Article
Biochemistry & Molecular Biology
Jonah Ee Hsiang Kua, Chun Wei Siow, Wee Keng Lim, Jeyakumar Masilamani, Monica Suryana Tjin, Joe Yeong, Tony Kiat Hon Lim, Toan Thang Phan, Alvin Wen Choong Chua
Summary: Human umbilical cord lining epithelial cells (CLECs) are a natural and ethical source of cells that can be recovered from routinely discarded cords. Using CLECs to treat cutaneous wounds has been shown to be feasible. Flow cytometry and skin organotypic cultures revealed differences in the expression level and location of basal cell markers between CLECs and skin keratinocytes. In a porcine wound model, CLEC application promoted accelerated healing with no adverse reactions. CLECs have the potential to be a non-native and safe source of cells for treating cutaneous wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Santhosh Kacham, Tejal Sunil Bhure, Sindhuja D. Eswaramoorthy, Gaurav Naik, Subha Narayan Rath, Sreenivasa Rao Parcha, Sayan Basu, Virender Singh Sangwan, Sachin Shukla
Summary: Umbilical cord-derived mesenchymal stem cells promote the repair of injured corneal epithelium by stimulating the proliferation of corneal epithelial cells, potentially serving as a non-ocular source of stem cells for treating injury-induced bilateral corneal diseases.
Article
Biochemistry & Molecular Biology
Si-Qi Chen, Xue-Yan Chen, Ying-Zhe Cui, Bing-Xi Yan, Yuan Zhou, Zhao-Yuan Wang, Fan Xu, Yan-Zhou Huang, Yu-Xin Zheng, Xiao-Yong Man
Summary: Recent studies have shown that there are dense sensory nerve fibers in psoriatic lesions, which are closely connected to immune cells and keratinocytes. These nerve fibers play a vital role in the progression of psoriasis. Neurological intervention may be a new treatment strategy for psoriasis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Letter
Cell & Tissue Engineering
Shaoyang Zhang, Jing Yi Wang, Baojie Li, Feng Yin, Huijuan Liu
Summary: UC-MSCs exhibit heterogeneity during in vitro expansion, but single-cell RNA sequencing has identified two distinct populations of freshly isolated UC-MSCs. These populations show different gene expression patterns, suggesting that they may be suitable for treating different diseases.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Reproductive Biology
Meriem Baouche, Agnieszka Krawczenko, Maria Paprocka, Aleksandra Klimczak, Pascal Mermillod, Yann Locatelli, Malgorzata Ochota, Wojciech Nizanski
Summary: This study investigates whether cells derived from the feline umbilical cord exhibit mesenchymal stromal/stem cells (MSCs) characteristics. The results show that MSCs derived from Wharton's jelly have the best proliferation ability, pluripotency gene expressions, and differentiation potential, making them the most valuable for feline regenerative medicine.
Review
Cell Biology
Hanxiao Yin, Mingzheng Hu, Dengwen Li
Summary: The epidermis is a barrier in the outermost layer of the skin that protects against pathogens. Basal keratinocytes, acting as stem cells, are crucial for epidermal development and skin damage recovery. Understanding the molecular mechanism of basal keratinocytes in epidermal development and stratification is important for preventing and treating skin lesions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Cell Biology
Jia Chen, Yuhan Chen, Xue Du, Guojun Liu, Xiaowei Fei, Jian Ru Peng, Xing Zhang, Fengjun Xiao, Xue Wang, Xiao Yang, Zhichun Feng
Summary: CB-MNCs and UC-MSCs show efficacy in alleviating BPD, with CB-MNCs having more pronounced effects in restoring lung function. Through analysis of lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA networks, it was found that therapeutic effects are related to regulation of GTPase activity, ERK signaling cascade, chromosome regulation, and cell cycle control.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Xiaobo Li, Qijing Huang, Xiangxiang Zhang, Changfeng Xie, Muyun Liu, Yueming Yuan, Jianjia Feng, Haoyu Xing, Li Ru, Zheng Yuan, Zhiyong Xu, YaoXiang Yang, Yan Long, Chengfeng Xing, Jianping Song, Xiang Hu, Qin Xu
Summary: The study evaluated the effects of intravenous injection of hUC-MSCs on reproduction and development in rats, finding no significant adverse effects within a certain dosage range, but high doses may lead to mortality in pregnant female rats, highlighting the importance of cautious use.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Mailin Gan, Lin Liu, Shunhua Zhang, Zongyi Guo, Ya Tan, Jia Luo, Qiong Yang, Hongmei Pan, Xuewei Li, Jinyong Wang, Linyuan Shen, Li Zhu
Summary: Differential expression of porcine umbilical cord blood miRNA may have differences in immunity and angiogenesis, with great potential in the treatment of human diseases due to their ability for cross-species transmission. miRNA in cord blood may be beneficial for muscle-related diseases and liver- and brain-related diseases, providing insights for potential applications in mother-fetal communication.
Article
Biochemistry & Molecular Biology
Yunxiuxiu Xu, Yu Lai, Linhui Cao, Yanshan Li, Guangcheng Chen, Liang Chen, Hanqin Weng, Tao Chen, Linyun Wang, Yibiao Ye
Summary: MiR-451a is up-regulated while ADAM10 is down-regulated in HCC cells after co-culture with HucMSC-derived exosomes, leading to suppression of paclitaxel resistance, cell cycle transition, proliferation, migration, invasion, and promotion of apoptosis of HCC cells. ADAM10 is verified to be a target gene of miR-451a, and ADAM10-MUT promotes HCC process independent of miR-451a mimic. HucMSC-derived exosomal miR-451a could restrict the epithelial-mesenchymal transition of HCC cells by targeting ADAM10, providing new targets for HCC treatment.
Review
Biochemistry & Molecular Biology
Adolfo Rodriguez-Eguren, Maria Gomez-alvarez, Emilio Frances-Herrero, Monica Romeu, Hortensia Ferrero, Emre Seli, Irene Cervello
Summary: This literature review analyzes the application of human umbilical cord mesenchymal stem cells (hUC-MSCs) and blood derivatives in the treatment of female infertility. It shows that these alternative therapies have high efficacy in promoting anti-inflammatory and regenerative processes. However, further clinical trials are needed to validate their application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eun Ah Ye, Ho Seok Chung, Yoonkyung Park, Jeong Hye Sunwoo, Whanseo Lee, Jin Kim, Hungwon Tchah, Hun Lee, Jae Yong Kim
Summary: This study demonstrated the differentiation of human umbilical cord-derived mesenchymal stem cells (UC-MSCs) into corneal endothelial cells (CECs). The efficacy of MSC-induced CEC injection was investigated in a rabbit model of corneal endothelial dysfunction (CED). The results showed that MSC-induced CEC injection improved corneal opacity and neovascularization in the rabbit model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Yu-Hsun Chang, V. Bharath Kumar, Yao-Tseng Wen, Chih-Yang Huang, Rong-Kung Tsai, Dah-Ching Ding
Summary: This study demonstrates the successful differentiation of human umbilical cord mesenchymal stem cells (HUCMSCs) into retinal pigment epithelial (RPE)-like cells using a co-culture system. The induced cells showed the characteristic markers and functions of RPE cells, including engulfing photoreceptor outer segments and secreting neurotrophic factors. These findings provide fundamental information for the clinical-scale generation of RPE-like cells from HUCMSCs.
CELL TRANSPLANTATION
(2022)
Review
Cell & Tissue Engineering
Yufeng Xi, Guang Yue, Shuqiang Gao, Rong Ju, Yujia Wang
Summary: Perinatal brain injury is a major cause of death and disability in children. Transplantation of human umbilical cord blood mononuclear cells has shown significant efficacy and safety in animal and clinical trials for the treatment of perinatal brain injury.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Allergy
Niklas Peter, Jutta Lichter, Lina Hagvall, Udo Bock, Brunhilde Bloemeke
Summary: This study evaluates the sensitization potency of fragrance chemicals using a 2D coculture model of keratinocytes and dendritic cells. The results suggest that α,β-unsaturated alcohols are weaker sensitizers compared to their corresponding aldehydes.
CONTACT DERMATITIS
(2023)