Article
Dermatology
Nermin Ozlen, Deniz Ercetin, Melike Sapmaz-Metin, Ozgur Gunduz
Summary: This study investigated the antipruritic and anti-inflammatory effects of hydrogen sulfide (H2S) in allergic contact dermatitis (ACD). The results showed that sodium sulfide (Na2S) can reduce ear thickness, inhibit the infiltration and proliferation of CD4(+) T lymphocytes, and decrease IL-2 synthesis.
DERMATOLOGICA SINICA
(2023)
Article
Biology
Dominik Nemeth, Gyorgyi Ponyai
Summary: The clinical characteristics of contact hypersensitivity in the elderly patient population were analyzed in this study. Contact dermatitis was the most common diagnosis, followed by psoriasis. The most common contact allergens identified were preservatives, balsam of Peru, and nickel. It is important to conduct patch testing to verify contact hypersensitivity in older individuals, even for conditions such as contact dermatitis, venous stasis dermatitis, rosacea, and atopic dermatitis.
Article
Allergy
Julien Ringuet, Caroline Lajoie, Serge Bourgault, David Simonyan, Marie-Claude Houle
Summary: The study aimed to identify the best method of cutaneous testing and brimonidine concentration for patch testing, with scratch PT proving to be an essential tool and 5% brimonidine concentration demonstrating the highest sensitivity for scratch PT.
CONTACT DERMATITIS
(2022)
Editorial Material
Dermatology
Sarah Fleming, Ian R. White, Louise Cunningham, Karen Eustace
Summary: Hypersensitivity reactions to corticosteroids present a clinical paradox due to their anti-inflammatory and immunomodulatory effects. This case report discusses a patient with positive patch test results to the corticosteroid series.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Puja Upadhaya, Felipe F. Lamenza, Suvekshya Shrestha, Peyton Roth, Sushmitha Jagadeesha, Hasan Pracha, Natalie A. Horn, Steve Oghumu
Summary: Berries and their active constituents have potential therapeutic effects in mitigating contact hypersensitivity (CHS). This study demonstrated that black raspberry extract (BRB-E) and certain natural compounds found in berries can inhibit the activation of dendritic cells (DCs) and reduce the production of proinflammatory cytokines, suggesting potential novel approaches for alleviating CHS.
Article
Immunology
Eva Sanchez Armengol, Aletta Blanka Kerezsi, Flavia Laffleur
Summary: Textile production is one of the most polluting industries worldwide, with chemical waste products posing risks to human health. Medical textiles, such as sutures and dressings, are being developed to aid in patient diagnosis, therapy, and recovery. The future of smart textiles in the medical field holds promising advancements for patient care and treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hannah L. Miller, Prabhakar Sairam Andhey, Melissa K. Swiecki, Bruce A. Rosa, Konstantin Zaitsev, Alexandra-Chloe Villani, Makedonka Mitreva, Maxim N. Artyomov, Susan Gilfillan, Marina Cella, Marco Colonna
Summary: This study revealed that depletion of pDCs in mice through injection of diphtheria toxin can enhance Th2-dependent skin inflammation, independent of reduced IFN-I. Additionally, treatment with DT alters the representation of conventional dendritic cells in the skin-draining lymph nodes, leading to Th2-driven contact hypersensitivity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Farzaneh Agha-Hosseini, Elahe Gholamrezayi, Mahdieh-Sadat Moosavi
Summary: In this study, oral lichen planus patients and healthy subjects were compared using patch tests with saliva, revealing significant differences in allergen reactions. The use of patch tests in OLP cases can help identify positive reactions to dental materials, highlighting the potential need for replacement of dental restorations.
SCIENTIFIC REPORTS
(2021)
Article
Allergy
Sebastian Vigand Svendsen, Carsten Bindslev-Jensen, Charlotte G. Mortz
Summary: The combination of budesonide, hydrocortisone-17-butyrate, and tixocortol-21-pivalate is an effective marker for corticosteroid contact allergy. Supplementary patch testing with corticosteroids is highly recommended for patients with clinical suspicion of corticosteroid contact allergy.
CONTACT DERMATITIS
(2023)
Article
Allergy
Fengxian Li, Changming Wang, Danyou Hu, Xinyu Zhang, Ran Shen, Yuan Zhou, Yan Yang, Chan Zhu, Zongxiang Tang, Guang Yu
Summary: This study provides the first evidence that Mrgprs are involved in ACD-induced chronic itch, with increased expression of MrgprC11 and MrgprA3 in the ACD model. Pharmacological blockade of hMrgprX1 in transgenic mice also significantly attenuated ACD itch.
CONTACT DERMATITIS
(2022)
Article
Allergy
Fabian Gendrisch, Lukas Voelkel, Melanie Fluck, Petya Apostolova, Robert Zeiser, Thilo Jakob, Stefan F. Martin, Philipp R. Esser
Summary: The study demonstrates that contact sensitizers can activate IRE-1 and PERK signaling pathways, leading to the unfolded protein response and ultimately determining inflammatory immune responses in vitro and in vivo. Blocking the unfolded protein response signaling pathway can reduce NF-kappa B activation and cytokine production, and can eliminate contact hypersensitivity responses in vivo.
Article
Obstetrics & Gynecology
Satit Klangsin, Chitkasaem Suwanrath, Saranya Wattanakumtornkul
Summary: Progestogen hypersensitivity is a rare adverse effect of both endogenous and exogenous progestogens. While the etonogestrel implant is highly effective for contraception, there have been reported cases of progestogen hypersensitivity. This case study presents a delayed-type progestogen hypersensitivity with elevated eosinophils against etonogestrel, which resolved after removal of the implant.
Article
Allergy
Toshiya Miyake, Gyohei Egawa, Zachary Chow, Ryota Asahina, Masayuki Otsuka, Saeko Nakajima, Takashi Nomura, Rintaro Shibuya, Yoshihiro Ishida, Satoshi Nakamizo, Teruasa Murata, Akihiko Kitoh, Kenji Kabashima
Summary: The magnitude of adaptive cutaneous allergic response depends on the circadian rhythm, which may improve the management of allergic contact dermatitis in humans.
Article
Pharmacology & Pharmacy
Akimasa Orii, Kohta Kurohane, Kota Sekiguchi, Masato Tsutsumi, Yasuyuki Imai
Summary: The number of allergy sufferers is increasing due to the increasing exposure to chemicals. A study found that tributyrin, a short-chain triacylglycerol (TAG), enhanced contact hypersensitivity in a mouse model. Another study examined the effect of medium-chain triacylglycerols (MCTs) with different side chain lengths on skin sensitization and found that MCTs up to side chain carbon number 10 also have an adjuvant effect on skin hypersensitivity.
Article
Dermatology
Jonathan Silverberg, Alexander Hou, Erin M. Warshaw, Howard Maibach, Donald Belsito, Joel G. DeKoven, Kathryn A. Zug, James S. Taylor, Denis Sasseville, Anthony F. Fransway, Vincent A. DeLeo, Melanie D. Pratt, Margo J. Reeder, Amber R. Atwater, Joseph F. Fowler, Matthew J. Zirwas, James G. Marks
Summary: Nearly half of patients with a final diagnosis of SD were also diagnosed with ACD, indicating the importance of patch testing in select SD patients. Patients with a final SD diagnosis had higher odds of allergic reactions to specific allergens compared to those without a final SD diagnosis. The most common relevant allergens in patients with final SD diagnosis were fragrance mix I, Myroxylon pereirae, bacitracin, quaternium-15, and formaldehyde.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)