Article
Pathology
Thibault Kervarrec, Anne Tallet, Nicolas Macagno, Arnaud de la Fouchardiere, Daniel Pissaloux, Franck Tirode, Ignacio G. Bravo, Alain Nicolas, Sylvain Baulande, Pierre Sohier, Brigitte Balme, Amelie Osio, Marie-Laure Jullie, Isabelle Moulonguet, Benjamin Bonsang, Emilie Tournier, Michael Herfs, Eric Frouin, Anoud Zidan, Eduardo Calonje, Patricia Berthon, Antoine Touze, Alice Seris, Laurent Mortier, Thomas Jouary, Bernard Cribier, Maxime Battistella
Summary: This study genetically characterized acral sweat gland tumors and identified various oncogenic drivers and genetic alterations. The findings are valuable for the diagnosis of rare and difficult-to-determine tumors in this group.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Engineering, Biomedical
Xingyu Yuan, Xianlan Duan, Enhejirigala, Zhao Li, Bin Yao, Wei Song, Yuzhen Wang, Yi Kong, Shijun Zhu, Fanliang Zhang, Liting Liang, Mengde Zhang, Chao Zhang, Deling Kong, Meifeng Zhu, Sha Huang, Xiaobing Fu
Summary: The incorporation of vasculature is crucial for tissue or organ functional regeneration. This study investigated the interaction between epidermal appendages and their vascular niches, specifically in the context of sweat gland development and maintenance. Using 3D bioprinting and sacrificial templates, the researchers successfully replicated this interplay in vitro and in vivo, leading to physiologically relevant vascularized glandular morphogenesis. They also identified a reciprocal regulatory mechanism involving contact-independent cell communication and direct cell-cell interactions between sweat glands and the vasculature.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Tomer Rosen, Elizabeth M. Nolan
Summary: Human S100A12 is a Zn(II)-sequestering protein that can interfere with Mn(II) acquisition by capturing Zn(II) ions from PsaA and MntC. EPR spectroscopy shows that S100A12 promotes Mn(II) binding to SBPs by sequestering Zn(II) from Zn(II)-bound PsaA and MntC.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Carmen Costas-Ferreira, Lilian R. F. Faro
Summary: Pesticides from different chemical classes exert toxic effects on the nervous system by altering calcium homeostasis, leading to oxidative stress, neuroinflammation, and ultimately neuronal death. Proposed strategies to counteract these effects are also discussed in the review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pathology
Keisuke Goto, Yoji Kukita, Keiichiro Honma, Nobuyuki Ohike, Takaya Komori, Yoshihiro Ishida, Misawo Ishikawa, Takashi Nakatsuka, Soichi Fumita, Koichi Nakagawa, Aya Okabayashi, Yoshifumi Iwahashi, Tomoyuki Tanino, Keisuke Kikuchi, Yoshie Kawahara, Tsunekazu Hishima, Jiro Uehara, Takuma Oishi, Taiki Isei
Summary: LGNECS, proposed in 2017, is a rare skin tumor with neuroendocrine differentiation, renamed as SCAND. Most cases show intraepidermal pagetoid spreading and stromal mucin deposits. Tumor size may be a better prognostic factor than nuclear atypia, mitotic count, and Ki67 index.
Article
Oncology
Giancarlo Pecorari, Claudia Pizzo, Marco Briguglio, Ester Cravero, Giuseppe Riva
Summary: This retrospective study evaluated the clinical features and prognosis of malignant epithelial tumors of the parotid gland, comparing primary and secondary cancer and performing survival analyses. The results showed that secondary cancer had worse survival than primary tumors, highlighting the need for multimodality treatment to improve outcomes.
Article
Biochemistry & Molecular Biology
Michio Yamashita, Junko Shibato, Randeep Rakwal, Naoko Nonaka, Takahiro Hirabayashi, Brian J. Harvey, Seiji Shioda, Fumiko Takenoya
Summary: Sweat plays a critical role in thermoregulation and skin health. Abnormalities in sweat secretion can lead to excessive sweating and anhidrosis. PACAP has been identified as a potential regulator of sweat secretion and translocation of AQP5 in sweat glands. Understanding the signaling mechanisms of PACAP can contribute to the development of new therapies for sweating disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Soo-Bin Cheon, Wan Hee Kim
Summary: This study evaluated the expression of the SLUG gene in canine mammary gland tumors (MGTs) and found that its upregulation is associated with poor prognosis. These results suggest that SLUG protein may serve as a novel biomarker and therapeutic target for canine patients with MGT.
BMC VETERINARY RESEARCH
(2023)
Article
Medicine, General & Internal
Despoina Pouloudi, Maria Manou, Panagiotis Sarantis, Nikolaos Tsoukalas, Gerasimos Tsourouflis, Eougken Dana, Michalis V. Karamouzis, Jerzy Klijanienko, Stamatios Theocharis
Summary: This study explored the immunohistochemical expression of HDAC-1, -2, -4, and -6 in SGTs and their potential as prognostic biomarkers. The results indicated that HDAC-2 expression was associated with longer overall survival in patients with malignant SGTs, while HDAC-2 positivity and absence of HDAC-6 expression were related to prolonged survival in patients with high-grade malignant SGTs. Moreover, high HDAC-2 expression was significantly associated with longer overall survival in high-grade malignant SGT patients.
Article
Biochemistry & Molecular Biology
Guilherme G. G. Moreira, Claudio M. Gomes
Summary: The S100B protein has been found to regulate tau LLPS by interacting with tau and preventing aggregation, reducing toxicity. Additionally, S100B protein regulates tau LLPS by interacting with metal ions and crowding agents. This study uncovers the importance of S100B as a proteostasis regulator in neurodegenerative diseases.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Pathology
Marie Csanyi-Bastien, Marie-Delphine Lanic, Ludivine Beaussire, Sandra Ferric, Arnaud Francois, Didier Meseure, Fabrice Jardin, Michel Wassef, Philippe Ruminy, Marick Lae
Summary: The study aimed to evaluate the utility of pan-TRK immunohistochemistry in distinguishing secretory carcinoma (SC) from other salivary gland tumors, with nuclear pan-TRK staining showing high specificity for SCs with ETV6-NTRK3 fusion. Pan-TRK staining serves as a strong diagnostic marker to distinguish SC from its mimics and select patients eligible for TRK inhibitor clinical trials.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Chemistry, Medicinal
Jufeng Sun, Joey I. Ambrus, Jennifer R. Baker, Cecilia C. Russell, Peter J. Cossar, Jennette A. Sakoff, Christopher J. Scarlett, Adam McCluskey
Summary: Virtual screening identified a lead compound that bound to the S100A2-p53 binding groove and inhibited the growth of pancreatic cancer cell line. Focused compound libraries were developed to explore the structure-activity relationship of this compound class. The observed docking poses and binding scores supported the hypothesis that these analogues function via S100A2-p53 binding groove inhibition.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Angelo Mandarino, Swetha Thiyagarajan, Allana C. F. Martins, Roberto da Silva Gomes, Stefan W. Vetter, Estelle Leclerc
Summary: Pancreatic cancer is difficult to treat, and S100 proteins and HMGB1 protein play important roles in the tumorigenesis process. By analyzing the transcript levels of 13 cancer-related S100 genes and HMGB1 in 19 pancreatic cancer tumor samples and 8 human pancreatic cancer cell lines, statistically significant positive correlations were found in 5.5% (5 out of 91) and 37.4% (34 of 91) of the possible S100/S100 or S100/HMGB1 pairs in cells and tumors, respectively. These findings suggest that S100 proteins may interact with each other and with HMGB1, providing valuable insights for further characterization of pancreatic tumors based on S100 and HMGB1 transcription profiles.
Article
Chemistry, Analytical
Xiaohe Wang, Anwei He, Bo Yu, Liang Zhang, Wei Pang, Haolong Zhang, Pengfei Niu
Summary: This study clarifies the chemical compositions and distributions of sweat fouling, providing insights into resolving the problem of limited continuity in wearable sweat sensors.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jufeng Sun, Jennifer R. Baker, Cecilia C. Russell, Hong N. T. Pham, Chloe D. Goldsmith, Peter J. Cossar, Jennette A. Sakoff, Christopher J. Scarlett, Adam Mccluskey
Summary: Four focused libraries were designed and synthesised based on an in silico modelling driven hypothesis. Modifications of the phenylacetamide and 3-OCH3Ph moieties led to the discovery of more active analogues against pancreatic cancer cell lines. Alkyl moieties resulted in more potent analogues, while benzenesulfonamide replacements were less active. Two additional analogues showed sub-micromolar potencies against pancreatic cancer cell lines.
RSC MEDICINAL CHEMISTRY
(2023)