcium ion (Ca2+).
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Biology
Ahmad Taha Khalaf, Yuanyuan Wei, Jun Wan, Jiang Zhu, Yu Peng, Samiah Yasmin Abdul Kadir, Jamaludin Zainol, Zahraa Oglah, Lijia Cheng, Zheng Shi
Summary: Trauma and bone loss pose significant challenges in orthopedic, craniofacial, and plastic surgeries. The combination of 3D-printed bone tissue engineering scaffolds with stem cells has shown promising results. Bioceramic scaffolds are a promising solution. Advancements in 3D printing technology allow for the simulation of mechanical and biological properties of bone tissue and the printing of complex structures. This article reviews the current methods in orthopedic bioprinting technology and discusses the challenges and prospects in this field.
Review
Green & Sustainable Science & Technology
Ahmad Taha Khalaf, Yuanyuan Wei, Jun Wan, Samiah Yasmin Abdul Kadir, Jamaludin Zainol, Hua Jiang, Ahmed N. Abdalla
Summary: Since the declaration of the COVID-19 pandemic by the WHO in January 2020, there has been a global interest in understanding its impact on people and the environment. The pandemic resulted in unprecedented measures such as air traffic halt, factory closures, and transportation stoppages, leading to a positive effect on air pollution and carbon dioxide emissions. The concept of sustainability has gained more importance, emphasizing the responsibility of every individual towards future generations' survival. This article summarizes and discusses studies documenting the effects on health and the environment globally and provides recommendations to promote sustainability.
Review
Biochemistry & Molecular Biology
Yuanyuan Wei, Ahmad Taha Khalaf, Cao Rui, Samiah Yasmin Abdul Kadir, Jamaludin Zainol, Zahraa Oglah
Summary: Integral membrane proteins, called TRP channels, act as cellular sensors in various systems, and their sequence similarity classifies them into nine subfamilies, providing a wide range of physiological functions. Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer. Despite the difficulty in studying human tissue samples, recent research has made progress in understanding the molecular mechanisms of TRP channel disturbance. This review summarizes the current understanding of TRP channels' role in the development and progression of pancreatic ductal carcinoma, aiming to identify potential therapeutic interventions.
Article
Medicine, General & Internal
Saeid Reza Doustjalali, Negar Shafiei Saber, E. B. Rowena, V. S. Shakthi, A. H. S. Muhammad, S. Asma, L. C. F. Clement, Nyan Htain Linn, Khin Thant Zin, S. Saravana Kumar, Hlaing Thaw Dar, Khin Thane Oo, Rebecca S. Y. Wong, W. W. L. Su, Noraasyikin Ramli, Shushan Low, Muftah Abdusalam Elbahloul, Ahmad Yusuf, Mohd Nasir Mohd Desa, M. H. M. Nazmul, Karim Al-Jashamy, Ahmad Taha Khalaf, Jamal Hussaini
Summary: The study revealed that Malay males and females had the highest BMI values, while Indians had the highest mean value of systolic blood pressure. Indian males and Chinese females had the highest mean value of diastolic blood pressure. There was a statistically significant correlation between BMI and blood pressure among overall participants, male participants, and female participants.
PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
(2021)
Article
Medicine, General & Internal
Saeid Reza Doustjalali, Negar Shafiei Sabet, E. B. Rowena, V. S. Shakthi, A. H. S. Muhammad, S. I. Asma, L. C. F. Clement, Nyan Htain Linn, Khin Thant Zin, S. Saravana Kumar, Hlaing Thaw Dar, Khin Thane Oo, Rebecca S. Y. Wong, W. W. L. Su, Noraasyikin Ramli, Shushan Low, Muftah Abdusalam Elbahloul, Ahmad Yusuf, Mohd Nasir Mohd Desa, M. H. M. Nazmul, Karim Al-Jashamy, Ahmad Taha Khalaf, Jamal Hussaini
Summary: The study found that Malay males and females had the highest BMI values, followed by Chinese and Indians in males, but in females, it was followed by Indians and Chinese. Indians had the highest mean value of systolic blood pressure in both genders, followed by Malays and Chinese. Indian males and Chinese females had the highest mean value of diastolic blood pressure.
PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
(2021)
Article
Medicine, General & Internal
Saeid Reza Doustjalali, Negar Shafiei Sabet, Muhammadefs, Aly-Ahmed Amm, Saniyab, K. Sreemathi, Abdulazizaz, Nyanhtain Linn, Khin Thant Zin, S. Saravana Kumar, Hlaing Thaw Dar, Khin Thane Oo, Rebecca Sy Wong, W. W. L. Su, Noraasyikin Ramli, Shushan Low, Muftahabdusalam Elbahloul, Ahmad Yusuf, Mohd Nasir Mohd Desa, Nazmul Mhm, Karim Al-Jashamy, Ahmad Taha Khalaf, Jamal Hussaini
PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
(2020)
Meeting Abstract
Pharmacology & Pharmacy
Ahmad Taha Khalaf, Jun Wan
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2020)
Article
Pharmacology & Pharmacy
Ahmad Taha Khalaf, Jun Wan, Karim Al-Jashamy, Samiah Yasmin Abdul Kadir, Jamaludin Zainol, Saeid Reza Doustjalali, Negar Shafiei Sabet, May Kyi Aung, Yassin Hani Arafeh, Jessica Lok Xia Shin, Izzatul Akmal Binti Sahrom, A. E. Muftah
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
(2019)
Meeting Abstract
Pharmacology & Pharmacy
Liu Yao, Hai Tao, Jiang Ming Xin, Ahmed N. Abdalla, Ahmad Taha Khalaf
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2019)
